Clinical trials: Skin Diseases, Papulosquamous
Psoriasis
A Study of BMS-582949 in Patients With Moderate to Severe Plaque Psoriasis
The purpose of this clinical research study is to learn if BMS-582949 alone is an effective treatment for moderate to severe psoriasis. The safety of the drug and the effectiveness of each dose will also be studied.
- Trial name
- NCT00399906
- Testing
- BMS-582949
- Where
- 21 sites in Australia, Canada and 1 more
- Volunteers
- 99 people
- Sponsor
- Bristol-Myers Squibb
Psoriasis, Neuroinflammation
Neuroinflammation, Affective and Cognitive Symptoms in Major Depression and Psoriasis
Objectives: To identify peripheral neuroinflammatory markers in patients suffering from major depression or psoriasis in relation to affective symptoms (anxiety, depression, irritability), fatigue and cognitive symptoms; and…
- Conditions
- Psoriasis, Neuroinflammation, Major Depressive Disorder, Cognitive Symptom
- Trial name
- INPSYDER (NCT04423471)
- Testing
- Sociodemographic variables
- Where
- Spain
- Sponsor
- Germans Trias i Pujol Hospital
Psoriasis
Addition of Modulators of Homocysteine to Adalimumab Therapy in the Treatment of Moderate to Severe Plaque Psoriasis
Vitamins modulating homocysteine affect both TNF-alpha, vascular endothelial growth factor, and theoretically enhance the anti-inflammatory version of NOS thus hopefully increasing the efficacy and reducing the chance of some…
- Trial name
- NCT01704599
- Testing
- Humira Then Humira plus 3 B vitamins
- Volunteers
- 8 people
- Sponsor
- Wayne State University
Psoriasis, Psoriasis Vulgaris
Biofeedback for Psoriasis
We are conducting a proof-of-concept trial to study the impact of HRV-biofeedback, a mind-body technique designed to improve stress resilience, on the quality of life, mood, and clinical skin severity of patients with psoriasis.
- Conditions
- Psoriasis, Psoriasis Vulgaris, Psychophysiological Disorder, Anxiety
- Trial name
- NCT05506644
- Testing
- HRV-Biofeedback/Mind-Body Therapy
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Bastyr University
Psoriasis
Impact of Secukinumab on Clinical and Patient Reported Outcomes in Patients With Psoriasis
The study was conducted to describe the demographics, disease characteristics, disease severity, comorbidities and patient reported outcomes at baseline and follow-up periods among adult patients diagnosed with PsO in CorEvitas'…
- Trial name
- NCT05513014
- Testing
- Secukinumab
- Where
- United States
- Volunteers
- 1,518 people
- Sponsor
- Novartis Pharmaceuticals
Psoriasis
Use of Transcutaneous Electrical Nerve Stimulation for Reducing Biologic Injection Site Pain(TENS Study)
The purpose of this research study is to determine the efficacy of TENS therapy in reducing the pain experienced by patients during and after the injection of biological medications.
- Trial name
- NCT04058652
- Testing
- transcutaneous electrical nerve stimulation (TENS) unit
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Wake Forest University Health Sciences
Atopic Dermatitis, Psoriasis
Skin Microbial Ecology in Atopic Dermatitis
Everybody's skin has bacteria that normally lives on it. Previous research has shown that people with eczema (or atopic dermatitis [AD]) have much higher concentrations of a certain bacteria (S.
- Conditions
- Atopic Dermatitis, Psoriasis, Healthy
- Trial name
- NCT04170244
- Testing
- AD subject visit sampling procedures, PS subject visit sampling procedures, Healthy control visit sampling procedures
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Psoriasis
An Efficacy and Safety Study of CNTO 1275 Compared to Etanercept in Patients With Plaque Psoriasis
The purpose of this study is to compare the efficacy and safety of CNTO 1275 to etanercept in patients with moderate to severe plaque psoriasis.
- Trial name
- NCT00454584
- Testing
- CNTO 1275 45 mg, CNTO 1275 90 mg, Etanercept 50 mg
- Volunteers
- 903 people
- Sponsor
- Centocor, Inc.
Vaginal Atrophy, Lichen Sclerosus
Fractional / Pixel CO2 Laser Treatment of Vulvar Atrophy and Lichen Sclerosus
The study will examine the effects of fractional/pixel CO2 laser treatment in vaginal atrophy and in vulvar lichen sclerosus by means of histological and immuno-histochemical characterization of the epithelial layers and markers…
- Trial name
- NCT03063684
- Testing
- Fractional / Pixel CO2 Laser
- Where
- Israel
- Volunteers
- 16 people
- Sponsor
- Hadassah Medical Organization
Arthritis, Psoriatic
Study Evaluating the Safety of Enbrel (Etanercept)
The purpose of this study is to collect post-marketing information on the safety of Enbrel in Filipino patients.
