Clinical trials: Skin Infections, Bacterial
Onychomycosis
Safety and Efficacy of NAB001 in the Treatment of Mild to Moderate Onychomycosis of the Toenails
The objectives of this study are to assess the safety of NAB001 for topical treatment of mild to moderate distal onychomycosis of the toenails over 52 weeks and to compare the efficacy of NAB001 to vehicle alone at the end of the…
- Trial name
- NCT01208129
- Testing
- NAB001
- Where
- 25 sites in United States
- Volunteers
- 458 people
- Sponsor
- Promius Pharma, LLC
Skin Disease, Infectious
Sivextro in Acute Bacterial Skin and Skin Structure Infection (ABSSSI) in Hospitalized Patients. A Global Observational Study
This open-label, prospective, multi-center, non-interventional, observational, parallel cohort study intended to provide real life data on the treatment duration, effectiveness and safety of tedizolid and linezolid when treating…
- Trial name
- DART (NCT02991131)
- Testing
- Tedizolid (Sivextro, BAY1192631), Linezolid
- Where
- 3 sites in Mexico, Russia and 1 more
- Volunteers
- 108 people
- Sponsor
- Bayer
Hidradenitis Suppurativa
A Study of LAD191 in Adults With Hidradenitis Suppurativa
The main purpose of this study is to assess the efficacy of multiple dosing regimens of LAD191 compared to placebo in participants with moderate-to-severe Hidradenitis Suppurativa (HS) and to access the safety, tolerability…
- Trial name
- NCT07151937
- Testing
- LAD191, Adalimumab
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Almirall, S.A.
Tinea
Efficacy Study to Evaluate the Effect of Nitric Oxide on the Treatment of Tinea Pedis (Athlete's Foot)
The purpose of this study is to determine the fungicidal efficacy of nitric oxide and it's effect on the clinical signs and symptoms associated with Tinea Pedis
- Trial name
- NCT00771342
- Testing
- Nitric Oxide, Nitrogen
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Nitric BioTherapeutics, Inc
Gram-Positive Bacterial Infections, Skin and Connective Tissue Diseases
Time To Efficacy and Onset Of Action Of Linezolid
To assess the onset of action of linezolid
- Trial name
- NCT00147511
- Testing
- linezolid
- Volunteers
- 118 people
- Sponsor
- Pfizer
Onychomycosis
TDT 067 Open Label Multi-Dose Onychomycosis Study
The aim of this study is to establish a clinical bridge to Lamisil® tablets by conducting a clinical pharmacokinetic (PK) study comparing the systemic exposure of a Lamisil® tablet with that of with TDT 067 under maximal use…
- Trial name
- NCT01790165
- Testing
- TDT067 and Lamisil
- Volunteers
- 27 people
- Sponsor
- Celtic Pharma Development Services
Fungal Infection, Onychomycosis
An Open-label Study Evaluating the Effectiveness of CGB-400 Topical Gel for Fungal Infection
The goal of the current study is to evaluate the ability of CGB-400, a proprietary eutectic mixture of GRAS compounds, to clear the toenail fungal growth and improve the appearance of the fungus affected area(s).
- Conditions
- Fungal Infection, Onychomycosis, Tinea Unguium
- Trial name
- NCT05202366
- Testing
- CGB-400 Topical Gel
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- CAGE Bio Inc.
Onychomycosis
Optimizing the Treatment of Toenail Onychomycosis Using a New Transdermal Patch Combined With Terbinafine/Ketoconazole
This study is to explore the optimization of anti-onychomycosis patch with various formulation contents (three patch groups: 3%, 6% and 8% of terbinafine (contains 3-mg, 6-mg and 8-mg/patch terbinafine, respectively) combined…
- Trial name
- NCT01615913
- Testing
- 3 mg terbinafine and 2 mg ketoconazole containing patch, 6 mg terbinafine and 2 mg ketoconazole containing patch, 8 mg terbinafine and 2 mg ketoconazole containing patch
- Where
- Taiwan
- Volunteers
- 18 people
- Sponsor
- Taiwan Biotech Co., Ltd.
Tinea Pedis
Three-Arm Trial of Novel Treatment for Tinea Pedis
This is a three-arm randomized controlled trial to assess the efficacy of an experimental treatment in the treatment of tinea pedis (athlete's foot).
- Trial name
- NCT03135912
- Testing
- Experimental Drug SESC 01, Terbinafine Hydrochloride
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- South End Skin Care
Tinea Pedis
Evaluate the Safety and Efficacy of Naftifine Hydrochloride Cream 2% and Naftin® Cream 2% in Patients With Tinea Pedis
The objective of this study is to compare the efficacy and safety of the test formulation of Naftifine Hydrochloride Cream 2% to Naftin® (Naftifine Hydrochloride) 2% Cream in a 6 week study in patients with tinea pedis.
- Trial name
- NCT02132260
- Testing
- Naftifine Hydrochloride Cream 2%, Naftin® (Naftifine Hydrochloride) Cream 2%
- Volunteers
- 890 people
- Sponsor
- Sun Pharmaceutical Industries, Inc.
