Clinical trials: Skin Scarring
Scar
Effect of PDRN in Post-operative Scars
The investigators aimed to evaluate the efficacy of PDRN administration in early wound healing phase on prevention of post-operative scars after open thyroidectomy.
- Trial name
- NCT05149118
- Testing
- Polydeoxyribonucleotide (PDRN)
- Where
- South Korea
- Volunteers
- 22 people
- Sponsor
- Seoul National University Bundang Hospital
Hematoma, Subdural, Chronic, Hematoma, Subdural, Intracranial
Covers to Improve Esthetic Outcome After Surgery for Chronic Subdural Hematoma
The clinical-functional result after frontal and parietal burr-hole trepanation for the treatment of chronic subdural hematoma (cSDH) is effective with regards to control of the hematoma and regression of symptoms (headache…
- Conditions
- Hematoma, Subdural, Chronic, Hematoma, Subdural, Intracranial, Haematoma;Subdural;Traumatic
- Trial name
- CORRECT-SCAR (NCT03755349)
- Testing
- Placement of burr-hole covers, No placement of burr-hole covers
- Where
- Switzerland
- Volunteers
- 83 people
- Sponsor
- University of Zurich
Keloid, Stem Cell
The Effect of Intralesian Injection of Umbilical Cord Mesenchymal Stem Cells, Its Conditioned Medium, and Triamcinolone Acetonide on Type 1:3 Collagen Ratio and Interleukin-10 Levels in Keloid: A Randomised Controlled Trial
The objective of this study is to observe the potency of umbilical cord-derived mesenchymal stem cells (UC-MSC) and umbilical cord-derived conditioned medium (UC-CM), or triamcinolone acetonide (TA) in keloid therapy, measured by…
- Trial name
- NCT05939817
- Testing
- umbilical cord-derived mesenchymal stem cells (UC-MSC), umbilical cord-derived mesenchymal stem cells conditioned medium (UC-CM), Triamcinolone Acetonide (TA)
- Where
- Indonesia
- Volunteers
- 24 people
- Sponsor
- Rumah Sakit Pusat Angkatan Darat Gatot Soebroto
Scars
Cutaneous Scarring of Scalpel Versus Cautery
Cutaneous scarring after elective surgery is a concern for surgeons of all types, perhaps even more so to plastic surgeons. Cautery is often used on the "cut" setting to make or extend incisions; however very few studies have…
- Trial name
- NCT00803140
- Testing
- Cautery vs Active Control Arm (Scalpel)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Scott and White Hospital & Clinic
Burn Scar
Effect of Pulsed Electromagnetic Field on Pruritus in Burn Scars
This study will be conducted to evaluate the effectiveness of pulsed electromagnetic field therapy in pruritus in patients with burn scars.
- Trial name
- PEM (NCT07443358)
- Testing
- pulsed electromagnetic field therapy, standard care
- Volunteers
- 40 people
- Sponsor
- Cairo University
Keloid
Exploratory Study of the Efficacy and Safety of Juvista 250ng When Administered Following Excision of Ear Lobe Keloids
This trial will explore the efficacy and safety of 250ng Juvista per Linear cm, administered by intradermal injection following the excision of ear lobe keloids.
- Trial name
- NCT00836147
- Testing
- Avotermin (Juvista)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Renovo
Scar Keloid
Intralesional Triamcinolone Acetonide and Its Combination With 5-fluorouracil in Keloids and Hypertrophic Scars
Summary: Keloids and hypertrophic scars are benign fibrous growth, differing mainly by overgrowth beyond the initial defect in keloid whereas hypertrophic scar is confined to initial lesion and tends to regress over the years.
- Trial name
- NCT04812626
- Testing
- 5-Fluorouracil
- Where
- Nepal
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- B.P. Koirala Institute of Health Sciences
Burn Scar, Scar
Mechanistic Basis of Ablative Carbon Dioxide Laser in Treating Hypertrophic Scars
This is an observational cohort study which will look at the biomarkers from blood and tissue sample for adult patients with hypertrophic scarring due to burns/trauma incident over 12 months from date of recruitment.
- Trial name
- SMOOTH (NCT04736251)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Naiem Moiemen
Herpes Genitalis, Genital Wart
Safety and Efficacy of Laser Therapy in Gynaecology
The aim of this study is to retrospectively evaluate the effectiveness and safety of Er:YAG laser for treatment of different gynecological indication, e.g.
- Conditions
- Herpes Genitalis, Genital Wart, Lichen Sclerosus, Cervical Intraepithelial Neoplasia
- Trial name
- NCT04073082
- Where
- Slovenia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Juna d.o.o.
Scarring
Prospective Observation of Wound Healing With Prevena Incision Management System
This study aims to assess the quality of wound healing in abdominal scars with and without the Prevena Incision Management System.