- Trial name
- NCT00683384
- Testing
- Etanercept (Enbrel)
- Where
- Philippines
- Volunteers
- 93 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Psoriatic Arthritis
Guselkumab vs Golimumab in PsA TNF Inadequate Responder Patients
The trial is an open-label randomized study that will examine whether switching to a selective IL23 inhibitor (guselkumab) is more effective than switching to a second TNFi (golimumab) among patients with PsA who have an…
- Trial name
- EVOLUTION (NCT05669833)
- Testing
- Guselkumab, Golimumab
- Where
- 14 sites in United States
- Volunteers
- 63 people
- Sponsor
- University of Pennsylvania
Psoriasis
A Study in Japanese Participants With Moderate-to-Severe Psoriasis
This study will assess the safety and efficacy of ixekizumab in participants with moderate to severe psoriasis in Japan.
- Trial name
- UNCOVER-J (NCT01624233)
- Testing
- 80 mg ixekizumab
- Where
- 17 sites in Japan
- Volunteers
- 91 people
- Sponsor
- Eli Lilly and Company
Palmoplantar Pustulosis
A Study to Evaluate RIST4721 in Palmoplantar Pustulosis (PPP)
A Randomized, Double-Blind, Placebo-Controlled, Phase 2a Study to Evaluate the Efficacy and Safety of RIST4721 in Subjects with Palmoplantar Pustulosis
- Trial name
- NCT03988335
- Testing
- RIST4721
- Where
- 17 sites in Canada, Germany
- Volunteers
- 35 people
- Sponsor
- Aristea Therapeutics, Inc.
Osteoarthritis, Psoriasis
Chondroitin Sulphate Efficay/Safety in Patients With Knee Osteoarthritis and Psoriasis
The purpouse of this study is to determine the efficacy and safety of chondroitin sulphate conventional treatment in patients with both knee osteoarthritis and plaque psoriasis.
- Conditions
- Osteoarthritis, Psoriasis, Joint Diseases, Muskuloskeletal Diseases
- Trial name
- NCT00669123
- Testing
- Chondroitin sulphate
- Where
- 2 sites in Spain
- Volunteers
- 126 people
- Sponsor
- Bioiberica
Psoriasis
Phase I Randomized, Open-label, Parallel-controlled, Pharmacokinetic and Safety Study of BR201 Injection Versus Cosentyx in Healthy Male Subjects
This is a randomized, open-label, controlled Phase I study of BR201 administered by subcutaneous injection. This study will characterize the pharmacokinetic, safety and immunogenicity of BR201 versus Cosentyx（Secukinumab ） in…
- Trial name
- NCT06126718
- Testing
- BR201, Cosentyx（Secukinumab ）
- Where
- China
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- BioRay Pharmaceutical Co., Ltd.
Psoriasis
Brodalumab Drug-Drug Interaction (DDI) and Intensive Pharmacodynamic (PK) Study in Psoriasis Subjects
This is a phase 1, multi-center, open-label, drug-drug interaction (DDI) and PK study in subjects with moderate to severe plaque psoriasis.
- Trial name
- NCT01937260
- Testing
- Brodalumab
- Where
- 10 sites in United States, Australia and 1 more
- Volunteers
- 31 people
- Sponsor
- Bausch Health Americas, Inc.
Oral Lichen Planus
Low Level Laser Therapy With Injectable Platelet Rich Fibrin in Management of Oral Lichen Planus
The Injectable PRF (i-PRF) is a variant of PRF, which is a liquid blood derivative rich in leukocytes and acts as a growth factor release, with its potential anti-inflammatory role, it may alleviate the symptoms of OLP.
- Trial name
- NCT07846891
- Testing
- Injectable Platelet Rich Fibrin, Low Level Laser Therapy, Triamcinolone acetonide (injection)
- Where
- 2 sites in Egypt
- Volunteers
- 39 people
- Sponsor
- Ain Shams University
Psoriatic Arthritis
Impact of Concomitant MTX on Efficacy, Safety and Adherence of Ustekinumab-treatment in Patients With Active PsA
Methotrexate (MTX) co-medication can improve the therapeutic effect of biological therapies (e.g. Tumor necrosis factor (TNF) -inhibitors) in rheumatoid arthritis (RA), but its role in Psoriatic Arthritis (PsA) remains unclear.
- Trial name
- MUST (NCT03148860)
- Testing
- Methotrexate, Ustekinumab
- Where
- Germany
- Volunteers
- 186 people
- Sponsor
- Dr. Frank Behrens
Psoriasis
A Study of PRCL-02 in Healthy Volunteers and Plaque Psoriasis
This study consists of three parts: single oral dose escalation in healthy volunteers (Part A), and multiple oral dose escalations in healthy volunteers (Part B) and in participants with chronic plaque psoriasis (Part C)
- Trial name
- NCT03062618
- Testing
- PRCL-02
- Where
- 6 sites in Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- PRCL Research Inc.
Psoriasis, Cardiovascular Diseases
Prevalence and Risk Factors asSOciated With CArdiac comorbiDIty in psoriAsis
In a prospective cohort study (n = 1.000), the investigators aim to investigate the correlation between cardiac biomarkers and advanced echocardiography and determine whether these are prognostic markers of heart disease in…
- Conditions
- Psoriasis, Cardiovascular Diseases, Cardiovascular Risk Factor, Cardiovascular Pathology
- Trial name
- PSOCADIA (NCT04950218)
- Where
- Denmark
- Volunteers
- 1,000 people
- Sponsor
- Herlev and Gentofte Hospital
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