Clinical trials: Sinus Tract
Chronic Sinusitis
Photodynamic Therapy for the Treatment of Chronic Rhinosinusitis
The purpose of this study is to determine whether the use of light and a topically applied photosensitizer can relieve symptoms and clinically improve patients with chronic rhinosinusitis.
- Trial name
- NCT01854619
- Testing
- Photodisinfection (antimicrobial photodynamic therapy, aPDT), Saline irrigation
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Ondine Biomedical Inc.
Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer
This phase I trial is studying the side effects and best dose of erlotinib hydrochloride when given together with cetuximab and to see how well they work in treating patients with advanced gastrointestinal cancer, head and neck…
- Conditions
- Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum, Advanced Adult Primary Liver Cancer, Carcinoma of the Appendix
- Trial name
- NCT00397384
- Testing
- cetuximab, erlotinib hydrochloride, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- National Cancer Institute (NCI)
Bladder Cancer, Cervical Cancer
Health Education Counseling With or Without Bupropion in Helping African Americans Stop Smoking
RATIONALE: A stop-smoking plan that includes health education counseling and bupropion may help African-American smokers stop smoking.
- Conditions
- Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT00666978
- Testing
- smoking cessation intervention, bupropion hydrochloride, gene expression analysis
- Where
- 2 sites in United States
- Volunteers
- 540 people
- Sponsor
- Lisa Sanderson Cox, PhD
Sinusitis, Cystic Fibrosis
Pulmozyme in Cystic Fibrosis With Sinusitis
The hypothesis is that the intranasal use of Pulmozyme will decrease the severity of sinusitis in Cystic Fibrosis and lead to an improved quality of life.
- Trial name
- NCT01155752
- Testing
- Pulmozyme single use ampule
- Where
- United States
- Sponsor
- Milton S. Hershey Medical Center
Sinusitis
Hot Saline Irrigation Study
Many methods have been used to reduce bleeding during sinus surgery (FESS) in order to allow for the best surgical view and to reduce risk while in surgery.
- Trial name
- HSI (NCT01717274)
- Testing
- Hot saline irrigation
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- St. Paul's Hospital, Canada
Sinusitis, Nasal Polyps
In-clinic Endoscopic Polypectomy for Chronic Sinusitis With Nasal Polyps
Chronic rhinosinusitis, also called chronic sinusitis, is a very common life-long disease affecting over 5% of the Canadian population.
- Trial name
- NCT02975310
- Testing
- Endoscopic polypectomy in clinic (EPIC), Endoscopic Sinus Surgery (ESS), General Anesthesia
- Where
- 4 sites in Canada
- Volunteers
- 140 people
- Sponsor
- Ottawa Hospital Research Institute
Biliary Fistula
Early Versus Late Intervention After Biliary Tract Injury Post Cholecystectomy
Bile duct injury following cholecystectomy is an iatrogenic catastrophe associated with significant peri operative morbidity and mortality(1, 2) reduced long term survival(3) and quality of life(4, 5) and high rates of subsequent…
- Trial name
- NCT04134546
- Testing
- CBD exoloration
- Volunteers
- 30 people
- Sponsor
- Assiut University
Sinusitis
Triamcinolone Packing Following Endoscopic Sinus Surgery
Endoscopic sinus surgery (ESS) is a well-established treatment strategy for medically refractory chronic rhinosinusitis. Middle meatus spacers are currently used following ESS to prevent scarring, synechiae formation, and middle…
- Trial name
- NCT04841343
- Testing
- Triamcinolone
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of California, Los Angeles
Sinusitis
The Study of Nasonex® Compared With Placebo for the Relief of Symptoms Associated With Acute Bacterial Sinusitis When Used With Antibiotics (Study P04824AM3)
The purpose of this study is to evaluate the efficacy and safety of Nasonex® (mometasone furoate nasal spray), when used together with an antibiotic, for the relief of symptoms associated with acute bacterial sinusitis.
- Trial name
- NCT00423176
- Testing
- MFNS and antibiotic
- Volunteers
- 237 people
- Sponsor
- Organon and Co
Nasal Cavity and Paranasal Sinus Cancer
Evaluation of Endoscopic Management of Sinonasal Tumors In Difficult Anatomical Locations
Research outcome measures: 1. Primary (main): To Evaluate the Gross Total Resection Rate Using Endoscopic Approach for Lesions Extended To Anatomically Challenging Areas 2. Secondary (subsidiary): 1.
