Clinical trials: Sexually Transmitted Infection (STI)
HIV Infections
A Phase I Concentration-Targeted Multidose Study of Atevirdine Mesylate ( U-87201E ), AZT, and ddI or ddC
To determine the safety, toxicity, pharmacokinetic profile, and antiretroviral activity of atevirdine mesylate ( U-87201E ) in HIV-infected patients.
- Trial name
- NCT00000753
- Testing
- Atevirdine mesylate, Zidovudine, Zalcitabine
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cervical Cancer, Human Papilloma Virus
HPV Vaccine Effectiveness Study in Rwandan Women Living With HIV
Our study will assess and measure population effectiveness of prophylactic HPV vaccine in reducing cervical, anal, and/or oral prevalent and 6-month persistent infections among HPV-vaccinated and 757 HPV-unvaccinated Rwandan WLWH…
- Conditions
- Cervical Cancer, Human Papilloma Virus, Human Immunodeficiency Virus, HPV-Related Carcinoma
- Trial name
- NCT05247853
- Testing
- Blood collection, Oral, cervicovaginal and anal specimen collection, Anoscopy & Biopsy of Acetowhite Lesions
- Where
- Rwanda
- Volunteers
- 3,127 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
HIV Prevention, Pre-exposure Prophylaxis
Hybrid Evaluation of a Home-based HIV Pre-exposure Prophylaxis Program
The study's aim is to implement a home-based PrEP (HB-PrEP) monitoring system (self-collected blood and extragenital specimens at home and telehealth follow-up) into a large, urban sexual health clinic while also evaluating the…
- Conditions
- HIV Prevention, Pre-exposure Prophylaxis, STI
- Trial name
- HOT4PrEP (NCT05856942)
- Testing
- Health service - home-based PrEP monitoring
- Where
- United States
- Volunteers
- 458 people, healthy volunteers welcome
- Sponsor
- University of Washington
Neuropathy, AIDS
Safety and Preliminary Evidence of Efficacy of Escalating Doses of Dimiracetam in AIDS Patients With Painful Neuropathy
One hundred consenting AIDS patients suffering from treatment induced painful neuropathy will be blindly randomize to Active and Placebo groups (ratio A/P = 3/2 and will receive increasing oral doses of dimiracetam starting from…
- Trial name
- NCT01135251
- Testing
- dimiracetam, sugar pill
- Where
- South Africa
- Volunteers
- 116 people
- Sponsor
- Neurotune AG
HIV Infections, Herpes Simplex
HSV-2 Suppression to Reduce HIV-1 Levels in HIV-1 Co-infected Persons
Over 80% of HIV-1 infected persons are also seropositive for HSV-2. Increasingly, clinical and epidemiologic evidence show the role of HSV in increasing HIV infectiousness.
- Conditions
- HIV Infections, Herpes Simplex, Sexually Transmitted Diseases
- Trial name
- NCT00465205
- Testing
- Valacyclovir
- Where
- Peru
- Volunteers
- 20 people
- Sponsor
- University of Washington
HIV Infections
A Multicenter, Randomized, Placebo-Controlled, Double-Blind Trial to Evaluate the Safety and Immunogenicity of the Therion Recombinant Vaccinia-HIV-1 IIIB ENV/GAG/POL Vaccine (TCB-3B) and MN RGP 120/HIV-1 In Alum.
To evaluate the safety of administering Therion Recombinant Vaccinia-HIV-1 IIIB env/gag/pol Vaccine (TBC-3B) vaccinations to vaccinia-naive individuals.
- Trial name
- NCT00000866
- Testing
- MN rgp120/HIV-1, TBC-3B Vaccine
- Where
- 4 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
A Study of DAPD Alone Versus DAPD Plus MMF for Treatment of HIV Infection
The purpose of this study is to evaluate the safety, efficacy, and side effects of beta-D-2,6-diaminopurine dioxolane (DAPD) compared to DAPD plus mycophenolate mofetil (MMF) when these drugs are added to the anti-HIV treatment…
- Trial name
- NCT00038272
- Testing
- Mycophenolate mofetil, Amdoxovir
- Where
- 17 sites in United States
- Volunteers
- 56 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
AIDS
Efficacy and Safety of GSK Biologicals HIV Vaccine in Antiretroviral Therapy (ART)-naïve HIV-1 Infected Persons
This study is designed to determine whether administration of the GSK Biologicals HIV vaccine 732462 can lead to a reduction in viral load, and impact on the course of human immunodeficiency virus type 1 (HIV-1) infection.
- Trial name
- NCT01218113
- Testing
- GSK Biologicals HIV Vaccine 732462
- Where
- 42 sites in United States, France and 2 more
- Volunteers
- 191 people
- Sponsor
- GlaxoSmithKline
HIV Infection, HIV Infections
Phase 1 Dose Escalation Study of Autologous T-cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases in HIV-Infected Patients
This research study is being carried out to study a new way to possibly treat HIV. This agent is called a "Zinc Finger Nuclease" or ZFN for short. ZFNs are proteins that can delete another protein named CCR5.
