Clinical trials: Skin Physiology
Ataxia Telangiectasia
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside
Study design: Single arm open-label clinical trial in ataxia-telangiectasia to test the effects of nicotinamide riboside on ataxia scales, immune function, and neurofilament light chain.
- Trial name
- ATNAD (NCT06324877)
- Testing
- Nicotinamide riboside
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- The University of Queensland
Skin Barrier Function, Skin Hydration
Study of a Peptide Cream's Effect on the Facial Skin Barrier Using a Side-by-Side Comparison
The goal of this clinical trial is to evaluate whether a topical face cream containing the peptide Acetyl Hexapeptide-37 improves skin hydration and strengthens the skin barrier compared to a placebo cream in healthy adult…
- Conditions
- Skin Barrier Function, Skin Hydration, Topical Peptide Effects on Facial Skin Barrier Function
- Trial name
- NCT07548424
- Testing
- Acetyl Hexapeptide-37 Cream
- Where
- Croatia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Split, School of Medicine
Pectus Excavatum, Pectus Carinatum
Chest Wall Deformities Beyond the Chest Wall
Pectus excavatum (PE) and pectus carinatum (PC) are chest wall deformities that may influence respiratory function, physical capacity, posture, and quality of life.
- Trial name
- BEYOND (NCT07844382)
- Where
- Turkey (Türkiye)
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Breast Cancer, Chemotherapeutic Agent Toxicity
Effects of Chemotherapy on the Brain in Women With Newly Diagnosed Early-Stage Breast Cancer
RATIONALE: Gathering information over time from laboratory tests, imaging scans, and assessment tests may help doctors learn more about the side effects of chemotherapy and plan the best treatment.
- Conditions
- Breast Cancer, Chemotherapeutic Agent Toxicity, Cognitive/Functional Effects, Fatigue
- Trial name
- NCT00755313
- Testing
- trastuzumab, aromatase inhibition therapy, carboplatin
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Head Injury, Traumatic Brain Injury (TBI)
The Head Injury-associated Photosensitivity and Pupillary Function (HIPP) Study
After a head injury, many people find that exposure to light causes them increased discomfort. By measuring how the pupil in the eye constricts to flashes of red and blue light, this study will investigate whether this phenomenon…
- Conditions
- Head Injury, Traumatic Brain Injury (TBI), Photosensitivity, Photophobia
- Trial name
- HIPP (NCT01942564)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Rheumatoid Arthritis, Psoriatic Arthritis
Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis
The aim of this study is to evaluate the influence of anti tumor necrosis factor-alpha (TNF-α) treatment on blood pressure, endothelial function and immune cell phenotype in patients with rheumatoid arthritis, psoriatic arthritis…
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Hypertension
- Trial name
- NCT02132234
- Testing
- Etanercept, Adalimumab, Certolizumab
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Jagiellonian University
Amputation, Hyperhidrosis
Qbrexza Cloths for Hyperhidrosis of Amputation Sites
This is a Prospective, Double Blinded, Placebo Controlled, Randomized, Cross-over trial using Qbrexza Cloths to treat hyperhidrosis of amputation sites.
- Trial name
- NCT04924036
- Testing
- glycopyrronium cloths
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Utah
Breast Cancer, Painful Neuropathy
The Effect of an Inter-Disciplinary Program, Including MBSR, in Breast Cancer Survivors With Chronic Neuropathic Pain
Chronic neuropathic pain is a common problem for breast cancer survivors. Even with the best medical treatment, some survivors continue to experience disabling pain.
- Conditions
- Breast Cancer, Painful Neuropathy, Chronic Pain, Worries; Pain or Disability
- Trial name
- InDepth (NCT02125006)
- Testing
- Mindfulness-Based Stress Reduction
- Where
- Canada
- Volunteers
- 118 people
- Sponsor
- Ottawa Hospital Research Institute
Obesity, Breast Cancer
Simulated-altitude to Optimize Aerobic Exercise Among Breast Cancer Survivors With Limited Mobility
The study will evaluate the utility of hypoxic exercise training to improve cardiovascular and metabolic health among obese breast cancer survivors.
- Trial name
- NCT03029182
- Testing
- Walking+simulated-altitude, Walking (control)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Alabama at Birmingham
Cancer, Chemotherapy-induced Peripheral Neuropathy
Chemotherapy-induced Peripheral Neuropathy (CIPN) on Motor and Sensory Function
As cancer survival rates have been increased due to technological developments and early detection strategies, there has been been a growing need to assess the effect of long-term complications and adverse effects upon patients'…
- Conditions
- Cancer, Chemotherapy-induced Peripheral Neuropathy, Chemotherapeutic Toxicity, Breast Cancer
- Trial name
- NCT04799080
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Izmir Bakircay University
Hirschsprung Disease, Ganglion
The Association Between Calretinin and the Function of Ganglion Cells in Hirschsprung Disease
This study aims to compare the outcomes of patients with long segment Hirschsprung disease or total colonic aganglionosis who had negative calretinin staining and positive ganglion cells on the proximal resection margins to those…
- Conditions
- Hirschsprung Disease, Ganglion, Hirschsprung Disease, Long-Segment, Hypoganglionosis
- Trial name
- NCT04149093
- Testing
- Calretinin staining
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- St. Justine's Hospital
Lupus Nephritis
Per-protocol Repeat Kidney Biopsy in Incident Cases of Lupus Nephritis
Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus (SLE). Among people living with SLE, 35-60% will develop LN during the course of the disease.
- Trial name
- REBIOLUP (NCT04449991)
- Testing
- Repeat kidney biopsy
- Where
- Sweden
- Volunteers
- 206 people
- Sponsor
- Karolinska Institutet
Upper Extremity Dysfunction, Gait, Unsteady
The Effect of Improvement in Function on Foot Pressure, Balance and Gait in Children With Upper Extremity Affected
It has been shown that movements of the upper extremity during walking are associated with lower extremity mobility. For example, when walking at a slow pace, the swing frequency of the arms is 2: 1 compared to the legs, while…
- Conditions
- Upper Extremity Dysfunction, Gait, Unsteady, Juvenile Idiopathic Arthritis, Balance
- Trial name
- NCT04671524
- Testing
- Exercise protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Venous Leg Ulcer
A Study in Patients With Venous Leg Ulcers and Measuring the Effects of Using Geko™ Device
This is a single centre open label study measuring lower limb physiology in patients with venous leg ulcers at the University Hospital of South Manchester.
- Trial name
- NCT02884323
- Testing
- geko™ device
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- Firstkind Ltd
Lupus Erythematosus, Systemic, Pulmonary Disease
Pulmonary Disease Among Patients With Systemic Lupus Erythematosus
Pulmonary diseases are common among patients with Systemic Lupus Erythematosus (SLE) and associated with a significantly increased morbidity, mortality, and lower self-reported health related quality of life.
- Trial name
- NCT06087523
- Testing
- Multidisciplinary discussion
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Odense University Hospital
Psoriasis
Influence of Atorvastatin on Psoriasis Severity and Endothelial Function
Patients with psoriasis seem to have increased risk for developing atherosclerosis. This may be due to the fact that psoriasis and atherosclerosis are both caused by inflammation and involvement of cells of the immune system.
- Trial name
- NCT01527097
- Testing
- Atorvastatin
- Where
- Israel
- Sponsor
- shmuel fuchs
Atopic Dermatitis Eczema
Effect of Ectoin Dermatitis Cream 7% on Skin Hydration and Skin Barrier Function
The aim of this prospective, uncontrolled clinical study is to evaluate the clinical effect of Ectoin® Dermatitis Cream-EHK02 on skin hydration and transepidermal water loss (TEWL) in subjects with atopic dermatitis after single…
- Trial name
- NCT04097327
- Testing
- Ectoin Dermatitis Cream 7% (EHK02)
- Where
- Germany
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Bitop AG
Rheumatoid Arthritis, Pain
The Effectiveness of Kinesiologic Taping in Patients With Knee Rheumatoid Arthritis
The goal of this clinical trial is to learn if kinesiologic taping works to treat individuals with Rheumatoid Arthritis. The main questions it aim to answer: Is kinesiologic taping applied to the knee joint an effective treatment…
- Conditions
- Rheumatoid Arthritis, Pain, Kinesiophobia
- Trial name
- Taping (NCT07253766)
- Testing
- kinesiologic taping
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul Rumeli University
Atopic Dermatitis
Study to Determine the Effect of an Anti-IgE Agent on Inflammatory Cells in the Skin of Atopic Dermatitis Patients
Elevated levels of immunoglobuline E in blood are said to promote the occurence of atopic dermatitis; in fact, many patients with atopic dermatitis have high IgE levels.
- Trial name
- NCT00822783
- Testing
- Omalizumab
- Where
- Austria
- Sponsor
- Medical University of Vienna
Skin Cancer, Non-Melanoma, Skin Cancer Melanoma
Interpolated Flap Study
The primary purpose of this study is to address the limited knowledge regarding patient well- being and nasal function after interpolated flap repair of post-Mohs surgical defects on the nose.
- Conditions
- Skin Cancer, Non-Melanoma, Skin Cancer Melanoma, Mohs Micrographic Surgery
- Trial name
- NCT04164550
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- University of Pennsylvania