Clinical trials: Sleep Apnea Syndromes, Obstructive
Obstructive Sleep Apnea
Variable Negative External Pressure (vNEP) - An Alternative to Continuous Positive Airway Pressure (CPAP) for the Treatment of Obstructive Sleep Apnea (OSA): A Pilot Study
Non-compliance rates estimated at 50% pose a major issue for CPAP therapy, the primary treatment for OSA. Negative external pressure, applied over the anterior neck under the mandible, has shown encouraging results as an…
- Trial name
- NCT04718142
- Testing
- vNEP
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Somne, LLC
Obesity, Bariatric Surgery Candidate
Impact of Bariatric Surgery in Obese Patients With and Without Obstructive Sleep Apnea Syndrome
It has been shown to date that obesity is associated with increased mortality and that weight loss significantly improves cardiovascular risk factors.
- Conditions
- Obesity, Bariatric Surgery Candidate, Apnea, Obstructive
- Trial name
- COLOSS (NCT04179188)
- Testing
- Bariatric surgery
- Where
- France
- Volunteers
- 400 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Obstructive Sleep Apnoea Hypopnoea Syndrome, Biomarkers of Fibrin Clot Structure
New Markers to Measure Clotting in Patients With the Obstructive Sleep Apnoea Hypopnoea Syndrome
Obstructive Sleep Apnoea Hypopnoea Syndrome(OSAHS)affects at least 4% of males and 2% of females. OSAHS is the combination of excessive daytime sleepiness, snoring and apnoeas (stopping breathing at night).
- Conditions
- Obstructive Sleep Apnoea Hypopnoea Syndrome, Biomarkers of Fibrin Clot Structure, Biomarkers of Vascular Endothelial Injury
- Trial name
- NCT01525160
- Where
- United Kingdom
- Volunteers
- 66 people
- Sponsor
- Hywel Dda Health Board
Sleep Apnea, Obstructive, Patient Compliance
Continuous Positive Airway Pressure (CPAP) Compliance in Obstructive Sleep Apnea
This study aims to determine the average compliance of a patient under CPAP therapy for obstructive sleep apnea as well as the various factors that influence it.
- Trial name
- CPAPcompl (NCT02301923)
- Where
- Lebanon
- Volunteers
- 450 people
- Sponsor
- Saint-Joseph University
Snore, Obstructive Sleep Apnea
LATERAL PHARYNGOPLASTY OUTCOMES IN THE TREATMENT OF SNORE AND OBSTRUCTIVE SLEEP APNEA
The aim of this study is to describe the results of Lateral Pharyngoplasty in the treatment of snore and OSAS.
- Trial name
- NCT01574768
- Testing
- Lateral Pharyngoplasty
- Where
- Brazil
- Volunteers
- 300 people
- Sponsor
- Hospital do Servidor Publico Estadual
Obstructive Sleep Apnea
Mucosal Inflammation in Children With OSA
Objectives: Variability of clinical phenotypes in childhood obstructive sleep apnoea (OSA) has prompted research for biomarkers to identify patients at risk of developing OSA-related complications.
- Trial name
- NCT06452979
- Where
- Hong Kong
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Influenza
Response to Live Attenuated Influenza Vaccine in Tonsillar Tissues and Blood
This is one project of a larger ongoing study related to the immune system's response to the flu virus. This study is designed to investigate the immune response to a nasal flu immunization in tonsillar tissue compared to what…
- Trial name
- FLU-Tonsil (NCT03884296)
- Testing
- FluMist
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stanford University
Endothelial Dysfunction
Circulating Exosomes and Endothelial Dysfunction in Patients With Obstructive Sleep Apneas Hypopneas Syndrome
Evaluation of miRNA contained in exosomes in obese and OSA patients with endothelial dysfunction evaluated by digital plethysmography (ENDOPAT) compared to obese and OSA patients without endothelial dysfunction.
- Trial name
- EXODYS (NCT04459182)
- Testing
- ENDOPAT
- Where
- France
- Volunteers
- 99 people
- Sponsor
- University Hospital, Angers
Obstructive Sleep Apnea
Prospective Study Between Polysomnography (PSG) and Novel Ultrasonic Jaw Tracking Device in Patients with Sleep Apnea
Obstructive sleep apnea (OSA) affects over 936 million adults worldwide, leading to significant morbidity and reduced quality of life.
- Trial name
- NCT06862297
- Testing
- Ultrasonic Jaw Tracking Device
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Sleep Apnea, Obstructive
Study to Predict the Need for Humidification Use and Comparison of the Effect of ThermoSmart™ and no Humidification on Adherence
Despite the effectiveness of continuous positive airway pressure (CPAP) in abolishing upper airway obstruction, acceptance of and adherence with therapy has been sub-optimal.