- Trial name
- NCT01044654
- Testing
- SB-728-T
- Where
- 9 sites in United States
- Volunteers
- 19 people
- Sponsor
- Sangamo Therapeutics
HIV Infections
A Randomized Trial to Prevent HIV Among Gay Couples
The proposed study is a randomized controlled intervention to reduce sexual risk for HIV among HIV-negative concordant and HIV discordant gay couples.
- Trial name
- NCT03189394
- Testing
- PRIDE, ePRIDE, Men's Health
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- San Francisco State University
HIV/AIDS
HIV Self-Testing to Empower Prevention Choices in Sex Workers
Transgender, male, and female sex workers are 49, 21 and 14 times as likely to be HIV-infected as other adults in the general population.
- Trial name
- NCT03426670
- Testing
- OraQuick HIV Self-Test
- Where
- Uganda
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Makerere University
HIV Seropositivity, Adherence, Medication
Supporting Health Behavior Among Persons Living With HIV Using Tech, MOST, and Behavioral Economics
The present study focuses on adult persons living with HIV in the New York City and Newark, New Jersey metropolitan areas who are not highly adherent to HIV medication and who do not evidence undetectable HIV viral load (the…
- Trial name
- SCAP2 (NCT04518241)
- Testing
- MI sessions, TMQQ, Type of compensation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- New York University
HIV/AIDS
Interventions to Improve HIV Care Engagement After Hospital Discharge
A quasi-experitmental study of the efficacy interventions, including additional HIV care team daily inpatient round and three telephone calls to remind the upcoming clinic appointment, in improving HIV care engagement within 30…
- Trial name
- NCT02578654
- Testing
- Strategies to improve HIV care engagement
- Where
- Thailand
- Volunteers
- 240 people
- Sponsor
- Thammasat University
HIV Infections
HIV Prevention With the Mentally Ill
The purpose of this study is to determine whether motivational interviewing and skills building interventions reduce HIV risk behavior for adults with serious and persistent mental illness.
- Trial name
- NCT00643305
- Testing
- Skills Building with Motivational Interviewing, Skills Building
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Acquired Immunodeficiency Syndrome, HIV Infections
Computer-Assisted Adherence Program for Patients Taking Anti-HIV Drugs
The purpose of this study is to evaluate the effectiveness of a computer-assisted, self-administered adherence program for patients on complicated anti-HIV drug regimens.
- Trial name
- NCT00051766
- Testing
- Computer-based Intervention
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Kaletra Monotherapy in HIV/HCV Co-infected Subjects
The study has been designed to test the hypothesis that in patients co-infected with HIV and HCV who exhibit maximal virologic suppression on a double class antiretroviral (ARV) regimen, including two Nucleoside Reverse…
- Trial name
- NCT00508222
- Testing
- Kaletra Tablets
- Where
- 2 sites in Canada
- Volunteers
- 22 people
- Sponsor
- Ottawa Hospital Research Institute
HIV Infections
Impact of Point-of-care (POC) Viral Load (VL) Testing During Pregnancy in Zimbabwe
The Ministry of Health and Child Care (MOHCC) in collaboration with Clinton Health Access Initiative (CHAI) will conduct an observational cohort study to determine the impact and cost-effectiveness of POC VL testing for pregnant…
- Trial name
- NCT04048629
- Testing
- Point-of-care (POC) viral load (VL) testing plus refresher training, Standard of care central laboratory VL testing plus refresher training
- Where
- 20 sites in Zimbabwe
- Volunteers
- 1,715 people
- Sponsor
- Clinton Health Access Initiative Inc.
HIV Infections, Acquired Immunodeficiency Syndrome
Efficacy of Thrice Weekly Directly Observed Treatment, Short-course (DOTS) in HIV-associated Tuberculosis
Tuberculosis (TB) is the most common opportunistic infection among HIV infected persons living in developing countries. Directly observed treatment, short-course (DOTS) is the internationally recommended strategy for the…
- Conditions
- HIV Infections, Acquired Immunodeficiency Syndrome, Tuberculosis
- Trial name
- NCT00698334
- Testing
- INH, Rifampicin, Ethambutol and Pyrazinamide
- Where
- India
- Volunteers
- 150 people
- Sponsor
- All India Institute of Medical Sciences
HIV Infections, Hepatitis B
Project UNITY - HIV Risk Reduction and Vaccine Education Interventions
To determine the efficacy of an enhanced HIV risk reduction intervention delivered concurrently with a vaccination schedule to reduce the number of unprotected vaginal and anal sex acts among HIV-negative, high-risk non-injection…
- Trial name
- NCT00150098
- Testing
- Enhanced HIV risk reduction and HIV vaccine education
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- New York Blood Center
HIV-1, HIV Infections
Genotypic Resistant HIV Strains in Taiwan
Based on the investigators previous study, seventy-four of 786 HIV-1 isolates (9.4%), collected between 1999 to 2006, harbored one or more primary mutations associated with antiretroviral resistance to reverse-transcriptase…
- Trial name
- NCT00954863
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
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