Clinical trials: Skin Wound
Diabetic Foot, Diabetes Type 2 With Diabetic Ulcer of Toe, Skin Breakdown
CGM and DFU Healing Post-discharge
The purpose of this study is to look at the benefits of using a Continuous Glucose Monitoring (CGM) system compared with standard-of-care testing for patients with type 2 diabetes and diabetic foot ulcers (DFU) and how this will…
- Trial name
- NCT06054659
- Testing
- Real Time Continuous Glucose Monitoring (rt-CGM), Fingerstick blood glucose (FBG) monitoring, Diabetes Education
- Where
- 2 sites in United States
- Volunteers
- 116 people
- Sponsor
- Emory University
Diabetic Foot Ulcers
A Study to Investigate the Safety and Clinical Effect of Nexagon® as a Topical Treatment for Subjects With a Diabetic Foot Ulcer (DUNE)
This study is for Type I or Type II diabetic subjects with with a diabetic foot ulcer. The study is being done to determine if Nexagon® plus standard of care is more effective than placebo plus standard of care.
- Trial name
- DUNE (NCT01490879)
- Testing
- Nexagon® Low Dose, Nexagon® Medium Dose, Nexagon® High Dose
- Where
- 25 sites in United States, Russia and 1 more
- Volunteers
- 168 people
- Sponsor
- OcuNexus Therapeutics, Inc.
Cardiac Toxicity, Malignant Neoplasm
MRI in Detecting Heart Damage in Patients With Cancer Receiving Chemotherapy With Exercise Capacity Addendum
This trial studies how well magnetic resonance imaging (MRI) works in detecting heart damage in patients with cancer receiving chemotherapy.
- Conditions
- Cardiac Toxicity, Malignant Neoplasm, Breast Cancer
- Trial name
- NCT01719562
- Testing
- Magnetic resonance imaging, Physical Activity, Healthy Living
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Wake Forest University Health Sciences
Burns
Fish Skin Compared to Cadaver Skin as Temporary Cover for Full Thickness Burns
Objectives and rationale: Optimal burn management involves removing all the dead or burned tissue as early as feasible and cover with an autograft called split thickness skin graft (STSG) taken from the patient.
- Trial name
- Kereburn (NCT03984331)
- Testing
- Fish skin, Cadaver skin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Kerecis Ltd.
Breast Cancer
PEAK PlasmaBlade™ 4.0 Versus Traditional Electrosurgery in Lumpectomy
The purpose of this clinical study is to quantify the difference in thermal injury depth at the surgical margin in breast lumpectomy specimens excised with the PlasmaBlade; to subjectively assess histopathologic sample quality…
- Trial name
- PRECISE (NCT00960154)
- Testing
- PEAK PlasmaBlade, Traditional Electrosurgery with scalpel
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Medtronic Surgical Technologies
Pancreatic Neoplasms, Biliary Tract Neoplasms
Comparing Endoscopic Based Stent Strategy Versus Bypass Surgery in Non-resectable Periampullary Cancer
Randomized study comparing endoscopic stent insertion strategy versus double-bypass surgery in non-resectable periampullary cancer
- Conditions
- Pancreatic Neoplasms, Biliary Tract Neoplasms, Duodenal Neoplasms
- Trial name
- NCT00487851
- Testing
- surgery, endoscopic strategy
- Where
- Sweden
- Sponsor
- Karolinska Institutet
Foot Diseases, Ankle Disorders Injuries
Baropodometric Assessment of the Podiatric Profile of Nursing Students in Clinical Settings
The nursing profession is highly affected by exhausting positions, namely prolonged standing and walking, which are the second work-related factor hindering foot health.
- Trial name
- NCT05197166
- Testing
- Acute Clinical Settings
- Where
- Portugal
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Escola Superior de Enfermagem de Coimbra
Wound Closure Techniques
Use of 2-octylcyanoacrylate (Dermabond) Versus 5-0 Fast Absorbing Gut During Cutaneous Wound Closure
The purpose of this study is to determine whether the use of 2-octylcyanoacrylate during repair of linear cutaneous surgery wounds improves scar cosmesis compared to wound closure with 5-0 fast absorbing gut.
- Trial name
- NCT02547077
- Testing
- Wound Closure with 2-octylcyanoacrylate, Wound Closure with 5-0 Fast Absorbing Gut Sutures
- Volunteers
- 50 people
- Sponsor
- University of California, Davis
Exuding Wounds, Ulcer, Leg
Clinical Study of Moisture Sensor Dressing Used for Exuding Wounds
Observational prospective study of the clinical use of a wound dressing with a moisture sensor for use on exuding wounds.
- Conditions
- Exuding Wounds, Ulcer, Leg, Wound
- Trial name
- NCT04890769
- Testing
- Moisture sensor wound dressing
- Where
- Sweden
- Volunteers
- 4 people
- Sponsor
- Fredrik Iredahl
Burn Injuries
Testing an Innovative Biomarker: Expression of HIF-1α and Its Isoforms in the Blood and Skin Tissue of Major Burns
Burn injury with full-thickness skin damage that encompass large body surface areas can induce local and systemic perturbations that are costly in terms of human suffering as well as in strains on the health care system.
