Clinical trials: Skeletal Disorders
Heart Failure
Impact of Heart Failure on Calcium Homeostasis and Mitochondrial Function in Human Skeletal Muscle
The aim of this project is to investigate the impact of heart failure (HF) on calcium homeostasis, mitochondrial function and oxydative stress in human skeletal muscle.
- Trial name
- CALCICARD2 (NCT01956721)
- Testing
- Exercise training,, Muscle biopsy
- Where
- France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Class III Malocclusion
Corticotomy-Assisted Class III Elastic Applications
This prospective randomized clinical study aimed to evaluate the effectiveness of corticotomy-assisted maxillary protraction with three different miniplate and intermaxillary elastic applications after corticotomy in patients…
- Trial name
- CACIIIEA (NCT06763900)
- Testing
- Skeletal anchorage and intermaxillary elastic assisted maxillary protraction
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- TC Erciyes University
Class II Malocclusion, Division 1
3D Evaluation of Powerscope Appliance in Treatment of Skeletal Class 2 Malocclusion
The study is aiming to evaluate the efficacy of Powerscope appliance in treatment of skeletal Class 2 malocclusion by three-dimensional image.
- Trial name
- Powerscope app (NCT04972084)
- Testing
- Powerscope group
- Where
- Egypt
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Maxillofacial Abnormalities, Mandible Prognathism
Condylar Position Changes and TMJ Functions After BSSO Mandibular Setback, Low Medial Cut.
This study hypotheses that using low medial cut osteotomy BSSO in mandibular setback can be an efficient and effective method to limit the bony segment interferences , decreasing muscles stripping during osteotomy ,decrease…
- Conditions
- Maxillofacial Abnormalities, Mandible Prognathism, Skeletal Malocclusion
- Trial name
- NCT05713084
- Testing
- mandibular setback using BSSRO
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Critical Illness
Functional Outcomes in Children Post Critical Illness
Improvements in medical care have led to decreasing mortality rates in critically ill children, which have been reported to be as low as 5%.
- Trial name
- NCT03730844
- Where
- Singapore
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Spinal Cord Injury
Exoskeletal-assisted Walking Combined With Transcutaneous Spinal Cord Stimulation: Effect on Imaging and Serum Biomarkers of Skeletal Muscle Mass and Bone Strength.
Immobilization following spinal cord injury (SCI) results in muscle and bone loss below the level of injury, which ultimately predisposes to fracture at several sites throughout the legs and can lead to several medical…
- Trial name
- NCT07418398
- Testing
- Exoskeleton-Assisted Walking (EAW), Active Transcutaneous Spinal Cord Stimulation (tSCS)
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- VA Office of Research and Development
Multiple Trauma
Inflammatory Response After Muscle and Skeleton Trauma
The purpose of this study is to determine the inflammatory response after multiple trauma in humans.
- Trial name
- IRAMST (NCT00710411)
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Spinal Cord Injury
Blood Flow Restriction Exercise for Those With SCI
Spinal cord injuries (SCI) are among the most debilitating conditions an individual can sustain with the estimates of SCI incidence in the United States at 12,000 new cases per year.
- Trial name
- NCT04889092
- Testing
- Blood Flow Restriction exercise, Traditional resistance exercise
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- VA Office of Research and Development
Underdosing of Skeletal Muscle Relaxants for Laparotomy, Reversal of Skeletal Muscle Relaxant
Optimal Relaxation Technique for Laparotomies With Rocuronium Infusion Followed by Sugammadex Reversal
Muscle relaxation using rocuronium infusion with sugammadex reversal hypothetically provide better quality of muscle relaxation and rapid recovery from anaesthesia compared with intermittent bolus of rocuronium muscle relaxant…
- Trial name
- ProjectO5Rs (NCT01539044)
- Testing
- Neostigmine, atropine, Sugammadex
- Where
- Malaysia
- Volunteers
- 49 people
- Sponsor
- Hospital Sultanah Aminah Johor Bahru
Cardiovascular Diseases
Prehabilitation's Effect on Skeletal Muscle Mass in Cardiac Patients
The study will investigate the effect prehabilitation on skeletal muscle mass via a scanner.
- Trial name
- NCT06624774
- Testing
- Prehabilitation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Manchester Metropolitan University
Dental Malocclusion
Evaluation of Dental and Skeletal Effect of TPA and Nance as a Space Maintainers in Children: A Prospective Clinical Trial
This study will aim to evaluate the dental and skeletal effect of the Transpalatal arch and Nance holding arch as a space maintainers in children.
- Trial name
- NCT05896618
- Testing
- TPA, Nance appliance
- Where
- 2 sites in Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Diabetes Type 2, Frail Elderly Syndrome
Involvement of Muscle Mitochondrial Dysfunction in Frailty in Older Adults. Role of Exercise
This study aims to investigate the role of skeletal muscle mitochondrial dysfunction in the development of frailty in older adults and to evaluate whether a short-term, supervised resistance training intervention can improve…
- Conditions
- Diabetes Type 2, Frail Elderly Syndrome, Mitochondrial Function, Bioenergetics, Functionality
- Trial name
- MITOSTRENGTH (NCT07828847)
- Testing
- Short-duration resistance training
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Impaired Glucose Tolerance
Mechanisms of Exercise Resistance in Metabolic Disease
This project will determine exercise capacity and molecular markers of the response to acute exercise in human subjects with impaired or normal glucose tolerance.
- Trial name
- NCT03945435
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Malocclusion, Angle Class II, Division 1
Evaluation of Mini Plates Anchorage With Forsus Fatigue Resistant Device
The purpose of this study is to determine if the Forsus Fatigue resistant Device appliance with direct skeletal mini plates anchorage is capable of achievement of skeletal mandibular effects while preventing the excessive…
- Trial name
- NCT02475785
- Testing
- FFRD and mini plates group, Conventional FFRD
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Sherif A. Elkordy