Clinical trials: Single Coronary Vessel Disease
Coronary Heart Disease
Safety and Efficacy of APL180 in Healthy Volunteers and Patients With Coronary Heart Disease (CHD)
The purpose of this study is to determine: (1) the safety and pharmacokinetics of APL180 administered as a single intravenous infusion in healthy volunteers, and (2) the safety, pharmacokinetics and pharmacodynamics of single and…
- Trial name
- NCT00568594
- Testing
- APL180
- Where
- 11 sites in United States, Belgium and 5 more
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Novartis
Single Coronary Vessel Disease
A First-in-Man Study of IBS
The study is a pilot clinical trial for Sirolimus-eluting Iron Bioresorbable Coronary Scaffold System（IBS）. The main purpose of this study is to evaluate the feasibility, preliminary safety and efficacy of IBS.
- Trial name
- IBS-FIM (NCT03509142)
- Testing
- Sirolimus-eluting Iron Bioresorbable Coronary Scaffold System
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Lifetech Scientific (Shenzhen) Co., Ltd.
Coronary Artery Disease, Coronary Atherosclerosis
Prognostic Value of SPECT-imaging Myocardial Perfusion Heterogeneity
Endothelial dysfunction has been demonstrated to be an early marker of coronary artery disease (CAD). On the other hand, myocardial perfusion single photon emission computed tomography (MP-SPECT) is a widely used technique for…
- Trial name
- EVAPERF (NCT02208765)
- Testing
- Stress Single Photon Emission Computed Tomography
- Where
- France
- Volunteers
- 1,600 people
- Sponsor
- University Hospital, Grenoble
Refractory Angina
Allopurinol in Patients With Refractory Angina to Improve Ischemic Symptoms
Despite numerous advances in medical treatment and revascularization procedures for the treatment of patients with stable angina, debilitating symptoms that are unresponsive to conventional therapy may occur in patients…
- Trial name
- ARAMIS (NCT04368819)
- Testing
- Allopurinol 300 MG
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Ministry of Health, Brazil
Coronary Occlusion
Supplemental Study to Evaluate the Safety and Effectiveness of the NovaCross™ Micro-catheter
This study will include up to 60 eligible male and female subjects. The purpose of this trial is to evaluate the safety and effectiveness of the NovaCross™ micro-catheter when used to facilitate crossing of Chronic Total…
- Trial name
- NCT03717675
- Testing
- NovaCross™ Chronic Total Occlusion micro-catheter
- Where
- 3 sites in Israel, Poland and 1 more
- Volunteers
- 40 people
- Sponsor
- Nitiloop Ltd.
Coronary Artery Disease, High Bleeding Risk Patients
ULTRA LONG: BioFreedom Ultra
The goal of this Prospective, multi-center, open-label single-arm study is to Assess the Safety and Effectiveness of additional sizes of the BioFreedom Ultra CoCr Biolimus A9 coated coronary stent system in Patients at high risk…
- Trial name
- NCT05643430
- Testing
- BioFreedom Ultra
- Where
- 9 sites in France, United Kingdom
- Volunteers
- 86 people
- Sponsor
- Biosensors Europe SA
Single-ventricle, Fontan Procedure
Hemodynamic, Vascular and Muscular Parameters of Exercise Capacity in Single-Ventricle Patients With Fontan Procedure
After the Fontan procedure applied in patients with a functional or anatomical single ventricle, patients are faced with significant morbidity and mortality risk.
- Conditions
- Single-ventricle, Fontan Procedure, Hemodynamic Instability, Arterial Stiffness
- Trial name
- NCT05011565
- Testing
- Demographic and Clinical Characteristics, Maximal Exercise Capacity, Submaximal Exercise Capacity, Hemodynamic Parameters, Muscle Strength, Muscle Oxygenation, Vascular Function
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Myocardial Infarction
IRI-EXPLORE: A Study to Test Whether BI 765845 Helps People Who Have Had a Heart Attack
This study is open to adults aged 18 and over who have just had a heart attack. The purpose of this study is to find out whether a medicine called BI 765845 helps people who have had a heart attack.
- Trial name
- IRI-EXPLORE (NCT06139328)
- Testing
- BI 765845
- Where
- 53 sites in Australia, Canada and 12 more
- Volunteers
- 160 people
- Sponsor
- Boehringer Ingelheim
Healthy Volunteers
Study to Compare the Pharmacodynamics and Pharmacokinetics of Acetylsalicylic Acid Powder for Oral Inhalation With Non-enteric-coated Chewable Aspirin in Healthy Adults.
The goal of this clinical trial is to compare the pharmacodynamics (PD), pharmacokinetics (PK), safety, and tolerability of acetylsalicylic acid powder for oral inhalation (i-ASA) with non-enteric-coated chewable aspirin (C-ASA)…
- Trial name
- NCT05625334
- Testing
- ASA, non-enteric-coated chewable aspirin
- Where
- 2 sites in United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Vectura, Inc.
