Clinical trials: Skin Absorption
Onychomycosis
Absorption and Systemic Study of AN2690 in Patients With Moderate to Severe Onychomycosis (ADME II)
The purpose of the study is to determine the absorption and systemic pharmacokinetics of AN2690 following daily application to all ten (10) toenails for 28 days.
- Trial name
- NCT00679601
- Testing
- AN2690
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Pfizer
Rosacea, Erythematotelangiectatic
Metronidazole SC Penetrance With Moisturizers
Topical metronidazole is a widely used first line treatment for erythemotelangiectatic and inflammatory rosacea. Commonly, a moisturizer is also used to restore the skin barrier and reduce inflammation.
- Trial name
- NCT06434519
- Testing
- Metronidazole cream, Cetaphil moisturizer, CeraVe moisturizer
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Duke University
Non-melanomatous Skin Cancer
Photodynamic Therapy in Treating Patients With Skin Cancer
RATIONALE: Photodynamic therapy uses light and drugs that make cancer cells more sensitive to light to kill tumor cells. Photodynamic therapy using aminolevulinic acid cream may be effective in treating patients with skin cancer.
- Trial name
- NCT00002963
- Testing
- aminolevulinic acid hydrochloride, conventional surgery
- Where
- United States
- Sponsor
- Roswell Park Cancer Institute
Oral Lichen Planus, Oral Lichenoid Reaction
Systemic Absorption of Dexamethasone Oral Rinse in Patients With Oral Lichen Planus
The objective of this study is to see the amount of systemic absorption of a standard dose of dexamethasone oral rinse for patients with symptomatic oral lichen planus (OLP) or oral lichenoid reactions (OLR) and healthy subjects…
- Trial name
- NCT06428630
- Testing
- dexamethasone oral rinse
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Tufts University
Juvenile Rheumatoid Arthritis
Supplementation With Vitamin D, Calcium or Both on Calcium Absorption and Bone Mineral Content in Children With JRA
2000 international units (IU) vitamin D, 1 gram (gm) calcium, or both given to children with Juvenile Rheumatoid Arthritis (JRA) may increase percent true calcium absorption, bone mineral turnover and/or bone mineralization.
- Trial name
- NCT00570934
- Testing
- Cholecalciferol, Calcium, Calcium and cholecalciferol
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Missouri-Columbia
Rheumatoid Arthritis, Crohn's Disease
Tumor Necrosis Factor Decreases Vitamin D Dependant Calcium Absorption
This study is a pilot study to determine whether patients with TNFα excess have decreased calcium absorption in response to calcitriol (1,25-dihydroxyvitamin D, the active form of vitamin D) compared to normal controls.
- Trial name
- NCT00427804
- Testing
- calcitriol
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Atlanta VA Medical Center
Soil-transmitted Helminth Infection, Onchocerciasis (River Blindness)
A Study to Learn About How Much Emodepside Gets Absorbed in the Blood and How Food Affects Its Absorption When Given as a New Type of Tablet to Healthy Participants
Onchocerciasis or river blindness is an infectious disease caused by a parasitic worm. It spreads through the bite of an infected blackfly.
- Trial name
- NCT06412926
- Testing
- BAY 44-4400
- Where
- Germany
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Bayer
Zinc Absorption, Iron Absorption
Guatemala Biofortified Maize Study
Zinc (Zn) and iron (Fe) deficiencies are common in Guatemala, and maize is a staple food throughout the country. The primary aim of this study is to demonstrate if utilizing nixtamalized biofortified maize has the potential to…
- Trial name
- NCT06650397
- Testing
- Biofortified maize
- Where
- Guatemala
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Psoriasis
Efficacy and Safety of Topical ALT-2074 (SYI-2074) for Treatment of Chronic Plaque Psoriasis
The primary objective of this study will be to evaluate the efficacy of topical ALT-2074 applied twice daily for 28 days for treatment of chronic plaque psoriasis in adult subjects.
- Trial name
- NCT00782613
- Testing
- 4,4-dimethyl-benziso-2H-selenazine
- Where
- 3 sites in Israel
- Volunteers
- 30 people
- Sponsor
- Synvista Therapeutics, Inc
Psoriasis
INulin-type Fructans-induced Gut Microbiota Modulation Impact on GUT-SKIN Axis Parameters in Psoriasis
There is increasing evidence of a strong, bidirectional correlation between the gut and the skin, that associates gastrointestinal health with skin homeostasis and allostasis.
- Trial name
- INGUTSKIN (NCT05971992)
- Testing
- Chicory-derived inulin-type β-fructans, Maltodextrin
- Where
- 2 sites in Poland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Polish Academy of Sciences
Muscle Protein Synthesis
Effects of Ingesting Multiple Boluses of Collagen on Muscle & Skin Connective Protein Synthesis in Vivo in Humans
Rationale: Collagen protein is the central structural component of extracellular connective tissues within skeletal muscle, bone, cartilage and skin.
- Trial name
- CODIAK (NCT06435637)
- Testing
- Collagen protein, Resistance exercise
- Where
- Netherlands
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Acne Vulgaris
Open-Label, Randomized Study Evaluating the Absorption and Systemic Pharmacokinetics of Topically Applied IDP-126 Gel in Comparison With Control Gel
This will be an open-label study designed to assess the safety and plasma PK of topically applied IDP-126 Gel compared to Control Gel.
- Trial name
- NCT03653403
- Testing
- IDP-126 Gel, Control Gel
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Bausch Health Americas, Inc.
Acne
Absorption and Systematic Pharmacokinetics of Topically Applied IDP-120 Gel
Study designed to assess the safety and plasma PK of tretinoin and its metabolites from topically applied IDP-120 gel.
- Trial name
- NCT02850003
- Testing
- IDP-120 Gel
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Bausch Health Americas, Inc.