Clinical trials: Skin Cancers - Basal Cell Carcinoma
Basal Cell Carcinoma (BCC)
Intralesional Cryosurgery for Basal Cell Carcinoma - a Feasibility Study
A feasibility study for the treatment of Basal Cell Carcinoma of the lower extremities in the elderly utilizing intralesional cryosurgery.
- Trial name
- NCT01633515
- Testing
- Intralesional cryotherapy
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Carmel Medical Center
Mucositis, Oral Complications
Acetylcysteine Rinse in Reducing Saliva Thickness and Mucositis in Patients With Head and Neck Cancer Undergoing Radiation Therapy
This randomized pilot clinical trial studies whether acetylcysteine oral rinse will lessen saliva thickness and painful mouth sores in patients with head and neck cancer undergoing radiation therapy.
- Conditions
- Mucositis, Oral Complications, Recurrent Adenoid Cystic Carcinoma of the Oral Cavity, Recurrent Basal Cell Carcinoma of the Lip
- Trial name
- NCT02123511
- Testing
- acetylcysteine, quality-of-life assessment, questionnaire administration
- Where
- 5 sites in United States
- Volunteers
- 34 people
- Sponsor
- Mayo Clinic
Carcinoma, Basal Cell
Safety and Efficacy Study of Imiquimod 5% Cream Applied 3x Per Week for 8 or 12 Weeks in Low Risk Nodular Basal Cell Carcinoma
Results from a pilot study demonstrated that topical imiquimod could clear superficial and nodular BCCs. Three phase II dose response studies in subjects with nodular BCC (nBCC) showed that the histological cure rates with…
- Trial name
- NCT00204555
- Testing
- Imiquimod
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University Hospital Tuebingen
Advanced Solid Tumor, Unresectable Solid Tumor
A Beta-only IL-2 ImmunoTherapY Study
This is a Phase 1/2, multi-center, open-label, dose-escalation and expansion study to evaluate safety and tolerability, PK, pharmacodynamic, and early signal of anti-tumor activity of MDNA11 alone or in combination with a…
- Conditions
- Advanced Solid Tumor, Unresectable Solid Tumor, Clear Cell Renal Cell Carcinoma, Triple Negative Breast Cancer
- Trial name
- ABILITY-1 (NCT05086692)
- Testing
- MDNA11, Pembrolizumab (KEYTRUDA®)
- Where
- 25 sites in United States, Australia and 6 more
- Volunteers
- 160 people
- Sponsor
- Medicenna Therapeutics, Inc.
Skin Basal Cell Carcinoma
Pembrolizumab With or Without Vismodegib in Treating Metastatic or Unresectable Basal Cell Skin Cancer
This phase 1-2 trial studies how well pembrolizumab with or without vismodegib works in treating patients with skin basal cell cancer that has spread to other places in the body or cannot be removed by surgery.
- Trial name
- NCT02690948
- Testing
- Pembrolizumab, Vismodegib
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Anne Chang
Neoplastic Syndrome, Non-melanomatous Skin Cancer
Topical Sirolimus in Patients With Basal Cell Nevus Syndrome and in Healthy Participants
RATIONALE: Studying samples of blood and tissue from patients with basal cell nevus syndrome and from healthy participants in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers…
- Trial name
- NCT00433485
- Testing
- sirolimus, comparative genomic hybridization, gene expression analysis
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Yale University
Skin Cancer
An Appearance-Based Intervention to Reduce Teen Skin Cancer Risk
The purpose of this study is to determine whether a skin cancer prevention website is effective at reduce female teenagers' desire to use indoor tanning and ultimately their use of indoor tanning over an 18 month period.
- Trial name
- iSTART (NCT01508013)
- Testing
- Appearance-Focused Website Intervention, Control Website
- Where
- United States
- Volunteers
- 443 people, healthy volunteers welcome
- Sponsor
- East Tennessee State University
Non-Melanomatous Skin Cancer
Low Fat Diet to Prevent Disease Progression in Patients With Skin Cancer
RATIONALE: A low-fat, balanced diet may prevent disease progression in patients with nonmelanomatous skin cancer. PURPOSE: Randomized phase II trial to study the effectiveness of a low-fat, balanced diet to prevent disease…
- Trial name
- NCT00003097
- Testing
- preventative dietary intervention
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- Baylor College of Medicine
Non-melanomatous Skin Cancer
Celecoxib in Preventing Skin Cancer
RATIONALE: Celecoxib may be effective in preventing skin cancer by decreasing redness caused by exposure to ultraviolet light and changing potential skin cancer biomarkers.
- Trial name
- NCT00025051
- Testing
- celecoxib, anti-cytokine therapy, antiangiogenesis therapy
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Carcinoma, Basal Cell
VISmodegib for ORbital and Periocular Basal Cell Carcinoma
Basal cell carcinoma (BCCA) is the most common human cancer, and frequently affects facial structures. While rarely fatal, facial BCCA can be disfiguring and expensive to treat.
- Trial name
- VISORB (NCT02436408)
- Testing
- Vismodegib
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Michigan Rogel Cancer Center
Skin Cancer
A Community-based Educational Initiative to Raise Awareness of Melanoma and Other Skin Cancers.
This is a pilot study of a community- based melanoma educational intervention in Bensonhurst, Brooklyn conducted in-person by a community-health worker employed by the Perlmutter Cancer Center.
