Clinical trials: Skin Infection
Herpes Simplex, HIV Infections
A Phase I/II Study of the Safety and Efficacy of Topical 1-(S)-(3-Hydroxy-2-Phosphonylmethoxypropyl)Cytosine Dihydrate (Cidofovir; HPMPC) in the Treatment of Refractory Mucocutaneous Herpes Simplex Disease in Patients With AIDS
To evaluate the safety and tolerance of topical cidofovir (HPMPC) therapy for refractory mucocutaneous herpes simplex virus disease in AIDS patients.
- Trial name
- NCT00002116
- Testing
- Cidofovir
- Where
- 9 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Gilead Sciences
Malignant Melanoma, Neoplasm Metastasis
Safety and Efficacy Study of INGN 241 Gene Therapy in Patients With In Transit Melanoma
This is a research study to look at the ways in which a treatment called INGN241 can kill melanoma cells or help the patient's immune system kill melanoma cells.
- Trial name
- NCT00116363
- Testing
- investigational drug INGN 241
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Introgen Therapeutics
Herpes Simplex
Safety Study of Herpes Simplex Vaccine in HSV Seronegative and Seropositive Females Between 10 and 17 Years Old
Main goal of this study is to compare the occurrence of serious adverse events (SAEs) between the herpes simplex (gD2-AS04) vaccine group and the Saline control group throughout the study period (up to month 12).
- Trial name
- NCT00224484
- Testing
- GSK208141, Havrix (investigational formulation)
- Where
- 151 sites in United States, Australia and 16 more
- Volunteers
- 5,960 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pseudofolliculitis Barbae, Unwanted Hair
Clinical Evaluation to Assess the Safety and Efficacy of GentleMax Pro Plus
Demonstrate the safety and efficacy of the GentleMax Pro Plus™ laser system for its intended uses: hair removal including pseudofolliculitis barbae (PFB), clearance of pigmented and/or vascular lesions, temporary increase of…
- Conditions
- Pseudofolliculitis Barbae, Unwanted Hair, Pigmented Lesions, Vascular Lesion
- Trial name
- NCT04993066
- Testing
- GentleMax Pro Plus
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Candela Corporation
Onychomycosis
Study of Erchonia Low Level Laser Light Therapy to Treat Toenail Fungus
The purpose of this study is to determine whether low level laser light therapy is effective in the treatment of toenail onychomycosis.
- Trial name
- NCT02242019
- Testing
- Erchonia LUNULA
- Where
- Ireland
- Volunteers
- 109 people
- Sponsor
- Erchonia Corporation
HIV-Associated Lipodystrophy Syndrome
Study of Reyataz in HIV-infected Patients With Lipodystrophy Syndrome
The purpose of this clinical research study is to learn if human immunodeficiency virus (HIV)-infected subjects with abdominal fat accumulation on their highly active antiretroviral treatment (HAART) regimen have better changes…
- Trial name
- NCT00135356
- Testing
- Atazanavir (ATV) + ritonavir (RTV), continuation of backbone 2 nucleoside reverse transcriptase inhibitor (NRTIs), continuation of current HAART (boosted protease inhibitor [PI] combination + 2 NRTIs)
- Where
- 30 sites in United States, Canada and 7 more
- Volunteers
- 219 people
- Sponsor
- Bristol-Myers Squibb
Cervical Cancer, Gastric Cancer
A Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignancies
The purpose of this study is to determine the safety, tolerability, and preliminary efficacy of INCAGN02390 in participants with select advanced malignancies.
- Conditions
- Cervical Cancer, Gastric Cancer, Stomach Cancer, Gastroesophageal Junction Cancer
- Trial name
- NCT03652077
- Testing
- INCAGN02390
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Incyte Corporation
Multiple Myeloma
A Safety and Efficacy of Pomalyst® Capsules Under the Actual Use in All Patients Who Are Treated With Pomalyst at a Dose of 1 mg, 2 mg, 3 mg, or 4 mg
1. Planned enrollment period One year (The planned number of patients to be enrolled is set to 400 patients.) Since all patients who are prescribed with Pomalyst are registered in RevMate®, enrollment using the Registration Form…
- Trial name
- NCT02921828
- Where
- 2 sites in United States, Japan
- Volunteers
- 1,149 people
- Sponsor
- Celgene
Rheumatoid Arthritis
Study of Enbrel in Rheumatoid Arthritis (RA) Subjects With Comorbid Disorders
The objective of this study was to evaluate the safety of Enbrel (etanercept) in rheumatoid arthritis (RA) subjects with greater than or equal to 1 documented comorbid disease (diabetes mellitus; chronic pulmonary disease…
- Trial name
- NCT00132418
- Testing
- Enbrel
- Volunteers
- 564 people
- Sponsor
- Amgen
Skin Diseases, Bacterial
Avelox in Complicated Skin and Skin Structure Infections
This international, prospective, non-interventional, non-controlled observational study obtains data on efficacy, safety and tolerability of Avelox treatment under daily-life treatment conditions.
