Clinical trials: Skin Diseases, Bacterial
Onychomycosis
A Study to Evaluate the Efficacy and Safety of Oral VT-1161 in Patients With Onychomycosis of the Toenail
Several properties of VT-1161 suggest that it might be a safer and more effective treatment for onychomycosis of the toenail (also known as toenail fungus) than other oral antifungal medicines.
- Trial name
- NCT02267356
- Testing
- VT-1161
- Where
- 33 sites in United States
- Volunteers
- 259 people
- Sponsor
- Viamet
Acquired Hallux Valgus
Prevalence and Clinical Characteristics of the Fungal Nail and Feet Infection in Patients With Hallux Valgus
This study was designed to demonstrate the prevalence of onychomycosis in hallux valgus patients. Additionally, all the prevalence of tinea pedis, the pattern of clinical manifestations, risk factors and coexistence foot…
- Trial name
- NCT02464839
- Where
- Thailand
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Rheumatic Fever
Clinical Trial to Assess Safety and Immunogenicity of a Synthetic Vaccine Against Streptococcus Pyogenes
This is a double-blind, randomized, placebo-controlled phase I clinical trial with dose-escalation of a synthetic vaccine against Streptococcus pyogenes.
- Trial name
- NCT03998592
- Testing
- Streptococcus pyogenes vaccine (50 µg), Streptococcus pyogenes vaccine (100 µg), Streptococcus pyogenes vaccine (200 µg)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Butantan Institute
Psoriasis, Alopecia Areata
Development and EValuation of an Online Intervention to Reduce Self-Stigma in People With Visible Chronic Skin disEases
This project aims to develop and evaluate an online intervention to prevent and/or reduce self-stigma in German patients with visible chronic skin diseases.
- Conditions
- Psoriasis, Alopecia Areata, Hidradenitis Suppurativa, Vitiligo
- Trial name
- DEVISE (NCT06324695)
- Testing
- HautKompass
- Where
- 12 sites in Germany
- Volunteers
- 298 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Onychomycosis
Efficacy Safety, and Tolerability of Topical Terbinafine in Patients With Mild to Moderate Toenail Fungus of the Big Toenail
This study is designed to assess the efficacy, safety and tolerability of a topical formulation of terbinafine solution applied daily in patients with toenail fungus.
- Trial name
- NCT00443820
- Testing
- terbinafine
- Where
- 23 sites in United States, France and 1 more
- Volunteers
- 526 people
- Sponsor
- Novartis Pharmaceuticals
Tinea Pedis
A Dose Response Trial to Evaluate Clinical and Mycological Effect of Nitric Oxide in Subjects With Tinea Pedis
A multi-arm trial to evaluate the efficacy and safety of using gaseous nitric oxide to treat moderate to severe tinea pedis.
- Trial name
- NCT00893880
- Testing
- 1% gaseous Nitric Oxide blended in Oxygen
- Where
- 4 sites in Canada, Saint Kitts and Nevis
- Volunteers
- 92 people
- Sponsor
- Nitric BioTherapeutics, Inc
Erythema Migrans Lesions, Erythema Migrans
Analysis of Lyme Disease Lesions
This study will analyze cells from erythema migrans lesions, the "bull's eye" rash of Lyme disease. Little is known about what happens in the skin when it is infected with Borrelia burgdorferi, the bacteria that cause Lyme…
- Trial name
- NCT00132327
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pressure Ulcer
Evaluating Blast-X® in Combination With Negative Pressure Wound Therapy
A Multi-center, Prospective Clinical Trial Evaluating the Combination of BlastX and Negative Pressure Wound Therapy (VAC).To evaluate the 4-week healing trajectory/wound area reduction with BlastX/VAC as compared with historical…
- Trial name
- BlastVac-001 (NCT04265170)
- Testing
- BlastX with negative pressure therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- SerenaGroup, Inc.
Distal, Subungual Onychomycosis
Study of Different Doses of a Novel Treatment for Onychomycosis
The purpose of the study is to determine the safety and efficacy of 2.5%, 5.0%, and 7.5% AN2690 Solutions compared to the vehicle alone in the treatment of distal, subungual onychomycosis of the great target toenail.
- Trial name
- NCT00679770
- Testing
- AN2690, 2.5%, AN2690, 5%, AN2690, 7.5%
- Where
- 4 sites in United States
- Volunteers
- 28 people
- Sponsor
- Pfizer
Onychomycosis
Clinical Investigation for the Evaluation of Efficacy and Safety of Two Medical Devices for Onychomycosis Treatment
The goal of this clinical trial is to evaluate the effectiveness of FORTE, ACTIVE COVER LIGHT and Loceryl® in the treatment of onychomycosis based on the blinded evaluation of the percentage of healthy nail surface compared to…
- Trial name
- NCT06254027
- Testing
- Forte, Active Cover Light, Loceryl
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Oystershell NV
Necrotizing Soft Tissue Infection, Necrotizing Fascitis
Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study
The investigators will analyze biomarkers related to the prognosis and treatment of necrotizing soft tissue infections (NSTI). The focus will be on whether certain endothelial and immune system biomarkers can function as markers…
- Conditions
- Necrotizing Soft Tissue Infection, Necrotizing Fascitis, Gas Gangrene, Fournier Gangrene
- Trial name
- ProTreat (NCT03147352)
- Testing
- Hyperbaric oxygen therapy
- Where
- Denmark
- Volunteers
- 260 people
- Sponsor
- Ole Hyldegaard
Infected Toenails, Onychomycosis
PinPointe FootLaser for the Treatment of Onychomycosis
To evaluate the safety and efficacy of the PathoLase FootLaser treatment of infected toenails.
- Trial name
- NCT00935649
- Testing
- PinPointe FootLaser
- Where
- 4 sites in United States, Canada
- Volunteers
- 134 people
- Sponsor
- PathoLase, Inc.
Hidradenitis Suppurativa, Mediterranean Diet
Nutritional Status and Hidradenitis Suppurativa (Acne Inversa)
Hidradenitis suppurativa (HS) is a chronic inflammatory, debilitating skin disorder. The exacerbating factors of HS include nutrition and adiposity.
- Conditions
- Hidradenitis Suppurativa, Mediterranean Diet, Body Composition, Vitamin D Deficiency
- Trial name
- NutriHidra (NCT03683238)
- Testing
- Mediterranean Diet
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Federico II University
Plague, Bubonic; Plague, Skin
Testing of a New Rapid Antigen Test for Plague in Ituri, Democratic Republic of the Congo.
This study is being done to learn more about the disease in Ituri and to evaluate a new rapid test that may help doctors find the disease more quickly.
- Conditions
- Plague, Bubonic; Plague, Skin, Plague, Pneumonic
- Trial name
- RAPID-IT (NCT07174648)
- Where
- Democratic Republic of the Congo
- Volunteers
- 300 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Hidradenitis Suppurativa
A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy
Hidradenitis suppurativa (HS) is an inflammatory skin disease that causes painful lesions in the axilla (underarm), inguinal (groin) and anogenital (anal/genital) regions.
- Trial name
- Step-Up HS (NCT05889182)
- Testing
- Upadacitinib
- Where
- 285 sites in United States, Argentina and 35 more
- Volunteers
- 1,328 people
- Sponsor
- AbbVie
Hidradenitis Suppurativa
A Study for Evaluating Safety & Efficacy of Topical Roflumilast 0.3% Foam in Hidradenitis Suppurativa
This is a phase 2a, open label study. As psoriasis and Hidradenitis Suppurativa (HS) share multiple inflammatory pathways, the investigators hypothesize that the use of topical roflumilast 0.3% foam is a safe and efficacious…
- Trial name
- NCT07077902
- Testing
- Topical roflumilast 0.3% foam
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- Tulane University
Onychomycosis of Toenail
Safety, Tolerability and Efficacy of Trichostatin A in Patients With Mild to Severe Onychomycosis
This is a multicenter, open label study designed to evaluate the safety, tolerability, and efficacy of topically administered VTR-297 solution.
- Trial name
- NCT07065773
- Testing
- Trichostatin A
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- Vanda Pharmaceuticals
Tinea Pedis
Efficacy and Safety of Terbinafine Film Forming Solution in Patients With Tinea Pedis
This study will compare the efficacy and safety of a single dose of terbinafine film forming solution 1% with a single dose of placebo film forming solution in the treatment of tinea pedis.
- Trial name
- NCT01433107
- Testing
- Terbinafine
- Where
- 6 sites in China
- Volunteers
- 290 people
- Sponsor
- Novartis
Metastatic Melanoma, Immune Checkpoints Inhibitors
Biomarkers in Immunotherapy of Melanoma
Background: Immunotherapy has been successful in treating advanced melanoma, but a large proportion of patients do not respond to the treatment with immune checkpoint inhibitors (ICIs).
- Conditions
- Metastatic Melanoma, Immune Checkpoints Inhibitors, Gastrointestinal Microbiome (Bacterial and Viral), Exosomal mRNA Expression of PD-L1 and IFNγ
- Trial name
- NCT05878977
- Testing
- Immune checkpoint inhibitor
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- Institute of Oncology Ljubljana
Onychomycosis
Clinical Trial on Onychomycosis With P-3058 Nail Solution in Pediatric Population
Pediatric patients affected by mild-to-moderate distal subungual onychomycosis (DSO) or affected by white superficial onychomycosis (WSO), due to dermatophytes, will be treated topically with P-3058 nail solution according to the…
- Trial name
- NCT02547701
- Testing
- P-3058
- Where
- 5 sites in Belgium, Germany and 3 more
- Volunteers
- 20 people
- Sponsor
- Polichem S.A.