Clinical trials: Sexually Transmitted Infection (STI)
Toxoplasmosis, Cerebral, HIV Infections
A Study of Pyrimethamine in the Treatment of Infection by a Certain Parasite in HIV-Positive Patients
To determine the manner in which pyrimethamine is metabolized and excreted in patients currently receiving zidovudine (AZT). An important goal of this measurement is to establish the optimal dose of pyrimethamine necessary to…
- Trial name
- NCT00000973
- Testing
- Pyrimethamine, Leucovorin calcium, Zidovudine
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cytomegalovirus Retinitis, HIV Infections
A Study to Evaluate the Effects of Stopping Maintenance Therapy for Cytomegalovirus (CMV) Retinitis After Effective Anti-HIV Therapy
The purpose of this study is to see if it is safe to stop maintenance therapy in HIV-positive patients with treated and healed CMV retinitis (eye disease) who have responded well to anti-HIV (antiretroviral) therapy.
- Trial name
- NCT00000905
- Where
- 25 sites in United States
- Volunteers
- 75 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis, Tuberculosis (TB)
Questioning the Epidemiology of Asymptomatic TB
Tuberculosis (TB) remains one of the world's leading causes of morbidity and mortality. Current TB control strategies focus largely on the binary paradigm of TB, which tackle Mtb infection and the symptomatic stages of the…
- Conditions
- Tuberculosis, Tuberculosis (TB), HIV, HIV (Human Immunodeficiency Virus)
- Trial name
- TB QUEST (NCT07312266)
- Where
- Mozambique
- Volunteers
- 6,770 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
HIV Infections
Safety of and Immune Response to a DNA Vaccine and a Recombinant HIV-1-MVA Vaccine, Separately and in Combination, in Healthy Adults
The purpose of this study is to determine the safety of and immune response to two experimental vaccines, designed for use in combination, for the prevention of HIV infection in healthy adults.
- Trial name
- NCT00428337
- Testing
- EP-1233, MVA-mBN32
- Where
- 3 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
A Phase IIA Trial to Evaluate the Safety and Immunogenicity of a DNA HIV-1 Vaccine Followed by an MVA HIV-1 Vaccine in HIV-uninfected Volunteers
The purpose of this study is to evaluate the safety and tolerability of plasmid DNA and recombinant MVA (Modified Vaccinia Virus Ankara) in a prime-boost regimen.
- Trial name
- NCT01371175
- Testing
- DNA.HIVA, MVA.HIVA
- Where
- 2 sites in Kenya, United Kingdom
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
Osteoporosis, HIV Infections
Efficacy of Alendronate Versus Placebo in the Treatment of HIV-associated Osteoporosis (ANRS120)
Osteopenia and osteoporosis are being described more frequently in people with HIV infection. This study will test the efficacy of alendronate in comparison with a placebo after 2 years, in people with primary osteoporosis.
- Trial name
- NCT00120757
- Testing
- Alendronate
- Where
- 3 sites in France
- Volunteers
- 140 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
HIV/AIDS, HIV Infections
HIV Self-Testing and Comic Intervention With Refugee Adolescents and Youth
HIV is the leading cause of death for adolescents and young people (AYP) in sub-SaharanAfrica (SSA). Uganda hosts 1.4 million refugees/displaced persons and the Bidi Bidi refugee camp in Northern Uganda is the second-largest…
- Conditions
- HIV/AIDS, HIV Infections, Knowledge, Attitudes, Practice
- Trial name
- NCT05213689
- Testing
- Educational comic book, HIV Self-testing
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Adherence, Patient, TB
Leveraging mHealth to Enable and Adapt CHW Strategies to Improve TB/HIV Patient Outcomes in SA
mHealth solutions designed to support affordable human resources for health, such as community health workers (CHWs), offer the opportunity to reimagine a patient-centered, system-level solution that may radically change care…
- Conditions
- Adherence, Patient, TB, HIV/AIDS, Care Coordination
- Trial name
- LEAP-TB-SA (NCT04298905)
- Testing
- CHW mHealth patient intervention for trigger escalation
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Johns Hopkins University
HIV Infections
Effectiveness of an HIV Prevention Program That Targets the Inner Workings of High-risk Social Networks
This study will determine whether an HIV prevention program that targets the inner workings of social networks at high risk for HIV and other sexually transmitted diseases is effective in reducing frequency of high-risk sexual…
- Trial name
- NCT00705705
- Testing
- Network leader training, Standard HIV risk-reduction counseling
- Where
- United States
- Volunteers
- 852 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Human Immunodeficiency Virus, Human Papillomavirus
Feasibility of Intravaginal Artesunate as Adjuvant HPV & Cervical Precancer Treatment in Kenya
The objective of this randomized, placebo-controlled trial is to evaluate whether intravaginal artesunate pessaries (vaginal inserts) can be used as adjuvant therapy following thermal ablation to improve Human papillomavirus…
- Conditions
- Human Immunodeficiency Virus, Human Papillomavirus, Cervical Precancer
- Trial name
- NCT06519994
- Testing
- Artesunate vaginal inserts
- Where
- Kenya
- Volunteers
- 120 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
HIV-1, HIV Infections
A Phase 2 Study to Evaluate Pharmacokinetics, Safety and Efficacy of TMC114/Ritonavir (Rtv) in Human Immunodeficiency Virus (HIV)-1 Infected Children and Adolescents
The purpose of this study is to evaluate the pharmacokinetics (the study of the way a drug enters and leaves the blood and tissues over time), safety, tolerability and antiviral activity to support dose recommendations of TMC114…
- Trial name
- NCT00355524
- Testing
- TMC114, Ritonavir
- Where
- 22 sites in United States, Argentina and 6 more
- Volunteers
- 80 people
- Sponsor
- Tibotec Pharmaceuticals, Ireland
HIV Preexposure Prophylaxis
The SwissPrEPared Study
Nested within the SwissPrEPared Program, the "SwissPrEPared Study" - a large, multicentric, nation-wide cohort study - aims to longitudinally follow individuals asking for PrEP prescription over a period of 3 years.
