Clinical trials: Sickle Cell Disorders
Sickle Cell Disease
A Phase 1 Study of Continuous Intravenous L-citrulline During Sickle Cell Pain Crisis or Acute Chest Syndrome
Sickle cell disease is a genetic red blood cell disorder characterized by vaso-occlusion from sickling of red blood cells, that can lead to pain or organ complications such as acute chest syndrome.
- Trial name
- NCT02697240
- Testing
- Intravenous citrulline
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Mississippi Medical Center
Sickle Cell Anemia
Carbon Monoxide Monitor for the Measurement of End-Tidal Carbon Monoxide Levels in Children With or Without Hemolysis
People who have Sickle Cell Anemia (HbSS) produce red blood cells with shorter lifespans. These red blood cells breakdown faster, and this is called hemolysis.
- Trial name
- NCT01848691
- Testing
- Measurement of carbon monoxide level in exhaled breath
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ashutosh Lal
Sickle Cell Disease
A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease
This study is conducted to confirm whether etavopivat works well at reducing the number of Vaso-occlusive crisis VOCs (sickle cell pain crises) caused by obstructions in blood vessels in adults and adolescents living with sickle…
- Trial name
- Hibiscus 2 (NCT06612268)
- Testing
- Etavopivat
- Where
- 175 sites in United States, Australia and 19 more
- Volunteers
- 510 people
- Sponsor
- Novo Nordisk A/S
Sickle Cell Disease, Stress
Feasibility of a Stress Reduction Intervention Study in Sickle Cell Disease
Stress is known to trigger acute pain crisis of sickle cell disease (SCD). SCD is an inherited blood disorder that afflicts about 100,000 people in the United States, and is among the most common lethal genetic diseases in the…
- Trial name
- NCT02501447
- Testing
- Guided audio-visual relaxation
- Volunteers
- 28 people
- Sponsor
- University of Illinois Chicago
Sickle Cell Disease, Measles Vaccination
Verifying Antibodies After Live Immunization Delivery (VALID): A Study of Measles Vaccine Immunogenicity in Children With Sickle Cell Disease
The goal of this study is to learn if infants with sickle cell disease (SCD) develop adequate protection after measles vaccines. (not looking at any prolonged duration)
- Conditions
- Sickle Cell Disease, Measles Vaccination, Sickle Cell Anemia
- Trial name
- VALID (NCT07356050)
- Where
- 3 sites in United States, Ghana and 1 more
- Volunteers
- 130 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Chuvash Polycythemia, Cerebrovascular Disease
Pulmonary Hypertension, Hypoxia and Sickle Cell Disease
The study will look at the risk factors for pulmonary hypertension (high blood pressure in the lungs) in children and adolescents with sickle cell anemia (SCA) and examine the role of hypoxia (oxygen shortage) in the disease.
- Conditions
- Chuvash Polycythemia, Cerebrovascular Disease, Pulmonary Hypertension, Sickle Cell Anemia
- Trial name
- NCT00495638
- Where
- 7 sites in United States, Russia
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Malaria, Sickle Cell Crisis
Intermittent Preventive Treatment for Malaria in Patient With Sickle Cell Disease
Malaria prophylaxis is recommended for sickle cell disease patients. In Nigeria, daily proguanil or weekly pyrimethamine are the most commonly prescribed regimens, but the current policy is not effective due to poor compliance…
- Trial name
- NCT01319448
- Testing
- Proguanil, mefloquine plus artesunate, Sulfadoxine-pyrimethamine plus amodiaquine
- Where
- Nigeria
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Anemia, Sickle Cell, Blood Disease
Cerebrovascular Involvement in Sickle Cell Disease - Comprehensive Sickle Cell Center
To continue studies on the two major neurological complications of sickle cell disease (SCD): namely, stroke and chronic encephalopathy.
- Conditions
- Anemia, Sickle Cell, Blood Disease, Cerebrovascular Accident
- Trial name
- NCT00005326
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Sickle Cell Disease, Beta-thalassemia
Partial Stem Cell Transplant for Sickle Cell Disease From Matched Donors
This is a non-ablative (partial) stem cell transplant for patients with severe sickle cell disease or beta-thalassemia requiring red cell transfusions.
