Clinical trials: Skin Wrinkling
Facial Aging
Facial Muscle Exercises vs Fractional Microneedling Radiofrequency for Facial Rejuvenation
This randomized controlled trial compared the effectiveness and safety of fractional microneedling radiofrequency (FMR) and facial muscle exercises (FME) for facial rejuvenation in females with mild to moderate facial aging.
- Trial name
- NCT07285577
- Testing
- Facial Muscle Exercise Program, Vivace® Fractional Microneedling Radiofrequency
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Kasr El Aini Hospital
Face, Skin Fold
Efficacy of Prabotulinum and Onabotulinum Toxin-A for Facial Wrinkles
The appearance of facial wrinkles, lines, or folds is a natural phenomenon during aging. Different scales help classify wrinkles objectively, such as the Facial Wrinkle Scale.
- Conditions
- Face, Skin Fold, Rejuvenation
- Trial name
- NCT05840445
- Testing
- Onabotulinum toxin A, Prabotulinumtoxin A
- Where
- 2 sites in Mexico
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Wrinkle, Fine Lines
Study To Assess A Radiofrequency Microneedling Device For Dermatologic Conditions
Subjects are to be enrolled in this clinical study if they are 18 - 55 years old. Up to 120 subjects will be enrolled at multiple study centers.
- Conditions
- Wrinkle, Fine Lines, Crepey Skin, Acne Scars
- Trial name
- NCT05097157
- Testing
- Potenza
- Where
- 4 sites in United States
- Volunteers
- 79 people
- Sponsor
- Cynosure, Inc.
Facial Wrinkles, Skin Aging
Anti-Wrinkle Efficacy of a Syringic Acid-Containing Emulsion
This randomized, double-blind, split-face controlled study was conducted to evaluate the anti-wrinkle efficacy and safety of a Syringic acid-containing emulsion in healthy female subjects.
- Trial name
- NCT07850817
- Testing
- Synox-containing Emulsion, Control Emulsion
- Where
- South Korea
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- BioSpectrum Inc
Facial Wrinkles, Anti-Aging
Safety and Efficacy Evaluation of the Monopolar Radiofrequency Device for the Improvement of Facial Wrinkles
The goal of this clinical trial is to evaluate the safety and efficacy of the monopolar radiofrequency therapy device developed by CLASSYS Inc. for improving facial and periorbital wrinkles.
- Conditions
- Facial Wrinkles, Anti-Aging, Wrinkles and Rhytides, Wrinkles Such as Nasolabial Folds
- Trial name
- NCT06657365
- Testing
- Radiofrequency (RF) Treatment with Volnewmer, Radiofrequency (RF) Treatment with Thermage CPT
- Where
- China
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- CLASSYS Inc.
Skin Aging, Skin Wrinkling
Evaluation of Safety and Efficacy of Using EndyMed Pro Skin Treatment System for Skin Wrinkle Treatment on Body Areas
Skin aging is a multifactorial process involving the 3 layers of the skin: Epidermis, dermis and hypodermis. Skin aging process involves among others: skin roughness (epidermis), skin dyschromia (epidermis, dermis), wrinkles and…
- Trial name
- NCT01029301
- Testing
- Device: EndyMed Pro System for Skin Tightening
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Endymion Medical Ltd
Wrinkle, Aging
Evaluation of Performance and Safety of INNEA and INNEA AQUA for the Treatment of Cheek and décolletage Wrinkles
A Post-Market, Single-arm, Confirmatory Interventional Clinical Investigation to evaluate the Performance and Safety of INNEA and INNEA AQUA for the treatment of cheek and décolletage wrinkles
- Trial name
- NCT07331181
- Testing
- Innea, Innea Aqua
- Where
- 3 sites in Italy
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Innate srl
Visible Skin Aging Signs, Wrinkles and Folds in Lower Face
Efficacy of a Combined Oral and Topical Collagen Regimen Compared to Topical Collagen or Oral Collagen Regimens in Women With Skin Ageing Signs
This clinical study is conducted at one study site and in 165 women with visible signs of skin aging. It compares after 13 weeks the benefit of a combined oral collagen supplement and topical collagen serum regimen compared with…
- Conditions
- Visible Skin Aging Signs, Wrinkles and Folds in Lower Face, Skin Ageing, Skin Elasticity
- Trial name
- NCT07473037
- Testing
- Oral collagen, topical application of collagen serum
- Volunteers
- 165 people
- Sponsor
- Vichy Laboratoires
Skin Aging, Skin Wrinkling
Effects of Microtox on Facial Skin Quality, Fine Wrinkles, and Texture
The goal of this split-face clinical trial is to test the efficacy of microtox in improving facial skin quality, fine wrinkles, and texture.
- Trial name
- NCT06604832
- Testing
- PrabotulinumtoxinA-Xvfs, IncobotulinumtoxinA
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kalpna Kay Durairaj, MD, FACS
Facial Aging, Skin Rejuvenation
Performance and Safety of Semical Dermal Fillers in Facial Rejuvenation
The aim of the study is to verify safety and performance of Semical dermal fillers according to real-world data.
