Clinical trials: Sickle Cell Disorder
Acute Chest Syndrome, Sickle Cell Anemia
Awake Prone Positioning for Severe Acute Chest Syndrome
Acute chest syndrome (ACS) is the leading cause of admission to intensive care and the leading cause of death in patients with sickle cell disease.
- Trial name
- PRONE-ACS (NCT06698120)
- Testing
- Awake prone positioning (APP)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sickle Cell Disease
A Study Aimed to Assess the Needs of Subjects With Sickle Cell Disease and Healthcare Professionals Managing Sickle Cell Disease Patients in Selected Nigerian Centres
This pilot research is aimed to assess the needs of patients and health workers involved in Sickle Cell Disease (SCD) management in Nigeria.
- Trial name
- NCT04505969
- Testing
- Questionnaire to assess needs
- Where
- 4 sites in Nigeria
- Volunteers
- 192 people
- Sponsor
- Fondazione per la Ricerca Farmacologica Gianni Benzi Onlus
Sickle Cell Disease
Ph I/II Study of Allogeneic SCT for Clinically Aggressive Sickle Cell Disease (SCD)
The investigators propose to determine the engraftment and transplant related morbidity and mortality after a non-myeloablative allogeneic hematopoietic stem cell transplant protocol using immune- suppressive agents and low-dose…
- Trial name
- NCT01499888
- Testing
- Allogeneic Non-Myeloablative Stem Cell Transplantation, Alemtuzumab, Sirolimus
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Illinois Chicago
Sickle Cell Disease
Substudy of CADRE: for People With Extreme Phenotype: BIOCADRE
BIOCADRE is a CADRE substudy and aims to characterize more precisely the sickle cell patients with extreme phenotype.
- Trial name
- BIOCADRE (NCT03352986)
- Testing
- biological analysis, peripheral arterial tonometry
- Where
- 2 sites in Mali, Senegal
- Volunteers
- 300 people
- Sponsor
- Cardiologie et Développement
Sickle Cell Disease
Stem Cell Transplantation With Identical Donors for Patients With Sickle Cell Disease
This protocol studied the effect of administration of a myeloablative pretransplant preparative regimen followed by an infusion of donor stem cells in children with severe sickle cell disease.
- Trial name
- NCT00186810
- Testing
- Busulfan, Cyclophosphamide, Horse ATG, Allogeneic stem cell transplant
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- St. Jude Children's Research Hospital
Sickle Cell Disease, Thalassemia
Use of Mobile Technology for Intensive Training in Medication Management
Purpose: Assess whether intensive training with education and daily remote monitoring with provider involvement has a lasting positive impact on adherence to medication management.
- Trial name
- NCT02133560
- Testing
- Video recording, Medication Administration Log, Education
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Duke University
Sickle Cell Disease
Stem Cell Gene Therapy for Sickle Cell Disease
This Phase I clinical trial will assess the safety and initial evidence for efficacy of an autologous transplant of lentiviral vector modified peripheral blood for adults with severe sickle cell disease.
- Trial name
- NCT02247843
- Testing
- βAS3-FB vector transduced peripheral blood CD34+ cells
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Donald B. Kohn, M.D.
Cancer, Sickle Cell Disease
The Feasibility of Text Messaging to Assess Secondhand Smoke Exposure Among Youngsters With Cancer or Sickle Cell Disease
Exposure to secondhand smoke is a leading preventable cause of child morbidity and mortality, and the adverse health consequences of secondhand smoke are magnified among youngsters with cancer and sickle cell disease.
- Trial name
- NCT01591187
- Testing
- Text messaging, Questionnaire, Interviews
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- St. Jude Children's Research Hospital
Sickle Cell Disease
Voxelotor Neurocognitive Function Study
This is a Phase 3b, randomized, double-blind, placebo-controlled, multicenter study to assess the treatment effect of voxelotor on neurocognitive function as assessed by the National Institute of Health (NIH) Toolbox Cognition…
- Trial name
- NCT05228834
- Testing
- Voxelotor Only Product in Oral Dose Form
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Pfizer
SC Disease, Pain, Chronic
Ketamine Sickle Cell Disease
Sickle cell disease (SCD) often results in acute vaso-occlusive crisis (VOC), an obstruction of blood vessels resulting in ischemic injury and pain.
