Clinical trials: Sexually Transmitted Diseases, Viral
Hepatitis C Virus, HIV Infections
Trends in Risk Factors for Mother-to-Child Transmission of Hepatitis C Among a Southern European Population
According to the centres taking part in the ALHICE survey, the number of HIV-HCV co-infected women is currently decreasing. This drop was first noted in 2006 and persisted in 2007.
- Conditions
- Hepatitis C Virus, HIV Infections, Pregnancy
- Trial name
- EPIALHICE B (NCT00894257)
- Where
- 3 sites in France
- Volunteers
- 142 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
HIV Infections
Safety of and Immune Response to Two HIV Vaccines: SAAVI DNA-C2 Boosted With SAAVIMVA-C, in HIV-Negative Adults
The purpose of this study is to evaluate the safety of and immune response to an experimental DNA HIV vaccine followed by boosting with an experimental modified vaccinia HIV vaccine (MVA) in HIV uninfected adults.
- Trial name
- NCT00574600
- Testing
- SAAVI DNA-C2 vaccine, SAAVI MVA-C vaccine
- Where
- 4 sites in United States, South Africa
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, Depression
Antidepressant Medication Plus Directly Observed Therapy for Improving Adherence to Antiretroviral Therapy
This study will evaluate the effectiveness of directly observed therapy plus antidepressant medication in improving adherence to antiretroviral drug therapy among HIV-infected homeless and marginally housed people with depression.
- Trial name
- NCT00338767
- Testing
- Directly Observed Therapy (DOT), Fluoxetine
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Massachusetts General Hospital
HIV Infections, Episodic Substance Use
Reducing HIV Risk Among Episodic Substance Using Men Who Have Sex With Men (SUMSM)
The purpose of this study is to determine if persons randomized to receive adapted Personalized Cognitive Risk-reduction Counseling (PCC) will report greater reductions in unprotected anal sex behavior compared with persons who…
- Trial name
- NCT01279044
- Testing
- Adapted Personalized Cognitive Risk-reduction Counseling intervention (PCC), Standard HIV testing with information only
- Where
- United States
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- San Francisco Department of Public Health
Cervical Intraepithelial Neoplasia, Low-Grade Squamous Intraepithelial Lesions
Aminolaevulinic Acid Photodynamic Therapy for HPV+ Low Grade Cervical Intraepithelial Neoplasia (LSIL;CIN1)
This trial will study the effectiveness of photodynamic therapy with aminolaevulinic acid for the treatment of patients with HPV+ low grade cervical intraepithelial neoplasia (LSIL;CIN1).
- Conditions
- Cervical Intraepithelial Neoplasia, Low-Grade Squamous Intraepithelial Lesions, Papillomavirus Infections
- Trial name
- NCT02631863
- Testing
- Aminolaevulinic acid
- Where
- 4 sites in China
- Volunteers
- 60 people
- Sponsor
- Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.
HIV Infections, HIV Seronegativity
Safety of Intradermal Versus Intramuscular Administration of HIV Lipopeptides in HIV Uninfected Adult Volunteers
Intramuscular (IM) administration of HIV lipopeptide vaccines have been shown to be able to induce HIV-1-specific T cell-mediated immune responses.
- Trial name
- NCT00121121
- Testing
- Lipopeptides LIPO-4
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
HIV Infections, Syphilis Infection
Multiplo Near Patient Non-HCP Study
To help reach the undiagnosed living with HIV and/or syphilis in Canada, point-of-care (POC) tests for HIV and Syphilis may have substantial utility for increased identification of infected individuals through their relative ease…
- Trial name
- NCT06463314
- Testing
- Multiplo TP/HIV Antibody Test
- Where
- 4 sites in Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Unity Health Toronto
HIV/AIDS
Adapting and Evaluating an EBI to Prevent HIV/AIDS Risk Among Apache Youth
The investigators seek to adapt, implement and evaluate a randomized controlled trial of an evidence based intervention delivered by Apache interventionists to reduce HIV/AIDS risk, targeting Apache adolescents.
- Trial name
- NCT01910714
- Testing
- Focus On Youth, Health Education Control Condition
- Where
- United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Cervical Cancer
Acceptability and Validity of Self Sampling for High Risk HPV Detection Among Women in Maharashtra
The study goals are, 1. To determine the test characteristics (sensitivity, specificity, positive predictive value, negative predictive value, false positivity rates, false negativity rates) of health personnel collected and self…
- Trial name
- HPV (NCT03386695)
- Testing
- Education by Pamphlets, Health education programme
- Where
- India
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Tata Memorial Hospital
HIV Infections
A Study to Evaluate Various Combinations of Anti-HIV Medications to Treat Early HIV Infection
The purpose of this study is to compare the effectiveness of various combinations of anti-HIV drugs in HIV-positive men and women.
