Clinical trials: Sleep Apnea Syndromes, Obstructive
Obstructive Sleep Apnea
A Post-market Clinical Follow up of the Genio® System for the Treatment of Obstructive Sleep Apnea in Adults
The primary objective of this study is to confirm the safety and clinical effectiveness of the Genio® system in moderate to severe Obstructive Sleep Apnea (OSA) adult patients over a period of 5 years post-surgery.
- Trial name
- EliSA (NCT04031040)
- Testing
- Genio® system therapy
- Where
- 19 sites in Belgium, France and 3 more
- Volunteers
- 110 people
- Sponsor
- Nyxoah S.A.
Diabetic Macular Edema, Obstructive Sleep Apnea
Obstructive Sleep Apnea and Diabetic Macular Edema Inflammatory Mediators
Obstructive sleep apnea (OSA) is characterized by intermittent nocturnal hypoxemia, frequent arousals, fragmented sleep and daytime sleepiness.
- Conditions
- Diabetic Macular Edema, Obstructive Sleep Apnea, Diabetic Retinopathy
- Trial name
- NCT04648618
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Uptown Eye Specialists
Sleep Apnea, Obstructive, Sleep Apnea, Central
DreamKit Diagnostic Validation
This study has been developed in order to demonstrate diagnostic efficacy of the DreamKit device against polysomnography.
- Trial name
- NCT04671342
- Testing
- DreamKit
- Where
- 7 sites in United States
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- Philips Clinical & Medical Affairs Global
Obstructive Sleep Apnea
Domiciliary Transcutaneous Electrical Stimulation in Obstructive Sleep Apnoea
The aim of this study is to assess the efficacy of transcutaneous electrical stimulation of the pharyngeal dilator muscles in patients with obstructive sleep apnoea in the community compared to usual care, and follow the patients…
- Trial name
- TESLA-home (NCT03160456)
- Testing
- Transcutaneous electrical stimulation, Continuous positive airway pressure
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Adherence, Treatment, Health Literacy
Sociological Determinants of Positive Airway Pressure Adherence in OSA Patients
Multicentric, prospective, opened study to evaluate the impact of Health Literacy Levels on CPAP withdrawal in Obstructive Sleep Apnea patients within 6 months of inclusion.
- Conditions
- Adherence, Treatment, Health Literacy, Obstructive Sleep Apnea
- Trial name
- SOCIO-SAS (NCT05385302)
- Where
- 2 sites in France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Grenoble
Obstructive Sleep Apnea
Efficacy and Compliance of the Mandibular Advancement Devices ONIRIS® vs. Custom Made Devices
To evaluate the efficacy (non-inferiority) in terms of response between patients using custom fitted mandibular advancement devices ONIRIS® and patient using laboratory custom made devices TALI, after 2 months of use.
- Trial name
- IRIS (NCT02348970)
- Testing
- ONIRIS®, TALI
- Where
- 10 sites in France
- Volunteers
- 211 people
- Sponsor
- ONIRIS
Obstructive Sleep Apnea of Adult, Heart Valve Diseases
Loop Gain in the Reversion of OSA Treated by Either CPAP or Cardiac Valve Replacement
Sleep apnea including obstructive sleep apnea (OSA) and central sleep apnea (CSA), are common in patients with cardiovascular disease.
- Trial name
- NCT03839654
- Testing
- continuous positive airway pressure
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Nanjing Medical University
Obstructive Sleep Apnea
Pre and Post Orthopedic Surgery Sleep and Cardiac Testing (PROSPECT)
Evaluate sleep disordered breathing before and after orthopedic surgery utilizing a FDA cleared to market (510k) home sleep study device (Nexan Inc., ClearPath System) Compare Berlin Questionnaire and Epworth Sleep Scale…
- Trial name
- PROSPECT (NCT00785070)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Memorial Health System
Obstructive Sleep Apnea
Validation of Sleep Apnea Screening Device
Obstructive sleep apnea (OSA) is the most common type of sleep apnea. OSA affects an estimated 18-40 million adults and 0.7-3% of all children in the US.
- Trial name
- NCT02814227
- Testing
- Zansors® sleep screening device
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Michigan
Obstructive Sleep Apnea
To Study the Impact of CPAP on Gait Parameters in OSA Patients
To study the impact of CPAP therapy on gait in patients with obstructive sleep apnea syndrome.
