Clinical trials: Sleep Apnea/Hypopnea Syndrome
Sleep Disorder, Sleep Apnea Syndromes
Respiratory Rehabilitation in Obstructive Sleep Apneas
The Obstructive Sleep Apnea is characterized by obstruction of the upper airway during sleep (for at least 10 sec), with repeated breathing pauses, accompanied by oxygen desaturation in the blood and by sleep interruption with…
- Trial name
- OSA20 (NCT04412941)
- Testing
- Myofunctional exercises, The rules of sleep hygiene
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Università degli Studi 'G. d'Annunzio' Chieti e Pescara
Obstructive Sleep Apnea
Non-invasive Device for the Screening and Diagnosis of Sleep Apnea Syndrome
This prospective study aims to establish and evaluate a predictive model to diagnose OSA with maxillofacial characteristics 3D acquisition.
- Trial name
- Episas (NCT03632382)
- Testing
- 3D acquisition of maxillofacial characteristics
- Where
- France
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Obstructive Sleep Apnea (OSA), Down Syndrome
Endotype DIrected Treatment for OSA in Down Syndrome
Down syndrome is the most common genetic cause of intellectual disability. People with Down syndrome often have obstructive sleep apnea (OSA), a condition where people have difficulties with breathing while asleep.
- Trial name
- EDIT OSA (NCT07280468)
- Testing
- ato-oxy, Oxygen
- Where
- 5 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Arizona
Sleep Apnea, Obstructive
Evaluation of the Effect of AVE0657 on Obstructive Sleep Apnea
The primary objective of this study is to assess the activity of 4 escalating doses of AVE0657 in comparison to placebo in patients with Obstructive Sleep Apnea Hypopnea Syndrome.
- Trial name
- NCT00614250
- Testing
- AVE0657
- Where
- 3 sites in France, Germany and 1 more
- Volunteers
- 38 people
- Sponsor
- Sanofi
Ventilator-Induced Lung Injury
Intraop Ventilation Management and Postop Pulmonary Complications in High Risk Patients for OSA
Lung protective ventilation (LPV) has been proposed to reduce the incidence of postoperative pulmonary complications (PPCs), and protect against ventilator induced lung injury (VILI).
- Trial name
- NCT03135691
- Where
- United States
- Sponsor
- Ohio State University
Obstructive Sleep Apnea
Endotype-Targeted Therapy to Rescue OSA Patients Struggling With CPAP Adherence (TOP-CPAP)
More than 10% of the US population have obstructive sleep apnea (OSA). Standard of care is therapy with CPAP (continuous positive airway pressure) which virtually eliminates OSA.
- Trial name
- TOP-CPAP (NCT05951023)
- Testing
- Eszopiclone 2 mg
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of California, San Diego
Sleep Apnea, Chronic Kidney Diseases
Impact of Obstructive Sleep Apnea (OSA) Treatment on Blood Pressure Control in Chronic Kidney Disease
The role of obstructive sleep apnea (OSA) on chronic kidney disease (CKD) is not clear. This randomized clinical trial will test the impact of OSA treatment on blood pressure (BP) and on the estimated glomerular filtration rate…
- Trial name
- NCT05846490
- Testing
- CPAP, Usual care
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- University of Sao Paulo
Obstructive Sleep Apnea
Prospective Study Between Polysomnography (PSG) and Novel Ultrasonic Jaw Tracking Device in Patients with Sleep Apnea
Obstructive sleep apnea (OSA) affects over 936 million adults worldwide, leading to significant morbidity and reduced quality of life.
- Trial name
- NCT06862297
- Testing
- Ultrasonic Jaw Tracking Device
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Obstructive Sleep Apnea, Hodgkin Lymphoma
Obstructive Sleep Apnea in Survivors of Hodgkin Lymphoma Treated With Thoracic Radiation
While thoracic radiation therapy (TRT) has been a primary component in successful treatment of Hodgkin lymphoma, exposure to this treatment has been associated with significant cardiovascular, cerebrovascular, and pulmonary…
- Trial name
- NCT03361020
- Where
- United States
- Volunteers
- 434 people
- Sponsor
- St. Jude Children's Research Hospital
Obstructive Sleep Apnea
Validation of Sleep Apnea Screening Device Phase II
Obstructive sleep apnea (OSA) is the most common type of sleep apnea. The marketplace currently does not have an affordable, easy-to-use, over-the-counter, home-based OSA screening device.