- Trial name
- SCD (NCT03502421)
- Testing
- Ketamine
- Sponsor
- University of South Florida
Sickle Cell Anemia
The Influence of micro-and Macro Vascular Dysfunction on Clinical Severity in Adults With Sickle Cell Anemia (SS) and Sickle Cell Hemoglobin C Disease (SC)
The primary aim of this study is to determine the implication of micro and macro vascular function on the clinical severity of SCD (SS, SC, Sß°) adults.
- Trial name
- VASCUDREPA (NCT07277023)
- Testing
- The influence of micro-and macro vascular dysfunction on clinical severity in adults with sickle cell anemia (SS) and sickle cell hemoglobin C disease (SC)
- Where
- Guadeloupe
- Volunteers
- 49 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Anemia, Sickle Cell Disease
Screening for Renal Complications in Children and Young Adults With Major Sickle Cell Disease
Sickle cell disease is the subject of targeted neonatal screening (carried out when one of the two parents is from an endemic country - sub-Saharan Africa, South-East Asia, Central America, the Caribbean) during the Guthrie test.
- Trial name
- NEPHRO-DREPA (NCT05211037)
- Testing
- Kidney function assessment
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Sickle Cell Disease
Role of Inflammasome in Platelet Activation in Sickle Cell Disease Patient
Sickle cell disease is characterized by chronic hemolytic anemia, painful crisis called vaso-occlusive crisis and chronic inflammation.
- Trial name
- DrePlaquette (NCT06986837)
- Where
- Guadeloupe
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Sickle Cell Disease
Oxbryta® Product Registry An Observational Study Designed to Evaluate the Effect of Oxbryta in Individuals With SCD
This registry is an observational study designed to evaluate the effect of Oxbryta in individuals with SCD in a real-world setting.
- Trial name
- PROSPECT (NCT04930445)
- Testing
- Oxbryta® (voxelotor) 500mg Tablets
- Where
- 43 sites in United States
- Volunteers
- 265 people
- Sponsor
- Pfizer
Pulmonary Hypertension
Imatinib and Carvedilol for High Blood Pressure in the Lungs in Adults With Sickle Cell Disease
Background: About one-tenth of adults with sickle cell disease have pulmonary hypertension (high blood pressure in the lungs). This condition can cause shortness of breath, pain crisis, and congestive heart failure.
- Trial name
- NCT01568645
- Testing
- Carvedilol, Imatinib
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Anemia, Sickle Cell
MBSR for Pain Catastrophizing in SCD
Significance: The purpose of this exploratory study is to test the feasibility, accessibility, and effects of a mindfulness-based stress reduction program (MBSR) on reducing pain catastrophizing in persons with sickle cell…
- Trial name
- NCT02394587
- Testing
- Mindfulness-based Stress Reduction
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Renal Impairment
Study of GBT021601 in Participants With Renal Impairment
Renal Impairment study of GBT021601.
- Trial name
- NCT05878704
- Testing
- GBT021601
- Where
- 4 sites in United States
- Volunteers
- 8 people
- Sponsor
- Pfizer
Anemia, Sickle Cell
MAST - Magnesium for Sickle Cell Acute Crisis in Children
The purpose of this study is to determine if intravenous magnesium sulfate treatment is effective in reducing the length of stay and pain in children with sickle cell disease suffering an acute vaso-occlusive episode.
- Trial name
- NCT00313963
- Testing
- Magnesium Sulfate, Normal Saline
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- The Hospital for Sick Children
Anemia, Sickle Cell, Healthy Volunteers
A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics and pharmacodynamics, pH and food effect, and preliminary efficacy of BMS-986470 in healthy volunteers and participants with sickle cell…
- Trial name
- NCT06481306
- Testing
- BMS-986470, Famotidine, Pantoprazole
- Where
- 32 sites in United States, Canada and 3 more
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Sickle Cell Disease
A Dose Escalation Study of Intravenous L-citrulline in Steady-state Sickle Cell Disease
The purpose of this study is to assess the maximum tolerated dose, safety and pharmacokinetics of an investigational drug, intravenous (IV) citrulline, in subjects in steady-state sickle cell disease.
- Trial name
- NCT02314689
- Testing
- Intravenous (IV) citrulline
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Suvankar Majumdar
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