Clinical trials: Skin Physiology
Breast Cancer
Exercise Program in Cancer and Cognition
This randomized control trial will examine whether a well-controlled and monitored exercise intervention improves cognitive function in postmenopausal women with early-stage breast cancer and will explore whether neuroimaging…
- Trial name
- EPICC (NCT02793921)
- Testing
- Moderate-Intensity Aerobic Exercise Intervention
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- University of Pittsburgh
Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2 in Obese
From Skin Fibroblasts to Neural Stem Cells to Investigate in Vitro the Impact of Diabetes on Adult Neurogenesis
Obesity and glucose intolerance or overt diabetes are increasing at an alarming rate in the population, and are bound to become a public health issue and a major cause of disability, loss of independence and high social costs in…
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2 in Obese, Diabetes Mellitus Type 2 in Nonobese, Obesity
- Trial name
- NCT05755321
- Testing
- Skin biopsy
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Breast Cancer (Early Breast Cancer), Postoperative Shoulder Dysfunction
Prehabilitation in Breast Cancer Surgery
This prospective, randomized, assessor-blinded, parallel-group clinical trial evaluates the effectiveness of a home-based upper extremity-focused prehabilitation program in women undergoing breast cancer surgery.
- Conditions
- Breast Cancer (Early Breast Cancer), Postoperative Shoulder Dysfunction, Lymphedema Arm, Cancer Rehabilitation
- Trial name
- NCT07425379
- Testing
- Home-Based Prehabilitation Exercise Program, Usual Care
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Breast Neoplasms
EXercise Influence on Taxane Side Effects (EXIT) Study
This study is a randomized control cross over trial of exercise training during or after taxane-containing chemotherapy treatment for breast cancer.
- Trial name
- EXIT (NCT02473861)
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- University of British Columbia
Systemic Sclerosis, Vulvovaginal Signs and Symptoms
Effects of Fractional CO2 Laser Treatment on Vaginal Symptoms and Sexual Dysfunction in Women With Systemic Sclerosis
Women affected by Systemic Sclerosis and Vulvovaginal Atrophy will be submitted to a cycle composed of five vaginal CO2 laser treatment (SmartXide2 V2LR, Monalisa Touch, DEKA, Florence, Italy - Hi Scan V2LR con sonda vaginale a…
- Conditions
- Systemic Sclerosis, Vulvovaginal Signs and Symptoms, Sexual Function Disturbances
- Trial name
- SCLERDERMCO2 (NCT06231433)
- Testing
- CO2 Vaginal Laser
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- IRCCS San Raffaele
Jaundice
Effect of Methylene Blue on Perioperative Organ Function in Patients With Obstructive Jaundice
Increased production of vasodilating substances such as NO plays an important role in the development of vasoplegic syndrome caused by obstructive jaundice.Methylene blue plays a role in raising blood pressure by inhibiting the…
- Trial name
- NCT04109859
- Testing
- Saline, Methylene Blue
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Jiaolin Ning,MD
Kidney Disease, Proteinuria
Determination of Kidney Function
Much more about kidney disorders can be learned by determining kidney function. This research proposes to study the kidneys function by several parameters known as glomerular filtration rate (GFR), Renal Plasma Flow (RPF), and…
- Conditions
- Kidney Disease, Proteinuria, Autoimmune / Connective Tissue Diseases
- Trial name
- NCT00001978
- Where
- United States
- Volunteers
- 456 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Myositis, Juvenile
Exercise, Creatine and Coenzyme Q10 for Childhood Myositis
Children with Juvenile Idiopathic Inflammatory Myopathies (JIIM) are weak and get tired because their muscles aren't able to work like healthy muscles.
- Trial name
- NCT04286178
- Testing
- creatine monohydrate, ubiquinol, glucose tablet
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- The Hospital for Sick Children
Acute Kidney Injury
Pharmacokinetics of MB-102 and Use of the Non-invasive Optical Renal Function Monitor (ORFM) Device in Subjects With Normal and Impaired Renal Function and a Range of Skin Color Types
This study was a pilot, safety, and pharmacokinetic study of MB-102 versus iohexol and the use of the non-invasive optical renal function monitor (ORFM) device in normal and compromised renal function participants with different…
- Trial name
- NCT02772276
- Testing
- MB-102-- single dose of 4 µmol/kg, MB-102-- single dose of 130 mg, MB-102-single dose of 130 mg or 2 doses of 130 mg 12 hours apart
- Where
- 3 sites in United States
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- MediBeacon
Breast Cancer, Lymphoma
The Effects of Anthracycline-based Chemotherapy on Peripheral Vascular Function
The overall goal of this project is to determine the effects of anti-cancer chemotherapy on reflex control of blood pressure and vascular function.
