Clinical trials: Sickle Cell Disorder
Anemia, Sickle Cell
Dexamethasone to Treat Acute Chest Syndrome in People With Sickle Cell Disease
People with sickle cell disease (SCD) may develop acute chest syndrome (ACS), which is a common and serious lung condition that usually requires hospitalization.
- Trial name
- NCT00530270
- Testing
- Dexamethasone
- Where
- 6 sites in United States
- Volunteers
- 12 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Hemoglobin SC Disease
Hydroxyurea and Magnesium Pidolate to Treat People With Hemoglobin Sickle Cell Disease
Sickle cell disease (SCD), also known as sickle cell anemia, is an inherited blood disease that can cause intense pain episodes. Hemoglobin SCD (HbSC) is a form of SCD that is characterized by dense red blood cells.
- Trial name
- NCT00532883
- Testing
- Hydroxyurea, Magnesium Pidolate
- Where
- 19 sites in United States
- Volunteers
- 44 people
- Sponsor
- St. Jude Children's Research Hospital
Sickle Cell Disease
Haploidentical Stem Cell Transplant for Patients With Sickle Cell Disease and Prior Stroke or Abnormal Transcranial Ultrasound
Sickle cell disease is a life-long blood condition that can cause damage to the brain and other organs of the body. Children may develop severe, debilitating clinical states, with stroke or abnormal blood flow to the brain.
- Trial name
- NCT00152113
- Testing
- Hematopoietic Stem Cell Transplantation, CliniMACS, See intervention description
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- St. Jude Children's Research Hospital
HbS Disease, Hemoglobin S Disease
A Trial to Assess Haploidentical T-depleted Stem Cell Transplantation in Patients With SCD
HSCT is currently the only curative option for SCD but less than 20% of SCD patients have a MD donor available. So far, all curative approaches beyond a MSD HSCT at young age are non-satisfactory.
- Conditions
- HbS Disease, Hemoglobin S Disease, Sickle Cell Anemia, Sickle Cell Disorders
- Trial name
- NCT04201210
- Testing
- TCRα/β+ and CD19+ depleted haploidentical stem cell transplantation, Matched sibling donor transplantation
- Where
- 9 sites in Austria, Germany
- Volunteers
- 212 people
- Sponsor
- University of Regensburg
Sickle Cell Disease, Quality of Life
Improving Disease Knowledge in Adolescents With Sickle Cell Disease
Increased knowledge about an illness can increase self-management among those afflicted. In order to facilitate people with sickle cell disease living a longer and healthier life, they should be taught to manage their illness.An…
- Trial name
- KNOW-IT (NCT01945073)
- Testing
- Educational Booklet (BK), Formal Counselling (CB)
- Where
- Jamaica
- Volunteers
- 150 people
- Sponsor
- The University of The West Indies
Sickle Cell Disease
A Rehabilitation Program in Children With Sickle Cell Disease and Cognitive Deficits: a Pilot Study
The overall goal of this project is to determine the feasibility of conducting a cognitive intervention for children with sickle cell disease.
- Trial name
- NCT00895154
- Testing
- General Tutoring, Memory Training
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Washington University School of Medicine
Sickle Cell Disease
iPeer2Peer Program for Youth With Sickle Cell Disease
The iPeer2Peer Sickle Cell Disease (SCD) study matches youth (12-18 years of age) with SCD to a mentor (trained young adult) who has learned to manage their SCD well, transitioned to adult care, and can support youth participants…
- Trial name
- NCT03989986
- Testing
- iPeer2Peer Mentorship
- Where
- 4 sites in United States, Canada
- Volunteers
- 28 people
- Sponsor
- The Hospital for Sick Children
Sickle Cell Disease
Gene Correction in Autologous CD34+ Hematopoietic Stem Cells (HbS to HbA) to Treat Severe Sickle Cell Disease
This study is a first-in-human, single-arm, open-label Phase I/II study of nula-cel in approximately 15 participants, diagnosed with severe Sickle Cell Disease.
- Trial name
- Restore (NCT04819841)
- Testing
- nula-cel Drug Product
- Where
- 6 sites in United States
- Volunteers
- 15 people
- Sponsor
- Kamau Therapeutics
Sickle Cell Disease, Pediatric
Impact on the Length of Stay in Incentive Spirometry and Pain in the Decompensation of Sickle Cell Disease: .
In this prospective observational study among sickle cell children aged 7 to 17 years, who face many experience of pain, pain will be assessed during incentive spirometry sessions.
- Trial name
- SPIDO (NCT04041180)
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Sickle Cell Crisis
Low Dose Ketamine and Acute Pain Crisis
BACKGROUND: Current treatment standard for acute pain crisis in sickle cell disease (SCD) is largely supportive care: opioid analgesics, hydration, oxygen, and blood transfusion.
