Clinical trials: Skeletal Muscle Physiology
Chronic Knee Pain, Fibromyalgia
Investigating the Role of Central Pain Hypersensitivity in Skeletal Muscle Neural Drive
Background: pain lasting for 12 weeks or beyond, which is often referred to as chronic pain, is common for people living with musculoskeletal conditions (e.g. arthritis, low back pain and fibromyalgia).
- Trial name
- Pain-Drive (NCT07281651)
- Testing
- Central Pain Hypersensitivity
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Healthy Volunteers, Muscle Hypertrophy
Glycolytic Phenotype (vLapeak) and Magnitude of Skeletal Muscle Hypertrophy After Resistance Training
The HyperLa study investigates whether a person's "glycolyticness"-the efficiency with which their body uses glycolysis for energy-can predict how much their muscles will grow (hypertrophy) in response to resistance training.
- Conditions
- Healthy Volunteers, Muscle Hypertrophy, Glycolysis, Moderately Trainend
- Trial name
- HyperLa (NCT07721766)
- Testing
- Hypertrophy-focused Resistance Training
- Where
- 8 sites in Finland, Germany and 2 more
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Cigarette Smoking
The Association of Cigarette Smoking on Exercise Capacity and Skeletal Muscle Function in Taiwan Adult Smokers
Background and purpose: Cigarette smoking would post threats to physical health. Even though studies suggested that long-term cigarette smoking would lead to cardiovascular diseases, pulmonary diseases, or even cancer…
- Trial name
- NCT04688177
- Testing
- Body Composition, Heart rate variability, Grip Strength
- Where
- Taiwan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Heart Failure
CHANges iN skEletal muscLe in Heart Failure
The mechanisms behind heart failure are largely unknown. Despite an increasing arsenal of pharmacological therapies, cardiovascular disease is still the most common cause of death in the western world, which demonstrates a…
- Trial name
- Channel-HF (NCT03401151)
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis
Skeletal Muscle Function in Interstitial Lung Disease
Dyspnea (i.e. breathlessness) and exercise intolerance are common symptoms for patients with interstitial lung disease (ILD), yet it is not known why.
- Conditions
- Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis, Hypersensitivity Pneumonitis, Scleroderma
- Trial name
- NCT03800017
- Testing
- Hyperoxia
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Heart Failure With Preserved Ejection Fraction
Effects of Sauna on Cardiac and Skeletal Muscle Function in Patients With HFpEF (SAUNA-HFpEF)
Heart failure with preserved ejection fraction (HFpEF) is a type of heart failure where the heart pumps normally but patients still experience symptoms like fatigue, shortness of breath, and reduced ability to exercise.
- Trial name
- SAUNA-HFpEF (NCT06978868)
- Testing
- Sauna Intervention in Clinically Stable Outpatients with HFpEF
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- Otto-von-Guericke University Magdeburg
Mitochondrial Function, Bioenergetics, Muscle Function
Bioenergetics and Muscle Function Improvement With AMAZ-02 in Elderly Skeletal Muscle (ENERGIZE Trial)
This is a randomized, double-blind, single-center, placebo-controlled Phase 2 trial enrolling 66 healthy elderly subjects (33 placebo and 33 AMAZ-02 administration) who are ≥65 and ≤ 90 years of age with evidence of low…
- Conditions
- Mitochondrial Function, Bioenergetics, Muscle Function, Aging
- Trial name
- NCT03283462
- Testing
- Mitopure
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Muscle Function
The Effects of 4 Week β-alanine Supplementation on Knee Extensor Contractile and Force Properties in the Over 60s
The older population is the fastest growing age group worldwide, but it is also the most susceptible to chronic diseases and disabilities.
- Trial name
- NCT03111979
- Testing
- beta-alanine
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Nottingham Trent University
Heart Failure
Impact of Heart Failure on Calcium Homeostasis and Mitochondrial Function in Human Skeletal Muscle
The aim of this project is to investigate the impact of heart failure (HF) on calcium homeostasis, mitochondrial function and oxydative stress in human skeletal muscle.
- Trial name
- CALCICARD2 (NCT01956721)
- Testing
- Exercise training,, Muscle biopsy
- Where
- France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Spinal Cord Injury
Blood Flow Restriction Exercise for Those With SCI
Spinal cord injuries (SCI) are among the most debilitating conditions an individual can sustain with the estimates of SCI incidence in the United States at 12,000 new cases per year.
- Trial name
- NCT04889092
- Testing
- Blood Flow Restriction exercise, Traditional resistance exercise
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- VA Office of Research and Development
Impaired Mitochondrial Function, Muscle Performance
Assessing the Effects of Increased Mitochondrial Function Exercise Training on Muscle Performance
As people grow older skeletal muscle gradually becomes smaller and weaker, causing reduced mobility and quality of life. To understand and reverse this negative process investigators need to find new ways of improving the ability…
- Trial name
- Rejuvenate2 (NCT03325491)
- Testing
- Acipimox
- Where
- United Kingdom
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Diabetes Type 2, Frail Elderly Syndrome
Involvement of Muscle Mitochondrial Dysfunction in Frailty in Older Adults. Role of Exercise
This study aims to investigate the role of skeletal muscle mitochondrial dysfunction in the development of frailty in older adults and to evaluate whether a short-term, supervised resistance training intervention can improve…
- Conditions
- Diabetes Type 2, Frail Elderly Syndrome, Mitochondrial Function, Bioenergetics, Functionality
- Trial name
- MITOSTRENGTH (NCT07828847)
- Testing
- Short-duration resistance training
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia