Clinical trials: Short Cervix
Preterm Birth, Short Cervix
Pessary Versus Progesterone in Singletons
This study compares the effectiveness of cervical pessary to vaginal progesterone for prevention of preterm birth in women with singleton pregnancies and a cervix ≤25 mm.
- Trial name
- NCT04300322
- Testing
- Cervical pessary, Vaginal Progesterone
- Where
- 3 sites in Vietnam
- Volunteers
- 804 people
- Sponsor
- Mỹ Đức Hospital
Pregnancy
Pessary to Prevent Prematurity in Twins in Case of Short Cervix
For 25 years, the twin pregnancy rate has regularly increased in the majority of European countries and in the United States, by 35% between 1981 and 2006.
- Trial name
- PESSAR'ONE (NCT02328989)
- Testing
- Pessary
- Where
- 18 sites in France
- Volunteers
- 324 people
- Sponsor
- University Hospital, Toulouse
Preterm Labor
Use of Pessary in Case of Cervical Insufficiency and Short Cervix
Prematurity is the most important cause of obstetric morbidity and mortality. Health centers and obstetricians are trying to reduce the preterm birth rate by taking into account the permanent effects of premature birth on human…
- Trial name
- NCT03096691
- Testing
- cervical pessary
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Short Cervix, Twins
Cerclage for Short Cervix in Twins
Through cervical length measurement in uncomplicated twin gestations, women with cervical length ≤ 25 mm will be approached for randomization to cerclage placement or expectant management with activity restriction and treatment…
- Trial name
- NCT02912390
- Testing
- Cerclage, Expectant management
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- St. Louis University
Short Cervix
Short Cervix - Twins
This is a retrospective chart review. The purpose of this study will be to look at the outcomes of twin pregnancies diagnosed with short cervix along with the intervention (treatment) that these patients received.
- Trial name
- NCT03022591
- Testing
- Management
- Volunteers
- 6 people
- Sponsor
- St. Louis University
Preterm Birth, Cervical Incompetence
Preventing Preterm Birth With a Negative Pressure Cervical Cup: a Feasibility Study
The goal of this Phase I clinical trial is to generate proof-of-concept data to demonstrate that a cervical cup in combination with vacuum application will create negative pressure on uterine cervical tissue, thereby creating…
- Conditions
- Preterm Birth, Cervical Incompetence, Cervical Insufficiency, Short Cervix
- Trial name
- NCT05512052
- Testing
- Hannah Cervical Cup (2 mm Delta), Hannah Cervical Cup (4 mm Delta), Hannah Cervical Cup (6 mm Delta)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Galena Innovations, LLC
Premature Birth
Comparing Double Dose of Vaginal Progesterone to no Treatment for Prevention of Preterm Birth in Twins and Short Cervix
Twin pregnancies are more likely to be delivered preterm than singleton pregnancies. Vaginal progesterone administration (200 mg Utrogestan) to asymptomatic women with a singleton pregnancy and sonographic short cervix reduced…
- Trial name
- NCT02329535
- Testing
- Micronized progesterone
- Where
- 2 sites in Israel
- Volunteers
- 15 people
- Sponsor
- HaEmek Medical Center, Israel
Preterm Birth, Microbial Colonization
Vaginal, Placental and Neonatal Buccal Mycobiota and Microbiome in Preterm Birth
Microbiota contributes to the immunological, hormonal and metabolic homeostasis of the host. As in all natural orifices in the body, there is also a microbiota and mycobiota specific to the vagina.
- Trial name
- NCT04165252
- Testing
- Collection of vaginal, neonatal buccal and placental samples
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Koç University
Preterm Birth, Short Cervix
Canadian Study on the Association of Pessary With Progesterone
Prematurity is the leading cause of neonatal morbidity causing more than 1 million deaths worldwide per year. In 2012, a randomized controlled trial (RCT) testing "pessary" (silicone ring placed around the cervix) versus "no…
- Trial name
- CAPP (NCT03227705)
- Testing
- Prometrium, Dr. Arabin, cerclage pessary perforated
- Where
- 8 sites in Canada
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Preterm Birth
Mechanical Environment Pregnancy With Short Cervix
The objective of this study is to quantify the mechanical environment of pregnancies complicated by a short cervix and randomized in the Trial of Pessary in Singleton Pregnancies with a Short Cervix study with ultrasound imaging…
- Trial name
- ATOPS (NCT03865108)
- Testing
- Ultrasound imaging, Cervical speculum examination
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Columbia University
Twin; Pregnancy, Affecting Fetus or Newborn
Role of 200 mg Versus 400mg Vaginal Progesterone in Prevention of Preterm Labor in Twin Gestation
The objective of the present study is to evaluate the effectiveness of two doses of vaginal progesterone(200mg versus400mg) and placebo in improving gestational age in twin pregnancy and its subsequent impact on perinatal outcome.
