Clinical trials: Skull Base
Skull Base Tumor, Postoperative Complications
Postoperative Complications Following Skull Base Tumor Resection
The skull base tumor is located in the deep intracranial layer and is closely related to the brain stem and intracranial nerves. The incidence of postoperative complications after skull base tumor resection is high.
- Trial name
- NCT06587906
- Testing
- Pulmonary ultrasound examination
- Where
- China
- Volunteers
- 122 people
- Sponsor
- Beijing Tiantan Hospital
Otolaryngological Diseases Requiring Mastoidectomy, Middle Ear Surgery, Endolymphatic Sac Surgery, Cochlear Implant, Labyrinthectomy, Petrous Apex Lesions, Facial Nerve Surgery, and Lateral Skull Base Tumors
AI Recognition of Important Structures in Otolaryngological Surgery
Developing a system for artificial intelligence to recognize anatomical landmarks in otolaryngological surgery, enabling real-time tracking of critical temporal bone structures during surgery.
- Trial name
- NCT06726551
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Skull Base Chordoma
Multi-parametric Imaging in Personalized Radiotherapy
The study consists in the retrospective and prospective collection of imaging data (along with clinical information related to treatment) of skull-base chordoma patients treated with particle therapy, to derive imaging biomarkers…
- Trial name
- NCT05888064
- Testing
- diffusion MRI sequences
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- CNAO National Center of Oncological Hadrontherapy
Indocyanine Green, Skull Base Neoplasms
ICG Angiogram as a Predictor of Postoperative Visual Function After EEA Surgery
Endonasal endoscopic approaches are an established treatment for suprasellar lesions compromising the optic nerves (ON). Surgery often involves dissecting tumors from the optic nerves and its blood supply, which can result in…
- Trial name
- NCT06501716
- Testing
- Indocyanine Green
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Optic Nerve Injuries, Sellar Tumor
Optic Nerve Stimulation To Prevent Visual Deficits After Endoscopic Cranial Approaches
Assessing the function of the optic nerve is paramount during various neurosurgical procedures. Effective optic nerve monitoring has remained elusive as Visual Evoked Potentials (the current existing tool) provides only diffuse…
- Conditions
- Optic Nerve Injuries, Sellar Tumor, Skull Base Neoplasms
- Trial name
- NCT06495580
- Testing
- Optic Nerve Stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Malignant Central Nervous System Neoplasm, Malignant Skull Base Neoplasm
Brain Imaging Changes Following Proton Therapy for Pediatric Primary Central Nervous System and Base of Skull Tumors
This trial gathers information from patients with primary central nervous system or base of skull tumors that receive proton beam therapy and see if certain imaging techniques can help detect radiation-related changes over time.
- Trial name
- NCT04296617
- Testing
- Medical Chart Review
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Mayo Clinic
Vestibular Schwannoma, Acoustic Neuroma
Auditory Nerve Test System During Vestibular Schwannoma Resection
The Auditory Nerve Test System (ANTS) is a novel device that stimulates the auditory nerve much like a cochlear implant. The purpose of this study is to demonstrate feasibility of the ANTS during translabyrinthine surgery for…
- Conditions
- Vestibular Schwannoma, Acoustic Neuroma, Sensorineural Hearing Loss, Asymmetric Sensorineural Hearing Loss
- Trial name
- ANTS (NCT04241679)
- Testing
- Auditory Nerve Test System
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Washington University School of Medicine
Skull Base Meningioma
Clinical Outcomes and Decision-making Choice of Skull Base Approaches for Petroclival Meningiomas
Petroclival meningioma (PCM) is a technically challenging lesion. We aimed to analyze the role of various skull base approaches and evaluate the therapeutic outcomes guided by the modified classification.
- Trial name
- NCT06319664
- Testing
- retrosigmoid approach (RSA), subtemporal transtentorial transpetrosal approach (STTA), extended pterional transtentorial approach (EPTA)
- Where
- China
- Volunteers
- 179 people
- Sponsor
- Xiangya Hospital of Central South University
Cranial Skull Base Bone Removal
The CUSA Clarity Bone Tip Study
The aim of the Study is to investigate the clinical performance and surgeon preferences of the CUSA Clarity Bone Tip during skull base surgery with removal of bony, and other cranial calcified tissue.
- Trial name
- NCT04300075
- Testing
- CUSABT
- Where
- 6 sites in Germany, Greece and 1 more
- Sponsor
- Integra LifeSciences Corporation
Chronic Sinusitis, Tumor of Nasal Sinus
Utility of Indocyanine Green Fluorescence in Endoscopic Sinonasal and Skull Base Surgery
The endoscope is a device placed into the nasal cavity to remove chronic sinus disease or tumor or create access into the skullbase for extensive tumor removal.