Tinea Pedis
A Dose Response Trial to Evaluate Clinical and Mycological Effect of Nitric Oxide in Subjects With Tinea Pedis
A multi-arm trial to evaluate the efficacy and safety of using gaseous nitric oxide to treat moderate to severe tinea pedis.
- Trial name
- NCT00893880
- Testing
- 1% gaseous Nitric Oxide blended in Oxygen
- Where
- 4 sites in Canada, Saint Kitts and Nevis
- Volunteers
- 92 people
- Sponsor
- Nitric BioTherapeutics, Inc
Onychomycosis
Evaluation of the Efficacy of CURE-EX Treatment in Onychomycosis
Open label study to evaluate the efficacy of CURE-EX device in the treatment of onychomycosis.
- Trial name
- NCT02436291
- Testing
- CURE-EX device
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- MB Mazor Ltd.
Tinea Pedis
Study With Nåva Foot Cream in Patients With Tinea Pedis Interdigitalis
A prospective, open post-market clinical investigation that will enroll male and female subjects diagnosed with foot fungus and at least one of the following conditions: heal cracks, calluses and/or dry feet.
- Trial name
- NCT03676686
- Testing
- Nåva Foot Cream
- Where
- 3 sites in Sweden
- Volunteers
- 46 people
- Sponsor
- Natumin Pharma AB
Staphylococcal Skin Infections
Safety and Efficacy of Daptomycin for the Treatment of Complicated Skin and Skin-structure Infections
This study will evaluate the safety and efficacy of daptomycin against complicated skin and skin-structure infections in adults
- Trial name
- NCT00463801
- Testing
- Daptomycin
- Where
- 2 sites in Italy
- Volunteers
- 52 people
- Sponsor
- Novartis
Hidradenitis Suppurativa
Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Hidradenitis Suppurativa (TRuE-HS1)
The purpose of this study is to evaluate the efficacy and safety of ruxolitinib cream in participants with hidradenitis suppurativa.
- Trial name
- NCT06959225
- Testing
- Ruxolitinib Cream, Vehicle Cream
- Where
- 101 sites in United States, Bulgaria and 6 more
- Volunteers
- 580 people
- Sponsor
- Incyte Corporation
Acute Bacterial Skin and Skin Structure Infections
Comparative Study of Levonadifloxacin (IV and Oral) With Linezolid (IV and Oral) in Acute Bacterial Skin and Skin Structure Infections (ABSSSI)
This is a phase III, multi-center, randomized, active-comparator, study in subjects with ABSSSI. The study has two subgroups for assessment of efficacy and safety - oral subgroup 1 and IV subgroup 2.
- Trial name
- NCT03405064
- Testing
- Oral Levonadifloxacin/Linezolid Tablet, Intravenous Levonadifloxacin/Linezolid Infusion
- Where
- 32 sites in India
- Volunteers
- 501 people
- Sponsor
- Wockhardt
Abdominal Wound Dehiscence, Necrotizing Soft Tissue Infection
Myriad™ Augmented Soft Tissue Reconstruction Registry
This is an observational study designed to evaluate the safety and clinical outcomes of Myriad™ in soft tissue reconstruction procedures.
- Conditions
- Abdominal Wound Dehiscence, Necrotizing Soft Tissue Infection, Lower Extremity Wound, Pilonidal Sinus
- Trial name
- MASTRR (NCT05243966)
- Testing
- Myriad Matrix™ and Myriad Morcells™
- Where
- 15 sites in United States
- Volunteers
- 800 people
- Sponsor
- Aroa Biosurgery Limited
Acute Bacterial Skin and Skin Structure Infections
Comparative Study of NXL103 Versus Linezolid in Adults With Acute Bacterial Skin and Skin Structure Infections (ABSSSI)
The objective of this study is to evaluate the efficacy and safety of oral NXL103 vs. established treatment of acute bacterial infection in adults.
- Trial name
- NCT00949130
- Testing
- NXL103, Linezolid
- Where
- 15 sites in United States, Guatemala
- Volunteers
- 180 people
- Sponsor
- Novexel Inc
Acute Bacterial Skin and Skin Structure Infection
Retrospective Effectiveness Study of Dalbavancin and Other Standard of Care of the Same Class in Patients With ABSSSI
The aim of this study is to collect the data on the effectiveness of dalbavancin in terms of save of hospitalization days on patients treated between June 2017 and June 2019 in two countries (Italy and Greece) vs the other…
- Trial name
- REDS (NCT04298463)
- Testing
- Xydalba, vancomycin, teicoplanin or daptomycin
- Where
- 16 sites in Greece, Italy
- Volunteers
- 184 people
- Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
Onychomycosis
Clinical Evaluation of the Efficacy of a Medical Device in Treatment of Toenail Onychomycosis
This study evaluates the effect of the medical device "Excilor® Fungal Nail Infection" in the treatment of toenail onychomycosis.
- Trial name
- NCT03289871
- Testing
- Excilor, Loceryl 5%
- Where
- 2 sites in Tunisia
- Volunteers
- 112 people
- Sponsor
- Oystershell NV