- Conditions
- Breast Cancer, Lymphoma, Chemotherapy Effect
- Trial name
- NCT03062878
- Testing
- Arterial blood pressure, Vascular Ultrasound, Venous blood sample
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Carl Ade, M.S., Ph.D.
Rheumatoid Arthritis
Study to Evaluate the Pharmacokinetics of Filgotinib in Participants With Impaired Hepatic Function
The primary objective of this study is to evaluate the pharmacokinetics (PK) of filgotinib and its metabolite, GS-829845, in participants with varying degrees of impaired hepatic function relative to matched, healthy controls.
- Trial name
- NCT03417778
- Testing
- Filgotinib
- Where
- 4 sites in United States, Germany and 1 more
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
PSORIASIS
Etanercept and Vascular Function in Psoriasis
The investigators plan to measure the health of the vascular system of subjects taking Etanercept for the treatment of plaque psoriasis.
- Trial name
- EVIP (NCT01989689)
- Testing
- Etanercept
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Emory University
Microcirculation
Use of Laser Speckle to Study Post Occlusive Reactive Hyperhemia in Healthy Subjects
The investigators aim to test the hypothesis that Laser speckle contrast imaging allows for the measurement of cutaneous blood flow following various durations of tourniquet ischemia.
- Trial name
- SpeckleShake (NCT01169974)
- Testing
- tourniquet ischemia
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Breast Cancer, Cognitive/Functional Effects
Cognitive Function in Postmenopausal Women With Breast Cancer Receiving Hormone Therapy on Clinical Trial IBCSG-1-98
RATIONALE: Studying cognitive function, such as thinking, attention, concentration, and memory, in postmenopausal women receiving hormone therapy for breast cancer may help improve quality of life and the ability to plan…
- Conditions
- Breast Cancer, Cognitive/Functional Effects, Fatigue, Psychosocial Effects of Cancer and Its Treatment
- Trial name
- NCT00343616
- Testing
- cognitive assessment, fatigue assessment and management, psychologic distress
- Where
- 12 sites in Australia, Belgium and 4 more
- Volunteers
- 135 people
- Sponsor
- ETOP IBCSG Partners Foundation
Rheumatic Arthritis, Lung Function
Manual Diaphragmatic Release on Ventilatory Functions in Women With Rheumatoid Arthritis
Evaluate the effect of manual diaphragmatic release on ventilatory functions in women with rheumatoid arthritis
- Trial name
- NCT06716008
- Testing
- Aerobic training, Manual Diaphragm Release
- Volunteers
- 60 people
- Sponsor
- Middle East University
Atopic Eczema
Softened Water for Eczema Prevention Pilot Trial
An outcome assessor-blinded pilot randomised controlled trial of an ion-exchange water softener for the prevention of atopic eczema in neonates, with an embedded mechanistic study
- Trial name
- SOFTER (NCT03270566)
- Testing
- Domestic ion-exchange water softener
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- King's College London
Breast Cancer
A Prospective Study on Effect of Systemic Adjuvant Therapy on Cognitive and Brain Function of Breast Cancer Patients
The purpose of the study is to examine cognitive and brain function in stage I-III breast cancer patients who have undergone adjuvant systemic therapy (chemotherapy or chemotherapy plus anti-hormonal therapy) in comparison to a…
- Trial name
- NCT02078531
- Where
- Singapore
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Breast Cancer, Breast Cancer Female
UPPER EXTREMITY FUNCTION AND LYMPHEDEMA IN BREAST CANCER SURVIVORS
In this study, the investigators investigated upper extremity function and breast cancer-related lymphedema in individuals following breast cancer surgery and treatments
- Trial name
- NCT07876375
- Where
- Turkey (Türkiye)
- Volunteers
- 175 people
- Sponsor
- Pamukkale University
Gastrointestinal Symptoms, Bloating
Probiotic Supplementation Among Adults With Recurrent Gastrointestinal Symptoms
Participants experiencing recurrent gastrointestinal symptoms in this double-blind, randomized, controlled trial will receive either a commercially-available probiotic dietary supplement or placebo.
- Conditions
- Gastrointestinal Symptoms, Bloating, Gas, Indigestion
- Trial name
- NCT02277431
- Testing
- Probiotic dietary supplement (Trenev Trio®)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Atopic Eczema/Dermatitis (Non-Specific)
Skin bioMARkers for Atopic Eczema Therapy Evaluation
The study aims to investigate two new non-invasive technologies for assessing skin properties to identify and validate a range of safety biomarkers that may be considered useful as primary outcome measures for evaluating the…
- Trial name
- SMART (NCT04194814)
- Testing
- crisaborole (2%) ointment, betamethasone valerate 0.1% cream
- Where
- United Kingdom
- Volunteers
- 37 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust