Clinical trials: Sildenafil
Persistent Pulmonary Hypertension of the Newborn
IV Sildenafil Persistent Pulmonary Hypertension Of The Newborn
To determine the efficacy of iv sildenafil in term and near term infants with PPHN (persistent pulmonary hypertension of the newborn), by measuring the need for inhaled nitric oxide (iNO) or extracorporeal membrane oxygenation…
- Trial name
- NCT01360671
- Testing
- Sildenafil
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Acute Kidney Injury
A Study to Determine the Pharmacokinetic Profile, Safety and Tolerability of Sildenafil (REVATIO®) in Cardiac Surgery
The objectives of the study are the following: To evaluate the pharmacokinetic profile of Sildenafil in cardiac surgery patients at risk of acute kidney injury To determine the safety and tolerability of Sildenafil in cardiac…
- Trial name
- Revaki-001 (NCT02136329)
- Testing
- Sildenafil
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- University of Leicester
Safety
FDA Phase IV - Commitment - Retinal Function Study
Vardenafil (Levitra) and Sildenafil (Viagra) are drugs that are marketed for use in patients with erectile dysfunction. The purpose of this study is to find out if there are any changes in the eye after taking at least 15 doses…
- Trial name
- NCT00461565
- Testing
- Sildenafil, Vardenafil (Levitra, BAY38-9456)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Bayer
Erectile Dysfunction, Testosterone Deficiency
Effect of Testosterone in Men With Erectile Dysfunction
The purpose of this placebo-controlled study is to determine if testosterone replacement therapy, administered by transdermal gel, can improve the response to sildenafil (Viagra R) treatment in men who have erectile dysfunction…
- Conditions
- Erectile Dysfunction, Testosterone Deficiency, Diabetes
- Trial name
- TED (NCT00512707)
- Testing
- Sildenafil citrate (open label), Testosterone gel
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Boston University
Ischemic Stroke
Sildenafil (Viagra) Treatment of Subacute Ischemic Stroke
Stroke is the third leading cause of death in the United States and the leading cause of serious long-term disability. Approximately 50% of the 750,000 people affected by stroke each year have residual physical impairment.
- Trial name
- NCT00452582
- Testing
- Sildenafil (Viagra), Usual care
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Henry Ford Health System
Fetal Growth Restriction
Sildenafil Citrate for Treatment of Growth-restricted Fetuses
The aim of this study is to assess the effect of Sildenafil citrate therapy on neonatal outcomes in women with fetal growth restriction.
- Trial name
- NCT03177824
- Testing
- Sildenafil Citrate 25Mg Tab
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Aortic Stenosis
Acute Hemodynamic Effects of Sildenafil in Patients With Severe Aortic Stenosis
Pulmonary hypertension is common in patients with aortic stenosis and is associated with worse operative and long-term outcomes.
- Trial name
- NCT01060020
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Washington University School of Medicine
Erectile Dysfunctions
Daily Tadalafil 5 mg Combined With On-Demand Sildenafil 100 mg for Treatment of Erectile Dysfunction in PDE-5I Non Responder Patients
The goal of this clinical trial is to evaluate whether daily dosing with tadalafil 5 mg combined with on-demand sildenafil 100 mg can improve erectile function in men with erectile dysfunction (ED) who do not respond to PDE5…
- Trial name
- NCT07391579
- Testing
- Tadalafil 5 mg & Sildenafil 100mg
- Where
- 11 sites in Egypt
- Volunteers
- 500 people
- Sponsor
- Mansoura University
Erectile Dysfunction
New Treatment in Erectile Dysfunction Patients.
Erectile dysfunction patients who are non responder to sildenafil will be treated with hyperbaric oxygen therapy with 100% concentration and at 2 ATM for 30 consecutive sessions each one 90 minutes and then will be reassessed.
- Trial name
- NCT05439486
- Testing
- hyperbaric oxygen therapy within hyperbaric oxygen therapy chamber.
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
Pulmonary Hypertension Associated With Connective Tissue Disease
VasoREACTivity Testing With Intravenous SILdenafil in Patients With Precapillary Pulmonary Hypertension
Sildenafil is a selective pulmonary vasodilator; in patients with a special kind of pulmonary hypertension it is approved for treatment.
