Clinical trials: Skull
Anemia of Prematurity
Near-Infrared Spectroscopy and Cranial Doppler in Premature Newborns With Anemia
It is aimed in this study to examine the changes in brain blood supply and oxygenation in neonatal premature babies who have anemia and who underwent erythrocyte suspension transfusion in the light of original guidelines by means…
- Trial name
- NCT04509375
- Testing
- Cranial Doppler Ultrasonography, Near-Infrared Spectroscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Hacettepe University
Strabismus, Retinal Thickening
Choroidal and Retinal Thickness Following Strabismus Surgery
Prospective study, conducted at Tanta University Ophthalmology Department Measurement of macular and choroidal thickness before and after strabismus surgery
- Trial name
- NCT04285177
- Testing
- Strabismus surgery
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Tanta University
Neck Pain
Additional Effect of Cranial Base Release on Cervical Range and Proprioception in Patients With Mechanical Neck Pain
Mechanical Neck pain is the second most commonly occurring musculoskeletal disorder worldwide, ranking 4th in overall disability.
- Trial name
- NCT05777408
- Testing
- Conventional Physical Therapy, Natural Apophyseal glides, Cranial Base Release
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- Foundation University Islamabad
Convergence Insufficiency, Divergence Insufficiency
A Prospective Observational Study of Adult Strabismus
The purpose of this study is to describe clinical characteristics, treatments, and one-year outcomes of adults with convergence insufficiency, divergence insufficiency, or small angle hypertropia.
- Conditions
- Convergence Insufficiency, Divergence Insufficiency, Hypertropia
- Trial name
- SAS1 (NCT02510040)
- Testing
- Prism, Orthoptic Exercises, Eye Muscle Surgery
- Where
- United States
- Volunteers
- 217 people
- Sponsor
- Jaeb Center for Health Research
Trigeminal Neuralgia
A Study to Validate a Pain Diary for Patient With Trigeminal Neuralgia
The aim of the study is to establish the validity of a patient reported diary in TN . The following objectives have been identified: 1.
- Trial name
- NCT06019338
- Testing
- Pain Diary use
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 30 people
- Sponsor
- Noema Pharma AG
Leber's Hereditary Optic Neuropathy
Expanded Access Program for Idebenone in Patients With Leber's Hereditary Optic Neuropathy Who Completed the LEROS Study
Expanded Access Program for Idebenone in Patients with Leber's Hereditary Optic Neuropathy who completed the LEROS Study
- Trial name
- US EAP LHON (NCT04381091)
- Testing
- Idebenone 150 MG Oral Tablet
- Sponsor
- Santhera Pharmaceuticals
Parkinson Disease, Multiple System Atrophy
Research of Biomarkers in Parkinson Disease
The main goal of the GENEPARK consortium is to employ innovative haemogenomic approaches to determine gene expression profiles specific for genetic and idiopathic Parkinson's disease (PD) patients.
- Conditions
- Parkinson Disease, Multiple System Atrophy, Progressive Supranuclear Palsy, Huntington Disease
- Trial name
- Genepark (NCT00465790)
- Where
- 5 sites in Croatia, France and 2 more
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Wolfram Syndrome
Efficacy Study of Daily Administration of VPA in Patients Affected by Wolfram Syndrome
Open label, phase II study non randomized single group assignment of 20 evaluable patients 13 years and older, over 37,5 kg body-weight, with sensorineural hearing loss of at least 20 dB at 8 kHz in high frequency average (HFA)…
- Trial name
- AUDIOWOLF (NCT04940572)
- Testing
- Depakine
- Where
- 2 sites in France, Spain
- Volunteers
- 23 people
- Sponsor
- Centre d'Etude des Cellules Souches
Head and Neck Cancer, Skull Base--Cancer
HRQoL in Patients With Solid Tumors Treated With Hadrontherapy
The Quality of Life of patients treated with hadrontherapy is still limited. Two cohorts are established, they will be receiving specific standardized questionnaires to be evalutaed in their results.
- Conditions
- Head and Neck Cancer, Skull Base--Cancer, Brain Cancer
- Trial name
- HadroQoL (NCT05947149)
- Testing
- questionnaires administration
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- CNAO National Center of Oncological Hadrontherapy
Cranial Skull Base Bone Removal
The CUSA Clarity Bone Tip Study
The aim of the Study is to investigate the clinical performance and surgeon preferences of the CUSA Clarity Bone Tip during skull base surgery with removal of bony, and other cranial calcified tissue.