- Trial name
- OSA_Gait (NCT02061046)
- Testing
- CPAP therapy
- Where
- Switzerland
- Volunteers
- 35 people
- Sponsor
- University Hospital, Geneva
Obesity Hypoventilation Syndrome
PAP Therapy in Patients With Obesity Hypoventilation Syndrome
The role of different levels of compliance and long-term effects of positive airway pressure (PAP) therapy on gas exchange, sleepiness, quality of life, depression and death rate in patients with obesity hypoventilation syndrome…
- Trial name
- NCT03449641
- Testing
- Positive airway pressure (PAP)
- Volunteers
- 252 people
- Sponsor
- University of Crete
Reduction of Initial AHI, Reduction of Initial Snoaring Index
Prospective Evaluation of a New Palatal Implant for Treatment of Snoring and Obstructive Sleep Apnea (OSAS)
Prospective Evaluation of a New Palatal Implant for Treatment of Snoring and Obstructive Sleep Apnea (OSAS)
- Trial name
- NCT02094482
- Testing
- The IMD is a resilient palatal implant which is introduced through a stab incision into the palate.
- Where
- Switzerland
- Volunteers
- 29 people
- Sponsor
- Medartis AG
Chronic Cough, OSA
Sham CPAP vs. Straight CPAP for Chronic Cough
Chronic cough is an important clinical problem in primary care and sub-specialty practice. Besides the distress experienced by patients with chronic cough, significant healthcare resources are expended to understand the role of…
- Trial name
- NCT03172130
- Testing
- Straight CPAP
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Krishna M. Sundar
Obstructive Sleep Apnea
Delphi Consensus Excessive Daytime Sleepiness in OSA
The objective of this study is to generate expert consensus statements on the differential diagnosis, definition, and management of EDS in patients with OSA who are adequately treated with primary therapy.
- Trial name
- NCT05055271
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- King's College London
Obesity, Obstructive Sleep Apnoea Syndrome
Study of Eating Behaviour and Sense of Taste Before and After Treatment With Nocturnal Continuous Positive Airway Pressure in Overweight Patients With Obstructive Sleep Apnea Syndrome.
Obstructive sleep apnea (OSA) is characterized by a repeated partial or complete obstruction of the airway that results in a intermittent hypoxia and sleep disturbance.
- Trial name
- GOUSAS (NCT03701737)
- Testing
- questionnaires, wrist actimeter, Blood samples
- Where
- France
- Volunteers
- 94 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
ST Elevated Myocardial Infarction, Sleep-Disordered Breathing
PRedictOrs, PHEnotypes and Timing of Obstructive Sleep Apnea in Acute Coronary Syndrome
Obstructive Sleep Apnea (OSA) is a well-known disorder of upper airways collapse during sleep time leading to oxygen desaturation and sleep fragmentation.
- Conditions
- ST Elevated Myocardial Infarction, Sleep-Disordered Breathing, Sleep, NSTEMI - Non-ST Segment Elevation MI
- Trial name
- PROPHET-ACS (NCT04002739)
- Testing
- Polygraphy
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sleep Disordered Breathing, Obstructive Sleep Apnea
The Natural History and Outcome of Sleep Disordered Breathing in Children
Sleep-disordered breathing in children is characterized by recurrent events of partial or complete upper airway obstruction during sleep, resulting in disruption of normal gas exchange (intermittent hypoxia and hypercapnia) and…
- Trial name
- NCT02043353
- Where
- Israel
- Volunteers
- 2,856 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Adherence to CPAP in Obstructive Sleep Apnea
Evaluating Behavioral Treatments to Improve Adherence to CPAP in People With Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a serious sleep disorder in which a person repeatedly stops breathing or experiences shallow breathing for short periods of time during sleep.
- Trial name
- BREATHE (NCT00939601)
- Testing
- Motivational Enhancement Therapy, Educational Counseling
- Sponsor
- Brown University
Hypertension
Treatment of OSA Associated Hypertension With Nebivolol or Hydrochlorothiazide
Patients who have obstructive sleep apnea (OSA) frequently stop breathing while they sleep. They often develop high blood pressure. We are not sure what drug is best to treat the high blood pressure.
- Trial name
- nebhctz (NCT02710071)
- Testing
- Nebivolol, Hydrochlorothiazide
- Volunteers
- 41 people
- Sponsor
- University of California, San Diego
Obstructive Sleep Apnea
Optiflow THRIVE for Delivery of Oxygen to Patients During Total Intravenous Anesthesia While Undergoing Radiology Procedures
This trial studies how well Optiflow THRIVE works in delivering oxygen to patients during total intravenous anesthesia while undergoing radiology procedures.
- Trial name
- NCT04171037
- Testing
- Oxygen Therapy, Questionnaire Administration, Optiflow THRIVE
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- M.D. Anderson Cancer Center
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