Clinical trials: Side Effects
Analgesia, Prehospital
Quality of Telemedically Guided Prehospital Analgesia
The purpose of this retrospective study is to analyze quality and adverse events of analgesia by telemedically supported paramedics in comparison to conventional treatment by on-scene emergency medical service (EMS) physicians in…
- Conditions
- Analgesia, Prehospital, Telemedicine, Ambulance
- Trial name
- NCT02928705
- Testing
- physician operated telemedical prehospital analgesia, prehospital analgesia by on-scene EMS physicians
- Where
- Germany
- Volunteers
- 381 people
- Sponsor
- RWTH Aachen University
Generalized Anxiety Disorder (GAD)
Study to Assess Adverse Events and Change in Disease Activity When Oral ABBV-932 is Added to Antidepressant Therapies in Adult Participants With Generalized Anxiety Disorder
Generalized anxiety disorder (GAD) is usually treated with antidepressant therapy (ADT); however, sometimes ADTs alone are not enough to adequately treat GAD.
- Trial name
- NCT06846320
- Testing
- ABBV-932, Antidepressant Therapy (ADT)
- Where
- 52 sites in United States, Puerto Rico
- Volunteers
- 315 people
- Sponsor
- AbbVie
Healthy
Single-center Study Evaluating the Safety and Efficacy of Viscogel® as Adjuvant in Act-HIB® Vaccine
The purpose of this study is to show that ViscoGel® is safe when administrated alone and as an adjuvant together with Act-HIB® vaccine in healthy volunteers and to evaluate the quantitative and qualitative effect on the immune…
- Trial name
- VSG-2011-101 (NCT01578070)
- Testing
- 0.2μg Act-HIB®, ViscoGel® and 0.2μg Act-HIB®, ViscoGel® and 2μg Act-HIB®
- Where
- Sweden
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Viscogel AB
Schizophrenia
Therapeutic Drug Monitoring for Individualized Clozapine Therapy
The purpose of this study is to evaluate the factors affecting the occurrence of adverse drug reactions (glucose and lipid metabolism abnormality, changes in liver function index and sleeping tendency) and clinical effects in…
- Trial name
- NCT03523741
- Testing
- Clozapine
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Communication
The Patient and Family Centered I-PASS LISTEN Study: Language, Inclusion, Safety, and Teamwork for Equity Now
In 2014, a team of parents, nurses, and physicians created Patient and Family Centered I-PASS (PFC I-PASS), a bundle of communication interventions to improve the quality of information exchange between physicians, nurses, and…
- Trial name
- NCT05591066
- Testing
- PFC I-PASS Intervention, PFC I-PASS+ Intervention
- Where
- 8 sites in United States
- Volunteers
- 14,400 people
- Sponsor
- Boston Children's Hospital
Adverse Effect
ED90 of Norepinephrine and Phenylephrine Infusions in Preeclamptic Patients
The objective of this study is to investigate the ED90 of norepinephrine and phenylephrine infusions for preventing postspinal anesthesia hypotension under intensive treatment in preeclamptic patients during cesarean section
- Trial name
- NCT06158022
- Testing
- Norepinephrine, Phenylephrine
- Where
- China
- Volunteers
- 60 people
- Sponsor
- General Hospital of Ningxia Medical University
Contrast-Induced Nephropathy
High Dose Atorvastatin for Preventing Contrast-induced Nephropathy
The aim of this study is to determine the efficacy of atorvastatin in the prevention of contrast-induced nephropathy in patients undergoing computed tomography coronary angiography.
- Trial name
- NCT02114346
- Testing
- Atorvastatin, 0.9% sodium chloride
- Where
- Iran
- Volunteers
- 250 people
- Sponsor
- Isfahan University of Medical Sciences
HIV Infections
Effectiveness of Coping Training for People With HIV Experiencing Treatment Side Effects (The Balance Project)
This study will evaluate the effectiveness of cognitive behavioral coping training in improving side effect management and treatment adherence in HIV-infected patients who are taking antiretroviral medications.
- Trial name
- NCT00643903
- Testing
- Cognitive behavioral coping effectiveness training, Standard care, Single group workshop on coping effectiveness training
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of California, San Francisco
Femur Fracture
Radiographic Influences of Bisphosphonate Treatment on Femur
Although there is strong evidence that bisphosphonates prevent certain types of osteoporotic fractures, there are concerns that these medications may be associated with rare atypical femoral fractures (AFF).
- Trial name
- NCT01969279
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Tomidahama Hospital
Angioplasty, Transluminal, Percutaneous Coronary
Efficacy Study of Cilostazol Loading in Elective Percutaneous Coronary Intervention
The purpose of this study is to investigate the effect of cilostazol loading before planned PCI on major adverse cardiac and cerebrovascular events in patients with coronary artery disease.
- Trial name
- PRECEDE (NCT00938522)
- Testing
- Cilostazol
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Samsung Medical Center
Chemotherapy Induced Peripheral Neuropathy (CIPN), Paresthesia
Gut Microbiome Profiles in Patients With Chemotherapy-induced Neuropathy in the RCT OzoParQT (NCT06706544).
