Clinical trials: Simvastatin
Cardiovascular Diseases
A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High-Risk Patients With Hypertriglyceridemia and on Statin
AMR101 (icosapent ethyl [ethyl-EPA]) is a highly purified ethyl ester of eicosapentaenoic acid (EPA) developed by Amarin Pharma Inc.
- Trial name
- REDUCE-IT (NCT01492361)
- Testing
- AMR101, Statin therapy
- Where
- 410 sites in United States, Australia and 9 more
- Volunteers
- 8,179 people
- Sponsor
- Amarin Pharma Inc.
Pulmonary Disease, Chronic Obstructive
Simvastatin Therapy for Moderate and Severe COPD
To determine the effect of daily administration of 40 mgms simvastatin taken for at least 12 months (range 12-36 months) on the frequency of exacerbations of chronic obstructive lung disease (COPD) in patients with moderate to…
- Trial name
- STATCOPE (NCT01061671)
- Testing
- simvastatin
- Where
- 51 sites in United States, Canada
- Volunteers
- 885 people
- Sponsor
- University of Minnesota
Acute Pancreatitis
Simvastatin in Reducing Pancreatitis in Patients With Recurrent, Acute or Chronic Pancreatitis
This randomized phase II trial studies how well simvastatin works in reducing pancreatitis (the inflammation of the pancreas) in patients with pancreatitis that occurs more than once (recurrent), has worsened quickly (acute), or…
- Trial name
- NCT02743364
- Testing
- Laboratory Biomarker Analysis, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 5 sites in United States
- Volunteers
- 8 people
- Sponsor
- National Cancer Institute (NCI)
Stable Angina
Antiplatelet and Anti-inflammatory Effects of Statins and Ezetimibe
Among patients with stable coronary artery disease (CAD), it is not clear if the pleiotropic effects of cholesterol reduction differ between high-dose simvastatin alone and combined ezetimibe/simvastatin.
- Trial name
- NCT00474123
- Testing
- Simvastatin 80 mg/day for 6 weeks, Ezetimibe 10 mg / Simvastatin 20 mg
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- University of Sao Paulo
Healthy
Drug-drug Interaction of Empagliflozin (BI 10773) and Simvastatin
The objective of the study is to investigate the drug-drug interaction potential between BI 10773 and simvastatin.
- Trial name
- NCT01304329
- Testing
- BI 10773, simvastatin
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Hypercholesterolemia, Dyslipidemia
Lipid Biomarker Study in Men With Dyslipidemia After Simvastatin Treatment (Study MK-0000-140)(COMPLETED)
The purpose of this study was to provide human lipidomics standards with simvastatin treatment that were to be used for comparison with similar preclinical studies.
- Trial name
- NCT00935259
- Testing
- Simvastatin
- Volunteers
- 31 people
- Sponsor
- Merck Sharp & Dohme LLC
Cardiovascular Disorder, Diabetes Mellitus
Ezetimibe/Simvastatin (MK-0653A) Versus Rosuvastatin Versus Doubling Statin Dose in Participants With Cardiovascular Disease and Diabetes Mellitus (MK-0653A-133)(COMPLETED)
The purpose of this study is to determine the efficacy of switching to a combination tablet ezetimibe/simvastatin (10mg/20mg) versus rosuvastatin (10 mg) versus doubling the statin dose in those patients who have cardiovascular…
- Trial name
- NCT00862251
- Testing
- ezetimibe (+) simvastatin, simvastatin 40 mg or atorvastatin 20 mg, Rosuvastatin
- Volunteers
- 808 people
- Sponsor
- Organon and Co
TBI-Traumatic Brain Injury
Simvastatin for mTBI
Study of simvastatin in Iraq/Afghanistan Veterans with multiple blast exposure and mTBI. The study will measure substances in cerebrospinal fluid (CSF) that are related to dementing disorders.
- Trial name
- NCT01952288
- Testing
- simvastatin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- VA Office of Research and Development
Hypercholesterolemia
A Study to Assess the Cholesterol Lowering Effect of an Ezetimibe/Simvastatin Combination Tablet Compared to Another Cholesterol Lowering Drug in Patients With High Cholesterol and With High Cardiovascular Risk (0653A-809)(COMPLETED)
This is a multicenter study to evaluate the safety and efficacy of ezetimibe/simvastatin versus rosuvastatin in participants with high cholesterol.
