Clinical trials: Skin Irritation
Skin Care
To Evaluate Skin Irritation and Skin Sensitisation of Developmental Cosmetic Facial Products
The aim of this study is to assess irritant or allergic response of 3 developmental cosmetic facial products following a conventional human repeated insult patch test methodology for 6 weeks.
- Trial name
- NCT04007159
- Testing
- Serum, Lotion, Cream
- Where
- Brazil
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Acne Vulgaris
Two-week Study to Compare the Tolerance and Irritation Potential of Two Combination Topical Gel Acne Medications
This is a single-blind (blinded expert grader), randomized, half-face study being conducted at one clinical site. On 1 side of the face, the subject will apply 1 of the 2 test products, antibiotic and benzoyl peroxide or benzoyl…
- Trial name
- NCT00926367
- Testing
- Clindamycin and benzoyl peroxide, benzoyl peroxide 2.5% and adapalene 0.1% gel
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Stiefel, a GSK Company
Healthy Skin
Adjunctive Usage of a Moisturizing Lotion (Cetaphil® Moisturizing Lotion) to Limit the Skin Irritation Linked to the Set-Up of a Treatment by Topical Retinoid (Differin® Gel 0,1%) in Healthy Subjects of Chinese Origins
This is a single-center study, randomized, Investigator/Evaluator-blinded bilateral (split-face) comparison. The objective: To assess the benefit of the concomitant use of a Moisturizing Lotion in reducing the skin irritation…
- Trial name
- NCT00971282
- Testing
- adapalen 0.1%, Cetaphil®
- Where
- Singapore
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Acne Vulgaris
Evaluation of Irritation That Could be Caused by Two Facial Gels Applied to Opposite Sides of the Face.
A study to compare the skin irritation potential of two marketed gels for acne treatment, each applied to half of the face of healthy volunteers.
- Trial name
- NCT00714714
- Testing
- Adapalene Gel, Tretinoin Gel
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bausch Health Americas, Inc.
Acne Vulgaris
Evaluation of Irritation That Potentially Could be Caused by Two Facial Gels Applied to Opposite Sides of the Face
A study to compare the skin irritation potential of two marketed gels for acne treatment, each applied to half of the face of healthy volunteers.
- Trial name
- NCT00952523
- Testing
- Tretinoin Facial Gel, Adapalene/Benzoyl Peroxide Facial Gel
- Where
- United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Bausch Health Americas, Inc.
Irritation/Irritant
21 Day Cumulative Skin Irritation of RUT058-60
The purpose of this study is to determine the skin irritation potential of RUT058-60 after repetitive patch application to abraded and non-abraded skin of human subjects.
- Trial name
- NCT02198963
- Testing
- Hypochlorous acid solution 106 mg/L, 0.1% (w/v) Sodium Lauryl Sulfate, 0.9% Physiological Saline, USP
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Pulmatrix Inc.
Vulvar and Vaginal Atrophy
Study to Evaluate the Equivalence of Estradiol Vaginal Cream to Reference Standard in the Treatment of Vaginal Atrophy
The objectives of this study are to evaluate the therapeutic equivalence of the Test formulation, Estradiol Vaginal Cream 0.01% (Prasco, LLC) to the marketed product, Estrace® Cream (estradiol vaginal cream, 0.01%) in patients…
- Trial name
- NCT03332303
- Testing
- Estrace® Cream, Estradiol Vaginal Cream, Vehicle Cream
- Where
- 27 sites in United States
- Volunteers
- 540 people
- Sponsor
- Prasco LLC
Acne Vulgaris
Study to Determine and Compare the Tolerance and Irritation Potential of Topical Acne Medications
This is a randomized, half-face study. On 1 side of the face, the subject will apply 1 of the 2 test products, clindamycin and benzoyl peroxide or dapsone gel and the contra lateral side of the face will remain non-treated to…
- Trial name
- NCT00964366
- Testing
- clindamycin and benzoyl peroxide, Dapsone gel
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Stiefel, a GSK Company
Acne Vulgaris
A Study That Evaluates the Decrease in Irritation When Using Additional Acne Treatment Products
This study is to see if there's any difference in the amount of facial irritation when two acne products are used together on one side of the face, compared to one acne treatment product used alone on the other side of the face.
- Trial name
- NCT01313728
- Testing
- Dapsone plus Tretinoin Gel, Tretinoin Gel
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Bausch Health Americas, Inc.
Hypersensitivity
Study to Determine Skin Irritation and/or Sensitization Potential of an Antifungal Cream Containing Trolamine (Repeated Insult Patch Test)
In this study researcher want to learn more about possible skin reactions such after repeated application of an antifungal cream containing Trolamine. They are especially interested in skin irritations or allergic skin reactions.
- Trial name
- NCT04531540
- Testing
- Butenafine HCl 1% (BAY1896425)
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Bayer
Dermal Irritation
14-Day Cumulative Irritation Patch Test in Subjects With Normal Skin - Chameleon
to determine the ability of the test article to cause irritation to the skin of humans under controlled patch test conditions
- Trial name
- NCT02737618
- Testing
- Trojan "Chameleon" Personal Lubricant
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Church & Dwight Company, Inc.
Acne Vulgaris
A Study of Acne Treatment in Children Ages 9 to 11
A study to determine if using Retin-A Micro 0.04% as facial acne treatment in patients ages 9 to 11 is safe and efficacious.
- Trial name
- NCT00907335
- Testing
- Retin-A Micro 0.04% facial acne treatment, Vehicle control
- Where
- 12 sites in United States
- Volunteers
- 110 people
- Sponsor
- Bausch Health Americas, Inc.
Healthy
Study to Evaluate the Safety, Local and Systemic Tolerability, and Pharmacokinetics of Multiple-Dose Topical Administration of PF-07038124 in Japanese Healthy Participants
The purpose of this study is to evaluate the safety, tolerability, skin irritation potential, and PK of PF-07038124 in Japanese healthy adult participants.
- Trial name
- NCT04863417
- Testing
- PF-07038124 or vehicle
- Where
- Japan
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Erythema, Sensitisation
Irritation Potential of Omeza Collagen Matrix Using Modified HRIPT
The primary objective of this study was to assess the sensitization potential of Omeza Collagen Matrix compared to that of a negative control based on a Modified Human Repeat Insult Patch Test.
- Trial name
- NCT04510675
- Testing
- Test Article, Negative Control
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Omeza, LLC
Skin Irritation
Cetaphil® Daily Facial Moisturizer With Sunscreen SPF 50+ - Human Repeat Insult Patch Test
This study examined the possible sensitization and irritation effects of a moisturizer with sunscreen SPF 50+.
- Trial name
- NCT01892657
- Testing
- Facial Moisturizer with SPF 50+
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Skin Sensitisation
HRIPT for Collagen Dressing
The objectives of this study are to determine by repetitive epidermal contact, the primary or cumulative irritation and the allergic contact sensitization potential of the ColActive Plus Collagen Matrix Dressing, under maximized…
- Trial name
- NCT06283173
- Testing
- ColActive Plus Collagen Matrix Dressing
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Covalon Technologies Inc.