- Trial name
- NCT07599176
- Testing
- Total Body Irradiation, Alemtuzumab, Abatacept
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Sickle Cell Disease
Examining the Knowledge, Attitudes, and Beliefs of Sickle Cell Disease Patients, Parents of Patients With Sickle Cell Disease, and Providers Towards the Integration of CRISPR in Clinical Care
Background: Sickle cell disease (SCD) is caused by a genetic defect that affects how hemoglobin is made. Due to this, people with SCD have abnormally-shaped red blood cells, which can result in poor oxygen transport in the body…
- Trial name
- NCT03167450
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Sickle Cell Disease, Cognitive Impairment
Cognitive Rehabilitation in Sickle Cell Disease
The majority of school-age children with sickle cell disease (SCD) experience neurocognitive deficits, even in the absence of stroke.
- Trial name
- NCT01793740
- Testing
- Cogmed
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Duke University
Sickle Cell Disease
Peripheral Arterial Tonometry and Neurocognition in Sickle Cell Disease
This study will examine sleep disordered breathing and sleep quality in participants (ages 12-25) diagnosed with sickle cell disease of any genotype.
- Trial name
- NCT06477289
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- St. Jude Children's Research Hospital
Sickle Cell Disease (SCD), Acute Chest Syndrome (ACS)
CPAP for Hypoxemic Acute Chest Syndrome in Sickle Cell Disease
Sickle cell disease (SCD) is a severe hemoglobinopathy, considered the first monogenic disease in the world. Acute chest syndrome (ACS), one of the most frequent and serious complications of SCD, is defined by the association of…
- Trial name
- SIPAP (NCT07703566)
- Testing
- O2+CPAP group
- Volunteers
- 140 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sickle Cell Disease, Attention Deficit
Feasibility and Efficacy of Attentional-Control Training in Sickle Cell Disease
Children with sickle cell disease (SCD) exhibit significantly reduced cognitive functioning (often difficulties with attention) compared to peers and siblings without SCD.
- Conditions
- Sickle Cell Disease, Attention Deficit, Cognitive Deficit in Attention
- Trial name
- ACT (NCT05099874)
- Testing
- EndeavorRx
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's National Research Institute
Sickle Cell Disease
Interest of Famotidine in Children With Sickle Cell Disease
The purpose of this study is to determine whether oral famotidine, a histamine type 2 receptor antagonist already widely used with very few side effects in other indications in children, is effective in reducing endothelial…
- Trial name
- FAMODREP (NCT05084521)
- Testing
- Famotidine 400 mg/50 mL
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sickle Cell Disease (SCD), Vaso-Occlusive Crises
Pleuropulmonary Ultrasound Imaging in Patients With Sickle Cell Disease in a Vaso-occlusive Crisis. "ECHODREP"
Introduction Sickle cell disease is the most common inherited genetic disorder in France and worldwide. Its main acute manifestation is vaso-occlusive crisis, a frequent reason for emergency department visits.
- Conditions
- Sickle Cell Disease (SCD), Vaso-Occlusive Crises, Acute Chest Syndrome
- Trial name
- ECHODREP (NCT07782489)
- Testing
- Pleuropulmonary ultrasound
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sickle Cell Disease (SCD)
Omega-3-Fatty Acids in Children With Sickle Cell Disease
The purpose of this feasibility study is to investigate the role of a dietary supplement in modulating the gut microbiota and improving pain outcomes in children with sickle cell disease (SCD).
- Trial name
- NCT07530965
- Testing
- Flaxseed
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Sickle Cell Anemia
Evaluation of the AMICUS RBCx System in Sickle Cell Patients
The purpose of this study is to evaluate the performance of the AMICUS Red Blood Cell Exchange (RBCx) System (Exchange and Depletion/Exchange procedures) in patients with sickle cell disease.
- Trial name
- NCT02372877
- Testing
- Amicus Red Cell Exchange in SCD patients
- Where
- 6 sites in United States
- Volunteers
- 83 people
- Sponsor
- Fenwal, Inc.
Sickle Cell Disease
Rollover Study for Patients With Sickle Cell Disease Who Have Completed a Prior Novartis-Sponsored Crizanlizumab Study
This is a multi-center multi-national rollover study to allow continued access to crizanlizumab for patients with sickle cell disease (SCD) who are on crizanlizumab treatment in a Novartis-sponsored study (parent study) and are…
- Trial name
- NCT04657822
- Testing
- Crizanlizumab
- Where
- 31 sites in United States, Belgium and 9 more
- Volunteers
- 130 people
- Sponsor
- Novartis Pharmaceuticals
Anemia, Sickle Cell
Specifying Interventions From the Sickle Cell Disease Implementation Consortium (SCDIC)
The goal of this study is to specify the interventions, implementation strategies and control conditions from the Sickle Cell Disease Implementation Consortium (SCDIC) using a mixed-methods approach to study site materials and…
- Trial name
- NCT03380351
- Testing
- SCDIC interventions
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine