Clinical trials: Skeletal Muscle Physiology
Pulmonary Rehabilitation, Sarcopenia
Pulmonary Rehabilitation in Advanced Non-small Cell Lung Cancer Patients
Lung cancer (LC) is usually diagnosed in advanced stages and continues to be the leading cause of cancer related deaths worldwide.
- Conditions
- Pulmonary Rehabilitation, Sarcopenia, Quality of Life
- Trial name
- NCT02978521
- Testing
- Pulmonary rehabilitation
- Where
- Mexico
- Volunteers
- 94 people
- Sponsor
- Instituto Nacional de Cancerologia de Mexico
Cardiomyopathy, Alcoholic, Alcoholism
Clinical Trial Studying the Effects of Spironolactone on Heart and Skeletal Muscle Function in Chronic Alcoholics
Chronic alcoholics suffer from weak skeletal and cardiac muscle. The investigators have discovered a beneficial effect of spironolactone-treatment in that regard.
- Trial name
- SPICA (NCT00226109)
- Testing
- spironolactone
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- University of Aarhus
Exercise, Ultra-endurance Running
Effect of Exogenous Ketosis During Ultra-endurance Exercise
The aim of this study is to investigate the effect of oral ketone administration during and immediately after an ultramarathon. Potential changes in cognitive function (reaction time, number of errors), running performance, jump…
- Conditions
- Exercise, Ultra-endurance Running, Ketosis, Skeletal Muscle
- Trial name
- NCT05407753
- Testing
- Ketone ester
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Mild Cognitive Impairment, Alzheimer Disease
Skeletal Muscle as a Mediator of Exercise Induced Effects on Metabolism & Cognitive Function: Role for Myokines & miRNAs
The purpose of this study is to determine specific changes in muscle secretory profile (myokines, miRNA) in association with neurodegenerative disease progression and metabolic dysfunction.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Parkinson Disease, Healthy Volunteers
- Trial name
- Brain-Muscle (NCT02253732)
- Testing
- 3 months exercise intervention program
- Where
- 2 sites in Slovakia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences
Skeletal Muscle Hypertrophy
Effects of a Multi-ingredient Supplement Study: a Randomized Controlled Trial in Men and Women
Resistance exercise training is a known stimulant for muscle protein synthesis (MPS) to occur, however the consumption of protein is also necessary to induce a shift towards a positive net protein balance.
- Trial name
- SRCT (NCT03525197)
- Testing
- Whey protein-based supplement, Collagen protein-based supplement
- Where
- 2 sites in Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- McMaster University
Copd, Athletes
Effects of CreaSafe® on Kidney, Muscle, and Cardiopulmonary Function in Athletes and COPD Patients
Creatine supplementation (CS) offers numerous health benefits, with no proven side effects reported to date. CS positively impacts all organs and systems of the body.
- Trial name
- NCT06991426
- Testing
- CreaSafe® creatine
- Where
- Brazil
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Fontan Circulation
Muscle Function in Patients With Single-chamber Heart
Groundbreaking cardiac surgery has significantly improved survival rates for patients with single-chamber hearts. However, despite these life-saving interventions, the long-term prognosis remains concerning, with an increased…
- Trial name
- Muscle in TCPC (NCT07420660)
- Where
- Sweden
- Volunteers
- 34 people
- Sponsor
- Karolinska Institutet
Polycystic Ovary Syndrome
Effect of Weight & Insulin Sensitivity on Reproductive Function in PCOS: Studies in Skeletal Muscle & Adipose
The overall objective of this ancillary study is to obtain skeletal muscle and subcutaneous adipose tissue biopsies from women with polycystic ovary syndrome enrolled in the PULSE Study (NCT01482286).
- Trial name
- PULSE-A (NCT01775176)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Pennington Biomedical Research Center
Metabolic Syndrome
Effect of Physical Activity and Diet on the Treatment of Metabolic Syndrome
Metabolic syndrome has been defined as a group of associated risk factors for cardio-vascular diseases and diabetes. It is usually treated with an association of restrictive diet, physical exercise and drugs.
- Trial name
- NCT00917917
- Testing
- Type of physical activity (resistance, endurance), Restrictive diet
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Healthly Volunteers, Oncologic Disease
A Two-Way Path to Health: Environmental Influences on Skeletal Muscle Endocrine Function
Given the well-established anti-inflammatory and health-promoting effects of physical activity as a non-pharmacological intervention, an important question remains whether different types of exercise differ in their ability to…
- Trial name
- COMPASS (NCT07706465)
- Testing
- Experimental: IWT- Interval Walking Training, Exercise training II, Walking
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Obesity & Overweight, Perimenopausal Women
Prebiotic Inulin for Late-Reproductive Individuals
This study aims to evaluate the effects of 2 weeks of inulin supplementation in perimenopausal women with overweight or obesity. The primary questions this study seeks to answer are: 1.
