Clinical trials: Skin Diseases, Papulosquamous
Psoriasis
A Real World Study Evaluating the Long-Term Quality of Life of Tildrakizumab in Adult Patients With Psoriasis
This is a Phase 4 multicenter, uncontrolled open-label study design. There will be a total of 10 study visits at Screening, Baseline, Week 4, Week 8, Week 12, Week 16, Week 28, Week 40, Week 52 and Week 64, with subjects…
- Trial name
- NCT03718299
- Testing
- Injections of tildrakizumab
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- Sun Pharmaceutical Industries Limited
Psoriatic Arthritis
Psoriatic Arthritis Study of Izokibep
Izokibep is a potent and selective inhibitor of interleukin (IL)-17A that is being developed for treatment of psoriatic arthritis (PsA). This study will evaluate the efficacy of izokibep in subjects with PsA.
- Trial name
- NCT05623345
- Testing
- Izokibep
- Where
- 71 sites in United States, Bulgaria and 6 more
- Volunteers
- 351 people
- Sponsor
- ACELYRIN Inc.
Psoriasis
Study of Subcutaneous (Injected Under the Skin) Risankizumab to Assess Change in Disease Symptoms in Adult Participants With Moderate to Severe Plaque Psoriasis With Palmoplantar Involvement
Plaque Psoriasis is a chronic inflammatory disease in which skin cells build up and develop scaly red and white patches on the skin. It is caused by an overactive immune system where the body attacks healthy tissue by mistake.
- Trial name
- IMMprint (NCT04713592)
- Testing
- Risankizumab
- Where
- 55 sites in United States, Canada and 2 more
- Volunteers
- 174 people
- Sponsor
- AbbVie
Psoriasis, Insulin Resistance
Machine Learning-Based Prediction of Insulin Resistance in Psoriasis Patients Emphasizing Interpretability
Psoriasis is a long-term inflammatory skin disease that can affect overall health. People with psoriasis have a higher risk of developing insulin resistance, a condition in which the body does not respond properly to insulin.
- Trial name
- NCT07321288
- Where
- China
- Volunteers
- 1,265 people
- Sponsor
- Chinese PLA General Hospital
Psoriasis Vulgaris, Topical Administration
Efficacy and Safety of a Botanical Total Coumarin (TC) Cream in Treating Patients With Psoriasis Vulgaris (PLANTCOAT-III)
The goal of this clinical trial is to learn if a botanical Total Coumarin topical cream (TC Cream) works to treat psoriasis in adults. It will also learn about the safety of the topical TC Cream.
- Conditions
- Psoriasis Vulgaris, Topical Administration, Phase III
- Trial name
- PLANTCOAT-III (NCT07426120)
- Testing
- Total coumarin (TC) cream, Vehicle cream
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Psoriasis Research Institute of Guangzhou
Oral Lichen Planus, Vitamin D Deficiency
The Role of Vitamin D in Amelioration of Oral Lichen Planus and Its Effect on Salivary IFN-γ Level
The goal of this clinical trial is to compare between the use of vitamin D supplement in conjunction with systemic steroids versus the use of systemic steroids alone in the management of patients with symptomatic Oral Lichen…
- Trial name
- NCT06204796
- Testing
- vitamin D supplement was given as 60,000 IU weekly in conjunction with systemic prednisone, Systemic prednisone
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Fayoum University
Psoriasis
A 36-Week Extension to Protocol ISA04-03
The purpose of this study is to determine the safety and efficacy of voclosporin in patients with plaque psoriasis.
- Trial name
- SPIRIT (NCT00258713)
- Testing
- voclosporin
- Where
- 29 sites in Canada
- Volunteers
- 309 people
- Sponsor
- Aurinia Pharmaceuticals Inc.
Psoriasis
A Study to Evaluate IBI112 in the Treatment of Psoriasis With Moderate to Severe Plaque Psoriasis
The purpose of this study is to evaluate the efficacy and safety of IBI112 in the treatment of participants with moderate to severe plaque-type psoriasis.
- Trial name
- NCT05645627
- Testing
- IBI112
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Psoriasis
Effect of Chronic Inflammation on Myocardial Perfusion and Function
Background: Heart failure (HF) is a public health burden. Studies have shown a link between inflammation, myocardial dysfunction, and HF.
- Trial name
- NCT04870827
- Testing
- 13N Amonia
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Arthritis, Psoriatic
A Study of the Safety and Efficacy of Ustekinumab in Patients With Psoriatic Arthritis With and Without Prior Exposure to Anti-TNF Agents
The purpose of this study is to evaluate the efficacy (improvement of signs and symptoms) and safety of ustekinumab in patients with psoriatic arthritis.
