Clinical trials: Skin Toxicity
Breast Cancer Stage IV
Clinical Outcome and Toxicity Data in Patients With Advanced Breast Cancer Treated With CDK Inhibitors Combined With Endocrine Therapy
The present study will assess real-world clinical outcomes and adverse events from treatment with endocrine therapy combined with CDKi in patients with HR-positive, HER2-negative advanced breast cancer.
- Trial name
- HeCOG/CDKi (NCT04133207)
- Where
- Greece
- Volunteers
- 340 people
- Sponsor
- Hellenic Cooperative Oncology Group
Abemaciclib, Abemaciclib-related Diarrhea
Pharmacokinetic Model of Abemaciclib: Correlation With Severe Diarrhea as the Primary Toxicity Endpoint in Patients With Localized Hormone Receptor-positive Breast Cancer
Remarkable progress has recently been made in the treatment of locally advanced, hormone receptor-positive, HER2-negative breast cancer with a high risk of recurrence, thanks to the addition of abemaciclib to endocrine therapy.
- Conditions
- Abemaciclib, Abemaciclib-related Diarrhea, Breast Cancer
- Trial name
- DOSABEMA (NCT07490509)
- Testing
- Blood samples for PK, Questionnaire
- Volunteers
- 235 people
- Sponsor
- Poitiers University Hospital
Food Hypersensitivity, Asthma in Children
Toxicity of Micro and Nano Plastics Combined With Environmental Contaminants on the Risk of Allergic Disease
Single-center, cross-sectional, longitudinal, observational, population based cohort study with stratified sample (by age group, gender, and residential area).
- Conditions
- Food Hypersensitivity, Asthma in Children, Rhinitis, Allergic, Dermatitis, Atopic
- Trial name
- Imptox (NCT05177744)
- Where
- Croatia
- Volunteers
- 1,156 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Srebrnjak
Breast Cancer
Financial Toxicity, Quality of Life, and Psychological Resources in Breast Cancer Survivors : A Longitudinal Study
Breast cancer survivors face significant financial stress (also called financial toxicity) due to the high costs of cancer treatment. This financial stress can worsen quality of life.
- Trial name
- FTQoL-BC (NCT07651267)
- Volunteers
- 160 people
- Sponsor
- Okayama University
Locally Advanced or Metastatic Breast Cancers
Study Aiming to Compare the Plasma Exposure of the Payload (Free-DXd) in Patients Treated by T-DXd for Locally Advanced or Metastatic Breast Cancer According to Their BMI.
This is a multicenter, prospective, non-randomized, open-label, pharmacokinetic study, aiming to compare the plasma exposure of the payload (free-DXd) in patients treated by T-DXd for locally advanced or metastatic breast cancer…
- Trial name
- TDXdose (NCT07195344)
- Testing
- Pharmacokinetics blood samples
- Where
- 10 sites in France
- Volunteers
- 210 people
- Sponsor
- Institut Claudius Regaud
Breast Cancer
Patient Registry: Partial Breast Irradiation
This is an Aurora Health Care system registry of patients receiving accelerated partial breast irradiation and external beam.
- Trial name
- PBI Registry (NCT01127971)
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- Wake Forest University Health Sciences
Radio Dermatitis, Mucositis Oral
Using Red Light Therapy to Ease Skin Side Effects and Mouth Side Effects, in Children and Young People Aged 0 to 16 Years Old, Receiving Radiotherapy
The goal of this interventional study is to see if the daily use of red light therapy called photobiomodulation can help sore skin and sore mouths in children having radiotherapy.
- Conditions
- Radio Dermatitis, Mucositis Oral, Oesophagitis
- Trial name
- RADIANT (NCT07183267)
- Testing
- Photobiomodulation
- Where
- United Kingdom
- Volunteers
- 248 people
- Sponsor
- The Christie NHS Foundation Trust
Breast Cancer, Proton Therapy
Safety and Efficacy of IMPT or IMRT for Breast Cancer
The purpose of this trial is to compare the toxicities and efficacy of intensity-modulated proton therapy (IMPT) and intensity-modulated radiation therapy (IMRT) for breast cancer patients indicated for radiotherapy including…
- Conditions
- Breast Cancer, Proton Therapy, Intensity Modulated Radiation Therapy, Efficacy and Safety
- Trial name
- SEPPT-BC (NCT06826885)
- Testing
- Postoperative radiotherapy, Preoperative Radiotherapy, Definitive Radiotherapy
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ruijin Hospital
Stevens-Johnson Syndrome, Toxic Epidermal Necrolyses
Meibomian Gland Probing in the Sub-Acute Phase of Patients With Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
The investigators' aim is to study the effects of mechanical expression of meibomian glands on eyelid disease, ocular surface health in the subacute phase of SJS/TEN.
- Conditions
- Stevens-Johnson Syndrome, Toxic Epidermal Necrolyses, Ocular Surface Disease, Meibomitis
- Trial name
- NCT05145959
- Testing
- Maskin Probe
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Breast Cancer
Glutamine for the Prevention of Radiation Toxicity in Subjects Conserving Therapy
This study is a single-centered, double-blind, two-arm randomized study to determine if oral glutamine will reduce radiation toxicity for the subjects undergoing Breast Conserving Therapy.
