Clinical trials: Sexually Transmitted Disease (STD)
HIV Infections
A Study of Dideoxycytidine in HIV-Infected Patients
To determine how much of a dose is absorbed by the body when zalcitabine ( dideoxycytidine; ddC ) is given orally and how long the drug stays in the body after absorption or intravenous (IV) administration.
- Trial name
- NCT00000997
- Testing
- Zalcitabine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lymphoma, Nonneoplastic Condition
S0816 Fludeoxyglucose F 18-PET/CT Imaging and Combination Chemotherapy With or Without Additional Chemotherapy and G-CSF in Treating Patients With Stage III or Stage IV Hodgkin Lymphoma
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00822120
- Testing
- bleomycin sulfate, filgrastim, ABVD regimen
- Where
- 423 sites in United States
- Volunteers
- 371 people
- Sponsor
- SWOG Cancer Research Network
Male Circumcision
Safety Study of the PrePex Device for Non-Surgical Adult Male Circumcision During Phased in National Implementation in an Effort to Prevent the Spread of HIV
It is well known from a range of observational and epidemiological studies that the lifetime risk of acquiring HIV among males can be significantly reduced via circumcision.
- Trial name
- RMC-07 (NCT01921608)
- Testing
- PrePex™ device
- Where
- Rwanda
- Volunteers
- 1,001 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Rwanda
Reproductive Health, Herpesvirus Infection
Cups or Cash for Girls Trial to Reduce Sexual and Reproductive Harm and School Dropout
A 4-armed cluster randomised controlled trial conducted among secondary schoolgirls in Siaya, western Kenya, where clusters are the unit of allocation and schoolgirls the unit of measurement.
- Conditions
- Reproductive Health, Herpesvirus Infection, HIV Infections, Woman Abuse
- Trial name
- CCg (NCT03051789)
- Testing
- Menstrual Cup, Cash transfer, Cups and Cash
- Where
- Kenya
- Volunteers
- 4,138 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
HIV Infections
Maraviroc Immune Recovery Study
Rationale: Improving cellular immunity by means of increasing CD4 cells is one of the goals of antiretroviral therapy in HIV, which is achieved by means of virological suppression.
- Trial name
- MIRS (NCT00875368)
- Testing
- maraviroc
- Where
- 10 sites in Netherlands
- Volunteers
- 85 people
- Sponsor
- S.F.L. van Lelyveld
Squamous Cell Carcinoma of the Oropharynx, Carcinomas of Unknown Primary Site
Observational Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx and Occult Tumors Positive for Papilloma Virus
Based on the evidence summarized in the introduction, the clinician hypothesize that the detection of the presence and expression of HPV-DNA, certain miRNAs, and a certain mutational profile in the tissues and biological fluids…
- Conditions
- Squamous Cell Carcinoma of the Oropharynx, Carcinomas of Unknown Primary Site, High-risk Human Papillomavirus Infection, Liquid Biopsy
- Trial name
- NCT05918510
- Testing
- Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx
- Where
- Italy
- Volunteers
- 142 people
- Sponsor
- Regina Elena Cancer Institute
HIV Infections
A Study of Three Different Anti-HIV Drug Combinations in HIV-Infected Patients
The purpose of this study is to compare the safety and effectiveness of three anti-HIV drug combinations. The three combinations are: (1) efavirenz (DMP 266) plus indinavir; (2) DMP 266 plus zidovudine (ZDV) plus lamivudine…
- Trial name
- NCT00002410
- Testing
- Indinavir sulfate, Lamivudine, Zidovudine
- Where
- 41 sites in United States, Puerto Rico
- Sponsor
- Dupont Merck
HPV InfectioN, HPV-Related Carcinoma
A Phase III Clinical Trial of a 11-valent Recombinant Human Papillomavirus Vaccine (Hansenulapolymorpha) in Chinese Women Aged 18-45 Years
A total of 13500 Chinese women aged 18-45 years old were divided into three age groups: 18-26 years old, 27-35 years old, and 35-45 years old. The experimental group and the placebo group were randomly assigned in a ratio of 1:1.
- Trial name
- NCT05262010
- Testing
- 11-valent recombinant human papilloma virus vaccine (Hansenula polymorpha)
- Where
- 8 sites in China
- Volunteers
- 13,500 people, healthy volunteers welcome
- Sponsor
- National Vaccine and Serum Institute, China
HIV Infections, Hypersensitivity
Predictors of Drug Hypersensitivity in HIV Infected Subjects
A case-control study to look at hypersensitive and tolerant individuals matched for HLA genetic predisposition, when considering predictors of drug hypersensitivity.The study aims to identify the immunological factors increasing…
- Trial name
- NCT00168220
- Where
- Australia
- Sponsor
- The Alfred
Sexually Transmitted Infection
Epidemiology of Sexually Transmitted Infections and Its iMpAcT on fEmale Infertility
A longitudinal study to investigate the prevalence of sexually transmitted infections among young women and determine the role of the female genital tract microbiome in fertility
- Trial name
- ESTIMATE (NCT05244967)
- Testing
- vaginal swab
- Where
- Germany
- Volunteers
- 533 people, healthy volunteers welcome
- Sponsor
- University of Luebeck
Candidiasis, Candidiasis, Esophageal
A Randomized, Prospective, Double-Blind Study Comparing Fluconazole With Placebo for Primary and Secondary Prophylaxis of Mucosal Candidiasis in HIV-Infected Women
To compare the efficacy of fluconazole versus placebo for the prevention of Candida esophagitis and vaginal/oropharyngeal candidiasis, including a comparison of the development of clinical resistance.
