Clinical trials: Sham-controlled
Dry Eye Syndromes
Multicenter Trial Evaluating Quality of Tears Produced by Nasal Neurostimulation
The objectives of this study are: To compare the change in levels of tear proteins and inflammatory mediators pre and post administration between the intranasal and extranasal applications To compare the goblet cell count…
- Trial name
- NCT02385292
- Testing
- Oculeve Intranasal Lacrimal Neurostimulator
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Oculeve, Inc.
ME/CFS, Post-COVID ME/CFS
Immunoadsorption in Patients With Chronic Fatigue Syndrome Including Patients With Post-COVID-19 CFS
The goal of this clinical trial is to learn about the effectiveness of repeated immunoadsorption intervention in patients with chronic fatigue syndrome (CFS) including patients with post-acute COVID-19 CFS (PACS-CFS).
- Trial name
- NCT05710770
- Testing
- Immunoadsorption
- Where
- Germany
- Volunteers
- 66 people
- Sponsor
- Charite University, Berlin, Germany
Pain Threshold, Pain Tolerance
Acute Effects of LLLT on Pain Threshold and Pain Tolerance
Pain is defined by the International Association for the Study of Pain as "an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage." Low-Level Laser…
- Conditions
- Pain Threshold, Pain Tolerance, Acute Pain, Low-level Laser Therapy
- Trial name
- NCT07422272
- Testing
- Low-Level Laser Therapy (LLLT)
- Where
- Cyprus
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- European University of Lefke
Recurrent Pregnancy Loss, Overweight , Obesity
Effects of High-frequency Left Dorsolateral Prefrontal rTMS on Heart-brain Coupling in Women With Recurrent Pregnancy Loss and Elevated BMI
This randomized, sham-controlled mechanistic trial will examine whether a single session of high-frequency repetitive transcranial magnetic stimulation, rTMS, applied to the left dorsolateral prefrontal cortex can modify…
- Conditions
- Recurrent Pregnancy Loss, Overweight , Obesity, Heart-Brain Coupling
- Trial name
- NEURO-CARD-BMI (NCT07561931)
- Testing
- Real repetitive transcranial magnetic stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shenyang Medical College
Arthroplasty, Replacement, Knee
Does Radiofrequency Ablation of the Articular Nerves of the Knee Prior to Total Knee Replacement Improve Pain Outcomes
More than 300,000 total knee joint replacement surgeries are performed per year in the United States and safe, effective management of post-operative pain in these patients, often elderly, deconditioned, obese, or with co-morbid…
- Trial name
- NCT02746874
- Testing
- Radiofrequency Ablation (RFA), Simulated Radiofrequency Ablation (RFA)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Northwestern University
Diabetic Foot Ulcer
Laser Therapy for At-Home Treatment of Diabetic Foot Ulcers - Canada
The global prevalence of diabetes is on the rise and with it increase in prevalence of diabetic foot ulcers (DFU). These recalcitrant wounds are difficult to manage and pose a heavy economic burden.
- Trial name
- LLL&DIAB-02 (NCT03687580)
- Testing
- B-Cure Laser Pro
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Scarborough Rouge Hospital
Knee Osteoarthritis
Evaluation of a Home-based NMES Therapy for Knee Osteoarthritis Pain
Evaluation of knee pain and functional mobility of knee osteoarthritis patients with a home-based neuromuscular electrical stimulation (NMES) therapy
- Trial name
- NMES (NCT04128618)
- Testing
- CyMedica e-vive NMES
- Where
- 2 sites in United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- CyMedica Orthopedics, Inc
Optic, Atrophy, Hereditary, Leber
Efficacy Study of GS010 for Treatment of Vision Loss From 7 Months to 1 Year From Onset in LHON Due to the ND4 Mutation (REVERSE)
The goal of this clinical trial is to assess the effectiveness of GS010, a gene therapy, in improving the visual outcome in participants with Leber Hereditary Optic Neuropathy (LHON) due to the G11778A ND4 mitochondrial mutation…
- Trial name
- REVERSE (NCT02652780)
- Testing
- GS010
- Where
- 7 sites in United States, France and 3 more
- Volunteers
- 37 people
- Sponsor
- GenSight Biologics
Postherpetic Neuralgia ( PHN )
Electroacupuncture for PHN: Efficacy and Biomarker Evaluation in a Multicenter, Randomized, Sham-Controlled Trial Protocol
The investigators are conducting a clinical study with the following objectives: to evaluate the clinical efficacy of electroacupuncture combined with pregabalin in treating Postherpetic Neuralgia(PHN); to investigate the…
- Trial name
- NCT06990854
- Testing
- Electroacupuncture (Hans-100A, Nanjing Jisheng Medical Technology, China), Pharmacotherapy：① Pregabalin ( Lyrica™ ，Pfizer Inc. America) ② Methylcobalamin ( Mecobalamin tablets， Weicai (China) Pharmaceutical Co., Ltd， China）
- Where
- China
- Volunteers
- 207 people
- Sponsor
- Dexiong Han
Age-Related Macular Degeneration, Age-related Macular Degeneration (ARMD)
Microcurrent Stimulation Therapy for Intermediate to Advanced Nonexudative Age-related Macular Degeneration
The goal of this clinical trial is to characterize the safety and effectiveness of the i-Lumen AMD transpalpebral microcurrent device and therapy in patients with intermediate to advanced nonexudative AMD.