Coronary Disease, Diabetes Mellitus
A Study Examining Torcetrapib/Atorvastatin And Atorvastatin Effects On Clinical CV Events In Patients With Heart Disease
The Torcetrapib project was terminated on December 2, 2006 due to safety findings. To demonstrate if torcetrapib/atorvastatin can reduce the risk for major cardiovascular disease events, when compared to atorvastatin alone, in…
- Trial name
- ILLUMINATE (NCT00134264)
- Testing
- torcetrapib/atorvastatin, atorvastatin
- Where
- 221 sites in United States, Australia and 5 more
- Volunteers
- 15,067 people
- Sponsor
- Pfizer
Hypertension, Blood Pressure
Performance of the Aktiia Optical Blood Pressure Monitoring Device Against Double Auscultation
This study with N = 225 participants (1 cohort of a minimum of 85 and maximum of 140 participants, and an additional cohort with 85 participants) over 9 visits has been designed to assess the accuracy of Aktiia.product-us…
- Conditions
- Hypertension, Blood Pressure, Heart Rate
- Trial name
- NCT05236348
- Testing
- Aktiia.product-us
- Where
- Switzerland
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Aktiia SA
Coronary Artery Calcification, Coronary Artery Disease
Intravascular Imaging-Guided Intravascular Lithotripsy for Severe Coronary Calcified Lesions.
This study aims to investigate the efficacy and safety of intravascular lithotripsy (IVL) balloon in treating coronary calcified lesions at our center.
- Trial name
- NCT07444346
- Testing
- percutaneous coronary intervention
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Angioplasty, Chronic Coronary Occlusion
XIENCE V Everolimus Eluting Coronary Stent System (EECSS) China: Post-Approval, Single-Arm Study
This is a prospective, observational, single-arm, open-label, multicenter, postapproval registry study in China. The purpose of this study is to: Evaluate the continued safety and effectiveness of the XIENCE V EECSS in a cohort…
- Conditions
- Angioplasty, Chronic Coronary Occlusion, Stent Thrombosis, Vascular Disease
- Trial name
- XV CHINA SAS (NCT01249027)
- Testing
- XIENCE V® Everolimus Eluting Coronary Stent System (EECSS)
- Where
- United States
- Volunteers
- 2,605 people
- Sponsor
- Abbott Medical Devices
Coronary Artery Disease
A Clinical Trial to Evaluate the Safety and Efficacy of IBS in Patients With Coronary Artery Disease
A prospective, multi-center, single-arm trial to assess the safety and efficacy of the Sirolimus-Eluting Iron Bioresorbable Coronary Scaffold System (IBS) in treating patients with coronary artery disease.
- Trial name
- IRONMAN-III (NCT05205499)
- Testing
- Sirolimus-Eluting Iron Bioresorbable Coronary Scaffold System
- Where
- China
- Volunteers
- 1,059 people
- Sponsor
- Biotyx Medical (Shenzhen) Co., Ltd.
Acute Coronary Syndrome, ST Elevation Myocardial Infarction
A Trial of Routine Aspiration Thrombectomy With Percutaneous Coronary Intervention (PCI) Versus PCI Alone in Patients With ST-Segment Elevation Myocardial Infarction (STEMI) Undergoing Primary PCI
This is an international, randomized, controlled, parallel group study in which patients with ST-Segment Elevation Myocardial Infarction (STEMI) will be allocated to one of the following: Manual aspiration thrombectomy with…
- Conditions
- Acute Coronary Syndrome, ST Elevation Myocardial Infarction, Percutaneous Coronary Intervention
- Trial name
- TOTAL (NCT01149044)
- Testing
- Percutaneous Coronary Intervention with or without manual aspiration thrombectomy
- Where
- 87 sites in United States, Australia and 18 more
- Volunteers
- 10,732 people
- Sponsor
- Population Health Research Institute
Coronary Artery Disease
Palmar Arch Insufficiency as a Risk Factor for Radial Artery Occlusion After Transradial Catheterization
Transradial access (TRA) is commonly used in different medical fields due to the superficial position of the radial artery and related advantages.
- Trial name
- PAIRAO (NCT03993834)
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Atrial Fibrillation, Ischemic Stroke
Using 14-day Continuous Electrocardiography Patch Monitoring to Detect Paroxysmal Atrial Fibrillation After Stroke
In this prospective, single-center, open-label, non-randomized, single- arm, historically controlled study, we will compare the detection rate of paroxysmal atrial fibrillation in acute ischemic stroke patients without known…
- Trial name
- NCT05218473
- Testing
- Prolonged ECG monitoring, Conventional procedure group
- Volunteers
- 150 people
- Sponsor
- Chang Gung Memorial Hospital
Coronary Artery Disease
Use of Stress-CMR Using Regadenoson and GE-267 in Adult Patients with Known or Suspected Coronary Artery Disease
Stress cardiac MRI is crucial for diagnosing coronary artery disease in adults. Currently, it is mainly performed with vasodilators in specialized centers.
- Trial name
- NCT06246188
- Testing
- Cardiac MRI using Regadenoson and GE-267
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- German Heart Institute
Diabetes Mellitus Type 2, Coronary Artery Diseases
Comparison of Effects of Buffered and Enteric-coated Forms of Aspirin on Platelet Aggregation in Patients With Diabetes Mellitus and Chronic Coronary Syndrome
Patients with diabetes mellitus are characterized by "hyperreactive" platelets and a reduced response to ASA compared to individuals without diabetes.
- Conditions
- Diabetes Mellitus Type 2, Coronary Artery Diseases, Aspirin Resistance
- Trial name
- CASCADE (NCT06716255)
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Nizhpharm
Acute Coronary Syndrome
Brilinta DaYu Study
A multicenter, single arm, open label, Phase IV study to evaluate safety and to describe the incidence of major cardiovascular events of ticagrelor in Chinese patients with acute coronary syndrome
- Trial name
- DaYu (NCT01870921)
- Testing
- Ticagrelor
- Where
- 39 sites in China
- Volunteers
- 2,004 people
- Sponsor
- AstraZeneca