- Trial name
- LDK-SCD (NCT04330183)
- Testing
- Ketamine, Normal Saline
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Rhode Island Hospital
Sickle Cell Disease
Liver Fibrosis in Sickle Cell Disease
Patients with sickle cell disease many have a number of systemic complications, including liver problems. Some of these liver problems lead to liver fibrosis/cirrhosis, secondary to chronic blood transfusions.
- Trial name
- NCT02007746
- Testing
- Liver transient elastography (Fibroscan), Ferriscan, Liver biopsy in iron overloaded subjects.
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Miami
Sickle Cell Anemia, Chronic Kidney Disease
Efficacy, Safety Study and Benefit of Alkali Therapy in Sickle Cell Disease
The objective of this study is to assess the effect of alkali administration on bicarbonate and potassium levels in patients with Sickle Cell Disease (SCD) and depressed serum bicarbonate levels.
- Conditions
- Sickle Cell Anemia, Chronic Kidney Disease, Metabolic Acidosis
- Trial name
- NCT01894594
- Testing
- Sodium Bicarbonate
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University Hospitals Cleveland Medical Center
Sickle Cell Disease
Zinc for Infection Prevention in Sickle Cell Anemia-2 (ZIPS-2)
A randomized double-blinded placebo-controlled trial of zinc to reduce the incidence of severe or invasive infections in Ugandan children with sickle cell anemia (SCA)
- Trial name
- ZIPS-2 (NCT06561061)
- Testing
- zinc sulfate
- Where
- Uganda
- Volunteers
- 100 people
- Sponsor
- Indiana University
Sickle Cell Disease
Haploidentical Donor Hematopoietic Cell Transplant for Sickle Cell Disease
The purpose of this study it to evaluate a reduced toxicity conditioning regimen for haploidentical donor HCT followed by a GVHD prophylaxis regimen comprising of post-transplant cyclophosphamide, sirolimus and abatacept with the…
- Trial name
- NCT07616154
- Testing
- Cyclophosphamide 50mg, Abatacept, Alemtuzumab
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- St. Jude Children's Research Hospital
Sickle Cell Disease
THE IMPROVE TRIAL: Improving Pain Management and Outcomes With Various Strategies of Patient-Controlled Analgesia (PCA)
Patient-Controlled Analgesia (PCA) means that the patient is in control of his/her pain medicine. In this study two (2) different treatment plans of Patient-Controlled Analgesia will be used to treat people with sickle cell…
- Trial name
- IMPROVE (NCT00999245)
- Testing
- High Demand / Low Infusion, PCA Dosing Plan
- Where
- 28 sites in United States
- Volunteers
- 38 people
- Sponsor
- Carelon Research
Sickle Cell Disease
Sleep Apnea in Sickle Cell Disease
Despite the fact that obstructive sleep apnoea (OSA) is highly prevalent in the sickle cell population, studies focusing on the associations of the two diseases and their common pathophysiological mechanisms are scarce.
- Trial name
- DREPAPNEE (NCT03753854)
- Testing
- polysomnography and oxygen saturation exam, calculation of VOC frequency between the first polysomnography and the end of the first year of continuous positive airway pressure treatment, Blood samples
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Sickle Cell Disease
Gene Transfer for Sickle Cell Disease
A promising approach for the treatment of genetic diseases is called gene therapy. Gene therapy is a relatively new field of medicine that uses genetic material (mostly DNA) from the patient to treat his or her own disease.
- Trial name
- NCT03282656
- Testing
- single infusion of autologous bone marrow derived CD34+ HSC cells transduced with the lentiviral vector containing a short-hairpin RNA targeting BCL11a
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- David Williams
Hemoglobinopathies
Screening for Hemoglobinopathies in Pregnant Women
This prospective monocentric study project is to identify hemoglobinopathies in pregnant women in order to optimize antenatal care and to investigate the prevalence of hemoglobinopathies in pregnant women in Switzerland.
- Trial name
- NCT04029142
- Testing
- Review of routine lab data
- Where
- Switzerland
- Volunteers
- 1,785 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Sickle Cell Anemia, Sickle Cell Thalassemia
Clinical and Laboratory Characteristics of Sickle Cell Anemia Patients Admitted With Fever
This study will summarized the clinical and laboratory data and the outcome of all the patients suffering from Sickle Cell Anemia (Including Sickle cell thalassemia) admitted to the pediatric ward.
- Trial name
- NCT00736060
- Testing
- Observational
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- HaEmek Medical Center, Israel
Sickle Cell Disease
Delivering Patient-Facing Evidence-Based Guidelines Through mHealth to Adults With Sickle Cell Disease
In a hybrid type I effectiveness-implementation trial, our three-center research teams aim to examine whether empowering adults with sickle cell disease (SCD) with patient-facing SCD-specific guidelines through an mHealth…
- Trial name
- PF-Guide (NCT06919224)
- Testing
- mHealth app + booklets
- Where
- 4 sites in United States
- Volunteers
- 287 people
- Sponsor
- Ohio State University
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