- Trial name
- NCT01704924
- Testing
- Prevena, Standard of Care Dressing
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Irvine
Self Injurious Behaviour
Skin Camouflage for Women Prisoners With Self-Harm Scarring
Women prisoners are more likely to commit suicide or self-harm than women in the community or male prisoners. Healthcare services have improved how they manage self-harm in the community and prisons.
- Trial name
- COVER (NCT02638974)
- Testing
- Medical Skin Camouflage
- Where
- United Kingdom
- Volunteers
- 51 people
- Sponsor
- University of Manchester
Keloid
Case-control Study on Matrix Metalloproteinase Levels in Tissue in Patients With Keloid Scar
Purpose: To compare the levels of matrix metalloproteinase-1 (MMP-1), MMP-8, MMP-13 and tissue inhibitor of metalloproteinases (TIMPs) in keloid skin tissue with normal skin in the same patient and with normal discarded skin…
- Trial name
- NCT01125137
- Testing
- Removal of Keloid
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Acne Scars
Clinical Evaluation of Fractional Radiofrequency for the Treatment of Acne Scarring
Prospective, single centre, evaluator-blind study of the safety and performance of fractional radiofrequency (RF) for the treatment and reduction of acne scarring.
- Trial name
- NCT03767153
- Testing
- Venus Viva
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Venus Concept
Port Wine Stain, Nevus of Ota
Optical Clearing of the Skin in Conjunction With Laser Treatments
The research hypothesis is that topical application of a mixture of pre-polymers of polypropylene glycol and polyethylene glycol (an optical clearing agent) will reduce skin light scattering, increasing the amount of light…
- Conditions
- Port Wine Stain, Nevus of Ota, Tattoos, Scars
- Trial name
- NCT00580736
- Testing
- Optical Clearing
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of California, Irvine
Keloid, Wound Heal
Comparing the Effect of siSPARC Microneedle Patch Versus siSPARC+siLR4A Microneedle Patch on Post-surgical Scars
This randomized, double-blind controlled study aims to compare the effect on appearance of post- surgical scars between daily application of siSPARC microneedle patch versus siSPARC + siLR4A microneedle patches.
- Conditions
- Keloid, Wound Heal, Wound
- Trial name
- NCT06138964
- Testing
- siSPARC + siLR4A microneedle patches, siSPARC microneedle patch
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Skin Centre
Hypertrophic Scar
Intra-lesional ACE Inhibitor for Treatment of Hypertrophic Scars
Hypertrophic scarring is a difficult and debilitating condition where one develops excessive scarring after full thickness injury to the skin. This is very common in full thickness burn injury.
- Trial name
- NCT05259137
- Testing
- Intralesional enalaprilat injection
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Bariatric Surgery, Abdominoplasty
Effect of a Preoperative Oral Collagen-Based Formulation on Dermal Collagen Content, Wound Outcomes, and Scar Quality
This single-center, randomized, placebo-controlled trial evaluated whether approximately 8 weeks of preoperative supplementation with a 10-g daily collagen-based oral formulation affected dermal collagen content and postoperative…
- Conditions
- Bariatric Surgery, Abdominoplasty, Collagen Synthesis, Skin Physiology
- Trial name
- COLLAGEN (NCT06787924)
- Testing
- Collagen hydrolyzed peptides, Starch
- Where
- Egypt
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Mammoplasty, Scarring
A Study of Granexin® Gel for the Reduction of Scar Formation in Surgical Wounds Following Bilateral Anchor Incision Breast Surgery
The purpose of this study is to evaluate effectiveness of Granexin® gel in reducing scar formation in surgical incisional wounds.
- Conditions
- Mammoplasty, Scarring, Scar, Breast Reconstruction
- Trial name
- NCT04331080
- Testing
- Granexin® gel 100 μM, Granexin® gel 200 μM, Vehicle gel
- Where
- 11 sites in United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Xequel Bio, Inc.
Melanoma, Quality of Life
Quality of Life and Surgical Late Effects of Melanoma Treatment
Health-related Quality of life in Danish stage IB-III cutaneous melanoma patients.
- Conditions
- Melanoma, Quality of Life, Lymphedema, Depression
- Trial name
- NCT02352623
- Testing
- DXA scan, Clinical examination
- Where
- Denmark
- Volunteers
- 435 people
- Sponsor
- Herlev Hospital
Keloid
A Study for Safety and Efficacy Evaluation of Various Doses of STP705 in Reducing Keloid Recurrence
Phase 2, randomized, double-blind, multiple arm, controlled study to evaluate safety \& efficacy of various doses of STP705 in reducing post Keloidectomy keloid recurrence.
- Trial name
- NCT04844840
- Testing
- STP705
- Where
- 3 sites in United States
- Volunteers
- 29 people
- Sponsor
- Sirnaomics