- Trial name
- NCT03781674
- Testing
- progesterone 400mg, progesterone 200mg
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Aswan University Hospital
Pre-term Birth
fFN Clinical Evaluation in Asymptomatic Women at High Risk for Preterm Birth
This study is designed to determine if quantitative analysis of fetal Fibronectin (fFN) can be used to advance prediction of spontaneous preterm birth (sPTB).
- Trial name
- NCT01955148
- Where
- 16 sites in United States
- Volunteers
- 1,210 people, healthy volunteers welcome
- Sponsor
- Hologic, Inc.
Premature Birth
Cervical Pessary to Prevent Preterm Birth in Singleton Pregnancies With a Sonographically Measured Short Cervix
The purpose of this study is to learn if the Arabin pessary can reduce preterm birth less than 37 weeks 0 days in singleton pregnancies that have a short cervix.
- Trial name
- NCT02357394
- Testing
- Arabin Pessary
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- Gene Lee, MD
Short Cervical Length
A Trial of Pessary and Progesterone for Preterm Prevention in Twin Gestation With a Short Cervix
This protocol outlines a randomized trial of 630 women evaluating the use of micronized vaginal progesterone or pessary versus control (placebo) to prevent early preterm birth in women carrying twins and with a cervical length of…
- Trial name
- PROSPECT (NCT02518594)
- Testing
- Vaginal progesterone, Arabin Pessary
- Where
- 16 sites in United States
- Volunteers
- 1,311 people
- Sponsor
- The George Washington University Biostatistics Center
Short Cervix, PROM, Preterm (Pregnancy)
Microbiological and Biochemical Profiling of Amniotic Fluid in Women With Short Cervix or Premature Rupture of Membranes
This study aims at assessing the efficacy, reliability, and clinical impact of Amniotic Fluid analysis by Nanopore DNA sequencing compared to the standard bacterial cultures in detecting intra-amniotic/inflammation in patients…
- Trial name
- CIPRO (NCT07792083)
- Testing
- amniotic fluid collection
- Where
- Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Premature Labor, Pregnancy
Indomethacin PK and PD Therapy in Pregnancy
This study will follow pregnant women who are taking indomethacin as Standard of Care (SOC) for the indications of preterm labor (PTL), short cervix, or other indications, to evaluate the pharmacokinetics (PK), what the body does…
- Conditions
- Premature Labor, Pregnancy, Premature Birth
- Trial name
- NCT02451228
- Testing
- Serial blood collection
- Where
- 6 sites in United States
- Volunteers
- 62 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Preterm Birth, Premature Birth
Prevention of sPTB With Early Cervical Pessary Treatment in Women at High Risk for PTB
Prevention of preterm birth (PTB) is a key factor for a positive short-term and long-term outcome of the newborn children as mortality and morbidity are inversely related to gestational age at delivery.
- Trial name
- Prometheus (NCT03418012)
- Testing
- cervical pessary, Control-Group
- Where
- 9 sites in Australia, Germany and 2 more
- Volunteers
- 310 people
- Sponsor
- Bürgerhospital Frankfurt
Premature Birth
LATe Cerclage in High-risk Pregnancies (LATCH)
The goal of this clinical trial is to determine whether cervical cerclage reduces the risk of preterm birth in patients with a short transvaginal ultrasound (TVU) cervical length (CL) ≤25mm between 24 0/7-26 6/7 weeks.
- Trial name
- LATCH (NCT06036446)
- Testing
- Cervical cerclage, Vaginal Suppository Progesterone
- Where
- 2 sites in United States
- Volunteers
- 329 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Premature Labour
Vaginal Progesterone Versus Cervical Cerclage for Pregnant Women With Short Cervix and History of PTL and/or MTM
The aim of this study to compare vaginal progesterone supplementation to cervical cerclage for prevention of preterm labor in women with short cervical length and history of previous midtrimester miscarriage and/or preterm labor.
- Trial name
- NCT02673359
- Testing
- Progesterone, Cervical cerclage
- Where
- 3 sites in Egypt
- Volunteers
- 220 people
- Sponsor
- Mohamed Sayed Abdelhafez
Preterm Birth
Efficacy Study of a Cervical Pessary Containing Progesterone for the Prevention of Preterm Delivery
Assess the efficacy of 2 Cervical Pessaries containing 6.3 g and 7.7 g micronized progesterone for the prevention of preterm delivery, established through spontaneous birth before gestation weeks 32 (31 weeks and 6 days) and 34…
- Trial name
- PCP002 (NCT02225353)
- Testing
- Progesterone Cervical Pessary 6.3 g, Progesterone 200 mg vaginal capsules, Progesterone Cervical Pessary 7.7 g
- Where
- 4 sites in Chile
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH