Clinical trials: Skin Irritation
Osteoporosis, Postmenopausal
A Multiple-Dose Study to Evaluate Skin Irritation and Sensitization of Teriparatide Administered Transdermally in Healthy Postmenopausal Women
This study is a Phase 1, multi-center, 2-part, subject- and investigator-blind, randomized, placebo-controlled, multiple dose study of transdermal teriparatide (80-µg dose) in healthy postmenopausal women.
- Trial name
- NCT01250145
- Testing
- LY333334
- Where
- 5 sites in United States, Germany and 1 more
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Skin Care
A Photoxicity and Photoallergy Study of a Developmental Face Cream, Serum and Lotion
The purpose of this study is to demonstrate the absence of sensitisation and irritation potential of a product when applied to the skin and exposed to ultraviolet (UV) radiation.
- Trial name
- NCT04006795
- Testing
- Serum, Lotion, Cream
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Acne Vulgaris
A Study of Different Use Regimens Using Two Acne Treatments
A study to determine if using 2 acne products in the morning is as safe and efficacious as using one product in the morning and one product in the evening.
- Trial name
- NCT00907257
- Testing
- benzoyl peroxide wash, Tretinoin gel
- Where
- 12 sites in United States
- Volunteers
- 247 people
- Sponsor
- Bausch Health Americas, Inc.
Skin Care
To Investigate Primary Irritation Potential of Four Skin Serum Products on Human Subjects Assessed by 24 Hour Patch Test
To assess the irritation potential of four prototype daily defense serum formulations after 24 (± 2) hours under semi-occlusive patch application to the skin of healthy volunteers.
- Trial name
- NCT03233009
- Testing
- Experimental Daily Defense Serum A, Experimental Daily Defense Serum C, Experimental Daily Defense Serum G
- Where
- 2 sites in Brazil
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Peristomal Skin Complication
Preliminary Evaluation of CASTLE Barrier Prototype UK
The purpose of this study is to provide preliminary assessment of the safety and performance of a novel barrier formulation (CASTLE) in a small population of subjects with irritated peristomal skin.
- Trial name
- NCT01530087
- Testing
- CASTLE barrier
- Where
- United Kingdom
- Volunteers
- 3 people
- Sponsor
- Hollister Incorporated
Skin Care
To Assess the Cutaneous Irritation and Sensitization Potential of a Cosmetic Facial Product Using a Human Repeat Insult Patch Test (HRIPT) in Healthy Participants
The objective of this clinical study is to assess the irritation and sensitisation potential of a cosmetic test product after repeated semi-occlusive patch applications to healthy human participants by following a conventional…
- Trial name
- NCT03175562
- Testing
- Facial micellar cleanser, Saline Solution: Sodium Chloride (NaCl; 0.9%)
- Where
- Brazil
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Atopic Dermatitis (AD)
Tolerance Evaluation of a Nighttime Moisturizing Balm on Babies and Adults With Eczema
The purpose of this 14-day, two phase clinical study is to test the tolerance of a new over-the-counter moisturizing balm on subjects with eczema.
- Trial name
- NCT02357940
- Testing
- Experimental Product
- Where
- 2 sites in United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Healthy, Atopic Dermatitis
A Study of Crisaborole Ointment 2% in Adult Japanese Healthy Subjects and Adult Japanese Subjects With Mild To Moderate Atopic Dermatitis
This is a Phase 1 parallel-cohort study of crisaborole ointment 2% to evaluate the skin irritation potential in adult Japanese healthy subjects in Cohort 1, and to evaluate the safety, tolerability and PK in adult Japanese…
- Trial name
- NCT03260595
- Testing
- Crisaborole ointment 2%, Vehicle
- Where
- Japan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Pfizer
Irritation/Irritant
Study in Elderly Alzheimer's Patients to Assess Skin Tolerability, Irritation With 3, 7-Day Applications of DTP-System
This study is designed to assess skin tolerability, skin irritation, and adhesion of the 350 mg Donepezil Transdermal Patch (DTP-system), following 3, 7-day applications to 3 specific areas of the body (upper back, upper middle…
- Trial name
- DTP-System (NCT00916383)
- Testing
- 350 mg Donepezil Transdermal Patch
- Where
- 7 sites in United States
- Volunteers
- 49 people
- Sponsor
- Teikoku Pharma USA, Inc.
Acne Vulgaris
Compare the Tolerance of Clindamycin 1% /Benzoyl Peroxide (BPO) 5% Gel to Clindamycin 1.2%/ BPO 2.5% Topical Medications
This is a single-blind (blinded expert grader) study that will enroll 25-30 healthy volunteers without facial acne. On 1 side of the face, the subject will apply 1 of the 2 test products, clindamycin and benzoyl peroxide 5% or…
- Trial name
- NCT01015638
- Testing
- Clindamycin and BPO 5% gel, Clindamycin phosphate and benzoyl peroxide 2.5% gel.
