Clinical trials: Single Women
Polycystic Ovary Syndrome, PCOS
Randomized Controlled Trial of Combined Letrozole and Clomid (CLC II) Versus Letrozole Alone for Women With Anovulation
This study evaluates the addition of clomiphene citrate (CC) to letrozole for the treatment of infertility in women with polycystic ovary syndrome across a course of two treatment cycles with stair step dosing of letrozole…
- Conditions
- Polycystic Ovary Syndrome, PCOS, Infertility
- Trial name
- CLC II (NCT05206448)
- Testing
- Letrozole, Clomiphene Citrate
- Where
- 4 sites in United States
- Volunteers
- 190 people
- Sponsor
- Rachel Mejia
Healthy Volunteers
Bioequivalence of a Fixed Dose Combination Tablet Containing 400 mg Ibuprofen and 60 mg Pseudoephedrine-HCl Compared to Two Film Coated Fixed Dose Combination Tablets RhinAdvil(R)(200 mg Ibuprofen and 30 mg Pseudoephedrine-HCl) Administered in Healthy Subjects
Primary objective To demonstrate the bioequivalence of a fixed dose combination tablet containing 400 mg Ibuprofen and 60 mg Pseudoephedrine-HCl vs.
- Trial name
- NCT02963701
- Testing
- Ibuprofen, Pseudoephedrine-HCl
- Where
- South Africa
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Prosthetic Fixation After Cementless Total Hip Arthroplasty
The Efficacy Study of Aclasta on Prosthetic Fixation in Postmenopausal Women After THA
It's to investigate the efficacy of Zoledronic acid treatment on the early prosthetic fixation in post-menopausal osteoporosis women under cementless total hip arthroplasty after 24-month observation.
- Trial name
- NCT02333344
- Testing
- Zoledronic acid 5mg
- Where
- China
- Sponsor
- Novartis Pharmaceuticals
Alpha Thalassemia Major, Hemoglobinopathy; With Thalassemia
In Utero Hematopoietic Stem Cell Transplantation for Alpha-thalassemia Major (ATM)
The investigators aims to evaluate the safety of in utero hematopoietic stem cell transplantation in fetuses with alpha-thalassemia major performed at the time of in utero transfusion of red blood cells.
- Conditions
- Alpha Thalassemia Major, Hemoglobinopathy; With Thalassemia, Hemoglobinopathies, Fetal Anemia
- Trial name
- NCT02986698
- Testing
- in utero hematopoietic stem cell transplantation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of California, San Francisco
Nephrolithiasis, Lithotripsy, Laser
Comparison Between Ureterorenoscopy With Lithotripsy Alone Versus Combination With Hydrogel for Kidney Stone Removal
The incidence of kidney stones (urolithiasis) has surged in both developing and developed countries, affecting approximately 15% of the global population.
- Conditions
- Nephrolithiasis, Lithotripsy, Laser, Ureteroscopy
- Trial name
- NCT06469736
- Testing
- Standard of Care Ureterorenoscopy, Standard of Care Ureterorenoscopy with MediNiK
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Technical University of Munich
Type 2 Diabetes Mellitus (T2DM), Recurrent Urinary Tract Infections
Cranberry Proanthocyanidins and Lactobacilli for Recurrent UTI Prevention in Type 2 Diabetes
The purpose of this prospective, single-arm feasibility study was to evaluate the operational feasibility, tolerability, safety, and exploratory clinical outcomes of an oral supplement combining standardized cranberry…
- Trial name
- NCT07832409
- Testing
- Cranberry Proanthocyanidins and Lactobacilli
- Where
- Georgia
- Volunteers
- 100 people
- Sponsor
- National Institute of Endocrinology, Georgia
Locally Advanced or Metastatic Solid Tumors, PTEN Loss or Low Expression
A Single-arm, Open-label, Multicenter, Phase Ib/II Clinical Trial of CVL237 Tablets in Combination With Serplulimab Injection for the Treatment of Advanced Solid Tumors With PTEN Loss or Low Expression
This is a single-arm, open-label, multicenter, Phase Ib/II clinical trial of CVL237 tablets in combination with serplulimab injection for the treatment of advanced solid tumors with PTEN loss or low expression
- Trial name
- NCT07446049
- Testing
- CVL237 tablets
- Volunteers
- 180 people
- Sponsor
- Convalife (Shanghai) Co., Ltd.
Healthy
Relative Bioavailability of Dabigatran and Digoxin in Healthy Male and Female Volunteers
To investigate the bioavailability of dabigatran with and without concomitant administration of digoxin and the bioavailability of digoxin with and without concomitant administration of dabigatran etexilate
- Trial name
- NCT02171052
- Testing
- Dabigatran etexilate, Digoxin
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Septic Shock, Acute Kidney Injury
Norepinephrine / Vasopressin Combination for Resuscitation in Septic Shock
Although norepinephrine is commonly used and is the recommended agent for the treatment of hypotension in volume-resuscitated hyperdynamic septic shock, Low doses of vasopressin may be added to norepinephrine to maintain arterial…
- Trial name
- NCT04302584
- Testing
- norepinephrine / Vasopressin
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Recurrent Cervical Carcinoma, Persistent Advanced Cervical Carcinoma
First-line Chemotherapy for Recurrent Cervical Cancer
The response rate of traditional first-line chemotherapy for recurrent or persistent advanced cervical cancer was low. This single arm, open, phase II trial would recruit 37 eligible patients.