- Trial name
- HIF (NCT02870439)
- Testing
- Blood drawn
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Wound Healing, Surgical Wound Infection
The Application of Infrared Thermography in the Prediction of Skin Healing in Surgery
This study investigates whether infrared thermography, a harmless and non-invasive thermal camera technique, can help monitor how surgical wounds heal after skin surgery.
- Conditions
- Wound Healing, Surgical Wound Infection, Postoperative Complications, Skin Neoplasms
- Trial name
- THERMS (NCT07524062)
- Testing
- Infrared thermography
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Fibrosis, Scarring
High Fluence Light Emitting Diode-Red Light (LED-RL) in Human Skin
The goal of this study is to establish the safety of high fluence LED-RL from 160 J/cm2 up to 640 J/cm2 in healthy subjects. The hypothesis is that high fluence LED-RL phototherapy is safe in human skin.
- Conditions
- Fibrosis, Scarring, Scar, Wounds
- Trial name
- NCT02630303
- Testing
- LED-RL Phototherapy, Mock Therapy
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jared Jagdeo, MD, MS
Breast Cancer, Radiation Toxicity
Modulated Accelerated RAdiotherapy in Early Breast Cancer
This trial was a retrospective study on postoperative accelerated hypofractionated IMRT (MARA-1) in patients with early stage breast carcinoma, to compare late toxicity after this treatment and standard fractionated RT delivered…
- Trial name
- NCT03461224
- Testing
- accelerated hypofractionated RT, conventional fractionated RT
- Volunteers
- 447 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Edema, Ecchymosis
Effects of Hyperbaric Oxygen Therapy on Surgical Wound Healing
The aim of this study is to test the effect of Hyperbaric Oxygen Therapy) HBOT (100% oxygen; 2.0 ATA; 90 minute total exposure) and compare against a hyperbaric sham treatment (HBST) (patient's breathing room air; 2.0 ATA; 90…
- Trial name
- BLEPH (NCT01605110)
- Testing
- Hyperbaric oxygen treatment
- Where
- United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Restorix Research Institute, LLLP
Hearing Loss, Sensorineural, Hearing Loss, Conductive
Wide Frequency Band Test of Hearing in Veterans
The accurate assessment of auditory status is critical for planning treatment for Veterans with hearing loss to include medical and audiological management.
- Conditions
- Hearing Loss, Sensorineural, Hearing Loss, Conductive, Hearing Loss, Mixed Conductive-Sensorineural, Otosclerosis
- Trial name
- CWTBAFV (NCT02019888)
- Where
- 2 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Pressure Injury, Limitation, Mobility
Effect of Structured Pressure Injury Patient Education
This study was planned as a prospective quasi-experimental study with the control group to determine the effect of structured pressure injury patient education (program on the knowledge, participation, wound healing progress, and…
- Trial name
- SPIPE (NCT04944186)
- Testing
- Structured Pressure Injury Patient Education (mySPIPE), Standard Patient Education
- Where
- Malaysia
- Volunteers
- 116 people
- Sponsor
- University of Malaya
Skin Reaction to Mechanical, Thermal and Radiation Stimuli, Skin Sensitisation
Study Comparing iNPWT Dressing and Devices Affect on Bioburden Levels and Skin Condition After Seven Days
Incisional dressings aim to prevent contamination of an incisional wound and protect against skin irritation. Surgeons use incisional negative pressure wound therapy (iNPWT) to manage incisional wounds.
- Trial name
- HHiNPWT7DC (NCT05559697)
- Testing
- Sponsor incisional negative pressure wound therapy device and dressing, Standard of Care incisional negative pressure wound therapy system
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- DeRoyal Industries, Inc.
Breast Cancer, Radio Dermatitis
Autologous Fat Infiltration Versus General Measures as Treatment in Radiodermatitis Induced for Radiotherapy in Breast Cancer Patients
Radiodermatitis is a major problem in oncologic patients, fat grafts previously used for cosmetic procedures have been shown to have regenerative power due to their stem cell content.
- Conditions
- Breast Cancer, Radio Dermatitis, Radiotherapy
- Trial name
- NCT07023796
- Testing
- Autologous fat filtration
- Where
- Mexico
- Volunteers
- 22 people
- Sponsor
- Instituto Mexicano del Seguro Social
Surgical Wound, Bleeding
Serum Concentration of Tranexamic Acid After Topical Administration in Massive Weight Loss Skin Reducing Surgery
Tranexamic acid is a drug that prevents clotted blood from dissolving and hence reduces bleeding. It is routinely given intravenously in many surgical situations where there is a risk of major bleeding.
- Trial name
- NCT03101124
- Testing
- Tranexamic Acid 25 mg/ml for wound surface moistening, Tranexamic Acid 5 mg/ml as bolus in wound cavity, Tranexamic Acid Injectable Solution
- Where
- Norway
- Volunteers
- 36 people
- Sponsor
- St. Olavs Hospital
Cardiotoxicity., Anti Her2 Therapy.
Cardiotoxicity in Metastatic Her 2 Positive Patients Treated With Trastuzumab ,Pertuzumab and Taxanes
Approximately 15-25% of all breast cancers are human epidermal growth factor receptor 2 (HER2) positive and it has been well known that HER2 overexpression is associated with more aggressive phenotype and poor prognosis with…
- Conditions
- Cardiotoxicity., Anti Her2 Therapy., Metastatic Breast Cancer
- Trial name
- NCT02101879
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Rambam Health Care Campus