- Conditions
- Chronic Sinusitis, Tumor of Nasal Sinus, Posterior Epistaxis, Skull Base Neoplasms
- Trial name
- NIRFICG (NCT04374448)
- Testing
- Sinonasal Benign or Malignant Tumor Resection, Skull Base Surgery (Assessment of Nasoseptal Flap), Endoscopic Sinus Surgery
- Volunteers
- 40 people
- Sponsor
- St. Paul's Sinus Centre
Skull Base Meningioma
Comparison of Proton and Carbon Ion Radiotherapy With Advanced Photon Radiotherapy in Skull Base Meningiomas: The PINOCCHIO Trial.
In PINOCCHIO-Triayl, carbon ion radiotherapy is compared to proton and advanced photon radiotherapy in patients with skull base meningiomas.
- Trial name
- PINOCCHIO (NCT01795300)
- Testing
- Carbon Ion Radiotherapy, Proton Therapy, Hypofractionated Photon Radiotherapy
- Where
- Germany
- Sponsor
- University Hospital Heidelberg
Skull Base Neoplasms, Skull Neoplasms
Proposal for Intraoperative Administration of Intravenous Indocyanine Green to Evaluate Position of the Optic Canal, Position of the Internal Carotid Arteries, Tumor Vascularization, and Vessel Encasement in Endoscopic Endonasal Cranial Base Surgery
This study is being done to demonstrate the feasibility of using a nasal endoscope to perform intraoperative angiography of surgical field, with the goals to evaluate anatomical landmarks and tumor characteristics during skull…
- Conditions
- Skull Base Neoplasms, Skull Neoplasms, Bone Neoplasm, Neoplasms
- Trial name
- ICG2 (NCT03072186)
- Testing
- near-infrared light nasal endoscope used with ICG
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Ohio State University
Chronic Sinusitis, Frontal Sinusitis
Improvement of Outcomes in Draf III/Endoscopic Modified Lothrop Procedure
We propose a randomized, single-blinded, prospective trial in order to evaluate the efficacy of the Cook Biodesign ENT Repair graft in improving outcomes after the Draf III or Endoscopic Modified Lothrop procedure.
- Trial name
- NCT02981017
- Testing
- Porcine Intestinal submucosal xenograft
- Where
- United States
- Sponsor
- University of California, Los Angeles
Brain Tumor, Head and Neck Tumor
In-Room PET in Proton Radiation Therapy
The investigational part of this study is using a mobile PET/CT scanner to take images of the participants tumor immediately after they are treated with proton radiation.
- Conditions
- Brain Tumor, Head and Neck Tumor, Skull Base Tumor
- Trial name
- NCT01228448
- Testing
- PET scan
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Massachusetts General Hospital
Skull Base Neoplasms
Effects on the Awakening With Laryngeal Mask vs Endotracheal Tube in Endoscopic Endonasal Transsphenoidal Base Surgery
The endoscopic endonasal transsphenoidal surgery (EETS) is widely used. Although the incidence of complications is low, hypertensive episodes during surgery and awakening and cerebro spinal fluid (CSF) leakage have been…
- Trial name
- NCT02988804
- Testing
- endotracheal tube, Laryngeal mask
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Acupuncture, Tumor, Brain
Evaluation of Acupuncture Effects for Complications After Surgery of Cerebellopontine Angle Tumor in Skull Base
Skull base tumors are a type of tumor that grow in the area of several skulls behind the cranial cavity. The incidence rate is 2 to 18 per 100,000 people per year; males and females are likely to have a proportional difference in…
- Conditions
- Acupuncture, Tumor, Brain, Skull Base Tumor, Cerebellopontine Angle Tumor
- Trial name
- NCT04249921
- Where
- Taiwan
- Volunteers
- 32 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Brain Tumors
Fluorescence Guided Resection of Brain Tumors
Removing a tumor from your brain is hard to do because, very often, brain tumors do not have boundaries that are easy for your surgeon to find. In many cases, the surgeon can't tell exactly where the tumor begins or ends.
- Trial name
- FGR (NCT00870779)
- Testing
- 5-aminolevulinic acid
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- David W. Roberts
Post Operative Care, Endoscopic Skull Base Surgery
Prospective Quality of Life Study in Pituitary Surgery
Post-operative assessment and debridement are key components in patient care for surgery patients. However, a standardized protocol for management after endoscopic skull base surgery is unavailable.
- Conditions
- Post Operative Care, Endoscopic Skull Base Surgery, Postoperative Period
- Trial name
- NCT03694990
- Testing
- Follow-up schedule
- Volunteers
- 165 people
- Sponsor
- University of Virginia
Skull Base Neoplasms
Skull Base Reconstruction After Endonasal Cranio-endoscopic Resection Using Autologus Grafts
Endonasal endoscopic approach to the skull base has been expanded in the last several years owing to advances in the radiological aspect that provided a better evaluation of the lesions and the surrounding structures…
- Trial name
- NCT03448614
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Skull Base Neoplasms
ICG Use in Angiography for Nasoseptal Flap Harvest
This is a feasibility study in which indocyanine green (ICG) will be administered during routine expanded endonasal approach (EEA) for cranial base pathologies in which a nasoseptal flap harvest will be necessary.
- Trial name
- ICG (NCT02117310)
- Testing
- indocyanine green
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Ohio State University