Clinical trials: Signs and Symptoms
Stress Disorders, Post-Traumatic, Sleep Disorders
Prazosin vs Paroxetine in Combat Stress-Related Post-Traumatic Stress Disorder (PTSD) Nightmares & Sleep Disturbance
The purposes of this study are: to evaluate the efficacy and tolerability of the drug prazosin compared to placebo for combat stress-related nightmares, sleep disturbance and overall function in recently combat-exposed returnees…
- Trial name
- NCT00202449
- Testing
- prazosin, paroxetine
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Inguinal Hernia, Convalescence
Pain and Convalescence After Laparoscopic Groin Hernia Repair
The investigators want to identify limiting factors for short convalescence after laparoscopic groin hernia repair. Before the operation patients are given intensive structured information about one day´s convalescence.
- Trial name
- Lap-Lyske (NCT00962338)
- Testing
- Information
- Where
- Denmark
- Volunteers
- 210 people
- Sponsor
- Zealand University Hospital
Hepatocellular Carcinoma, Metastasis
Radiofrequency Ablation Using Octopus Electrodes for Treatment of Focal Liver Malignancies
The purpose of this study is to evaluate the clinical feasibility and short-term outcome of switching monopolar RFA using a separable cluster electrode in patients with primary and secondary liver malignancies.
- Conditions
- Hepatocellular Carcinoma, Metastasis, Cholangiocarcinoma
- Trial name
- NCT02683538
- Testing
- Separable cluster electrode (Octopus®)
- Where
- South Korea
- Volunteers
- 196 people
- Sponsor
- Seoul National University Hospital
Patient With Influenza Like Illness
Effect of Influenza Vaccination of Healthcare Workers (HCW) on the Risk of Influenza in Patients Hospitalized in Short Stays Units
Hospital acquired influenza is associated with significant morbidity and mortality in hospitalized patients notably elderly patients. Vaccination of HCW is recommended to prevent influenza transmission in healthcare setting.
- Trial name
- NCT02198638
- Testing
- A nasal swab
- Where
- 2 sites in France
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Long COVID
DAOIB for the Treatment of Brain Fog
This is a 24-week open trial. We will enroll long-COVID patients with cognitive impairments. All patients will receive DAOIB for 24 weeks.
- Trial name
- NCT05764538
- Testing
- DAOIB
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Chang Gung Memorial Hospital
Gastrointestinal Cancers, Frailty at Older Adults
FRAIL and FiND for Chemotherapy Toxicity in GI Cancer
Older adults with gastrointestinal cancer may experience serious side effects during chemotherapy, particularly when they have reduced physical strength, functional limitations, or other health conditions.
- Conditions
- Gastrointestinal Cancers, Frailty at Older Adults, Chemotherapy
- Trial name
- FRAIL-GI (NCT07272538)
- Testing
- No Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people
- Sponsor
- Ankara Etlik City Hospital
Delirium, Dementia
Delirium and Cognitive Impairment Development in Hospitalized Older Adults Under Isolation Conditions
The goal of this observational study is to examine if older patients who need to be under isolation precautions due to multidrug resistant bacteria or other reasons have an increased risk of suffering from delirium or cognitive…
- Conditions
- Delirium, Dementia, Cognitive Impairment
- Trial name
- DELiso (NCT07114458)
- Where
- Germany
- Volunteers
- 404 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Chronic Neck Pain
The Effect of East-West Collaborative Medicine on Chronic Cervical Pain
The purpose of this study is to assess the effect of East-West collaborative medicine on chronic cervical pain.
- Trial name
- NCT01205958
- Testing
- acupuncture
- Where
- South Korea
- Volunteers
- 45 people
- Sponsor
- Kyunghee University Medical Center
Lower Urinary Tract Symptoms, Urinary Incontinence
Turkish Validation and Reliability of LURN SI-29 Questionnaire in Patients With Lower Urinary Tract Symptoms
Lower urinary tract symptoms is quite frequent in men and women. To better understand the the symptoms that characterize lower urinary tract, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) has…
- Trial name
- NCT04722458
- Testing
- Lower Urinary Tract Dysfunction Research Network Symptom Index-29 (LURN SI-29), IPSS, UDI-6
- Where
- Turkey (Türkiye)
- Volunteers
- 290 people
- Sponsor
- Istanbul Medeniyet University
Leukemia
Fludarabine and Radiation Therapy in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Chronic Phase or Accelerated Phase Chronic Myelogenous Leukemia
RATIONALE: Giving low doses of chemotherapy, such as fludarabine, and radiation therapy before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells.