- Trial name
- NCT00000919
- Testing
- Indinavir sulfate, Lamivudine/Zidovudine, Ritonavir
- Where
- 80 sites in United States, Italy and 1 more
- Volunteers
- 900 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
AIDS Dementia Complex, HIV-1-Associated Cognitive Motor Complex
Effect of Cenicriviroc on HIV Neurocognitive Impairment
The study hypothesis is that cenicriviroc will improve cognition in HIV infected individuals with cognitive impairment. The investigators will study the effect of cenicriviroc on cognition in 24 subjects over a 24 week period.
- Conditions
- AIDS Dementia Complex, HIV-1-Associated Cognitive Motor Complex, Human Immunodeficiency Virus
- Trial name
- NCT02128828
- Testing
- cenicriviroc
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Hawaii
HIV Infections
Immune Responses in Patients Treated With Raltegravir
Hypothesis: Treatment with raltegravir does not alter V(D)J recombination or immune responses to neoantigens. A process known as V(D)J recombination is essential for developing lymphocytes and the specific functioning of the…
- Trial name
- RAG-1/2 (NCT00785967)
- Testing
- Various vaccines
- Where
- Canada
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
HIV Infections
The Effectiveness of Three Anti-HIV Drug Combinations in HIV-Infected Patients Who Have Never Used Anti-HIV Drugs
To determine drug efficacy and safety in HIV-infected patients treated with zidovudine ( AZT ) versus stavudine ( d4T ) versus both drugs. Also, to compare short- and long-term changes in magnitude of HIV RNA over time.
- Trial name
- NCT00001067
- Testing
- Lamivudine, Stavudine, Zidovudine
- Where
- 13 sites in United States, Puerto Rico
- Volunteers
- 105 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cryptosporidiosis, HIV Infections
Treatment of Chronic Cryptosporidiosis in AIDS Patients
The purpose of this study is to see if it is safe and effective to add interleukin-12 (IL-12) to the standard drug combination (paromomycin plus azithromycin) used to treat cryptosporidiosis in AIDS patients.
- Trial name
- NCT00001128
- Testing
- Interleukin-12, Paromomycin sulfate, Azithromycin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV/AIDS
Outcomes of HIV Infected Individuals After Ten Years on Antiretroviral Treatment
Study Title: Outcomes of HIV infected individuals after ten years on antiretroviral treatment Short Title/Study ID: ALT cohort Protocol Version and Date: Version 1.0 June 2013 Clinical Phase: NA Methodology: Prospective…
- Trial name
- ART Long Term (NCT02514707)
- Where
- Uganda
- Volunteers
- 1,000 people
- Sponsor
- Infectious Diseases Institute
Hiv, Sexually Transmitted Diseases
Evaluation of Implementation of Pre-exposure Prophylaxis (PrEP) in Norway
Despite the significant preventive efforts to reduce HIV infections in the past decades, the incidence in MSM has plateaued at a higher level after the turn of the millennium.
- Conditions
- Hiv, Sexually Transmitted Diseases, Mental Health Wellness 1
- Trial name
- NCT03436407
- Where
- 9 sites in Norway
- Volunteers
- 500 people
- Sponsor
- Oslo University Hospital
Human Immunodeficiency Virus
Leukapheresis to Obtain Lymphocytes for Studies on Antiretroviral Naive HIV-infected Patients
To further investigate differences in the immunologic function of various lymphocyte subsets in HIV-infected patients who are treated early in their infection and during the chronic phase of the infection.
- Trial name
- NCT00333892
- Testing
- leukapheresis
- Volunteers
- 220 people
- Sponsor
- Canadian Immunodeficiency Research Collaborative
HIV Infections
Safety and Blood Levels of Tenofovir Disoproxil Fumarate in HIV Infected Pregnant Women and Their Babies
To prevent mother-to-child transmission (MTCT) of HIV in resource-limited countries, a simple yet effective treatment plan is needed.
- Trial name
- NCT00120471
- Testing
- Tenofovir disoproxil fumarate
- Where
- 5 sites in Brazil, Malawi
- Volunteers
- 122 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Immunodeficiency Virus, Mental Disorder
Integrated Mental Health Care for Pregnant Women With HIV in Kenya: The Tunawiri Study
This study seeks to improve mental health, pregnancy, and HIV outcomes among pregnant and postpartum women living with HIV with common mental health disorders in Kenya.
- Trial name
- NCT06117163
- Testing
- Collaborative Care Model
- Where
- Kenya
- Volunteers
- 900 people
- Sponsor
- University of Colorado, Denver
HIV Infections
Assessment of Pre-Exposure Prophylaxis (PrEP) Administered at Sexually Transmitted Disease (STD) Clinics
This study will assess the uptake, acceptability, safety, and feasibility of HIV pre-exposure prophylaxis (PrEP), consisting of a once-daily fixed-dose combination tablet of emtricitabine (FTC)/tenofovir disoproxil fumarate…
- Trial name
- NCT01632995
- Testing
- FTC 200 mg/TDF 300 mg fixed-dose combination tablet
- Where
- 3 sites in United States
- Volunteers
- 557 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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