Clinical trials: Shock, Hemorrhagic
Trauma, Multiple
Early Norepinephrine in Trauma Patients With Hemorrhagic Shock
The goal of this clinical trial is to learn if norepinephrine works to treat trauma patients with hemorrhagic shock. It will also learn about the safety of norepinephrine.
- Trial name
- ENTHeS (NCT06977659)
- Testing
- Norepinephrine
- Where
- 2 sites in Thailand
- Volunteers
- 40 people
- Sponsor
- Visarat Palitnonkiat
Relapsed/Refractory Multiple Myeloma (RRMM)
Adult Outpatient Linvoseltamab With Tocilizumab Prophylaxis to Mitigate the Risk of Cytokine Release Syndrome (CRS)
This study is researching whether the use of tocilizumab before the first dose of linvoseltamab will decrease the risk of Cytokine Release Syndrome (CRS) in participants who have Relapsed or Refractory Multiple Myeloma (RRMM) who…
- Trial name
- POPLIN (NCT07609940)
- Testing
- Linvoseltamab, Tocilizumab
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- Regeneron Pharmaceuticals
Trauma, Trauma Injury
Whole Blood in Trauma Patients With Hemorrhagic Shock
This study aims to evaluate among trauma patients with hemorrhagic shock the clinical impact of hemostatic resuscitation between whole blood vs.
- Conditions
- Trauma, Trauma Injury, Trauma, Multiple
- Trial name
- WEBSTER (NCT05634109)
- Testing
- Transfusion of blood products
- Where
- Colombia
- Volunteers
- 220 people
- Sponsor
- Fundacion Clinica Valle del Lili
Hemorrhagic Shock, Trauma
Detection of Exhaled Methane Levels in Hemorrhagic Shock
This prospective observational study aims to test the efficacy of the continuous measurement of exhaled methane levels in monitoring the hemodynamic state of severely injured, bleeding trauma patients.
- Trial name
- NCT04987411
- Testing
- Measurement of methane concentrations in exhaled breath, Videomicroscopy of the sublingual microcirculation, Blood gas and laboratory analysis
- Where
- Hungary
- Volunteers
- 40 people
- Sponsor
- Szeged University
Septic Shock, Sepsis
Effects of Dexmedetomidine on Sublingual Microcirculation and Vascular Waterfall Phenomenon in Patients With Septic Shock
This prospective, multicenter, single-arm, open-label interventional pilot study aims to evaluate the short-term physiological effects of intravenous dexmedetomidine on sublingual microcirculation and vascular-waterfall…
- Conditions
- Septic Shock, Sepsis, Critical Illness
- Trial name
- DEX-MICRO (NCT07657715)
- Testing
- Dexmedetomidine Intravenous Infusion
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Cardiac Arrest From Trauma
Emergency Preservation and Resuscitation (EPR) for Cardiac Arrest From Trauma
The goal of this study is to rapidly cool trauma victims who have suffered cardiac arrest from bleeding with a flush of ice-cold sodium chloride to preserve the patient to enable surgical control of bleeding, followed by delayed…
- Trial name
- EPR-CAT (NCT01042015)
- Testing
- Emergency preservation and resuscitation, Standard resuscitation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Maryland, Baltimore
Hemorrhagic Shock, Trauma Injury
California Prehospital and In Hospital Antifibrinolytic Therapy Via TXA
The California Prehospital Antifibrinolytic Therapy (Cal-PAT) study seeks to evaluate the safety and efficacy of Tranexamic Acid (TXA) use in the civilian prehospital and in hospital setting in cases of traumatic hemorrhagic…
- Trial name
- Cal-PAT (NCT03469947)
- Testing
- Tranexamic Acid
- Volunteers
- 200 people
- Sponsor
- Arrowhead Regional Medical Center
Trauma, Hemorrhagic Shock
Control of Major Bleeding After Trauma Study
Bleeding is the most avoidable cause of death in trauma patients. Up to one-third of severely injured trauma patients are found to be coagulopathic and forty percent of the mortality following severe injury is due to…
- Trial name
- COMBAT (NCT01838863)
- Testing
- Type AB plasma, Crystalloid fluid (standard of care for resuscitation)
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Denver Health and Hospital Authority
Injury
Serum Vasopressin Levels and Severe Hemorrhagic Shock
The purpose of this study is to determine if vasopressin is used up by the body during traumatic shock (severe low blood pressure due to trauma).
- Trial name
- NCT01676454
- Where
- United States
- Sponsor
- Poudre Valley Health System