Clinical trials: Single Lung Ventilation
COPD Grade I
Comparative Effect of Pursed Lip Breathing Alone and Combined With Alternate Nostril Breathing on Pulmonary Function Test and Quality of Life in Patients in Grade I COPD Patients.
Chronic Obstructive Pulmonary Disease (COPD) is a progressive respiratory disorder characterized by airflow limitation, breathlessness, and reduced quality of life.
- Trial name
- NCT07531771
- Testing
- pursed lip breathing, Alternate Nostril breathing:
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Foundation University Islamabad
COVID 19
Core Warming of COVID-19 Patients
This is a small scale pilot study to evaluate if core warming improves respiratory physiology of mechanically ventilated patients with COVID-19, allowing earlier weaning from ventilation, and greater overall survival.
- Trial name
- NCT04426344
- Testing
- ensoETM device
- Where
- United States
- Sponsor
- Washington University School of Medicine
Lung Diseases
Comparison of Two Strategies of One-lung Ventilation in Patients Undergoing Carcinological Lung Resection Surgery.
During thoracic surgery, one-lung ventilation (OLV) is associated with hypoxemia, lung injury, and perioperative respiratory complications.
- Trial name
- I-PEEP-THO (NCT05525312)
- Testing
- "Open-lung" protective ventilation strategy, "Standard" protective ventilation strategy
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Montpellier
Mechanical Ventilation, Intensive Care Unit
Clinical Characteristics and Outcomes of Patients Requiring Mechanical Ventilation in an ICU- a Registry Based Study
Rationale: Patients admitted to the Intensive Care Unit (ICU) often require respiratory support in terms of mechanical ventilation (either non-invasive or invasive).
- Trial name
- NCT06890936
- Where
- Nepal
- Volunteers
- 1,800 people
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Pulmonary Disease, Chronic Obstructive
Six-Minute Walk Test Comparing Helium/Oxygen to Nitrogen/Oxygen for COPD Rehabilitation
The purpose of this study is to evaluate effects of inspired gas mixtures on the distance walked by patients with severe Chronic Obstructive Pulmonary Disease (COPD) during a Six-Minute Walk test.
- Trial name
- rehabilitate (NCT01355809)
- Testing
- Inhalation gas, Inhalation Nitrogen/Oxygen, Inhalation Helium/Oxygen
- Where
- Germany
- Volunteers
- 3 people
- Sponsor
- Air Liquide SA
Apnea, Anesthesia
Functional Residual Capacity Under Apnoeic Oxygenation with Different Flow Rates in Children
During induction of general anaesthesia physiological breathing stops and needs to be artificially established with facemask ventilation, and finally tracheal intubation or placement of a supraglottic airway.
- Conditions
- Apnea, Anesthesia, Intubation Complication, Children, Only
- Trial name
- FUTURE (NCT05672329)
- Testing
- 0.2 L/kg/min, FiO2 1.0 + continuous jaw thrust, 2 L/kg/min, FiO2 1.0 + continuous jaw thrust, 4 L/kg/min, FiO2 1.0 + continuous jaw thrust
- Where
- Switzerland
- Volunteers
- 108 people
- Sponsor
- Thomas Riva
One-lung Ventilation
Two-staged Approach in Positioning Endobronchial Blockers Without Fiberoptic Guidance
The purpose of this study is to find a novel method for placing endobronchial blockers without fiberoptic guidance to provide one-lung isolation during anesthesia for thoracic surgery.
- Trial name
- NCT02981537
- Testing
- two-staged endobronchial blocker insertion, single-staged endobronchial blocker insertion
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Seoul National University Hospital
Asthma, Bronchospasm
Epinephrine Inhalation Aerosol USP, a HFA-MDI Study for Assessment of Pharmacokinetics
This study examines the pharmacokinetic profile of Armstrong's proposed Epinephrine Inhalation Aerosol USP, an HFA-MDI (E004), using a stable isotope deuterium-labeled epinephrine (epinephrine-d3) to differentiate the…
- Conditions
- Asthma, Bronchospasm, Wheezing, Shortness of Breath
- Trial name
- NCT01188577
- Testing
- Epinephrine Inhalation Aerosol, HFA, Epinephrine Inhalation Aerosol
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Amphastar Pharmaceuticals, Inc.
Respiratory Insufficiency, Acute Respiratory Insufficiency
NIV-NAVA vs NIV-PS/PC in Respiratory Insufficiency
This study evaluates the difference between Non Invasive Ventilation with Neurally Adjusted Ventilatory Assist (NIV-NAVA) and Conventional Non Invasive Ventilation with Pressure Support (PS) or Pressure Control (PC).
