Clinical trials: Skin Diseases, Viral
Melanoma, Head and Neck Squamous Cell Carcinoma
Oncolytic Adenovirus TILT-123 and Avelumab for Treatment of Solid Tumors Refractory to or Progressing After Anti-PD(L)1
This is a phase 1, dose-escalation trial evaluating the safety of oncolytic adenovirus TILT-123 in combination with avelumab in patients with advanced solid tumors refractory to or progressing after anti-PD(L)1.
- Trial name
- AVENTIL (NCT05222932)
- Testing
- TILT-123, Avelumab
- Where
- 2 sites in United States, Finland
- Volunteers
- 15 people
- Sponsor
- TILT Biotherapeutics Ltd.
Endocrine/Neuroendocrine, Non-Small Cell Lung Cancer
Non-Viral TCR Gene Therapy
Background: A person s white blood cells can be modified in a lab to recognize certain changes in their tumor. Many of these cells are collected from the person, modified, then given back to the person.
- Conditions
- Endocrine/Neuroendocrine, Non-Small Cell Lung Cancer, Breast Cancer, Gastrointestinal/Genitourinary Cancers
- Trial name
- NCT04102436
- Testing
- Fludarabine, Cyclophosphamide, Aldesleukin
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Epstein-Barr Virus Infection, Infectious Mononucleosis
Trial Evaluating the Immunogenicity and Safety of an Adjuvanted Epstein-Barr Virus (EBV) Glycoprotein 350 Vaccine in EBV-seronegative Persons
Background: Epstein-Barr virus (EBV) causes most cases of infectious mononucleosis (mono). Mono can cause fatigue that lasts more than 6 months, and some people can have severe complications.
- Conditions
- Epstein-Barr Virus Infection, Infectious Mononucleosis, Herpesvirus
- Trial name
- NCT05683834
- Testing
- Matrix-M1 Adjuvant, EBV gp350-Ferritin Vaccine
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Warts, Verruca (Warts)
Intralesional Gardasil-9 for the Treatment of Recalcitrant Warts
This study will evaluate whether Gardasil-9, a vaccine normally used to prevent human papillomavirus (HPV) infection, may be effective for treating recurring warts that have not responded to standard treatments.
- Conditions
- Warts, Verruca (Warts), Verruca Vulgaris
- Trial name
- NCT07806617
- Testing
- 9-valent human papillomavirus vaccine, Sterile Saline
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Rush University Medical Center
Covid19, Muscle Atrophy
Electrical Stimulation for Critically Ill Covid-19 Patients
Unfortunately, hospital-acquired weakness is highly prevalent among COVID-19 hospitalized patients, who often require prolonged bed-rest or paralytics for an extended period of time in order to maintain oxygenation.
- Conditions
- Covid19, Muscle Atrophy, Muscle Weakness
- Trial name
- Phase I (NCT04685213)
- Testing
- Electrical Stimulation
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Baylor College of Medicine
Sarcoma, Kaposi, HIV Infections
A Phase I/II Study of Intralesional Recombinant Tumor Necrosis Factor in Patients With AIDS-Related Cutaneous Kaposi's Sarcoma
To evaluate tolerance, toxicity, and preliminary evidence of antitumor efficacy of intralesionally administered tumor necrosis factor (TNF) and to define a maximum tolerated dose (MTD) for single intralesional injections.
- Trial name
- NCT00002262
- Testing
- Tumor Necrosis Factor
- Where
- United States
- Sponsor
- University of California, San Francisco
Herpes Simplex
Antiviral Prophylaxis in a Burn Population
A prospective, randomized trial to calculate incidence of Herpes Simplex Virus in an in-patient burn population and determine efficacy of prophylactic antiviral therapy to prevent viral infection and/or reactivation.
- Trial name
- NCT02349828
- Testing
- Acyclovir
- Where
- United States
- Sponsor
- Southern Illinois University
Yellow Fever
A Pilot Study to Finetune Skin Processing Procedures in Recent Vaccinees, Prior to GeKoSkimm Study Initiation (GeKoSkimm-pilot)
This pilot study aims to optimize the sample processing techniques for collecting and analyzing skin biopsies obtained from individuals routinely vaccinated against yellow fever.
- Trial name
- NCT06539351
- Testing
- Skin biopsy
- Where
- Belgium
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Actinic Keratosis
Topical Ionic Contra-Viral Therapy in Actinic Keratosis
To explore the pharmacodynamics and evaluate safety, tolerability and clinical efficacy of ICVT comprised of digoxin and furosemide (dual agent), digoxin (single agent), furosemide (single agent) in patients with AK.
- Trial name
- NCT03684772
- Testing
- ICVT Topical Gel, Furosemide Topical Gel, Digoxin Topical Gel
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- Maruho Co., Ltd.
Condyloma, Genital Warts
Effectiveness Study of Gardasil on Condyloma
Overview and rationale: Through Swedish health care registers it is possible vaccine effectiveness. The overall aim is to develop tools for fast and reliable evaluation of vaccines focusing on effectiveness.
- Trial name
- NCT01553994
- Where
- Sweden
- Volunteers
- 500,000 people, healthy volunteers welcome
- Sponsor
- Lisen Arnheim Dahlstrom
Anogenital Warts, HIV Infection
Effectivity of Protein Purified Derivative Treatment for Anogenital Warts in HIV Patient
Warts are a common viral infection of the skin and are prevalent throughout the world, with an overall prevalence in the United States estimated at 2-20%.