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Stiefel, a GSK Company
Acne Vulgaris
A Study of a New Drug Treatment for Acne
A study to determine if three different doses of a new acne treatment are safe and better at reducing facial acne than a treatment without active ingredient.
- Trial name
- NCT01326780
- Testing
- 1.2% JNJ 10229570-AAA, 2.4% JNJ 10229570-AAA, 3.6% JNJ 10229570-AAA
- Where
- 18 sites in United States
- Volunteers
- 431 people
- Sponsor
- Bausch Health Americas, Inc.
Cumulative Irritation
14-Day Cumulative Irritation Patch Test in Subjects With Normal Skin
The objective of this study is to determine the ability of the study material to cause irritation to the skin of humans under controlled patch test conditions.
- Trial name
- NCT02309294
- Testing
- Novel lubricant Miami w/ fragrance, Novel lubricant Miami no fragrance, KY Liquid lubricant
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Church & Dwight Company, Inc.
Healthy
A 21 Day Irritation Study in Healthy Volunteers With Diacerein 1% Ointment
Single center, randomized, controlled, evaluator blinded, within-subject study to evaluate the irritation potential of diacerein1% ointment on normal skin of healthy volunteers, using a cumulative irritancy patch test (CIPT)…
- Trial name
- NCT03472534
- Testing
- diacerein 1% ointment
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Castle Creek Pharmaceuticals, LLC
Atrophic Vaginitis
A Comparison of Estradiol Vaginal Cream to Estrace® Cream in 350 Postmenopausal Females With Atrophic Vaginitis
The purpose of this study is to determine the therapeutic equivalence of Mylan's estradiol vaginal cream to Estrace® cream and superiority of both products to placebo.
- Trial name
- NCT02195986
- Testing
- Estradiol Vaginal Cream, 0.01%, Estrace® 0.01% cream
- Where
- 21 sites in United States
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- Mylan Pharmaceuticals Inc
Acne Vulgaris
Evaluation of Irritation by Two Facial Gels Applied to Opposite Sides of the Face
A study to compare the skin irritation potential of two marketed gels for acne treatment, each applied to half of the face of healthy volunteers.
- Trial name
- NCT00919191
- Testing
- Tretinoin gel, Adapalene and Benzoyl peroxide
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Bausch Health Americas, Inc.
Hypersensitivity
Study to Determine Skin Irritation Potential of an Antifungal Cream Containing Trolamine After Repeated Skin Application (Cumulative Irritation Patch Test)
In this study researchers want to study the potential skin reaction after repeated application of an antifungal cream containing trolamine.
- Trial name
- NCT04531813
- Testing
- Butenafine HCl 1% (BAY1896425), Positive Control-Sodium lauryl sulfate (SLS), Negative Control
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bayer
Skin Care
To Evaluate Skin Irritation and Skin Sensitisation of Developmental Cosmetic Facial Products
The aim of this study is to assess irritant or allergic response of 3 developmental cosmetic facial products following a conventional human repeated insult patch test methodology for 6 weeks.
- Trial name
- NCT04007159
- Testing
- Serum, Lotion, Cream
- Where
- Brazil
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Acne Vulgaris
Two-week Study to Compare the Tolerance and Irritation Potential of Two Combination Topical Gel Acne Medications
This is a single-blind (blinded expert grader), randomized, half-face study being conducted at one clinical site. On 1 side of the face, the subject will apply 1 of the 2 test products, antibiotic and benzoyl peroxide or benzoyl…
- Trial name
- NCT00926367
- Testing
- Clindamycin and benzoyl peroxide, benzoyl peroxide 2.5% and adapalene 0.1% gel
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Stiefel, a GSK Company
Healthy Skin
Adjunctive Usage of a Moisturizing Lotion (Cetaphil® Moisturizing Lotion) to Limit the Skin Irritation Linked to the Set-Up of a Treatment by Topical Retinoid (Differin® Gel 0,1%) in Healthy Subjects of Chinese Origins
This is a single-center study, randomized, Investigator/Evaluator-blinded bilateral (split-face) comparison. The objective: To assess the benefit of the concomitant use of a Moisturizing Lotion in reducing the skin irritation…
- Trial name
- NCT00971282
- Testing
- adapalen 0.1%, Cetaphil®
- Where
- Singapore
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Acne Vulgaris
Evaluation of Irritation That Could be Caused by Two Facial Gels Applied to Opposite Sides of the Face.
A study to compare the skin irritation potential of two marketed gels for acne treatment, each applied to half of the face of healthy volunteers.
- Trial name
- NCT00714714
- Testing
- Adapalene Gel, Tretinoin Gel
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bausch Health Americas, Inc.