- Conditions
- Age-Related Macular Degeneration, Age-related Macular Degeneration (ARMD), Intermediate AMD, Geographic Atrophy Secondary to Age-related Macular Degeneration
- Trial name
- i-SIGHT2 (NCT06662162)
- Testing
- i-Lumen AMD
- Where
- 13 sites in United States, Australia and 2 more
- Volunteers
- 100 people
- Sponsor
- i-Lumen Scientific AUS PTY LTD
Diabetes Mellitus, Diabetic Neuropathies
Use of taVNS for Painful Diabetic Neuropathy: 12-Week Randomized, Sham-Controlled Trial
This 12-week, randomized, double-blind, sham-controlled, parallel-group trial will evaluate the analgesic and mechanistic effects of home-based transcutaneous auricular vagus nerve stimulation (taVNS) in adults with painful…
- Conditions
- Diabetes Mellitus, Diabetic Neuropathies, Type2diabetes, Neuropathic Pain
- Trial name
- PAK-VAGUS (NCT06292962)
- Testing
- non-invasive transcutaneous vagal nerve stimulation (tVNS)
- Where
- Pakistan
- Volunteers
- 185 people
- Sponsor
- Saima Abass Tahammal
Proliferative Diabetic Retinopathy
Intravitreal Injection of Ranibizumab Versus Sham Before Vitrectomy in Patients With Proliferative Diabetic Retinopathy
Certain percent of the eyes with proliferative diabetic retinopathymay require pars plana vitrectomy (PPV) due to vitreous haemorrhage, proliferative membrane, and tractional retinal detachment.
- Trial name
- NCT02857491
- Testing
- ranibizumab, pars plana vitrectomy
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Sun Yat-sen University
Obesity, Craving
Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for Food Craving in Obese Individuals.
Background: Obesity is one of the most important diseases around the globe; with a continuous increase and public health concern. Current treatments present some limitations.
- Trial name
- taVNS (NCT03217929)
- Testing
- Active-taVNS
- Where
- Brazil
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Posttraumatic Stress Disorder
Effectiveness and Acceptability of Stellate Ganglion Block for Posttraumatic Stress Disorder Symptoms - Acceptability
This qualitative study will use focus groups, small group interviews, and individual interviews (both in person and over the phone) to compile a range of perspectives on service members' decision-making processes and information…
- Trial name
- NCT03302312
- Where
- 3 sites in United States, Germany
- Volunteers
- 54 people
- Sponsor
- RTI International
Fibromyalgia, Fibromyalgia (FM)
Multisite Transcutaneous Electrical Nerve Stimulation in Fibromyalgia: A Randomized, Double-Blind, Sham-Controlled Crossover Trial Comparing Two Stimulation Modalities
Fibromyalgia is a chronic and multifactorial disorder characterized by widespread musculoskeletal pain, heightened pain sensitivity, fatigue, sleep disturbances, cognitive complaints, and affective symptoms such as anxiety and…
- Conditions
- Fibromyalgia, Fibromyalgia (FM), Fibromyalgia (FM) OR Fibromyalgia Syndrome
- Trial name
- FIBROPULSE (NCT07872631)
- Testing
- EXOPULSE Mollii Suit
- Volunteers
- 24 people
- Sponsor
- Institut De La Colonne Vertebrale Et Des Neurosciences
Insomnia, Sleep Disturbance
Electrical Vestibular Nerve Stimulation (VeNS) as a Treatment for Insomnia
Insomnia is known to be one of the most common health concerns in in the general population and has been associated with several health consequences.
- Trial name
- NCT04452981
- Testing
- VeNS
- Where
- 2 sites in Hong Kong, United Kingdom
- Volunteers
- 153 people
- Sponsor
- Neurovalens Ltd.
Respiratory Distress Syndrome (Neonatal), Intubation Complication
InfasurfAero™ Versus Sham Treatment in Preterm Newborns With RDS
The purpose of this clinical study is to determine the effectiveness and safety of Infasurf® administered through the InfasurfAero™, a novel oral airway delivery device specifically designed to give Infasurf in a less complicated…
- Conditions
- Respiratory Distress Syndrome (Neonatal), Intubation Complication, Death; Neonatal
- Trial name
- Aero-05 (NCT05960929)
- Testing
- Infasurf Aero™
- Where
- 10 sites in United States
- Volunteers
- 220 people
- Sponsor
- ONY
Functional Neurological Disorder, Motor Symptoms
Investigating the Neurophysiology of the Motor System and the Feasibility of Vagus Nerve Stimulation in Functional Neurological Disorder (FND)
This clinical study will test if adding a non-invasive stimulation of the vagus nerve through the ear during physiotherapy brings an improvement to FND (Functional Neurological Disorder) patients with motor symptoms.
- Trial name
- TMS-VNS (NCT07710677)
- Testing
- Vagial Nerve Stimulation (VNS) active stimulation
- Where
- Switzerland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Fribourg
Osteoporosis, Vertebral Fracture
A Trial of Vertebroplasty for Painful Acute Osteoporotic Vertebral Fractures
The standard care in patients with a painful osteoporotic vertebral compression fracture (VCF) is conservative therapy. Percutaneous vertebroplasty (PV), is a new minimally invasive technique for pain treatment in which bone…
- Trial name
- VertosIV (NCT01200277)
- Testing
- percutaneous vertebroplasty
- Where
- 4 sites in Netherlands
- Volunteers
- 80 people
- Sponsor
- Elisabeth-TweeSteden Ziekenhuis
Metatarsalgia
Randomized Controlled Trial of Custom Foot Orthoses for Chronic Forefoot Pain
Background Chronic metatarsalgia (CM) causes significant pain and disability, affecting quality of life. Foot orthoses (FOs) including medially wedged designs with a metatarsal pad decrease excessive plantar pressure under the…
- Trial name
- NCT06962475
- Testing
- Podiatric advice, Customized foot orthoses
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Université du Québec à Trois-Rivières