- Trial name
- SIL-REACT (NCT01889966)
- Testing
- Sildenafil
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Kerckhoff Heart Center
Vascular Diseases
Sildenafil to Reduce Vascular Remodeling During Left Ventricular Assist Device Support
Contemporary left ventricular assist device (LVAD) therapy improves survival during advanced heart failure but vascular aging develops rapidly leading to major adverse events including stroke and bleeding in nearly half of…
- Trial name
- NCT06510322
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Montefiore Medical Center
Central Venous Pressure, Hepatectomy
Preoperative Sildenafil Administration for Hepatectomy
Hepatectomy is an important treatment for liver diseases, and bleeding is one of the most common complications during dissection of the liver parenchyma.
- Conditions
- Central Venous Pressure, Hepatectomy, Hemodynamics Instability, Sildenafil
- Trial name
- NCT06237751
- Testing
- Sildenafil 100 MG
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- First People's Hospital of Chenzhou
Diabetic Neuropathy
An Open Label, Dose Finding Trial of Viagra for the Treatment of Neuropathic Pain (in Diabetes Mellitus)
The purpose of this study is to study if sildenafil (Viagra) is effective in improving neuropathic pain. This will be an open label study at 3 doses of sildenafil (25 mg, 50 mg and 100 mg).
- Trial name
- NCT00194909
- Testing
- sildenafil (Viagra)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Weill Medical College of Cornell University
Coronary Vasospasm
Therapeutic Effect of Sildenafil in Patients With Coronary Vasospasm
This will be a prospective, phase IIIb, double-blind and randomized trial testing the effect of single dose sildenafil application in patients with coronary vasospasm compared to placebo application.
- Trial name
- NCT00454714
- Testing
- single dose Sildenafil
- Where
- Germany
- Sponsor
- Udo Sechtem
Migraine Without Aura
Effect of Sildenafil in Individuals With Migraine Pretreated With Erenumab
An outstanding scientific question, that merits further investigation, is whether dilation of intracranial arteries is implicated in the pathogenesis of cephalic pain in migraine.
- Trial name
- COMPETE (NCT05889455)
- Testing
- Sildenafil
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Danish Headache Center
Erectile Dysfunction
A Study in Patients With Erectile Dysfunction
The purpose of this study is to investigate if treatment in erectile dysfunction with a long-acting drug (Tadalafil) taken once a day or taken as needed results in a longer treatment adherence and better long term outcomes (over…
- Trial name
- NCT01122264
- Testing
- Tadalafil, Sildenafil Citrate
- Where
- 45 sites in France, Germany and 6 more
- Volunteers
- 770 people
- Sponsor
- Eli Lilly and Company
Erectile Dysfunction
A Study of Tadalafil and Sildenafil in Men With Erectile Dysfunction in China
The primary objective of this study is to evaluate whether, after two 8-week treatment periods, male patients with erectile dysfunction (ED) in China prefer 20 milligram (mg) tadalafil or 100 mg sildenafil.
- Trial name
- NCT01352507
- Testing
- Tadalafil, Sildenafil
- Where
- 9 sites in China
- Volunteers
- 383 people
- Sponsor
- Eli Lilly and Company
Recurrent Miscarriage
Role of Sildenafil Citrate in Patients With Unexplained Recurrent Miscarriages
The purpose of this study is to determine whether sildenafil citrate is effective in improving uterine artery blood flow and oxidative stress in patients with unexplained recurrent miscarriages
- Trial name
- NCT01419392
- Testing
- Sildenafil citrate
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Small Vessel Cerebrovascular Disease
Oxford Haemodynamic Adaptation to Reduce Pulsatility Trial
Chronic damage to small blood vessels deep in the brain is seen in half of patients over the age of 60 and almost all patients over the age of 80, and is responsible for up to a third of strokes and almost half of patients with…
- Trial name
- OxHARP (NCT03855332)
- Testing
- Sildenafil, Cilostazol
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- University of Oxford
Pulmonary Arterial Hypertension (PAH)
Randomized Study of Triple Therapy vs Sildenafil Dose Optimization in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a rare and progressive disease characterized by increased pressure in the pulmonary arteries, leading to right heart failure and premature death.
- Trial name
- ASCEND-PAH (NCT07713914)
- Testing
- Prostacyclin Pathway Agent, Sildenafil Dose Optimization
- Where
- Brazil
- Volunteers
- 196 people
- Sponsor
- University of Sao Paulo General Hospital