Clinical trials: Single Women
Cervical Cancer
A Study of RC48-ADC Combination With Zimberelimab Injection Therapies at Least First-line Platinum-containing Standard Therapy Failed With Recurrent or Metastatic Cervical Cancer
This study will evaluate the efficacy,safety of RC48-ADC in Combination with Zimberelimab Injection for the Treatment ,at least first-line platinum-containing standard therapy failed in HER2-expressing subject with Recurrent or…
- Trial name
- NCT06155396
- Testing
- Disitamab Vedotin, Zimberelimab
- Where
- 12 sites in China
- Volunteers
- 116 people
- Sponsor
- RemeGen Co., Ltd.
Cervical Dysplasia
A Phase II Single-arm Intervention Trial of Nelfinavir in Patients With Grade 2/3 or 3 Cervical Intraepithelial Neoplasia
Preliminary data showed that Nelfinavir has selective apoptotic effects on HPV+ cervical tumor cell lines. Furthermore, in a Phase I clinical trial, the combination of NFV and chemoradiotherapy showed acceptable toxicity and…
- Trial name
- NCT01925378
- Testing
- Nelfinavir
- Where
- United States
- Sponsor
- The University of Texas Health Science Center, Houston
Cervix Cancer, Cervical Cancer
Study of Pembrolizumab and Lenvatinib in Metastatic and Recurrent Cervix Cancer (LenPem Cervix)
The main purpose of this study is to gather information about an investigational drug combination, Lenvatinib in combination with pembrolizumab, that may help to treat cervical cancers.
- Trial name
- NCT06266338
- Testing
- Pembrolizumab, Lenvatinib
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Texas Southwestern Medical Center
Infertility, Female, Infertility
Vitamin D and Polycystic Ovarian Syndrome (PCOS)
Primary Objectives: To evaluate the efficacy of metformin and Vitamin D supplementation on serum insulin and serum androgen levels (Total testosterone, Steroid Hormone Binding Globulin, Free Androgen Index) levels compared…
- Conditions
- Infertility, Female, Infertility, Vitamin D Deficiency
- Trial name
- NCT03989778
- Testing
- Vitamin D
- Where
- 2 sites in Pakistan
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Gestational Trophoblastic Disease
Camrelizumab Combined With Apatinib for Recurrent Resistant GTN
This study is to evaluate the efficacy and safety of camrelizumab plus apatinib in patients with high-risk chemo-refractory or relapsed GTN.
- Trial name
- GTN (NCT04047017)
- Testing
- Apatinib, Camrelizumab
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking Union Medical College Hospital
HIV Infections
Reducing the Incidence of Nevirapine Resistance Mutations in Pregnant HIV Infected Women Who Receive Anti-HIV Drugs Prior to and After Giving Birth
The purpose of this study is to determine which of 3 different anti-HIV drug regimens given to HIV infected pregnant women during and after their pregnancies is most effective in reducing the incidence of nevirapine (NVP)…
- Trial name
- NCT00109590
- Testing
- Didanosine, enteric-coated, Lopinavir/ritonavir, Nevirapine
- Where
- 7 sites in Thailand
- Volunteers
- 175 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hirsuitism
Comparison of a Face Cream Plus a Laser Procedure and Face Cream Alone in Treatment of Excessive Face Hairs in Female
The study compares the effects of a cream alone and a combined effect of cream and laser for the treatment of excessive facial hairs in women .
- Trial name
- NCT06976424
- Testing
- Eflornithine Topical, Instense pulsed light
- Where
- 3 sites in Pakistan
- Volunteers
- 122 people
- Sponsor
- Khyber Teaching Hospital
High Risk for HIV
Zambia SiVET MMR Tdap-IPV
Participants will receive vaccination for measles, mumps, and rubella (MMR) and tetanus, diphtheria, pertussis, and inactivated polio (Tdap-IPV).
- Trial name
- SiVET (NCT02589678)
- Testing
- Tdap - IPV Vaccine, MMR Vaccine
- Where
- 2 sites in Zambia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Emory University
Uterine Cervical Neoplasm
ctDNA-guided First-line Immuno-de-escalation Therapy for IVB-stage and Recurrent Cervical Cancer
This study aims to evaluate the clinical feasibility of first-line immunochemotherapy for stage IVB and recurrent cervical cancer guided by circulating tumor DNA (ctDNA), in order to explore the optimal treatment duration or…
- Trial name
- NCT06878196
- Testing
- cadonilimab combined with cisplatin-based chemotherapy ± bevacizumab
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Obstetrics & Gynecology Hospital of Fudan University
Colorectal Cancer Metastatic, Triple Negative Breast Cancer
A Study of EDP1503 in Patients With Colorectal Cancer, Breast Cancer, and Checkpoint Inhibitor Relapsed Tumors
This study is being conducted to assess the safety, tolerability, and efficacy of EDP1503 alone and in combination with pembrolizumab in patients with advanced metastatic colorectal carcinoma, triple-negative breast cancer, and…
- Conditions
- Colorectal Cancer Metastatic, Triple Negative Breast Cancer, Non Small Cell Lung Cancer, Bladder Cancer
- Trial name
- NCT03775850
- Testing
- EDP1503, Pembrolizumab
- Where
- 8 sites in United States, Canada
- Volunteers
- 69 people
- Sponsor
- Evelo Biosciences, Inc.
