Clinical trials: Sjogren's Disease
Systemic Sclerosis, Gougerot Sjogren Syndrome
Echo Systemic Sclerosis
Systemic sclerosis is an autoimmune connective tissue disease with undefined etiology and characterized by progressive fibrosis of the skin and major organs.
- Conditions
- Systemic Sclerosis, Gougerot Sjogren Syndrome, Sicca-Asthenia-Polyalgia Syndrome
- Trial name
- NCT03143413
- Testing
- Ultrasonography
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Sjögren's Syndrome
HRR as a Novel Biomarker in Sjögren's Syndrome
Sjögren's syndrome (SS) is an autoimmune disorder characterized by chronic salivary and lacrimal gland dysfunction leading to dry mouth (xerostomia) and dry eye (xerophthalmia) sensation (1).
- Trial name
- NCT05633524
- Testing
- blood sample analysis
- Where
- China
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Autoimmune Disease
Confirmation of Systemic Autoimmune Diseases in the Agricultural Health Study
Autoimmune diseases may involve nearly any organ and are characterized by abnormal activation or response of certain cells. Evidence suggests that farm work, exposure to silica from farming activities and exposure to pesticides…
- Trial name
- NCT00341198
- Where
- 3 sites in United States
- Volunteers
- 700 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Sjögren's Syndrome
A Long-term Extension Study of Dazodalibep in Participants With Sjögren's Syndrome (SS)
The primary objective of this study is to evaluate the long-term safety and tolerability of dazodalibep.
- Trial name
- NCT06747949
- Testing
- Dazodalibep
- Where
- 174 sites in United States, Argentina and 24 more
- Volunteers
- 844 people
- Sponsor
- Amgen
Sjögren Syndrome, Dry Eye
Study to Evaluate Corneal Neurosensory Abnormalities in Patients With Sjögren's Dry Eye
Primary Objective To assess the proportion of patients with Sjögren's dry eye who demonstrate impaired corneal sensitivity. Secondary Objectives To assess corneal sensitivity via Cochet-Bonnet esthesiometer.
- Trial name
- GEMINAE (NCT06411132)
- Testing
- observational study
- Where
- 15 sites in United States
- Volunteers
- 103 people
- Sponsor
- Dompé Farmaceutici S.p.A
Sjogren Syndrome
Cross-sectional Study of Use of Speckle Method in Early Diagnosis of Cardiovascular Dysfunction
Speckle tracking (STE) is a novel echocardiographic technique which permits calculation of myocardial velocities and deformation parameters such as strain and strain rate (SR).
- Trial name
- SPEEDCARS (NCT02132585)
- Testing
- Speckle tracking echocardiography
- Where
- 2 sites in Italy
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Rheumatoid Arthritis, Lupus Erythematosus, Systemic
Lessening the Impact of Fatigue in Inflammatory Rheumatic Diseases
Fatigue is common and disabling for most patients with inflammatory rheumatic disease. Therapies designed to improve physical activity and 'talking' treatments, which positively help patients change the way they think and behave…
- Conditions
- Rheumatoid Arthritis, Lupus Erythematosus, Systemic, Axial Spondyloarthritis, Psoriatic Arthritis
- Trial name
- LIFT (NCT03248518)
- Testing
- Usual Care, Cognitive behavioural approach, Personalised Exercise Programme
- Where
- 6 sites in United Kingdom
- Volunteers
- 368 people
- Sponsor
- University of Aberdeen
Sjögren's Syndrome, Xerostomia
Effects of Hydroxychloroquine on Oral Complaints of Sjögren Patients
Chronic inflammation that comprises the exocrine glands' function leads to xerophthalmia and xerostomia in Sjögren's syndrome. The oral consequences range widely and they are related to decreased salivary output.
- Trial name
- NCT00873496
- Testing
- Hydroxychloroquine
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ege University
Sjogren's Syndrome, Dysautonomia
Evaluation of the Role of the Autonomic Nervous System in Sj(SqrRoot)(Delta)Gren s Syndrome
Background: Sj(SqrRoot)(Delta)gren s Syndrome (SS) is an autoimmune disease that affects the glands that produce saliva and tears, causing dry eyes and dry mouth.
- Trial name
- NCT00565526
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Sjogren's Syndrome, Vitamin D Deficiency
Corneal Nerve Structure in Sjogren's
Patients who are suspected of or diagnosed with Sjogren's disease will be evaluated for ocular symptoms and corneal nerve morphology.