- Trial name
- NCT07177638
- Testing
- Education Sessions to Improve Melanoma Knowledge and Awareness
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Superficial Basal Cell Carcinoma, Nodular Basal Cell Carcinoma
High Intensity Focused Ultrasound vs. Cryotherapy in the Treatment of Basal Cell Carcinomas and Bowen's Disease in Adults
This prospective, randomized, controlled, and single-blinded non-inferiority clinical trial compare the efficacy and tolerability of high intensity focused ultrasound (HIFU) to standard cryotherapy in the treatment of low-risk…
- Conditions
- Superficial Basal Cell Carcinoma, Nodular Basal Cell Carcinoma, Bowen's Disease, BCC
- Trial name
- HIFUvsCRYO (NCT07384078)
- Testing
- High Intensity Focused Ultrasound, Cryotherapy
- Where
- Finland
- Volunteers
- 294 people
- Sponsor
- Jussi Salonen
Basal Cell Carcinoma, Squamous Cell Carcinoma
Serum Concentration of Lidocaine After Local Injection During Mohs Micrographic Surgery
The primary objective of this study is to (1) determine whether local injection of lidocaine used during Mohs surgery will elevate serum lidocaine concentrations to a level that could cause systemic symptoms and (2) determine…
- Trial name
- NCT00793169
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Northwestern University
Basal Cell Carcinoma in Basal Cell Nevus Syndrome
Open-label Trial of SUBA™-Itraconazole (SUBA-Cap) in Subjects With Basal Cell Carcinoma Nevus Syndrome (BCCNS)
The study will assess the safety and efficacy of SUBA-Cap in subjects with Basal Cell Carcinoma Nevus Syndrome.
- Trial name
- NCT02354261
- Testing
- SUBA-Itraconazole
- Where
- 5 sites in United States
- Volunteers
- 38 people
- Sponsor
- HedgePath Pharmaceuticals, Inc.
Basal Cell Carcinoma, Skin Cancer
Open-Label Proof of Concept Study of VP-315 in Basal Cell Carcinoma
This is a 2-part, open-label, multicenter, dose-escalation, proof-of-concept study with a safety run-in designed to assess the safety, tolerability, MTD, and objective antitumor efficacy of ascending dose strengths of VP-315 when…
- Conditions
- Basal Cell Carcinoma, Skin Cancer, Cancer of the Skin, Basal Cell, Cancer of the Skin
- Trial name
- NCT05188729
- Testing
- Part 1: VP-315 3 Day Dosing/Week, Part 2: VP-315 3 Day Dosing/Week - Loading Dose, Part 2: VP-315 3 Day Dosing/Week - No Loading Dose
- Where
- 13 sites in United States
- Volunteers
- 92 people
- Sponsor
- Verrica Pharmaceuticals Inc.
Basal Cell Carcinoma, Cutaneous Squamous Cell Carcinoma
FLASH Radiotherapy for Skin Cancer
This is a single center randomized selected Phase II study of FLASH radiotherapy (RT) versus standard of care (SOC) radiotherapy in patients with localized Cutaneous Squamous Cell Carcinoma (cSCC) or Basal Cell Carcinoma (BCC).
- Trial name
- LANCE (NCT05724875)
- Testing
- FLASH RT, Conventional RT
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Cutaneous Squamous Cell Carcinoma, Basal Cell Carcinoma
Intralesional Cemiplimab for Adult Patients With Cutaneous Squamous Cell Carcinoma or Basal Cell Carcinoma
This study is researching an experimental drug called cemiplimab. The study is focused on Cutaneous Squamous Cell Carcinoma (CSCC) and Basal Cell Carcinoma (BCC).
- Trial name
- NCT03889912
- Testing
- Cemiplimab
- Where
- 18 sites in United States, Australia and 1 more
- Volunteers
- 97 people
- Sponsor
- Regeneron Pharmaceuticals
Cutaneous Squamous Cell Carcinoma, Squamous Cell Carcinoma
A Window of Opportunity Trial of Intratumoral Injection of Copaxone® in Patients With Percutaneously Accessible Tumors
The investigator believes that injecting Copaxone into tumors will help participants immune system fight cancer. This has been studied in mice and has shown encouraging results.
- Conditions
- Cutaneous Squamous Cell Carcinoma, Squamous Cell Carcinoma, Basal Cell Carcinoma
- Trial name
- NCT03982212
- Testing
- Copaxone
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Kansas Medical Center
Basal Cell Carcinoma of Skin, Squamous Cell Carcinoma
Two-photon Fluorescence Microscopy of Dermatologic Biopsies
The goal of this study is to investigate the ability of two-photon fluorescence microscopy to evaluate dermatologic biopsies. The main questions it aims to answer are: How well do two-photon fluorescence images of biopsies taken…
- Conditions
- Basal Cell Carcinoma of Skin, Squamous Cell Carcinoma, Melanocytic Lesion, Adult
- Trial name
- NCT07773688
- Testing
- Two photon microscopy imaging
- Where
- United States
- Volunteers
- 644 people
- Sponsor
- University of Rochester
Basal Cell Carcinoma
Rates of Positive Basal Cell Carcinomas (BCCs) in Re-excisions
Basal Cell Carcinoma (BCC) is the most common malignant growth in the world. Treatment is primarily surgical with the goal of excising the growth in its entirety.
- Trial name
- NCT01403480
- Volunteers
- 600 people
- Sponsor
- Rambam Health Care Campus