Clinical trials: Skin Toxicity
Breast Cancer
Effectiveness and Toxicity of Gemcitabine/Lobaplatin Versus Gemcitabine/Cisplatin as Second-line Treatment in Metastatic Breast Cancer
Gemcitabine plus cisplatin has been proved to be an effective regimen as second-line treatment for metastatic breast cancer patients, especially for those previously treated with anthracyclines and taxanes.
- Trial name
- NCT01483300
- Testing
- lobaplatin, cisplatin
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Harbin Medical University
Breast Cancer
Outpatient Clinic for Late Outcome for Breast Carcinoma in MAASTRO Clinic.
In order to evaluate the late outcome in patients curatively treated for breast cancer, a special outpatient clinic will be developed. There are two main purposes of the outpatient clinic.
- Trial name
- NCT01978756
- Testing
- Outpatient clinic
- Where
- Netherlands
- Volunteers
- 387 people
- Sponsor
- Maastricht Radiation Oncology
Hand-Foot Skin Reaction (HFSR)
ZINCLO-HAND: Zinc and Clobetasol for the Prevention of Regorafenib-Induced Hand-Foot Skin Reaction
This study aims to evaluate whether a combination of oral zinc supplementation and transdermal clobetasol cream is effective in preventing and reducing the severity of hand-foot skin reaction (HFSR) induced by regorafenib…
- Trial name
- ZINCLO-HAND (NCT06856590)
- Testing
- Zinc Supplementation, Clobetasol Propionate 0.05% Cream
- Where
- 13 sites in Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Gazi University
Breast Cancer
Effect of Genetic and Epigenetic Factors on the Clinical Response and Toxicity to Doxorubicin Among Egyptian Breast Cancer Patients
Recent advances in technologies, such as microarray and high-throughput sequencing, represented a deeper understanding of molecular biology, especially noncoding RNA (ncRNA).
- Trial name
- NCT05733026
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Ain Shams University
Breast Cancer, Drug/Agent Toxicity by Tissue/Organ
High-Dose Chemotherapy and Autologous Blood Cell Transplantation in Treating Patients With Primary, Locally Advanced, or Stage IV Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Trial name
- NCT00003068
- Testing
- amifostine trihydrate, cyclophosphamide, mitoxantrone hydrochloride
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Arizona
Breast Cancer
Assessment of Cardiotoxicity After Chemotherapy for Breast Cancer by Cardio-vascular Magnetic Resonance (MR)
Consecutive patients with a first diagnosis of breast cancer will be identified at the Tom Baker Cancer Centre (TBCC) and included into the study, if they are going to receive chemotherapy with anthracyclines and / or Trastuzumab…
- Trial name
- Cardiotox (NCT00679874)
- Testing
- Cardio-vascular MRI
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- University of Calgary
Breast Cancer
Predicting Response and Toxicity in Patients Receiving Paclitaxel and Avastin for Breast Cancer
This trial provides a unique opportunity in that it combines genomic, proteomic and pharmacogenomic assessments in patients receiving chemotherapy for advanced breast cancer.
- Trial name
- NCT00537173
- Testing
- Core Biopsy, Blood Collection, Paclitaxel
- Where
- 4 sites in United States
- Volunteers
- 11 people
- Sponsor
- Hoosier Cancer Research Network
Toxicity, Drug, Progression, Disease
Real-World Clinical Outcomes and Toxicity in Metastatic Breast Cancer Patients Treated With First or Second Line CDK 4/6 Inhibitors and Endocrine Therapy
To assess CDK4/6i toxicity and effect on PFS in the Egyptian population
- Trial name
- NCT06558084
- Testing
- CDK4/6 Inhibitor
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Ain Shams University
Breast Cancer, Radiation Toxicity
Pre- or Postoperative Accelerated Radiotherapy
20 non-metastasized breast cancer patients receiving neoadjuvant chemotherapy will be randomized between preop or postop RT. Patients with clinically suspicious axillary lymph nodes will receive a fine needle biopsy.
- Trial name
- POP-ART (NCT03783364)
- Testing
- Radiotherapy
- Where
- 2 sites in Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital, Ghent
Breast Cancer, Ductal Carcinoma in Situ
Preoperative Partial Breast Irradiation in Early-Stage Breast Cancer
In the management of early breast cancer patients, postoperative radiotherapy following breast-conserving surgery has been established as the standard treatment.
- Conditions
- Breast Cancer, Ductal Carcinoma in Situ, Invasive Breast Cancer
- Trial name
- NCT06677944
- Testing
- Preoperative PBI
- Where
- South Korea
- Volunteers
- 47 people
- Sponsor
- Yonsei University
Rash Due to Epidermal Growth Factor Receptor Inhibitors
Safety, Tolerability and Efficacy Study of Doxycycline Foam for the Prevention of EGFRI Skin Toxicity in Cancer Patients
The purpose of this study is to evaluate the safety, tolerability and efficacy of FDX104 Antibiotic Foam in the prevention of EGFRI skin toxicity in cancer patients receiving Cetuximab or Panitumumab.
- Trial name
- NCT02239731
- Testing
- FDX104 (4% Doxycycline)
- Where
- 7 sites in Israel
- Volunteers
- 24 people
- Sponsor
- Vyne Therapeutics Inc.
Radiation Toxicity, Fibrosis
Pilot Study of the Predictive Value of TREM1 Expression and Activation in Inflammation and Radio-induced Mammary Fibrosis
Breast cancer is the most common cancer in the world. Half of patients with such cancer are treated with radiation therapy. Some patients will develop cutaneous or subcutaneous fibrosis, more or less bothersome.
- Conditions
- Radiation Toxicity, Fibrosis, Breast Cancer
- Trial name
- TREM-1 (NCT04948840)
- Testing
- Blood sampling
- Where
- 3 sites in France, Luxembourg
- Volunteers
- 20 people
- Sponsor
- Centre Francois Baclesse, Luxembourg
Melanoma
Safety Study of a Melanoma Vaccine (GVAX) With or Without Cyclophosphamide in Patients With Surgically Resected Melanoma
The primary objective of this study is to evaluate the safety and feasibility of administering an allogeneic GM-CSF-secreting lethally irradiated whole melanoma cell vaccine ("melanoma GVAX"), alone or in combination with low…
- Trial name
- NCT01435499
- Testing
- melanoma GVAX, Cyclophosphamide
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Steven-Johnson Syndrome, Toxic Epidermal Necrolysis
Severe Cutaneous Adverse Reactions in Thailand
The multicenter registry of patients with severe cutaneous adverse reactions among tertiary medical institutes in Thailand to study clinical characteristics, etiologies, therapeutic outcomes, quality of life, and the values of in…
- Conditions
- Steven-Johnson Syndrome, Toxic Epidermal Necrolysis, Drug Reaction With Eosinophilia and Systemic Symptoms, Acute Generalized Exanthematous Pustulosis
- Trial name
- ThaiSCAR (NCT02574988)
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Chulalongkorn University
Breast Cancer, Hormone-resistant Prostate Cancer
Controlled Low Calorie Diet in Reducing Side Effects and Increasing Response to Chemotherapy in Patients With Breast or Prostate Cancer
This randomized phase II trial studies how well a controlled low calorie diet works in reducing side effects and increasing response to chemotherapy in patients with breast or prostate cancer.
- Conditions
- Breast Cancer, Hormone-resistant Prostate Cancer, Recurrent Prostate Cancer
- Trial name
- NCT01802346
- Testing
- dietary intervention, nutritional support, laboratory biomarker analysis
- Where
- 3 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of Southern California
HIV Infections, AIDS
Lactate Metabolism Study in HIV Infected Persons
Lactic acidosis is a potentially life-threatening disease associated with the treatment of chronic HIV infection. Although acidosis is rare, hyperlactatemia is common and may have long term consequences yet to be recognized.
- Conditions
- HIV Infections, AIDS, Lactic Acidosis, Lipodystrophy
- Trial name
- NCT00202228
- Testing
- cofactor supplementation (thiamine, riboflavin, L-carnitine)
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Queen's University
Rash, Systemic Treatments
Telemedicine Rash Evaluation and Assessment of Toxicity in Skin in Acute Oncology and Haematology Care: A Pilot Study
This study is being done to find out if video consultations (telemedicine) can be used to safely and effectively assess and manage skin problems caused by cancer treatments.
- Conditions
- Rash, Systemic Treatments, Tele-assessment
- Trial name
- TREATS (NCT07476807)
- Testing
- telem healthassessment
- Where
- Ireland
- Volunteers
- 25 people
- Sponsor
- Sligo General Hospital
Breast Cancer, Drug/Agent Toxicity by Tissue/Organ
Combination Chemotherapy After Surgery With or Without Chinese Herbal Therapy to Treat Symptoms in Women With Breast Cancer
RATIONALE: Herbs used in traditional Chinese medicine may decrease the side effects of chemotherapy. PURPOSE: Randomized phase I/II trial to study the effectiveness of herbs used in traditional Chinese medicine in decreasing the…
- Trial name
- NCT00028964
- Testing
- Chinese herbs, cyclophosphamide, doxorubicin hydrochloride
- Where
- United States
- Sponsor
- University of California, San Francisco
Skin Toxicity
Serum 25-OH Vitamin D Modulation by Sunbed Use According to EU Guideline EN 60335-2-27
Our study aims to clarify the impact of the use of a standard sunbed according to new EU guideline EN 60335-2-27 and possibly discount the positive effects of tanning beds.
- Trial name
- NCT01976481
- Testing
- sunbed exposure
- Where
- Switzerland
- Volunteers
- 56 people
- Sponsor
- University of Zurich
Breast Cancer
Combined Optical and Infrared Imaging for Early Prediction of Erythema During Breast and Chestwall Radiotherapy
The aim of this study is to develop a computer model, based on photographs and heat images of patients' skin, to provide early prediction of painful reddening of the skin during radiotherapy treatment.
- Trial name
- NCT04363892
- Testing
- Optical and infrared imaging
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- Nova Scotia Health Authority