- Trial name
- NCT03025464
- Testing
- Obstructive Sleep Apnea Screening Device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Michigan
Mild-Moderate Obstructive Sleep Disordered Breathing
Non-Inferiority Trial of Acute HFT Versus nCPAP
Order randomized crossover non-inferiority study evaluating the acute efficacy of High Flow Therapy (HFT) as compared to nasal Continuous Positive Airway Pressure therapy (CPAP) in the management of apnea / hypopnea index (AHI).
- Trial name
- NCT01860560
- Testing
- High-Flow Therapy, Continuous Positive Airway Pressure
- Where
- United States
- Sponsor
- Vapotherm, Inc.
Sleep Apnea, Obstructive
Intermitent Hypoxia and Its Pathophysiology Consequences in the Sleep Apnea-Hypopnea Syndrome.
Clinical trial on the effect of continuous positive pressure (CPAP). Objectives: 1) To assess the total or partial recovery of oxidative and inflammatory damage after recovering IH.
- Trial name
- NCT04444778
- Testing
- CPAP
- Where
- 2 sites in Spain
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Alberto Alonso Fernandez
Obstructive Sleep Apnea
Clinical Application of Ultrasound in Obstructive Sleep Apnea
We hypothesize the width air-colum of retropalatal region and tongue voulme by ultrsound through submental area is different between normal control with those with obstructive sleep apnea syndrome who was comfirmed by…
- Trial name
- NCT00674076
- Where
- Taiwan
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Obstructive Sleep Apnea
Airway Muscle Training for Obstructive Sleep Apnea
The purpose of this research study is to determine if muscle training will improve snoring and obstructive sleep apnea. Subjects will receive a sleep study to determine the severity of their apnea.
- Trial name
- OSA (NCT02259660)
- Testing
- Respiratory muscle strength training
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of Florida
Obstructive Sleep Apnea
An Investigation to Test the Efficacy of the High Flow (HF) Continuous Positive Airway Pressure (CPAP) in Patients With Obstructive Sleep Apnea (OSA)
Phase One: High Flow (HF) CPAP (HF-CPAP) Titration: Participants will attend the sleep lab to undergo a comprehensive split-night respiratory PSG.
- Trial name
- NCT01025440
- Testing
- Continuous Positive Airway Pressure
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Fisher and Paykel Healthcare
Diabetes, Sleep Apnea
CPAP in Diabetes Type 2 Patients With Sleep Apnea
Aim: To assess if six months of treatment with CPAP associated with conventional drug therapy, contribute to improved glycemic control in patients with type 2 diabetes and sleep apnea-hypopnea syndrome SAHS)
- Trial name
- DM-SAHS (NCT01801150)
- Testing
- CPAP nasal treatment
- Where
- Spain
- Volunteers
- 61 people
- Sponsor
- Hospital Universitario La Paz
Obstructive Sleep Apnea
PAP Systems Internal Clinical Studies (ICS)
This is a pre-market study for ongoing product development aiming to explore the usability and performance of the study PAP systems to guide product development.
- Trial name
- NCT06173050
- Testing
- PAP System A (with Amalfi) then PAP System B (with CLA11), PAP System B (with CLA11) then PAP System A (with Amalfi)
- Where
- Singapore
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ResMed
Obstructive Sleep Apnea-hypopnea Syndrome
The Role of Inflammatory Markers in OSAHS-Related White Matter Lesions and Asymptomatic Lacunar Infarction
This retrospective observational study aims to investigate the potential role of inflammatory markers associated with Obstructive Sleep Apnoea-Hypopnoea Syndrome (OSAHS) in the pathogenesis of white matter lesions (WML) and…
- Trial name
- NCT07061990
- Testing
- Polysomnography (PSG), Brain Magnetic Resonance Imaging (MRI), Serum Inflammatory Marker Measurement
- Where
- China
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Yanpeng Li
Obstructive Sleep Apnea (OSA)
C-LIFT Efficacy in Patients With Obstructive Sleep Apnea
The goal of this clinical trial is to evaluate the efficacy of the C-Lift Device as a non-invasive treatment for Sleep Disordered Breathing (SDB) within the population of adults diagnosed with moderate to severe Obstructive Sleep…
- Trial name
- EOSA (NCT07807124)
- Testing
- C-Lift
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Ata Murat Kaynar
Sleep Apnea, Snoring
Epigenetics Modifications in Obstructive Sleep Apnea
Changes in epigenetic regulation of genes involved in systemic inflammation and metabolic dysfunction in OSA are linked with accelerated cardiovascular morbidity.
- Trial name
- EPIOSA (NCT02131610)
- Where
- Spain
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Aragon Institute of Health Sciences
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