- Trial name
- NCT07512466
- Testing
- endoscopic approch
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Assiut University
Head and Neck Cancer, Tobacco Use Disorder
Cancer Risk Reduction Through Combined Treatment for Tobacco and Alcohol Use
RATIONALE: A counseling program that motivates patients to stop smoking and drinking may reduce the risk of oral cancer. It is not yet known whether motivational stop smoking counseling or motivational stop-smoking and stop…
- Trial name
- NCT00799669
- Testing
- smoking cessation intervention, counseling intervention, preventive intervention
- Volunteers
- 370 people
- Sponsor
- M.D. Anderson Cancer Center
Chronic Rhinosinusitis, Rhinosinusitis
Xylitol for Chronic Sinusitis
The purpose of this investigation is to conduct a randomized controlled trial within a subgroup of difficult-to-treat patients with CRS, evaluating the use of topical xylitol treatment concurrently with topical…
- Conditions
- Chronic Rhinosinusitis, Rhinosinusitis, Sinusitis, Drain Sinus
- Trial name
- NCT03229551
- Testing
- Xylitol, Saline
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Sinusitis
Effect of Reslizumab in Chronic Rhinosinusitis
The purpose of this study is to determine whether Reslizumab is effective for the treatment of chronic sinusitis.
- Trial name
- NCT02799446
- Testing
- Reslizumab
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Joshua S. Jacobs
Rhinosinusitis
Allele-specific Expression of a Bitter Taste Receptor
This single-site, within-subject experimental basic research study is designed to analyze the hypothesis that allele-specific expression of the bitter taste receptor T2R38 in taste tissue of individuals heterozygous for the taste…
- Trial name
- NCT02766959
- Testing
- Observational study
- Where
- 3 sites in United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Monell Chemical Senses Center
Esophageal Atresia, Tracheoesophageal Fistula
Transanastomotic Tube for Proximal Esophageal Atresia With Distal Tracheoesophageal Fistula Repair
This trial will compare the effectiveness of two common surgical practices for Type C esophageal atresia repair: esophageal atresia (EA) with distal tracheoesophageal fistula (TEF).
- Trial name
- TEF (NCT03730454)
- Testing
- Transanastomotic Tube (5FR), No Transanastomotic Tube
- Where
- 10 sites in United States
- Volunteers
- 142 people
- Sponsor
- Phoenix Children's Hospital
Chronic Rhinosinusitis With Nasal Polyps, Allergic Fungal Sinusitis
Comparing Budesonide Via MAD or INSI Prospective Cohort Study
Chronic Rhinosinusitis (CRS) is a common disorder in North America, affecting more than 31 million people annually. Common therapy for CRS includes intranasal corticosteroids (INCS) such as budesonide.
- Trial name
- NCT04267042
- Testing
- Budesonide, Mucosal Atomization Device, NeilMed squeeze bottle for Impregnated Nasal Saline Irrigation
- Volunteers
- 60 people
- Sponsor
- St. Paul's Hospital, Canada
Head and Neck Carcinoma, Malignant Parotid Gland Neoplasm
Customized 3D Printed Oral Stents During Head and Neck Radiotherapy
This clinical trial studies the effect of customized 3 dimensional (3D) printed oral tents on patients with head and neck cancer who are receiving radiotherapy.
- Conditions
- Head and Neck Carcinoma, Malignant Parotid Gland Neoplasm, Maxillary Sinus Carcinoma, Nasal Cavity Carcinoma
- Trial name
- NCT04870762
- Testing
- Best Practice, Medical Device Usage and Evaluation
- Where
- 7 sites in United States
- Volunteers
- 88 people
- Sponsor
- M.D. Anderson Cancer Center
Bile Leak, Anastomotic Leak Biliary
Factors Influencing Occurrence of Bile Leaks in Surgery
The objective of our study is to identify the factors influencing the occurrence of a biliary leak after performing surgery leading to the creation of a biliary anastomosis to any segment of the digestive tract.
- Conditions
- Bile Leak, Anastomotic Leak Biliary, Biliary Tract Fistula
- Trial name
- NCT04665427
- Testing
- bilioenteric anastomosis i
- Where
- Algeria
- Volunteers
- 108 people
- Sponsor
- University of Oran 1
Cystic Fibrosis, Infection, Bacterial
Manuka Honey Sinus Rinse Study
A trial investigating the effect of a sinus rinse in people with CF
- Trial name
- NCT04589897
- Testing
- Manuka honey sinus rinse, Standard sinus rinse
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Swansea University
Sinusitis, Maxillary Sinusitis
A Study of the Safety and Effectiveness of Levofloxacin Compared With Amoxicillin/Clavulanate Potassium in the Treatment of Adults With Rapid Onset of Severe Inflammation/Infection of the Sinuses
The purpose of this study is to evaluate the safety and effectiveness of levofloxacin, an antibiotic, compared with amoxicillin/clavulanate potassium in the treatment of adults with rapid onset of severe inflammation/infection of…
- Trial name
- NCT00249210
- Testing
- levofloxacin
- Volunteers
- 614 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.