Renal Failure
Comparing Everolimus and Sirolimus in Renal Transplant Recipients
This study is being done to compare the effectiveness and safety of two different kidney transplant immunosuppression drugs, Zortress (the study drug) and Rapamune (which is used in the current standard immunosuppression regimen).
- Trial name
- NCT01976390
- Testing
- Everolimus, Sirolimus
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ohio State University
Endometrial Neoplasms
Tislelizumab in Combination With Chemotherapy as a Neoadjuvant Treatment for Advanced Endometrial Cancer
The goal of this clinical trial is to evaluate the efficacy and safety of tislelizumab in combination with chemotherapy as a neoadjuvant treatment for advanced endometrial cancer.
- Trial name
- NCT06363708
- Testing
- Tislelizumab, Paclitaxel, Carboplatin
- Where
- 3 sites in China
- Volunteers
- 20 people
- Sponsor
- Zhongnan Hospital
Neonatal Salt Loss, Congenital Adrenal Hyperplasia (CAH)
Syndromes With Neonatal Salt Loss: Not Only Congenital Adrenal Hyperplasia Due to 21-hydroxylase Deficiency (21OH-ISC)
Neonatal salt loss can be caused not only by infections but also by rare endocrine disorders that resemble 21-hydroxylase deficiency but are not detected by neonatal screening.
- Trial name
- NCT07473804
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Breast Cancer
Vinorelbine With or Without Trastuzumab in Treating Women With Progressive Metastatic Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as vinorelbine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00103233
- Testing
- trastuzumab, vinorelbine tartrate
- Sponsor
- SWOG Cancer Research Network
Ureterohydronephrosis, Ureter Obstruction
Robot-Assisted Pyeloplasty in Young Children
The goal of this retrospective study is to analyse the outcomes of Robot-Assisted Pyeloplasty in participants younger than 5 years old: indication criteria clinical symptoms operating time length of stay complications follow-up
- Conditions
- Ureterohydronephrosis, Ureter Obstruction, Child, Only
- Trial name
- PYEROB (NCT06734455)
- Testing
- Robot-Assisted Pyeloplasty
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Destinval Christelle
HPV-Related Cervical Carcinoma, HPV-Related Malignancy
Efficacy and Safety of VB10.16 Alone or in Combination With Atezolizumab in Patients With Advanced Cervical Cancer.
This is a multi-center study in patients with recurrent or metastatic HPV16-positive, PD-L1 positive cervical cancer who has progressed during or after treatment with the first-line standard of care (pembrolizumab with…
- Conditions
- HPV-Related Cervical Carcinoma, HPV-Related Malignancy, Cervical Cancer
- Trial name
- NCT06099418
- Testing
- VB10.16, Atezolizumab Injection [Tecentriq]
- Sponsor
- Nykode Therapeutics ASA
Coronary Disease, Fatty Acids, Unsaturated
123I-BMIPP SPECT Analysis for Decreasing Cardiac Events in Hemodialysis Patients
The aim of this multi-center study is to determine the applicability of BMIPP to diagnosing cardiac disease and to predicting the outcome of patients on hemodialysis.
- Conditions
- Coronary Disease, Fatty Acids, Unsaturated, Radioisotopes, Hemodialysis
- Trial name
- B-SAFE (NCT00586950)
- Where
- Japan
- Volunteers
- 1,000 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Pharmacokinetic
Safety, Tolerability, and Pharmacokinetics of Single Ascending Oral Doses of INV-101 in Healthy Male and Female Subjects
Single center, randomized, double-blinded, placebo-controlled, single ascending-dose study for the evaluation of the safety, tolerability, and PK following single oral doses of INV-101.
- Trial name
- NCT04531150
- Testing
- INV-101
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Inversago Pharma Inc.
ADPKD (autosomal Dominant Polycystic Kidney Disease)
Study to Evaluate the Drug-drug Interaction of JMKX003142 in Healthy Subjects
To evaluate the effects of oral administration rifampicin or itraconazole capsules on the pharmacokinetics of JMKX003142 in healthy subjects.
- Trial name
- NCT06658964
- Testing
- Cohort 1: JMKX003142 and itraconazole, Cohort 2: JMKX003142 and rifampicin
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Jemincare
Kidney Transplant, Kidney Failure
Preventing Delayed Graft Function in Kidney Transplant Patients
The health and quality of life benefits of kidney transplantation are reduced by delayed graft function (DGF). There are a number of modifiable risk factors associated with DGF, such as intraoperative hypotension, the type of…
- Conditions
- Kidney Transplant, Kidney Failure, Kidney Injury
- Trial name
- PDF (NCT06724211)
- Testing
- Treatment bundle of care, Control Group
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
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