- Trial name
- NCT04300075
- Testing
- CUSABT
- Where
- 6 sites in Germany, Greece and 1 more
- Sponsor
- Integra LifeSciences Corporation
Trigeminal Neuralgia
Effect of Non-invasive Photobiomodulation Therapies in Patients With Trigeminal Neuralgia
The aim of this study was to compare the effectiveness of two different photobiomodulation (PBM) therapies as an alternative to medical treatment to reduce pain and improve quality of life in patients with trigeminal neuralgia…
- Trial name
- NCT06440356
- Testing
- laser therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Gaziantep
Parkinson Disease, Progressive Supranuclear Palsy
Cholinergic Mechanisms of Attentional-motor Integration and Gait Dysfunction in Parkinson Disease (UDALL)
To perform a prospective cohort study with [(18)F]fluoroethoxybenzovesamicol (FEOBV) brain PET at baseline and 2-year follow-up in PD subjects at risk of conversion to non-episodic and episodic (falls and FoG) PIGD motor features…
- Trial name
- NCT05459753
- Testing
- (18)F]fluoroethoxybenzovesamicol ([(18)F (FEOBV) PET, Dihydrotetrabenazine (DTBZ) PET
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Mitochondrial Diseases
A Long-term Extension of Study RP103-MITO-001 (NCT02023866) to Assess Cysteamine Bitartrate Delayed-release Capsules (RP103) in Children With Inherited Mitochondrial Disease
A long-term extension study to assess the safety, tolerability and efficacy of cysteamine bitartrate delayed-release capsules (RP103) in children with inherited mitochondrial diseases who previously enrolled into study…
- Trial name
- NCT02473445
- Testing
- Cysteamine Bitartrate
- Where
- 5 sites in United States
- Volunteers
- 22 people
- Sponsor
- Amgen
Neurofibromatosis Type 2
Efficacy and Safety of REC-2282 in Patients With Progressive Neurofibromatosis Type 2 (NF2) Mutated Meningiomas
This is a two-staged, Phase 2/3, randomized, multi-center study to investigate the efficacy and safety of REC-2282 in participants with progressive NF2 mutated meningiomas.
- Trial name
- POPLAR-NF2 (NCT05130866)
- Testing
- REC-2282
- Where
- 15 sites in United States, United Kingdom
- Volunteers
- 25 people
- Sponsor
- Recursion Pharmaceuticals Inc.
Optic Neuritis, Multiple Sclerosis
Visual Reconstitution Therapy After Optic Neuritis
Incomplete remission after an optic neuritis attack is not uncommon. Visual reconstitution therapy is a software-based approach that has been shown to substantially improve residual visual field deficits in patients with pre- and…
- Trial name
- VISION (NCT01274702)
- Testing
- Visual Reconstitutions Therapy, Saccadic Eye Movement Training
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Friedemann Paul
Myofacial Pain Syndrome
The Effect of Low Level Laser Therapy (LLLT) in Myofacial Pain Syndrome
Temporomandibular disorders (TMDs) are the major cause of non-dental pain in orofacial area. Laser therapy can be considered as one of the most recent treatment approaches in the field of physiotherapy.
- Trial name
- NCT01417637
- Testing
- Low level laser therapy
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Mashhad University of Medical Sciences
Orbital Fractures, Strabismus
Factors Associated With Postoperative Strabismus After Floor Fracture Repair
In patients suffered from floor fractures, there are 21.9% complaining about diplopia before fracture repair surgery and 20.8% after operation. Even after 6 months, there still are 16.4% had similar conditions.
- Trial name
- NCT02736461
- Testing
- Floor repair surgery
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Cerebrospinal Fluid Leak
Evaluate the Safety and Performance of Dura Sealant Patch in Reducing CSF Leakage Following Elective Cranial Surgery
The objective of the study is to clinically assess the safety and performance of the Dura Sealant Patch as a means of reducing intra- as well as post-operative CSF leakage in patients undergoing elective cranial intradural…
- Trial name
- NCT03566602
- Testing
- Dura Sealant Patch
- Where
- 3 sites in Netherlands, Switzerland
- Volunteers
- 40 people
- Sponsor
- Polyganics BV
Atrial Fibrillation, Frailty
the Dutch-GERAF Study
Geriatric patients are at high risk of cardiovascular complications, and for the development of atrial fibrillation. Often atrial fibrillation exists in these patients without specific symptoms, and could therefore remain…
- Conditions
- Atrial Fibrillation, Frailty, Major Bleed
- Trial name
- GERAF (NCT05337202)
- Testing
- HeartSDK
- Where
- 6 sites in Netherlands
- Volunteers
- 1,075 people
- Sponsor
- Dijklander Ziekenhuis
Vestibular Schwannoma
Novel Multimodality Imaging for Navigation in Skull Base Surgery
Successful neurosurgery to remove tumours around the base of the skull, such as a vestibular schwannoma, depends on achieving maximal tumour removal whilst preserving crucial neurological functions such as facial movement, and…
- Trial name
- SBN (NCT04128345)
- Testing
- Use of navigation system
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University College, London
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