- Trial name
- ARTOS (NCT00997997)
- Testing
- Moxifloxacin (Avelox, BAY12-8039)
- Where
- 12 sites in Austria, Bulgaria and 10 more
- Volunteers
- 6,127 people
- Sponsor
- Bayer
Mycoses, Candidiasis
A Pharmacokinetic Study of JK1211(Itraconazole [Itrizole]) Oral Solution in Participants With Deep Mycosis and Those With Febrile Neutropenia Suspected of Fungal Infection
The purpose of this study is to assess the pharmacokinetics (how the drug is absorbed in the body, distributed within the body, and how it is removed from the body over time) of itraconazole (ITCZ) oral solution in participants…
- Conditions
- Mycoses, Candidiasis, Aspergillosis, Cryptococcosis
- Trial name
- NCT00784368
- Testing
- ITCZ Oral Solution, ITCZ-IV
- Where
- Japan
- Volunteers
- 55 people
- Sponsor
- Janssen Pharmaceutical K.K.
Non-infectious Uveitis
Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis
This extension study will assess the safety and efficacy of AIN457 versus placebo for maintaining uveitis suppression when reducing systemic immunosuppression
- Trial name
- ENDURE (NCT01090310)
- Testing
- AIN457
- Where
- 35 sites in United States, Brazil and 6 more
- Volunteers
- 86 people
- Sponsor
- Novartis Pharmaceuticals
Advanced Solid Tumors, Genital Neoplasm, Female
A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors
This is an open label, multicenter, phase 1/2 study to assess the safety/tolerability and preliminary clinical activity of STAR0602 as a single agent and in combination with chemotherapy administered intravenously in participants…
- Conditions
- Advanced Solid Tumors, Genital Neoplasm, Female, Urogenital Neoplasms, Lung Neoplasm
- Trial name
- START-001 (NCT05592626)
- Testing
- STAR0602, Irinotecan (Camptosar), Docetaxel (Taxotere)
- Where
- 19 sites in United States, Canada and 2 more
- Volunteers
- 366 people
- Sponsor
- Marengo Therapeutics, Inc.
Onychomycosis
Safety & Efficacy of NAB001 in the Treatment of Mild to Moderate Onychomycosis of the Toenails
The objectives of this study are to assess the safety of NAB001 for topical treatment of mild to moderate distal onychomycosis of the toenails over 52 weeks and to compare the efficacy of NAB001 to vehicle alone at the end of the…
- Trial name
- NCT01208168
- Testing
- NAB001, Vehicle alone
- Where
- 24 sites in United States, Dominican Republic
- Volunteers
- 468 people
- Sponsor
- Promius Pharma, LLC
Tinea Cruris, Tinea Pedis
Safety, Tolerability, and Pharmacokinetics of UHE-103 Cream in Subjects With Tinea Cruris and/or Tinea Pedis
This Phase 1 study has been designed to determine the safety, tolerability and pharmacokinetics (PK) of UHE 103 Cream compared to Naftin Cream, 2% under maximal use conditions for 2 weeks treatment in subjects with tinea cruris…
- Trial name
- NCT05363449
- Testing
- UHE-103 Cream, Naftin (naftifine hydrochloride) Cream
- Where
- 5 sites in United States
- Volunteers
- 42 people
- Sponsor
- Therapeutics, Inc.
Immune Thrombocytopenic Purpura ( ITP ), HIV Infections
A Phase I Study of Recombinant Human CD4 Immunoglobulin G (rCD4-lgG) in Patients With HIV-Associated Immune Thrombocytopenic Purpura
To test the effectiveness of recombinant human CD4 Immunoglobulin G (CD4-IgG) in the treatment of HIV-associated immune thrombocytopenic purpura in patients with all levels of HIV infection.
- Trial name
- NCT00002250
- Testing
- CD4-IgG
- Where
- United States
- Sponsor
- Genentech, Inc.
Onychomycosis
Evaluation of the Efficacy of CURE-EX Treatment in Onychomycosis
Open label study to evaluate the efficacy of CURE-EX device in the treatment of onychomycosis.
- Trial name
- NCT02436291
- Testing
- CURE-EX device
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- MB Mazor Ltd.
Pediculosis
An Efficacy and Safety Study of Ha44 Gel Administered Topically for the Treatment of Head Lice Infestation
Phase 2 study to assess the safety and effectiveness of a product to treat children and adults with head lice
- Trial name
- NCT01336647
- Testing
- Group A - Low-Dose Ha44 0.37% w/w, Group B - High Dose Ha44 Gel 0.74% w/w
- Where
- 2 sites in United States
- Volunteers
- 142 people
- Sponsor
- Dr. Reddy's Laboratories Limited
Genital Warts
Study of Imiquimod Cream Prior to Ablative Therapy in External Ano-Genital Warts
The purpose of this study is to compare the recurrence rate following total clearance of external genital warts (EGWs) when clearance has been obtained by imiquimod (3 applications per week for 4 weeks) followed by ablative…
- Trial name
- NCT00189293
- Testing
- Imiquimod, vehicle cream
- Where
- 12 sites in Italy
- Volunteers
- 128 people
- Sponsor
- MEDA Pharma GmbH & Co. KG
Molluscum Contagiosum
A Phase 3 Molluscum Contagiosum Efficacy and Safety Study
This is a phase 3 multi-center, randomized, double-blind, vehicle-controlled, parallel group study to be conducted in up to approximately 850 subjects 6 months of age and older with molluscum contagiosum (MC).
- Trial name
- B-SIMPLE4 (NCT04535531)
- Testing
- SB206 10.3% berdazimer, vehicle gel
- Where
- 55 sites in United States
- Volunteers
- 891 people
- Sponsor
- Novan, Inc.