- Conditions
- Anogenital Warts, HIV Infection, Tuberculin Purified Protein Derivative
- Trial name
- NCT06587542
- Testing
- Injection of protein purified derivative
- Volunteers
- 30 people
- Sponsor
- Universitas Padjadjaran
COVID-19, SARS-CoV2
Anti-Androgen Treatment for COVID-19
This study is intended to explore the possible protective role of anti-androgens in SARS-CoV-2 infection
- Conditions
- COVID-19, SARS-CoV2, Androgenetic Alopecia, Prostate Cancer
- Trial name
- NCT04446429
- Testing
- Proxalutamide, Standard of Care
- Where
- Brazil
- Volunteers
- 268 people
- Sponsor
- Applied Biology, Inc.
Oral Lichen Planus, Recurrent Aphthous Stomatitis
Improving Prescribing Quality for Oral Mucosal Disorders Using a Pharmacist-Led Model
This study aims to improve how oral mucosal disorders-such as oral lichen planus, recurrent aphthous stomatitis, burning mouth syndrome, herpes viral infection and oral candidiasis-are treated in dental settings.
- Conditions
- Oral Lichen Planus, Recurrent Aphthous Stomatitis, Burning Mouth Syndrome, Oral Candidiasis
- Trial name
- NCT07721090
- Testing
- Pharmacist-Led Prescribing Optimization and Patient Counselling
- Volunteers
- 336 people
- Sponsor
- University of Fujairah
Advanced Solid Tumors, Lymphoma
FT500 as Monotherapy and in Combination With Immune Checkpoint Inhibitors in Subjects With Advanced Solid Tumors
FT500 is an off-the-shelf, iPSC-derived NK cell product that can bridge innate and adaptive immunity, and has the potential to overcome multiple mechanisms of immune checkpoint inhibitor (ICI) resistance.
- Conditions
- Advanced Solid Tumors, Lymphoma, Gastric Cancer, Colorectal Cancer
- Trial name
- NCT03841110
- Testing
- FT500, Nivolumab, Pembrolizumab
- Where
- 4 sites in United States
- Volunteers
- 37 people
- Sponsor
- Fate Therapeutics
Sepsis, Bacteraemia
Optimising Diagnosis and Antibiotic Prescribing for Acutely Ill Children in Primary Care
Acute illness is the most common presentation of children attending ambulatory care settings. Serious infections (e.g. meningitis, sepsis, pyelonephritis, pneumonia) are rare, but their impact is quite large (increased morbidity…
- Conditions
- Sepsis, Bacteraemia, Meningitis, Abscess
- Trial name
- ERNIE2 (NCT02024282)
- Testing
- Use of C-reactive protein (CRP) point of care test, Brief intervention and parent leaflet, Finger Pulse Oximeter
- Where
- 2 sites in Belgium
- Volunteers
- 8,962 people
- Sponsor
- KU Leuven
Breast Cancer, Chronic Myeloproliferative Disorders
Motexafin Gadolinium and Doxorubicin in Treating Patients With Advanced Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Motexafin gadolinium may increase the effectiveness of doxorubicin by making tumor cells more sensitive to…
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Colorectal Cancer, Head and Neck Cancer
- Trial name
- NCT00036790
- Testing
- doxorubicin hydrochloride, motexafin gadolinium
- Where
- 2 sites in United States
- Sponsor
- University of Wisconsin, Madison
Solid Tumor, Lymphoma
Safety and Efficacy of p53 Gene Therapy Combined With Immune Checkpoint Inhibitors in Solid Tumors.
This is a single arm Phase 2 study of the combination of adenoviral p53 (Ad-p53) gene therapy administered intra-tumorally with approved immune checkpoint inhibitors in patients with recurrent or metastatic cancers.
- Trial name
- NCT03544723
- Testing
- Ad-p53
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- MultiVir, Inc.
Skin Cancer, Infection Reactivation
Viral Reactivation and Skin Cancer
Several studies show that the incidence of skin cancer parallels the length and depth of immunosuppression. This study will analyze the correlation of viral reactivation and skin cancer in organ transplant recipients.
- Trial name
- NCT02395562
- Where
- Switzerland
- Volunteers
- 1,200 people
- Sponsor
- University of Zurich
Verruca Vulgaris, Molluscum Contagiosum
Cold Atmospheric Plasma Device Extension Study
Patients between 4-21 years of age with at least one wart or molluscum lesion are eligible to participate in this study. The duration of the study is a minimum of 4 weeks with the maximum duration of monthly treatments for one…
- Trial name
- NCT05937672
- Testing
- Floating electrode-dielectric barrier device (FE-DBD) cold atmospheric plasma (CAP)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Medical University of South Carolina
Lymphoma
Early Detection of Graft-Versus-Host Disease in Patients Undergoing a Donor Bone Marrow Transplant
RATIONALE: Studying samples of blood in the laboratory from patients who have undergone a donor bone marrow transplant may help doctors learn more about changes that occur in DNA and identify biomarkers related to…
- Trial name
- NCT00898612
- Where
- United States
- Sponsor
- Mayo Clinic
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