- Conditions
- Facial Aging, Skin Rejuvenation, Volume Defects in the Mid-face, Lip Augmentation and Correction of Perioral Rhytids
- Trial name
- SEMDERMA (NCT07160777)
- Testing
- cross-linked hyaluronic acid, Mesolifter
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Semikal Technology
Skin Manifestations, Skin Wrinkling
Effect of Oral Collagen Tripeptide on Skin Moisture and Wrinkles in Adult Women
Comparison of a randomized, double-blind, and control-group study for the effect of oral ingestion of collagen tripeptides derived from fish on dermal moistures and wrinkles body fat reduction in participants
- Trial name
- NCT03505684
- Testing
- CTP
- Where
- South Korea
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Wrinkles, Scars
Study of a Novel Microlens Array Device for Skin Rejuvenation
A single-center prospective, open-label uncontrolled pilot study. Subjects will receive laser treatments and will be followed at 12 weeks post-final treatment.
- Trial name
- NCT02888626
- Testing
- Microlens Array
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Cutera Inc.
Wrinkles, Fine Lines
Clinical Study to Assess Safety, Effectiveness and In-Use Tolerability of Saffron Extract Capsules for Improving Skin Health and Reducing Signs of Aging on Healthy Adult Male and Female Subjects.
This is a randomized, double-blind, comparative, two-arm, prospective, interventional, multi-centre clinical study to evaluate the safety, efficacy, and in-use tolerability of test products, standardized saffron extract capsules…
- Conditions
- Wrinkles, Fine Lines, Hyperpigmentation, Dark Spots
- Trial name
- GLOW (NCT07324759)
- Testing
- Standardized Saffron Extract (Crocus Sativus L) 10 mg Capsule
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd
Laxity; Skin, Volume Deficiency in the Mid-Face
Prospective Clinical Evaluation of the Safety and Performance of the Aesthetic Medical Device MEC REGENERATE® (Injectable Recombinant Collagen-based Product)
Prospective, spontaneous, open-label pre-market clinical trial with a single injection session; monitoring visits at baseline and 60 days post-treatment.
- Conditions
- Laxity; Skin, Volume Deficiency in the Mid-Face, Wrinkles
- Trial name
- NCT07413445
- Testing
- Treatment with experimental device
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- 303 Pharma s.r.l.
Skin Wrinkling
Mechanisms of Skin Repair by Topical Estrogen
The purpose of this study is to investigate the way by which estrogen improves the appearance of sun damaged human skin. Accumulating evidence suggests that estrogen, taken by post menopausal women, may cause skin to look younger…
- Trial name
- NCT00113100
- Testing
- Topical 17-beta estradiol in ethanol/propylene glycol (ETOH/PG)
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Aging
Superficial MFU-V and Diluted Calcium Hydroxyapatite for the Improvement of Lower Face Skin Quality and Wrinkles
Aging, genetics and environmental factors contribute to multiple changes on the surface of the skin. These present with pigmentation, volume loss, loss of elasticity and loss of collagen.
- Trial name
- NCT05469516
- Testing
- Ulthera System [Ulthera, Inc.], Merz Radiesse Injectable Implant
- Where
- Singapore
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Cutis Medical Laser Clinics Pte Ltd
Facial Skin Aging, Facial Volume Loss
Comparing Facial Aging Between Identical Twins With 3D Imaging
Identical twins share the same genes, which makes them a powerful way to study how lifestyle and environment - rather than genetics - affect how faces age.
- Conditions
- Facial Skin Aging, Facial Volume Loss, Wrinkle Appearance
- Trial name
- NCT07760532
- Testing
- GLP-1 Receptor Agonists
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ponsky Facial Aesthetics And Plastic Surgery, Llc
Lax Skin
Treatment to Lift Facial Lax Skin and Improve Facial Wrinkles Using Precise and Lift Applicators
Open-label, non-randomized single-arm prospective, multi-center, self-controlled clinical study with masked evaluation.
- Trial name
- NCT06333067
- Testing
- Sofwave
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sofwave Medical LTD
Wrinkles
Clinical Trial to Evaluate Safety and Efficacy of Ultherapy™ System for Lifting Skin on the Neck
Study is a prospective clinical trial to evaluate the efficacy of the Ulthera® System to improve Lifting Skin on the Neck. Changes from baseline in the FACE-Q Appraisal of Neck scale score and Global Aesthetic Improvement Scale…
- Trial name
- NCT02368925
- Testing
- Ultherapy™ System
- Where
- South Korea
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Anti-aging
Anti-aging Repairing Serum: Efficacy and Tolerability Study
The study aimed to evaluate the effectiveness and tolerability of a dermocosmetic serum containing hyaluronic acid, vitamin B5, madecassoside and La Roche-Posay Thermal Spring Water in reducing skin aging signs.
- Trial name
- NCT06059274
- Testing
- Topical serum
- Where
- Brazil
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International