- Trial name
- NCT01077362
- Testing
- ustekinumab 45 mg, ustekinumab 90 mg
- Where
- 80 sites in United States, Austria and 8 more
- Volunteers
- 312 people
- Sponsor
- Janssen Research & Development, LLC
Wrist Arthritis, Psoriatic Arthritis
Arthroscopic Synovectomy of the Wrist in Inflammatory Arthritis
Rationale: Psoriatic (PsA) and rheumatoid arthritis (RA) are inflammatory joint diseases that often involve the wrist and may result in progressive joint destruction followed by impaired wrist function and reduced quality of…
- Conditions
- Wrist Arthritis, Psoriatic Arthritis, Rheumatoid Arthritis, Surgery
- Trial name
- ARCTIC (NCT04755127)
- Testing
- Arthroscopic synovectomy of the wrist, Intra-articular corticosteroid injection
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Maasstad Hospital
Seborrheic Dermatitis
Topical Terbinafine Versus Hydrocortisone Combined With Oral Itraconazole for Seborrheic Dermatitis
The goal of this clinical trial is to compare two creams used together with oral itraconazole in adults with moderate-to-severe seborrheic dermatitis.
- Trial name
- NCT07906886
- Testing
- Itraconazole, Terbinafine 1% cream, Hydrocortisone 1% cream
- Where
- 2 sites in Vietnam
- Volunteers
- 76 people
- Sponsor
- Can Tho University of Medicine and Pharmacy
Psoriasis
A Priming Intervention to Increase Patient Willingness to Use Injectables for the Management of Psoriasis
Biologic medications have revolutionized the treatment of inflammatory diseases such as moderate-to-severe psoriasis. Though very effective with an excellent safety profile, patients may be apprehensive about choosing a biologic…
- Trial name
- NCT03465696
- Testing
- Group #2 (Intervention), Group #3 (Intervention)
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Wake Forest University Health Sciences
Psoriasis Vulgaris
Therapeutic Drug Monitoring of Brodalumab in Psoriasis Patients (BIOLOPTIM-BRO)
Biologics, such as brodalumab, are currently the most effective treatment option for patients with moderate-to-severe psoriasis.
- Trial name
- BIOLOPTIM-BRO (NCT04080635)
- Testing
- Venapuncture, Patient questionnaires
- Where
- 7 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Ghent
Psoriatic Arthritis
A Clinical Trial of TQH3906 Capsules in the Treatment of Active Psoriatic Arthritis
This study is a marketing-oriented clinical trial of TQH3906 Capsules. A total of 156 participants are planned to be enrolled, aiming to evaluate the dose-effect relationship of TQH3906 versus placebo in the treatment of active…
- Trial name
- NCT07406035
- Testing
- TQH3906 Capsule, Tofacitinib Citrate Tablet 5 mg
- Where
- 44 sites in China
- Volunteers
- 156 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.
Crohn Disease, Ulcerative Colitis
National Observational Study On The Use Of Inflectra™ An Infliximab Biosimilar In Real Life
National, prospective, multicentre observational study designed for eligible patients treated with Inflectra. Its objectives are to describe under real conditions of use, the profile of patients treated with Inflectra and the…
- Conditions
- Crohn Disease, Ulcerative Colitis, Rheumatoid Arthritis, Ankylosing Spondylitis
- Trial name
- ReFLECT (NCT02925338)
- Testing
- QOL questionaire
- Where
- 67 sites in France
- Volunteers
- 1,431 people
- Sponsor
- Pfizer
Psoriasis
1404003_OpenPsori.PlaqueTest to Eval.Eff.of Diff.Comp. to Mapracorat
Evaluation of efficacy and safety of Mapracorat 0.1% ointment and 4 comparator ointments in male and female subjects 18 to 65 years with stable plaque-type psoriasis treated once daily 6 days a week for a maximum of 4 weeks.
- Trial name
- NCT03399526
- Testing
- Mapracorat (ZK 245186, BAY 86-5319), Prednicarbate 0.25% ointment, Clobetasol 0.05% ointment
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Bayer
Psoriasis (PsO)
Global Healthcare Study on Psoriasis
The Global Healthcare Study on Psoriasis (GHSP) is an international, multicenter observational study hosted by the University of Zurich (UZH) investigating healthcare access, treatment patterns, disease severity, and quality of…
- Trial name
- GHSP (NCT07634016)
- Where
- Switzerland
- Volunteers
- 9,600 people
- Sponsor
- Julia Tatjana Maul
Psoriatic Arthritis
A Long-Term Efficacy and Safety Study of Ixekizumab (LY2439821) in Participants With Active Psoriatic Arthritis
The main purpose of this study is to evaluate the safety and long-term efficacy of ixekizumab compared to placebo in participants with active psoriatic arthritis.
- Trial name
- SPIRIT P3 (NCT02584855)
- Testing
- Ixekizumab
- Where
- 106 sites in United States, Bulgaria and 10 more
- Volunteers
- 394 people
- Sponsor
- Eli Lilly and Company
Psoriatic Arthritis
Efficacy and Safety of Subcutaneous Abatacept in Adults With Active Psoriatic Arthritis
The purpose of this study is to compare subcutaneous Abatacept to placebo in the treatment of psoriatic arthritis
- Trial name
- ASTRAEA (NCT01860976)
- Testing
- Abatacept
- Where
- 82 sites in United States, Argentina and 15 more
- Volunteers
- 489 people
- Sponsor
- Bristol-Myers Squibb
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