- Trial name
- NCT00479713
- Testing
- ezetimibe (+) simvastatin, Comparator : rosuvastatin calcium
- Volunteers
- 618 people
- Sponsor
- Organon and Co
Dyslipidemia
A Study of LY2484595 in Patients With High LDL-C or Low HDL-C
The primary purpose of your participation in this study is to help answer the following research question(s) Whether LY2484595 in combination with a statin drug (atorvastatin, simvastatin or rosuvastatin; currently used to treat…
- Trial name
- NCT01105975
- Testing
- LY2484595, Atorvastatin, Simvastatin
- Where
- 59 sites in United States, Denmark and 4 more
- Volunteers
- 398 people
- Sponsor
- Eli Lilly and Company
Hypertriglyceridemia
Effect of AMR101 (Ethyl Icosapentate) on Triglyceride (Tg) Levels in Patients on Statins With High Tg Levels (≥ 200 and < 500 mg/dL)
The primary objective is to determine the efficacy of AMR101 (ethyl icosapentate) compared to placebo in lowering high fasting triglyceride levels in patients with high risk for cardiovascular disease and fasting triglyceride…
- Trial name
- ANCHOR (NCT01047501)
- Testing
- AMR101 (ethyl icosapentate) - 4 g/day, AMR101 (ethyl icosapentate) - 2 g/day
- Where
- 80 sites in United States
- Volunteers
- 702 people
- Sponsor
- Amarin Pharma Inc.
Breast Cancer
Simvastatin in Preventing a New Breast Cancer in Women at High Risk for a New Breast Cancer
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming, growing, or coming back. The use of simvastatin may keep cancer from coming back in women who are at high risk for a new breast cancer after…
- Trial name
- NCT00334542
- Testing
- simvastatin
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Epilepsy
Effect of Repeated Administration of Eslicarbazepine Acetate on the Pharmacokinetics of Simvastatin in Healthy Subjects
The primary objective was to investigate whether multiple-dose administration of ESL 800 mg once daily affects the pharmacokinetics of simvastatin, a substrate of CYP34A.
- Trial name
- NCT00987558
- Testing
- Eslicarbazepine acetate, Simvastatin
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Coronary Artery Disease
Reduction in YEllow Plaque by Aggressive Lipid LOWering Therapy
The study will assess the regression of yellow plaque content of the lipid pool after aggressive lipid therapy by utilizing NIR spectroscopy.
- Trial name
- YELLOW (NCT01567826)
- Testing
- standard of care lipid therapy, Aggressive lipid therapy
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Annapoorna Kini
Hypercholesterolemia
To Evaluate Ezetimibe/Simvastatin and Niacin (Extended Release Tablet) in Patients With Type IIa or Type IIb Hyperlipidemia (0653A-091)(COMPLETED)
To evaluate the efficacy and safety of ezetimibe/simvastatin and niacin in patients with high cholesterol.
- Trial name
- NCT00271817
- Testing
- Comparator: ezetimibe/simvastatin + niacin (ER), Comparator: niacin (ER) tablet, Comparator: ezetimibe (+) simvastatin
- Volunteers
- 1,220 people
- Sponsor
- Organon and Co
Dyslipidemias
The Effect of XueZhiKang on Fatigue：Comparing With Simvastatin
Both XueZhiKang and Statins are cholesterol-lowering medications that are often prescribed for individuals with high cholesterol and who are at risk for cardiovascular disease (CVD).
- Trial name
- NCT01686451
- Testing
- XueZhiKang, simvastatin
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Wenzhou Medical University
Healthy, Obese
A Drug-Drug Interaction Study of Orforglipron (LY3502970) in Healthy Overweight and Obese Participants
The main purpose of this study is to determine effect of orforglipron capsule formulation on the amount of digoxin, rosuvastatin, acetaminophen, midazolam, and simvastatin (each given alone and together with orforglipron) that…
- Conditions
- Healthy, Obese, Overweight
- Trial name
- NCT06186622
- Testing
- Orforglipron, Simvastatin, Digoxin
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Hypercholesterolemia, Dyslipidemia
Study to Compare the Efficacy and Safety of Pitavastatin and Simvastatin
The purpose of this study is to compare the efficacy and safety of pitavastatin with that of simvastatin.
- Trial name
- NCT00309777
- Testing
- Pitavastatin, Simvastatin
- Where
- 42 sites in Finland, Italy and 3 more
- Volunteers
- 857 people
- Sponsor
- Kowa Research Europe
Periodontal Diseases
Effect of Locally-Applied Simvastatin on Clinical Attachment Level and Alveolar Bone in Periodontal Maintenance Patients
The purpose of this study is to determine of local application of commericially-available, FDA-approved preparation of simvastatin is effective in increasing clinical attachment levels (primary outcome), as well as alveolar bone…
- Trial name
- NCT03452891
- Testing
- Methylcellulose, Simvastatin-Methylcellulose
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nebraska