- Conditions
- Candidiasis, Candidiasis, Esophageal, HIV Infections
- Trial name
- NCT00000744
- Testing
- Fluconazole
- Where
- 16 sites in United States
- Volunteers
- 400 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV, Aging
Identifying Challenges to Healthy Aging in Persons With Human Immunodeficiency Virus (HIV) Age 50 and Older
The primary objective of this study is to identify and characterize frailty and pre-frailty in persons age 50 and older living with human immunodeficiency virus (HIV) followed by the Atrium Health Wake Forest Baptist Infectious…
- Trial name
- NCT05858034
- Testing
- Customized activity plan, Customized nutrition plan
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University Health Sciences
Cervical Cancer, Hpv
PopSci CHW4CervixHealth
Phase I: Validating self-collection kit by comparing their results with clinical Pap smear results in a cohort of 20 patients. Phase II: Evaluate the feasibility and acceptability of the CHW4CervicalHealth: Use of a…
- Conditions
- Cervical Cancer, Hpv, Human Papilloma Virus, HPV Infection
- Trial name
- NCT07336134
- Testing
- Evalyn® Brush, Copan Floqswab, CHW4CervicalHealth
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
HIV Infection
Healthy Choices to Promote Health and Reduce Risk in HIV-Infected Youth
Risk behaviors and their associated adverse health outcomes are becoming increasingly problematic among HIV-infected youth. This study is being conducted to test whether a brief motivational enhancement (ME) intervention will…
- Trial name
- NCT00103532
- Testing
- Healthy Choices - Motivational Enhancement Intervention, Standard care
- Where
- 6 sites in United States
- Volunteers
- 225 people
- Sponsor
- University of North Carolina, Chapel Hill
Hiv, Neurocognitive Dysfunction
Using Less Neurotoxic Drugs in Patients With HAND (MARAND-X)
Neurocognitive disorders are still highly prevalent in the HAART era; despite a dramatic reduction in dementia cases, 15-50% of patients may develop mild or asymptomatic neurocognitive disorders (HIV-associated neurocognitive…
- Trial name
- (MARAND-X) (NCT03163277)
- Testing
- emtricitabine, darunavir/cobicistat, maraviroc
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- Giovanni Di Perri
HIV Infections
Observational Cohort of HIV Infected Adults and Children in the PHPT Network Hospitals in Thailand
Since 2004, the Thai Ministry of Public Health has massively scaled up antiretroviral treatment programs to provide therapy to more than 80,000 patients with partial support of the Global Fund to fight AIDS, Tuberculosis and…
- Trial name
- NCT00433030
- Where
- 38 sites in Thailand
- Volunteers
- 2,816 people
- Sponsor
- Institut de Recherche pour le Developpement
HIV Infections, Alcohol Dependence
Cell Phone Technology Targeting ART and Naltrexone Adherence and Alcohol Use
The proposed study, for HIV positive alcohol dependent adults currently taking naltrexone, is a pilot randomized controlled trial (RCT) examining the outcomes of a 12-week behavioral support program delivered via text-messaging.
- Trial name
- ALCTXT (NCT02603471)
- Testing
- Informational group, Text Messaging CBT (TXT-CBT)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of California, Los Angeles
HIV-1, HIV Infections
Safety and Immunogenicity Study of Candidate HIV-1 Vaccine Given to Healthy Infants Born to HIV-1-infected Mothers
Objectives: Primary: Safety and immunogenicity of MVA.HIVA vaccine in 20-week-old healthy Kenyan infants born to HIV-1-infected mothers.
- Trial name
- PedVacc002 (NCT00981695)
- Testing
- MVA.HIVA
- Where
- Kenya
- Volunteers
- 72 people
- Sponsor
- Medical Research Council
HIV Infections, Tuberculous Meningitis
Immediate Versus Deferred Antiretroviral Therapy for HIV-Associated Tuberculous Meningitis
The optimal time to initiate antiretroviral therapy (ART) in HIV-associated tuberculous meningitis (TBM) unknown. There are concerns that immediate ART may worsen rather than improve outcome, because drug interactiond and…
- Trial name
- NCT00433719
- Testing
- Combivir and efavirenz
- Where
- 2 sites in Vietnam
- Volunteers
- 253 people
- Sponsor
- University of Oxford
HIV, HIV Infections
Mobile Phone Technology for Prevention of Mother-to-Child Transmission of HIV: Acceptability, Effectiveness, and Cost (Kenya)
Although gains have been made in achieving the health-related Millennium Development Goals (MDG), much is still needed in countries affected by high levels of HIV/AIDS.
- Conditions
- HIV, HIV Infections, AIDS, Antiretroviral Therapy
- Trial name
- NCT01645865
- Testing
- Control, Intervention
- Where
- Kenya
- Volunteers
- 600 people
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
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