- Trial name
- NCT03893188
- Where
- 41 sites in Switzerland
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Zurich
HIV Infection
Same-day ART Initiation Versus Standard of Care After Positive HIV-test Result in Rural Lesotho
The CASCADE-trial is a two-armed open-label randomized controlled trial conducted in rural Lesotho. Participants who were tested HIV-positive during community-based HIV testing and counseling campaigns are randomized to the…
- Trial name
- CASCADE (NCT02692027)
- Testing
- Same-day ART initiation, Standard of care
- Where
- Lesotho
- Volunteers
- 276 people
- Sponsor
- Swiss Tropical & Public Health Institute
HIV Infections, Sexually Transmitted Diseases
Comparing Mobile Health Strategies to Improve Pre-exposure Prophylaxis Use (PrEP) for HIV Prevention
The purpose of this study is to compare the effectiveness of two mobile health technologies (text messaging or a mobile app) designed to help people take HIV pre-exposure prophylaxis (PrEP) as directed by the clinic.
- Trial name
- PCORI PrEP (NCT04855773)
- Testing
- PrEPmate, Dot Diary
- Where
- 4 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Public Health Foundation Enterprises, Inc.
Human Immunodeficiency Virus, STDs
Computer-Assisted Tailored Cue-card Health [CATCH] Study
This study will draw from proven interventions to refine and pilot test a cue card driven computer-assisted intervention, along with HIV/STI testing, that will be tailored to each participant's demographic characteristics, risk…
- Conditions
- Human Immunodeficiency Virus, STDs, Hepatitis, Viral, Human
- Trial name
- CATCH (NCT01170741)
- Testing
- Tailored Cue Cards
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- RTI International
HIV, AIDS
Cell Phone Intervention to Support Antiretroviral Therapy (ART) Adherence in Kenya
A clinical study to evaluate the use of cell phones to support drug adherence and follow-up of patients taking antiretroviral therapy (ART) for treatment of HIV.
- Conditions
- HIV, AIDS, HIV Infections
- Trial name
- NCT00830622
- Testing
- Cell Phone Intervention
- Where
- Kenya
- Volunteers
- 536 people
- Sponsor
- University of Manitoba
HIV
A Pilot Study to Examine Efficacy of Peer Mentoring in Promoting Medication Adherence Among People Living With HIV/AIDS
This study aims to investigate the effectiveness of an in-person peer mentoring and health literacy intervention on improving medication adherence, HIV-1 viral load, CD4+ T lymphocyte counts, and HIV medical appointment…
- Trial name
- NCT02025322
- Testing
- Peer Mentoring
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Jury Candelario
Diarrhea, HIV Infections
Treatment of Patients With Human Immunodeficiency Virus (HIV)-Related Chronic Diarrhea With Saccharomyces Boulardii or Placebo: A Double Blind Trial
To assess the efficacy of Saccharomyces boulardii (a nonpathogenic yeast) in producing a significant reduction in diarrheal symptoms in HIV-infected patients with chronic diarrhea.
- Trial name
- NCT00002088
- Testing
- Saccharomyces boulardii
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Biocodex
Human Immunodeficiency Virus, Hypogonadism, Male
Gonadal Function in Young to Middle Aged HIV-infected Men
HIV infection is associated to premature decline of serum testosterone. However, prevalence and biochemical characterization of hypogonadism in HIV-infected men are still to be well defined.
- Conditions
- Human Immunodeficiency Virus, Hypogonadism, Male, Erectile Dysfunction
- Trial name
- NCT03747003
- Testing
- No intervention is provided
- Where
- Italy
- Volunteers
- 315 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Chronic Hepatitis C, Hepatitis C
Post-marketing Surveillance of HIV-infected Patients With Chronic Hepatitis C Treated With PegIntron Pen and Rebetol (Study P04584)
The objective of the study was to assess the safety and efficacy of peginterferon alfa-2b (PEG-IFN alfa-2b) and ribavirin (RBV) administered to participants coinfected with Human Immunodeficiency Virus (HIV) and Hepatitis C Virus…
- Conditions
- Chronic Hepatitis C, Hepatitis C, HIV Infections
- Trial name
- NCT00736242
- Testing
- PEG-IFN alfa-2b, RBV
- Volunteers
- 232 people
- Sponsor
- Merck Sharp & Dohme LLC
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