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating side effect of chemotherapy (CT), often requiring dose reductions or treatment interruptions, which can compromise efficacy of the planned CT…
- Conditions
- Chemotherapy Induced Peripheral Neuropathy (CIPN), Paresthesia, Numbness, Tingling
- Trial name
- OzoParQTmicrob (NCT06799351)
- Testing
- Ozone therapy
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Bernardino Clavo, MD, PhD
Diarrhea
Zinc Dosing Trial - Does Dose Reduction Reduce Side Effects But Retain Efficacy in Diarrhoea Management
Diarrhoea continues to be a major cause of child deaths. Current treatment of acute watery diarrhoea includes oral rehydration solution (ORS), zinc and continued feeding.
- Trial name
- ZTDT (NCT03078842)
- Testing
- Zinc tablets, 20 mg per day, Zinc tablets, 10 mg per day, Zinc tablets, 5 mg per day
- Where
- 2 sites in India, Tanzania
- Volunteers
- 4,500 people
- Sponsor
- Ayesha De Costa
Mid Face Volume Deficit
A Study to Assess Adverse Events and Change in Disease Activity of HArmonyCa Lidocaine Injectable Gel for Mid Face Soft Tissue Augmentation in Adult Participants
The cumulative effect of aging and environmental exposures (ie, ultraviolet, infrared, and visible light radiation and pollution) leads to wrinkles, discoloration, laxity, and roughness of sun exposed skin.
- Trial name
- NCT05452070
- Testing
- HArmonyCa Lidocaine Injectable Gel
- Where
- 12 sites in Canada, Spain and 1 more
- Volunteers
- 171 people
- Sponsor
- Allergan
Ampulla of Vater Adenoma, Ampulla of Vater Disease (Benign/Malignancy)
Predictors of Therapeutic Success and Adverse Events in Endoscopic Ampullectomy
Although ampullary tumors are rare (representing 0.6-0.8 % of all digestive cancers), their estimated incidence has increased in recent years (<1 per 100 000 per year).
- Trial name
- NCT06648746
- Volunteers
- 100 people
- Sponsor
- Universidade do Porto
Cisplatin Adverse Reaction, Cisplatin Nephrotoxicity
Evaluation of the Effect of N-acetylcysteine in Preventing Cisplatin-Induced Toxicities in Cancer Patients
Evaluation of the Effect of N-acetylcysteine in Preventing Cisplatin-Induced Toxicities in Cancer Patients
- Conditions
- Cisplatin Adverse Reaction, Cisplatin Nephrotoxicity, Cisplatin Induced Peripheral Neuropathy, Cancer Patients
- Trial name
- NCT06297369
- Testing
- N acetyl cysteine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Oral Mucositis, Head and Neck Cancer (H&N)
Oral Herpesviruses and Oral Mucositis in Patients Receiving Head and Neck Radiotherapy
Patients receiving radiotherapy for head and neck cancer often develop oral mucositis, a painful condition that causes redness and sores in the mouth.
- Conditions
- Oral Mucositis, Head and Neck Cancer (H&N), Radiotherapy Side Effects
- Trial name
- NCT07363031
- Testing
- Valacyclovir
- Where
- Brazil
- Volunteers
- 84 people
- Sponsor
- Instituto Oncoclinicas
Breast Cancer
An Innovative Smartphone Application for Adverse Event Management During Breast Cancer Adjuvant Chemotherapy
The aim of this study is to evaluate benefits of the app in breast cancer patients receiving the docetaxel, doxorubicin, and cyclophosphamide (TAC) chemotherapy.
- Trial name
- NCT05258461
- Testing
- use of a smartphone app for adverse event management, conventional adverse event management
- Volunteers
- 108 people
- Sponsor
- Peking Union Medical College Hospital
Breast Cancer, Cardiotoxicity
Exercise Prescription Guided by Heart Rate Variability in Breast Cancer Patients
Breast cancer is a chronic disease that has seen a boom in research into its treatments, improvements and effects in recent decades.
- Conditions
- Breast Cancer, Cardiotoxicity, Autonomic Imbalance
- Trial name
- NCT05040867
- Testing
- Physical exercise program
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- GO fit Lab- Ingesport
Acne Vulgaris
Clinical Trial on the Effects and Side Effects of ProOxy in the Treatment of Acne
This study was conducted to determine the effects and side effects of ProOxy facial spray in the treatment of acne.
- Trial name
- NCT01682200
- Testing
- ProOxy
- Where
- 2 sites in Philippines
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medivet Pty Ltd
Breast Cancer, eHealth
Mitigating Toxicity by Electronic Health Portal-mediated Interactive Monitoring of Patient-reported Side Effects
Chemotherapy induces side effects varying in severity, impacting patients' quality of life and necessitating unplanned hospital care. Patient-reported outcomes (PROs) could aid in early detection and management of side effects.
- Conditions
- Breast Cancer, eHealth, Symptom Monitoring, Self Management
- Trial name
- eChemoCoach (NCT06424054)
- Testing
- eChemoCoach
- Volunteers
- 746 people
- Sponsor
- Noordwest Ziekenhuisgroep