- Trial name
- NCT03203382
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Pennsylvania
Sjogren's Syndrome, Dry Eye Syndromes
Salivary Conductivity Screening for Dry Eye Disease and Sjögren's Syndrome
Dry eye disease, or keratoconjunctivitis sicca, is one of the most common diseases encountered at ophthalmologic clinics. Patient with dry eye disease commonly presented foreign body sensation, red eye, blurred vision, etc.
- Trial name
- NCT06406933
- Testing
- Carbomer Gel/Jelly
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Sjogren's Syndrome
Probiotics as a Prophylaxis to Prevent Clinical Manifestations of Oral Candidosis in Patients With Sjogren's Syndrome
Sjogren's syndrome is an autoimmune chronic disease. It has two forms Primary Sjogren's syndrome charactrized by dry eyes and dry mouth.
- Trial name
- NCT03840538
- Testing
- Probiotic Product - Cap
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Cairo University
Primary Sjogren's Syndrome, Secondary Sjogren's Syndrome
Abatacept for Patients With Inflammatory Arthritis Associated With Sjögren's Syndrome: an Open-Label Phase II Study
The primary purpose of this pilot study is to evaluate the efficacy and safety of Abatacept in subjects with Sjogren's Syndrome (SS).
- Conditions
- Primary Sjogren's Syndrome, Secondary Sjogren's Syndrome, Inflammatory Arthritis, Rheumatoid Arthritis
- Trial name
- NCT02027298
- Testing
- Abatacept
- Where
- United States
- Sponsor
- The Cleveland Clinic
Primary Sjogren's Syndrome, Lymphoma
Chimeric Antigen Receptor Natural Killer Cell Therapy for High-risk Lymphoma Patients With Primary Sjogren's Syndrome
This study is a phase I-II clinical trial of CAR-NK cell therapy for high-risk lymphoma patients with primary Sjogren's syndrome (pSS).
- Trial name
- CAR-NK (NCT06967038)
- Testing
- CAR-NK cell
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Bangdong Gong
Dry Eye, Sjogren's Disease
Multi-Colored Placido Disk Viability
The purpose of this study is to show that the multi-colored Placido Disk set-up can get reliable data over long time periods.
- Conditions
- Dry Eye, Sjogren's Disease, Healthy
- Trial name
- NCT02148497
- Testing
- Multi-colored Placido disk imaging
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Sjögren's Syndrome
DNA Exome Sequencing TCM for Sjögren's Syndrome
To explore the association among gene, TCM pattern, TCM tongue diagnosis and TCM pulse diagnosis with the DNA Exome sequencing tools for Sjögren's syndrome
- Trial name
- NCT03935373
- Testing
- DNA Exome sequencing, Oral microbiome, Proteomics
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Autoimmune Diseases, Autoinflammatory Diseases
Observational Study of Pediatric Rheumatic and Immunologic Diseases in China: The CAPRID Registry
An observational, multi-center, longitudinal registry study for Chinese pediatric patients with rheumatic and immunologic diseases.
- Trial name
- NCT06417502
- Where
- 9 sites in China
- Volunteers
- 20,000 people
- Sponsor
- Peking Union Medical College Hospital
Sjogren's Syndrome
Pilot Study of Raptiva to Treat Sjogren's Syndrome
This study will examine the effect of the drug Raptiva (efalizumab) in patients with Sjögren's syndrome (SS), an autoimmune disease affecting the glands producing saliva \& tears.
- Trial name
- NCT00344448
- Testing
- Raptiva
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Sjogren's Syndrome
Immune Profile of Saliva and Serum of Patients With Primary Sjögren´s Syndrome
Primary Sjögren's syndrome (pSS) is a chronic systemic inflammatory disease, which mainly affects the lacrimal and salivary glands, leading to sicca syndrome.
- Trial name
- pSS (NCT03711214)
- Testing
- Periodontal scaling
- Where
- 3 sites in Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Sjogren's Syndrome, Dry Eye
AST Combined With 0.05% Cyclosporin Eye Drop Improve Corneal Nerve Density in Patients With SS Dry Eye
The objective of the present study was to evaluate the efficacy of autologous serum tears combined with 0.05% cyclosporin eye drop in treating Sjögren's syndrome dry eye and their effect on corneal nerves.
- Conditions
- Sjogren's Syndrome, Dry Eye, Ocular Surface Disease
- Trial name
- AST/SS (NCT06013436)
- Testing
- Autologous serum tears combined with 0.05% cyclosporin eye drop
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine