Clinical trials: Skin Diseases, Bacterial
Lyme Disease
Searching for Persistence of Infection in Lyme Disease
Background: Lyme disease is an infection caused by Borrelia burgdorferi, a bacteria that is transmitted to humans by ticks. It can cause many different symptoms including rash, fever, headache, meningitis (infection of the…
- Trial name
- NCT01143558
- Testing
- Lyme Disease Xenodiagnosis
- Where
- 3 sites in United States
- Volunteers
- 45 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hidradenitis Suppurativa (HS)
Nd:YAG vs Alexandrite Laser Treatment in Hidradenitis Suppurativa
The purpose of this study is to evaluate whether Alexandrite laser treatment is non-inferior to Nd:YAG (neodymium-doped yttrium aluminum garnet) laser treatment of hidradenitis suppurativa (HS).
- Trial name
- NCT06960447
- Testing
- Nd:YAG Laser, Alexandrite Laser
- Volunteers
- 21 people
- Sponsor
- Geisinger Clinic
Hidradenitis Suppurativa
LTX-109 as Treatment for Hidradenitis Suppurativa
An Open label Phase II//proof of concept-study to demonstrate if percutaneous application of LTX-109 in a gel vehicle is a safe treatment of Hidradenitis suppurativa and to identify clinical response to intervention, as well to…
- Trial name
- NCT04756336
- Testing
- LTX-109 gel, 3% w/w
- Where
- Norway
- Volunteers
- 11 people
- Sponsor
- Pharma Holdings AS
Hidradenitis Suppurativa
Anakinra as a Treatment for Hydradenitis Suppurativa
This is an open-label, proof-of-concept research study to assess the effectiveness of anakinra in the treatment of patients with hidradenitis suppurativa (HS).
- Trial name
- NCT01516749
- Testing
- anakinra
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of California, San Francisco
Hidradenitis Suppurativa
Intralesional Diode Laser Treatment of Fistulas in Hidradenitis Suppurativa
Hidradenitis suppurativa (HS) is a common chronic skin disease where patients experience inflamed painful nodules and chronic suppurating tunnels under the skin that often leave mutilating scars.
- Trial name
- NCT04508374
- Testing
- 1470 nm intra-lesional diode laser treatment of right HS tunnel, 1470 nm intra-lesional diode laser treatment of left HS tunnel
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Zealand University Hospital
Skin Diseases, Bacterial
Avelox in Complicated Skin and Skin Structure Infections
This international, prospective, non-interventional, non-controlled observational study obtains data on efficacy, safety and tolerability of Avelox treatment under daily-life treatment conditions.
- Trial name
- ARTOS (NCT00997997)
- Testing
- Moxifloxacin (Avelox, BAY12-8039)
- Where
- 12 sites in Austria, Bulgaria and 10 more
- Volunteers
- 6,127 people
- Sponsor
- Bayer
Onychomycosis
Radiofrequency in Onychomycosis
Onychomycosis is the most common nail disease, representing more than 50% of all onychopathies.
- Trial name
- NCT05390190
- Testing
- Non ablative radiofrequency
- Volunteers
- 20 people
- Sponsor
- Cairo University
Knee Osteoarthritis, Chronic Inflammatory Rheumatism
IDENTIFICATION OF BIOMARKERS ASSOCIATED WITH THE SEVERITY AND RADIO-CLINICAL PROGRESSION OF KNEE OSTEOARTHRITIS
Knee osteoarthritis (OA) is an heterogeneous disease, both symptomatically and structurally, with very different evolving profiles.
- Trial name
- BIOGO (NCT06600958)
- Testing
- SA brief descriptive name used to refer to the intervention(s) studied
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Polymyalgia Rheumatica, Inflammatory Rheumatism
Justification of the Initial Diagnosis and Evaluation of the Overall Evolution of a Cohort of Recent Polymyalgia Rheumatica (JADORE)
Pseudo-rheumatoid arthritis (PRA) is a common inflammatory rheumatic disease of the elderly, characterized by inflammatory shoulder and/or hip pain.
- Trial name
- JADORE (NCT07132164)
- Testing
- biobank sample collection
- Where
- 30 sites in France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Brest
Hidradenitis Suppurativa
Hidradenitis Suppurativa (HS) Tunneling Wounds
The purpose of this study is to look at the change in the microbiome (bacterial composition) of an HS tunneling wound and examine if treatment with an antibiofilm surfactant wound gel (ABWG) (a topical medication that will fight…
- Trial name
- NCT04648631
- Testing
- antibiofilm surfactant wound gel (ABWG)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Miami
Bronchogenic Carcinoma, Chronic Granulomatous Disease
Diagnostic Effectiveness of Virtual Bronchoscopy
This study will evaluate a new technique for examining the air passages of the lungs called "virtual bronchoscopy." It involves using computed tomography (CT) images of the chest to generate a 3-dimensional model of the walls of…
- Conditions
- Bronchogenic Carcinoma, Chronic Granulomatous Disease, Job's Syndrome, Mycobacterium Infection
- Trial name
- NCT00001515
- Testing
- virtual bronchoscopy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Diabetic Foot Ulcer, Diabetes
Hyperbaric Oxygen Therapy in Diabetics With Chronic Foot Ulcers and Improvement of Quality of Life
This study evaluated the effect of hyperbaric oxygen therapy (HBOT) on wound healing, inflammation index, glycemic control, amputation rate, survival rate of tissue, bacterial wound cultures, and quality of life (QOL) in diabetic…
- Trial name
- NCT02328508
- Testing
- Hyperbaric oxygen therapy
- Volunteers
- 38 people
- Sponsor
- Chen-Yu Chen
Lyme Disease
Safety, Skin and Plasma Concentration of Azithromycin Dermal Formulation
IXODES GmbH intends to develop SHB001, an azithromycin dermal formulation in order to prevent Lyme disease at early stages of infection after tick bite.
- Trial name
- IXO-01 (NCT01243008)
- Testing
- Application of SHB001
- Where
- Switzerland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Tuberculosis
Specificity Trial of the Recombinant Tuberculosis Allergen in BCG Vaccinated Healthy Volunteers
The aim of this study is to test the recombinant tuberculosis skin test in the previously BCG vaccinated healthy adults with low risk of TB development, to determine the test specificity.
- Trial name
- NCT05203068
- Testing
- Recombinant tuberculosis allergen (RTA)
- Where
- Russia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Atopic Dermatitis
Bleach Bath Treatment of Adults With Atopic Dermatitis
This is pilot, mechanistic study to address whether bleach baths given to adult subjects with atopic dermatitis or eczema, who are colonized with the bacteria Staphylococcus aureus, will significantly alter their skin microbiome…
- Trial name
- NCT01996150
- Testing
- bleach bath (sodium hypochlorite)
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Rochester
Hidradenitis Suppurativa
Effectiveness of Adalimumab in Moderate to Severe HidrAdenitis SuppuRativa Patients - a Multi cOuNtry studY in Real Life Setting
This study will assess the effects of adalimumab treatment in moderate to severe Hidradenitis Suppurativa (HS) patients in the real world setting.
- Trial name
- HARMONY (NCT02786576)
- Where
- 83 sites in Austria, Belgium and 11 more
- Volunteers
- 236 people
- Sponsor
- AbbVie
Impetigo
Vehicle Controlled Efficacy and Safety Study of Two Dose Regimens of CD07223 1.5% Topical Gel in Impetigo
This study will be a multicenter, randomized, vehicle controlled, parallel, group, double blind study. Eligible subjects with a clinical diagnosis of impetigo will be randomized to one of four treatment groups: 1.5% CD07223…
- Trial name
- NCT01670032
- Testing
- Experimental: CD07223 1.5 % Topical Gel BID, Experimental: CD07223 1.5% Topical Gel TID
- Where
- 13 sites in United States, South Africa
- Volunteers
- 328 people
- Sponsor
- NovaBay Pharmaceuticals, Inc.
Onychomycosis
Systemic Antifungal Plus Q-Switched Nd:YAG Laser for Onychomycosis
This randomized controlled trial aims to compare the efficacy and safety of systemic terbinafine combined with Q-switched Nd:YAG laser versus systemic terbinafine alone in the treatment of onychomycosis.
- Trial name
- NCT07869706
- Testing
- Terbinafine, Q-switched Nd:YAG laser
- Volunteers
- 97 people
- Sponsor
- Assiut University
Tinea Pedis
SB208 for the Treatment of Tinea Pedis
This is a phase 2, multi-center, double-blind, randomized, vehicle-controlled study to be conducted in non immunocompromised adult subjects with interdigital tinea pedis.
- Trial name
- NCT02860052
- Testing
- SB208 2%, SB208 4%, SB208 16%
- Where
- Dominican Republic
- Volunteers
- 222 people
- Sponsor
- Novan, Inc.
Rhinoscleroma
Comparison Between Rifampicin and Gemifloxacin and Ciprofloxacin in Treatment of Rhinoscleroma
gemifloxacin versus ciprofloxacin and rifampicin in treatment of rhinoscleroma
- Trial name
- NCT03326050
- Testing
- Gemifloxacin, Ciprofloxacin, Rifampicin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University