- Trial name
- NCT01517750
- Testing
- ICON Auto CPAP™ with Thermosmart heated tube, ICON Auto CPAP™ without Thermosmart heated tube
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea, Hypopnea Syndrome
Retinal Nerve Fiber Layer Thickness Measurements in Patients With Sleep Apnea Syndrome
The purpose of this study was to measure the retinal nerve fiber layer (RNFL) thickness in eyes of Obstructive Sleep Apnea/hypopnea syndrome (OSAHS) using optical coherence tomography (OCT), and assess whether it is decreased.
- Conditions
- Obstructive Sleep Apnea, Hypopnea Syndrome, Glaucoma
- Trial name
- NCT01188291
- Where
- Israel
- Volunteers
- 166 people
- Sponsor
- Carmel Medical Center
Obstructive Sleep Apnea, Chronic Kidney Diseases
The Effect of OSA on Severity and Prognosis of Patients With CKD
This study aims to investigate the influence of obstructive sleep apnea hypopnea syndrome (OSA) on the severity and prognosis of patients with chronic kidney disease (CKD), and to evaluate the therapeutic effect of continuous…
- Trial name
- NCT06393023
- Testing
- Continuous Positive Airway Pressure
- Volunteers
- 200 people
- Sponsor
- Peking University First Hospital
Obstructive Sleep Apnea
Obstructive Sleep Apnea - Autonomic and Vascular Exploration
The goal of this clinical trial is to assess the effect of CPAP withdrawal on vascular and autonomic function in patients with obstructive sleep apnea.
- Trial name
- OSAVE (NCT05920083)
- Testing
- CPAP withdrawal
- Where
- Switzerland
- Volunteers
- 65 people
- Sponsor
- Raphael Heinzer
Obstructive Sleep Apnea (OSA)
Continous Positive Airway Pressure (CPAP) Compliance Study
Does an internet based text or email interaction and education improve CPAP compliance for patients with Obstructive sleep apnea (OSA) and reduce nursing intervention.
- Trial name
- ICAN (NCT01642160)
- Testing
- additional educational material, Standard of care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Obstructive Sleep Apnea, Down Syndrome
Validation of Sleep Questionnaires in the Down Syndrome Population
This will be a prospective validation study of a sample of consecutive pediatric Down syndrome patients who are seen through the weekly Down syndrome clinic at OHSU/Doernbecher's.
- Trial name
- NCT03771469
- Testing
- Sleep study
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Obstructive Sleep Apnea
Stimulation Therapy for Apnea Reduction (Www.theSTARtrial.Com)
The purpose of this clinical trial is to demonstrate long-term safety and efficacy of the Inspire system. The Inspire Upper Airway Stimulation (UAS) therapy is intended to treat moderate-to-severe obstructive sleep apnea by…
- Trial name
- STAR (NCT01161420)
- Testing
- Inspire Upper Airway Stimulation System
- Where
- 22 sites in United States, Belgium and 3 more
- Volunteers
- 929 people
- Sponsor
- Inspire Medical Systems, Inc.
Congestive Heart Failure, Chronic Obstructive Pulmonary Disease
Early Warning System
The study will begin in 2013 whereby patients having an early warning system (EWS) alert will be randomized to be seen by the rapid response team (RRT) for triage versus usual care.
- Conditions
- Congestive Heart Failure, Chronic Obstructive Pulmonary Disease, Cancer, Diabetes Mellitus
- Trial name
- NCT01741480
- Testing
- Early warning system monitoring., routine care
- Where
- United States
- Volunteers
- 571 people
- Sponsor
- Washington University School of Medicine
Obstructive Sleep Apnoea
The Use of Oral Appliances as an Adjunct to Continuous Positive Airway Pressure (CPAP) in the Treatment of Obstructive Sleep Apnoea
This study will look at whether patients with OSAHS already successfully treated with nasal CPAP could successfully use an oral appliance as a short-term treatment alternative and whether patients who could use an oral appliance…
- Trial name
- NCT00358605
- Testing
- The Klearway™ oral appliance
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University of British Columbia
Obstructive Sleep Apnea, Snoring
A Disposable Device NAS to Treat Obstructive Sleep Apnea and Snoring
The purpose of this research study is to test a new approach for treating patients with obstructive sleep apnea and/or snoring. The new nasal device, nastent (NAS: nasal airway stent), appears to be a useful alternative or…
- Trial name
- NCT02928770
- Testing
- Nastent
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Stanford University
Sleep Apnea, Obstructive
Nasal vs Oral Breathing in Drug Induced Sleep vs Natural Sleep
This project will provide important new information regarding (1) the relationship between route of breathing and airway collapsibility and (2) whether route of breathing during DISE (Drug-Induced Sleep Endoscopy) is…
- Trial name
- Nasal vs Oral (NCT06789770)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
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