- Conditions
- Obesity & Overweight, Perimenopausal Women, Prebiotics, Inulin
- Trial name
- PILI (NCT07724522)
- Testing
- Inulin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- George Washington University
Chronic Kidney Disease stage3, Chronic Kidney Disease stage4
Flywheel Exercise for CKD
Among Veterans, the prevalence of chronic kidney disease (CKD) is reported to be as high as 47.3% and a third higher than the general population. Muscle wasting and dysfunction have been identified as primary consequences of CKD.
- Trial name
- NCT03582982
- Testing
- Eccentric overload exercise
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Washington D.C. Veterans Affairs Medical Center
Sarcopenia
Dose Range Finding Study of Bimagrumab in Sarcopenia
The purpose of this study was to determine the efficacy of repeat dosing with multiple dose levels of bimagrumab on patient physical function, skeletal muscle mass and strength in older adults with sarcopenia.
- Trial name
- NCT02333331
- Testing
- bimagrumab
- Where
- 58 sites in United States, Australia and 11 more
- Volunteers
- 217 people
- Sponsor
- Novartis Pharmaceuticals
Obesity
Mechanisms Underlying Postoperative Insulin Resistance and Inflammation
Having an operation places an enormous burden on the body, leading to the development of inflammation and so called 'insulin resistance'.
- Trial name
- NCT01470534
- Testing
- carbohydrate drink, Muscle biopsy, Blood sampling
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University of Nottingham
Genetic Disorder
Skeletal Muscle Biomarkers in People With Fragile Sarcolemmal Muscular Dystrophy
Background: Some kinds of muscular dystrophy affect the skeletal muscle membrane. In these conditions, the muscle membrane is more fragile. This affects how the muscles contract and relax, which causes movement problems.
- Trial name
- NCT01851447
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Sarcopenic Obesity
Nutritional Strategies for Metabolic Health in Aging
Sarcopenic obesity in older individuals presents a clinical conundrum without an effective therapeutic strategy. This study will determine the impact of precision amino acid delivery as part of a meal replacement (EMR) during…
- Trial name
- NSMH (NCT04282603)
- Testing
- Weight Loss and Weight Maintenance
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Alaska Fairbanks
Healthy Volunteers, Exercise Intensity
Combined Effect of Exercise Intensity With Nutritional Supplementation on Skeletal Muscle Function
The main objective of this study is to determine the effectiveness of a nutritional intervention (olive leaf extract) combined with a specific training session (MICT or SIT) on PDH activation (as well as other protein…
- Conditions
- Healthy Volunteers, Exercise Intensity, Neuromuscular Fatigue, Skeletal Muscle Adaptations
- Trial name
- NUTSPORT (NCT05350566)
- Testing
- Olive leaf extract
- Where
- Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Menopause Related Conditions, Sarcopenia
Effects of Time-restricted Eating and Exercise Training on Skeletal Muscle Mass Quantity, Quality and Function in Postmenopausal Women With Overweight and Obesity
The goal of this randomized controlled trial] is to investigate the effects of a 12-week time restricted eating (TRE) and exercise combined intervention, as compared to (i) TRE alone, and to (ii) Caloric Restriction (CR) plus the…
- Conditions
- Menopause Related Conditions, Sarcopenia, Osteoporosis Postmenopausal, Obesity
- Trial name
- NCT05912309
- Testing
- Time Restricted Eating (TRE), Exercise, Caloric Restriction
- Where
- Spain
- Volunteers
- 78 people
- Sponsor
- Idoia Labayen
Muscle Loss
The Effect of Leucine on Carnitine Transport to Skeletal Muscle
The primary aim of the current research project is to explore whether leucine stimulates carnitine transport, and thus affecting muscle carnitine content.
- Trial name
- ROL (NCT05009654)
- Testing
- L-carnitine, L-leucine
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Barth Syndrome
Heart and Muscle Metabolism in Barth Syndrome
Barth syndrome (BTHS) is an X-linked disorder caused by abnormal cardiolipin metabolism and is characterized by skeletal and cardiomyopathy and high mortality rates.
- Trial name
- NCT01625663
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Duke University