Clinical trials: Sinus Pain
Sinusitis, Opioid Use
Pain Control Following Sinus Surgery
Given the ongoing national opioid epidemic, an increased interest has developed in optimizing opioid prescribing practices of physicians, including otolaryngologists.
- Conditions
- Sinusitis, Opioid Use, Opioid Abuse, Narcotic Use
- Trial name
- NCT03783702
- Testing
- OxyCODONE 5 Mg (milligram) Oral Tablet, Ibuprofen 600 Mg (milligram) Oral Tablet, Acetaminophen 650 MG (milligram) Oral Tablet
- Where
- 6 sites in United States, Canada
- Volunteers
- 118 people
- Sponsor
- Stanford University
Postoperative Nausea and Vomiting, Pain, Postoperative
Guanfacine for PONV and Pain After Sinus Surgery
Postoperative nausea and vomiting (PONV) and pain are the most common causes of Post Anesthesia Care Unit (PACU) discharge delay, with untreated PONV occurring in 20-30% of post-surgical patients.
- Trial name
- NCT02882854
- Testing
- Guanfacine
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Vanderbilt University Medical Center
Facial Pain
Treatment of Sinus Headache Using a Novel Device That Combines Acoustic Vibration With Oscillating Expiratory Pressure
The purpose of this study is to investigate if the SinuSonic device decreases facial pain and pressure compared to the placebo device.
- Trial name
- NCT05479604
- Testing
- SinuSonic
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Mayo Clinic
Pain Management
Regional Anesthesia to Reduce Opioid Use Following Functional Endoscopic Sinus Surgery
Opioids are prescribed for moderate to severe pain disorders; however, there are contraindications and side effects that are common to all opioids.
- Trial name
- NCT03757715
- Testing
- Bupivacaine, Dexamethasone
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Alabama at Birmingham
Post-operative Pain, Sinus Surgery
Postoperative Pain Control in Septum and Sinus Surgery
This study will evaluate if the use of acetaminophen round the clock (scheduled doses) will lead to less opiate use in the first week post-operative (after surgery) in sinus/septum surgery patients.
- Trial name
- NCT04149964
- Testing
- Acetaminophen 325 mg Oral Tablet, Acetaminophen 650 mg Oral Tablet, OxyCODONE 5 mg Oral Tablet
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Corewell Health East
Pain Control After Functional Endoscopic Sinus Surgery and Septoplasty
Are NSAIDs Effective Enough for Postoperative Pain Control After Functional Endoscopic Sinus Surgery and Septoplasty
The purpose of this study is to compare the level of pain control in patients receiving non-steroidal anti-inflammatory drugs (NSAIDs) to those receiving opioids in the postoperative period after endoscopic sinus surgery (ESS)…
- Trial name
- NCT03605914
- Testing
- diclofenac, Norco
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The University of Texas Health Science Center, Houston
Facial Pain, Rhinosinusitis
Erenumab for Idiosyncratic Facial Pain
This is a phase IV randomized, double-blinded, placebo-controlled study to evaluate the efficacy of Erenumab in subjects with midfacial pain or pressure, without clinical or radiographic evidence of sinusitis.
- Trial name
- NCT04249427
- Testing
- Erenumab Prefilled Syringe
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- David Jang, M.D.
Pain, Postoperative
Postoperative Pain and Functional Patient Outcomes After Functional Endoscopic Sinus Surgery
The aim of the study is to quantify postoperative pain after functional endoscopic sinus surgery (FESS) and investigate whether preemptive analgesia may positively impact intraoperative anesthetic management, decrease patient…
- Trial name
- NCT00927888
- Testing
- Bupivacaine Block
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Stanford University
Chronic Rhinosinusitis
Microcurrent Device (TIVIC Health)
The purpose of this study is to investigate whether daily use of a microcurrent neuromodulation device, which applies a small current of electricity to the forehead and maxillary region, will decrease the pain experienced by…
- Trial name
- NCT05198518
- Testing
- Microcurrent TENS device
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Postoperative Pain
Efficacy of Oral vs. Intravenous Acetaminophen
The comparative efficacy of intravenous (IV) to oral (PO-'per os') acetaminophen in the management of postoperative pain is understudied and largely unknown.
- Trial name
- NCT02643394
- Testing
- Oral Acetaminophen, Intravenous acetaminophen
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Texas Southwestern Medical Center
Sinus Pain, Congestion
ClearUP Longitudinal Pilot Study
Single arm, open label pilot study assessing the longitudinal home use of ClearUp Sinus Pain Relief for four weeks.
- Trial name
- NCT03888274
- Testing
- ClearUP Sinus Pain Relief
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Tivic Health Systems
Functional Endoscopic Sinus Surgery, Vagal Nerve Stimulation
Auricular Neuromodulation for FESS
In this blinded prospective randomized control trial the researchers will investigate the impact of cutaneous vagal nerve stimulation on surgical conditions in patients undergoing functional and ascorbic sinus surgery (FESS).
- Conditions
- Functional Endoscopic Sinus Surgery, Vagal Nerve Stimulation, Platelet Activation
- Trial name
- NCT06662422
- Testing
- Spark Biomedical Sparrow Ascent Transcutaneous Auricular Neurostimulation (tAN) System
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cancer
Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain
This is a phase III, randomized, double-blind, placebo-controlled, multicenter study of the clinical response to fentanyl sublingual spray as a treatment for breakthrough cancer pain.
- Trial name
- NCT00538850
- Testing
- Fentanyl sublingual spray
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- INSYS Therapeutics Inc
Chronic Sinusitis
Intraoperative and Post-operative Analgesic Effect of IV Acetaminophen for Sinus Surgery
The purpose of this study is to assess the use of IV acetaminophen (Ofirmev) as a and safe and efficacious agent in reducing post-operative pain; we hypothesize that its use will reduce post-operative pain when compared to a…
- Trial name
- IVAPAP (NCT01608308)
- Testing
- IV Acetaminophen
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- The University of Texas Health Science Center, Houston
Post Operative Pain, Recurrence
Video-assisted Anal Fistula Treatment Versus Seton in the Management of High Peri Anal Fistula
Anal fistula is the most common Peri anal disease. It's a disease with an incidence of 9 in 100,000. Anal fistula is classified on the basis of its location into high and low anal fistula, above or below dentate line…
- Trial name
- NCT02313597
- Testing
- SETON, VAAFT
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Dr. SamiUllah
Outpatient Surgery, Pain, Postoperative
Patient Narcotic Requirements After Outpatient Otolaryngology Procedures
Patient's pain level and narcotic requirements will be evaluated after routine outpatient Otolaryngology procedures. This will be done by having study participants record their pain level and medication usage from home.
- Trial name
- NCT03404518
- Testing
- Norco, Ibuprofen
- Where
- 2 sites in United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Head and Neck Cancer, Mucositis
Doxepin Hydrochloride in Treating Oral Mucositis Pain in Patients With Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy
RATIONALE: Doxepin hydrochloride may be an effective treatment for oral mucositis pain in patients undergoing radiation therapy with or without chemotherapy.
- Conditions
- Head and Neck Cancer, Mucositis, Oral Complications of Radiation Therapy, Pain
- Trial name
- NCT01156142
- Testing
- doxepin hydrochloride
- Where
- 120 sites in United States
- Volunteers
- 155 people
- Sponsor
- Alliance for Clinical Trials in Oncology