- Trial name
- NCT02012608
- Testing
- Glutamine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Arkansas
Myeloma Multiple
Evaluation of a Range of Dermo-cosmetic Products to Treat Skin and Nail Toxicity Linked to Bispecific Anti-GPRC5D Bispecific Antibodies in Multiple Myeloma Patients". Myeloma". Descriptive Pilot Study
The aim of this study is to assess the efficacy of range of dermo-cosmetic products (hand/feet serum, nail strengthening solution nail strengthening solution, dissolving oil and gloves/slippers) based on natural products and…
- Trial name
- DELICATESSE (NCT06418750)
- Testing
- dermo-cosmetic product
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Nantes University Hospital
Breast Cancer, Brain Metastasis
Evaluation of the Efficacy of Hippocampal Avoidance on the Cognitive Toxicity of Whole-Brain Radiation Therapy After Surgical Resection of Single Brain Metastasis of Breast Cancer
The incidence of brain metastases (BM) in metastatic breast cancer is increasing, due to the improvement in the control of systemic disease, and due to an improved detection through imagery.
- Trial name
- NCT01942980
- Testing
- Radiation therapy Brain metastasis in breast cancer
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Institut Paoli-Calmettes
Breast Cancer
Pharmacogenetics as a Predictor of Toxicity in Pre-Menopausal Women Receiving Doxorubicin and Cyclophosphamide in Early Breast Cancer
The goal of this pilot study is to delineate the role of genetic variations in premature menopause, hot flashes, and other toxicities in a cohort of premenopausal women with early breast cancer.
- Trial name
- NCT00352872
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Indiana University
Cardiac Toxicity, Malignant Neoplasm
MRI in Detecting Heart Damage in Patients With Cancer Receiving Chemotherapy With Exercise Capacity Addendum
This trial studies how well magnetic resonance imaging (MRI) works in detecting heart damage in patients with cancer receiving chemotherapy.
- Conditions
- Cardiac Toxicity, Malignant Neoplasm, Breast Cancer
- Trial name
- NCT01719562
- Testing
- Magnetic resonance imaging, Physical Activity, Healthy Living
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Wake Forest University Health Sciences
Cancer, Breast, Cardiotoxicity
Exercise to Prevent AnthraCycline-based Cardio-Toxicity Study 2.0 (EXACT2)
Although great progress has been made in treating breast cancer, long-term health may be impaired by cancer therapy. For example, some chemotherapy drugs (e.g., anthracyclines) are known to cause declines in heart health.
- Conditions
- Cancer, Breast, Cardiotoxicity, Cardiovascular Diseases
- Trial name
- EXACT2 (NCT03748550)
- Testing
- Aerobic exercise
- Where
- 2 sites in Canada
- Volunteers
- 7 people
- Sponsor
- Nova Scotia Health Authority
Arthralgia, Breast Neoplasms
Omega-3 Supplementation in Prevention of Aromatase Inhibitor-Induced Toxicity in Patients With Stage I-III Breast Cancer
This clinical trial studies the use of omega-3 fatty acid supplementation in preventing aromatase inhibitor-induced toxicity in patients with stage I-III breast cancer.
- Trial name
- NCT02831582
- Testing
- Omega-3 Fatty Acid
- Where
- 3 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Tinea Infections Such as Tinea Corporis, Tinea Cruris, Tinea Pedis, Tinea Mannum, Tinea Barbae, Tinea Capitis Are Studied
Evaluation of Preclinical Toxicity andTherapeutic Efficacy of Kandhaga Rasayanam in Padarthamarai
this study is intended to find out the therapeutic efficacy of the siddha drug Kandhaga Rasayanam in Padarthamarai ( Ring worm infection )
- Trial name
- KR (NCT02238912)
- Testing
- kandhaga rasayanam
- Where
- India
- Volunteers
- 50 people
- Sponsor
- National institute of Siddha
HIV-Associated Focal Segmental Glomerulosclerosis, HIV-Associated Collapsing Glomerulopathy
Evaluation of Albuminuria HIV-Infected Patients
This study will examine the following: 1) how common albuminuria and proteinuria are among HIV-positive patients, 2) what causes albuminuria or proteinuria in these patients and 3) whether the condition becomes more severe over…
- Conditions
- HIV-Associated Focal Segmental Glomerulosclerosis, HIV-Associated Collapsing Glomerulopathy, Proteinuria, Albuminuria
- Trial name
- NCT00524992
- Where
- 2 sites in United States
- Volunteers
- 252 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Breast Cancer, Radiation Dermatitis
Randomized Phase III Trial With Mepitel Film for the Prophylaxis of Radiation Dermatitis in Breast Cancer Patients
Breast cancer patients undergoing adjuvant radiotherapy commonly experience radiation-induced skin reactions which adversely impact quality of life.
- Trial name
- NCT04166799
- Testing
- Mepitel Film
- Where
- Canada
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Metastatic Breast Cancer
Phase II Open-Label Trial of Tarceva in Women With Metastatic, Hormone- and HER2-Negative Breast Cancer
The goal of this trial is to determine the activity of erlotinib in a rationally selected population of women with ER-negative, PR-negative, HER2/neu-negative, EGFR-positive breast cancer.
- Trial name
- NCT00597597
- Testing
- Erlotinib
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Rush University Medical Center