- Conditions
- Recurrent Cervical Carcinoma, Persistent Advanced Cervical Carcinoma, Chemotherapy, Vascular Endothelial Growth Factor 2 Inhibitor
- Trial name
- NCT04188847
- Testing
- Chemotherapy plus apatinib
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Lei Li
Healthy
A Drug-drug Interaction Study of Oral 1250 mg of Vatalinib Administered Under Fasting and Fed Conditions With a Proton-pump Inhibitor in Healthy Sterile or Postmenopausal Female Volunteers
This study will determine the effect of acidic drugs such as proton-pump inhibitors on the pharmacokinetics of Vatalinib under fasting and fed conditions.
- Trial name
- NCT00426452
- Testing
- Vatalinib
- Volunteers
- 24 people
- Sponsor
- Novartis
Chronic Pain
A Study of the Safety, Tolerability and Pharmacokinetics of MEDI0618 in Healthy Volunteers
This is a randomised, placebo-controlled study of the safety and tolerability of single doses of MEDI0618 in healthy volunteer subjects.
- Trial name
- NCT04198558
- Testing
- MEDI0618
- Where
- Germany
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Cervical Neoplasms
Neoadjuvant Short-course Hypofractionated Radiotherapy Plus Adebrelimab and Platinum Chemotherapy in Locally Advanced Cervical Cancer: A Single-arm Phase II Trial
Brief Summary A Phase II Single-Arm Clinical Trial of Short-Course Radiotherapy Combined with Adebrelimab and Platinum-Based Neoadjuvant Therapy for Locally Advanced Cervical Cancer Background \& Objective: This is a…
- Trial name
- NCT07731828
- Testing
- Adebrelimab
- Where
- China
- Volunteers
- 35 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Chronic Kidney Disease, Hyperparathyroidism, Secondary
Safety & Tolerability of Cinacalcet in Pediatric Patients With Chronic Kidney Disease and Secondary Hyperparathyroidism
The primary objective was to characterize corrected serum calcium levels on treatment with cinacalcet in pediatric patients with secondary hyperparathyroidism (HPT).
- Trial name
- NCT01439867
- Testing
- Cinacalcet hydrochloride, Standard of Care
- Where
- 42 sites in United States, Belgium and 11 more
- Volunteers
- 18 people
- Sponsor
- Amgen
Osteoporosis, Postmenopausal
Safety/Efficacy of Letrozole Monotherapy or in Combination With Zoledronic Acid as Extended Adjuvant Treatment of Postmenopausal Patients With Primary Breast Cancer
This was a prospective, randomized, open-label, two arm phase III trial designed to evaluate the efficacy and safety of zoledronic acid in preventing bone loss in postmenopausal women with operable breast cancer who had received…
- Trial name
- NCT00332709
- Testing
- Letrozole, Zoledronic acid
- Where
- 23 sites in Germany
- Volunteers
- 83 people
- Sponsor
- Novartis
Pharmacokinetic
Open-Label Study to Evaluate the Effect of Rifaximin on Midazolam in Normal Healthy Volunteers
The primary objective of this study is to determine if rifaximin, administered daily has an effect on the cytochrome P450 (CYP) isoenzyme 3A4, by examining any changes in the pharmacokinetics of midazolam (a CYP3A4 substrate)…
- Trial name
- NCT00743912
- Testing
- rifaximin
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bausch Health Americas, Inc.
Pelvic Venous Congestion Syndrome, Lower Limb Varicose Veins
Prevalence of Pelvic Venous Congestion Syndrome in Female Patients With Lower Extremity Varicose Veins and Its Impact on Postoperative Quality of Life Improvement Following Radiofrequency Ablation: A Single-Center Prospective Cohort Study（PCSRFStudy）
Research Summary: Impact of Pelvic Congestion Syndrome on Lower Limb Varicose Vein Treatment This prospective cohort study investigates the prevalence of Pelvic Congestion Syndrome (PCS) among women undergoing lower limb varicose…
- Conditions
- Pelvic Venous Congestion Syndrome, Lower Limb Varicose Veins, Radiofrequency Ablation
- Trial name
- NCT07680465
- Testing
- Pelvic MRI ， Radiofrequency Ablation
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Breast Cancer
Filgrastim Plus Chemotherapy Compared With Filgrastim Alone In Treating Women Undergoing Peripheral Stem Cell Transplantation For Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Colony-stimulating factors such as filgrastim may increase the number of immune cells found in bone marrow or…
- Trial name
- NCT00002836
- Testing
- Filgrastim (G-CSF), Carmustine, Cisplatin
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- M.D. Anderson Cancer Center
Preterm Birth, Respiratory Distress Syndrome
Surfactant Nebulization for the Early Aeration of the Preterm Lung
Respiratory distress syndrome is the most common cause of respiratory failure in preterm infants. Treatment consists of respiratory support and exogenous surfactant administration.
- Conditions
- Preterm Birth, Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal
- Trial name
- SUNSET (NCT04315636)
- Testing
- Surfactant nebulisation
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- University of Zurich
Overactive Bladder
A Study to Evaluate Safety, Tolerability and Pharmacokinetics of DA-8010 in Healthy Subjects
This study is a Phase I, Randomised, Double-Blind, Placebo-Controlled, Dose-Escalation Study to Evaluate Safety, Tolerability and Pharmacokinetics After Single and Multiple Oral Administration of DA-8010 in Healthy Subjects.
- Trial name
- NCT02821312
- Testing
- DA-8010
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Dong-A ST Co., Ltd.
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