- Trial name
- NCT00110058
- Testing
- recombinant interferon alfa, therapeutic allogeneic lymphocytes, cyclosporine
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Fred Hutchinson Cancer Center
Advanced Malignant Solid Neoplasm, RAS Mutation
A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies
RSC-101 is a Phase 1a/1b clinical trial of RSC-1255 in adult study participants with advanced solid tumor malignancies who are intolerant of existing therapies known to provide clinical benefit, have disease that has progressed…
- Conditions
- Advanced Malignant Solid Neoplasm, RAS Mutation, Lung Cancer, Colon Cancer
- Trial name
- NCT04678648
- Testing
- RSC-1255 Dose Escalation, RSC-1255 Dose Expansion
- Where
- 3 sites in United States
- Volunteers
- 134 people
- Sponsor
- RasCal Therapeutics, Inc.
Amyotrophic Lateral Sclerosis
Effects of Nocturnal Non-invasive Ventilation in Patients With Amyotrophic Lateral Sclerosis
Specific aims: Aim 1. To determine the incidence of hypoventilation in Amyotrophic Lateral Sclerosis (ALS) patients. Aim 2. To identify the clinical characteristics and risk factors associated . Aim 3.
- Trial name
- NCT00958048
- Testing
- non-invasive ventilation
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Taiwan University Hospital
Sleep Deprivation, Menstrual Cycle
The Effects of Night Shift Work on Health Across the Menstrual Cycle
The study aims to investigate the effects of sleep deprivation on women's health across different phases of the menstrual cycle.
- Conditions
- Sleep Deprivation, Menstrual Cycle, Brain Health, Metabolism
- Trial name
- MENSLEEP (NCT06683248)
- Testing
- Investigate sleep deprivation
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Coronary Artery Disease, Arterial Occlusive Diseases
The ENDEAVOR II Clinical Trial: The Medtronic Endeavor Drug Eluting Coronary Stent System in Coronary Artery Lesions
To demonstrate the safety and efficacy of the Driver Coronary Stent coated with 10 mcg/mm ABT-578 compared to the uncoated Driver Stent for the treatment of single de novo lesions in native coronary arteries 2.25-3.5 mm in…
- Conditions
- Coronary Artery Disease, Arterial Occlusive Diseases, Coronary Disease, Coronary Arteriosclerosis
- Trial name
- ENDEAVOR II (NCT00614848)
- Testing
- Endeavor drug eluting coronary stent
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Medtronic Vascular
Post-operative Pain, Symptomatic Irreversible Pulpitis
Role of Propolis Endodontic Irrigant on Post-Operative Pain
The goal of this clinical trial is to compare propolis and sodium hypochlorite as endodontic irrigants in patients presenting with symptomatic irreversible pulpitis. .
- Trial name
- NCT05974748
- Testing
- Sodium hypochlorite 5.25%, Propolis 20%
- Where
- Pakistan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Chronic Pancreatitis
Exercise Inhibit Innate Immune Response and Ameliorate Chronic Pancreatitis
The goal of this observational study is to learn about the effects of different physical exercise on disease progression in patients with chronic pancreatitis.
- Trial name
- NCT06534138
- Testing
- Physical exercise
- Where
- China
- Volunteers
- 121 people
- Sponsor
- Changhai Hospital
Obesity
Safety and Efficacy of MET-3 in Obese Human Subjects
A pilot study to explore the metabolic effect and safety of a 3-week course of therapy with MET-3 in obese subjects
- Trial name
- NCT03660748
- Testing
- MET-2
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- NuBiyota
Astrocytoma, Glioblastoma
Detecting Malignant Brain Tumor Cells in the Bloodstream During Surgery to Remove the Tumor
Glioblastomas, the most frequent malignant brain tumor in adults, are widespread in the brain, despite their discrete appearance on computed tomography (CT) or magnetic resonance imaging (MRI).
- Conditions
- Astrocytoma, Glioblastoma, Glioma
- Trial name
- NCT00001148
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Hypoxemic Respiratory Failure
Correlation of Peak Tidal Inspiratory Flow Measured Before and After Extubation in Adult Patients With Hypoxemia
In this study, patients who are ready for extubation and indicated for high-flow nasal cannula therapy after extubation will be enrolled, the investigators would measure the patient peak tidal inspiratory flow (PTIF) pre and post…
- Trial name
- NCT04971148
- Testing
- HFNC flow set at patient peak tidal inspiratory flow, HFNC flow set at 1.33 times of patient peak tidal inspiratory flow, HFNC flow set at 1.67 times of patient peak tidal inspiratory flow
- Where
- 2 sites in United States, Spain
- Volunteers
- 5 people
- Sponsor
- Rush University Medical Center
Hemorrhage, Vascular Injury
A Transparent Elasticized Adhesive Occlusive Compression Bandage for Use as an Arterial Tourniquet
This cross-over study of twenty five (anticipated) healthy human subjects will utilize two active control devices, and two different widths of the investigational device.
- Trial name
- NCT02592655
- Testing
- Pneumatic Tourniquet, One Windlass Tourniquet, Two Windlass Tourniquets
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Marcus Migura