- Trial name
- NCT02592512
- Testing
- NIV-NAVA, NIV-PS/PC
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Vejle Hospital
Dysphagia
Post Critical Illness Dysphagia in the Intensive Care Unit
The aims of the study are to determine: 1) the prevalence of ICU acquired dysphagia, 2) identify risk factors for ICU Acquired dysphagia, and 3) consequences of ICU acquired dysphagia including: ICU mortality, hospital mortality…
- Trial name
- DysphagiaICU (NCT04349462)
- Testing
- VideoFlurosocopy Swallow Study, Water Sip Test
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Thoracic Surgery, Cognitive Dysfunction
Cerebral Desaturation and Postoperative Dysfunction After Thoracic Surgery
The purpose of this study prospective observational study is to determine cognitive dysfunction incidence after thoracic surgery.
- Trial name
- NCT03805880
- Testing
- cerebral desaturation monitoring and cognitive examination
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
One-lung Ventilation
Clamping the Double Lumen Tube
Nowadays, lung isolation techniques are an essential part of thoracic anesthesia. The two principal devices used in order to achieve one-lung ventilation (OLV) are the double lumen tube (DLT) and the bronchial blocker (BB).
- Trial name
- C-TDL (NCT03508050)
- Testing
- Clamping the Double Lumen Tube
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- Jean Bussières
Lung Cancer (Diagnosis)
Effect of Apneic Oxygenation of the Non-ventilated Lung During Lung Cancer Surgery.
This study investigates the effect of apneic oxygenation of the non-ventilated lung on local and systemic inflammatory response during lung cancer surgery.
- Trial name
- NCT07393490
- Testing
- Apnoeic Oxygenation, Standard Ventilation
- Where
- Croatia
- Volunteers
- 56 people
- Sponsor
- Osijek University Hospital
Mechanical Ventilation Complication
Effect of Intermittent Versus Continuous Subglottic Secretion Drainage on Tracheal Mucosa Damages
Endotracheal tubes with subglottic secretion drainage (incorporating a suction port above the cuff) have been shown to reduce the incidence of ventilator-associated pneumonia.
- Trial name
- ASPIRE (NCT01555229)
- Testing
- Intermittent subglottic secretion drainage, Continuous subglottic secretion drainage
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Rennes University Hospital
Pain, Pain Management
Individualized Analgesia in the Intensive Care Unit With a New Pain Assessment Bundle and Protocolized Analgesia Adjustments
Both severe pain and opioid therapy are associated with negative effects. The experience of pain is common in the intensive care unit, but it is highly individual and difficult to assess, as patients are often unable to…
- Conditions
- Pain, Pain Management, Critical Illness
- Trial name
- INVISIBLE (NCT07473115)
- Where
- Switzerland
- Volunteers
- 400 people
- Sponsor
- University of Zurich
Double Lumen Tube
One Lung Ventilation: Double Lumen Tube
One lung ventilation (OLV) has become a standard procedure for the vast majority of interventions in pulmonary surgery. It is used in both techniques: thoracotomy and videothoracoscopy (VATS).
- Trial name
- NCT02857504
- Testing
- double lumen tube with a hook, double lumen tube without a hook
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Prematurity
Nasal Cannula Versus Single Nasal Prong for Non-Invasive Ventilation in Preterm Infants
Preterm infants frequently require non-invasive ventilation (NIV) to treat respiratory distress after birth. The effectiveness of NIV may be influenced by the interface used to deliver respiratory support.
- Trial name
- NCT07725614
- Testing
- Experimental, Intervention Name: Nasal Cannula, Active comparator: single nasal prong
- Where
- Indonesia
- Volunteers
- 140 people
- Sponsor
- Universitas Indonesia
COPD
Investigate the Safety, Tolerability and Pharmacokinetics of CHF6523 in Healthy and in COPD Subjects
This study is designed to investigate the safety, tolerability and pharmacokinetics of inhaled CHF6523 DPI in healthy male subjects first and then in COPD subjects after single or repeated dosesof CHF6523.
- Trial name
- CHF6523 (NCT04032535)
- Testing
- CHF6523
- Where
- United Kingdom
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Thoracic Diseases
Mechanical Insufflator-exsufflator in Patients After Video-assisted Thoracoscopic Operations With One-lung Ventilation
Postoperative pulmonary complications (PPC) are a common problem in patients undergoing surgery using one-lung invasive ventilation.
- Trial name
- NCT06180148
- Testing
- Mechanical insufflator-exsufflator
- Where
- Russia
- Volunteers
- 31 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Thoracic Anesthesia, One Lung Ventillation (OLV)
Association Between One Lung Ventilation and Myocardial Injury Markers (Troponin T and I) in Thoracic Surgical Procedures (OLVTIS)
This prospective single-group cohort study aims to investigate the association between the One-Lung Ventilation (OLV) technique and myocardial injury, as measured by postoperative Troponin T and Troponin I levels, in patients…
- Trial name
- OLVTIS (NCT07302243)
- Where
- Indonesia
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Universitas Jenderal Soedirman