Clinical trials: Sleep Apnea Syndromes, Obstructive
Ischemic Stroke, Obstructive Sleep Apnea
Nasal EPAP for Stroke Patients With Sleep Apnea: a Pilot Trial.
Specific aim: To test the effects of nasal expiratory positive airway pressure (EPAP) therapy on sleep apnea severity among patients with recent ischemic stroke.
- Trial name
- NCT01703663
- Testing
- EPAP
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Obstructive Sleep Apnea
Pharmacological Activation of HMN for OSA
Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. OSA patients show a marked reduction in upper airway (UA) dilator muscle activity at sleep onset and this phenomenon…
- Trial name
- OSA12 (NCT03640052)
- Testing
- LTM1201L, LTM1201LN, LTM1201LB
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Brigham and Women's Hospital
Type 2 Diabetes, Obstructive Sleep Apnea
Diabetes-Obstructive Sleep Apnea Treatment Trial
Diabetes self-management is important to help adults with type 2 diabetes achieve glucose control. Obstructive sleep apnea often co-exists with type 2 diabetes and may act as a barrier to diabetes self-management and glucose…
- Trial name
- DOTT (NCT01901055)
- Testing
- CPAP, Diabetes Education
- Where
- 4 sites in United States
- Volunteers
- 98 people
- Sponsor
- Eileen R. Chasens
Obstructive Sleep Apnea
Evaluation of Acclimate Feature for Positive Airway Pressure (PAP) Therapy
The purpose of the study is to evaluate if using the Acclimate feature at the beginning of Positive Airway Pressure (PAP) therapy results in patients using their PAP therapy at least as long as they would standard therapy.
- Trial name
- NCT01421654
- Testing
- S9 Elite with Acclimate, S9 Elite
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- ResMed
Obstructive Sleep Apnea, OSA
Predictability of OSA With a Subjective Screening Scale (OSASSS1)
the study aims to evaluate the accuracy correlation between subjective perception of the air flow through airways from patients and survey and/or polysomnography they spent, using a brief clinical protocol they answered with a…
- Trial name
- OSASSS1 (NCT06092710)
- Testing
- neuro-sensorial subjective evaluation of the airways collapsibility
- Where
- Belgium
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Center for Sleep Medicine - Clinique André Renard
Obstructive Sleep Apnea
Sleep Apnea Intervention for Cardiovascular Disease Reduction
Moderate to severe sleep apnea (a high number of breathing pauses on a sleep study) is a common health problem that is often associated with loud snoring and sleepiness.The medical term for this problem is obstructive sleep apnea…
- Trial name
- BestAIR (NCT01261390)
- Testing
- Conservative Medical Therapy (CMT), Active PAP with RT Support (Active-Beh), Active PAP with Behavioral Modification (Active+Beh)
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- Brigham and Women's Hospital
Sleep Apnea, Obstructive
Validation of a Novel Device for Screening Patients With Symptoms of Obstructive Sleep Apnea
The purpose of this study is to evaluate the sensitivity and specificity of the Belun Ring Pulse Oximetry system for screening of obstructive sleep apnea (OSA) in adults during standard polysomnography sleep study conditions.
- Trial name
- NCT04121923
- Testing
- Belun Ring Pulse Oximeter
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Belun Technology Company Limited
Obstructive Sleep Apnea
Lifestyle Modification Program to Treat Obstructive Sleep Apnea Patients
Obstructive sleep apnea syndrome (OSAS) is a common form of sleep-disordered breathing (SDB) characterized by repetitive episodes of cessation of breathing during sleep due to upper airway collapse.
- Trial name
- OSA (NCT01384760)
- Testing
- Lifestyle modification, Simple lifestyle advice
- Where
- China
- Volunteers
- 185 people
- Sponsor
- Chinese University of Hong Kong
Sleep Apnea, Obstructive Sleep Apnea
Intraoperative Low-dose Ketamine Infusion for Patients With Obstructive Sleep Apnea
The aim of this study is to substantially reduce overall postoperative morbidity and mortality associated with obstructive sleep apnea.
- Conditions
- Sleep Apnea, Obstructive Sleep Apnea, Postoperative Complications
- Trial name
- NCT03109418
- Testing
- Ketamine, Control
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Perennial Allergic Rhinitis, Obstructive Sleep Apnea
The Effects of Mometasone Furoate Nasal Spray in Subjects With Sleep-disordered Breathing (SDB) Associated With Perennial Allergic Rhinitis (Study P04726)
This is a Phase 4 randomized, placebo-controlled, parallel-group, single-center, double-blind study to evaluate the effects of mometasone furoate nasal spray (MFNS) in subjects with Sleep-disordered Breathing (SDB) associated…
- Conditions
- Perennial Allergic Rhinitis, Obstructive Sleep Apnea, Sleep Disorder
- Trial name
- NCT00359216
- Testing
- Mometasone furoate nasal spray
- Volunteers
- 30 people
- Sponsor
- Organon and Co
Obstructive Sleep Apnea Syndrome
Upper Airway Physical Therapy for the Treatment of Obstructive Sleep Apnea
The purpose of this study is to determine the effectiveness and feasibility of upper airway muscle physical therapy utilizing negative airway pressure (NAP) breathing training in patients with Obstructive Sleep Apnea Syndrome…
- Trial name
- NCT02109731
- Testing
- Negative airway pressure delivery
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Rochester
Excessive Daytime Sleepiness, Narcolepsy
Extension Study of the Safety and Efficacy of Armodafinil in the Treatment of Patients With Excessive Sleepiness
A 12 Month, Open-Label, Flexible Dosage Extension Study of the Safety and Efficacy of Armodafinil (CEP-10953) in the Treatment of Patients with Excessive Sleepiness Associated with Narcolepsy, Obstructive Sleep Apnea/Hypopnea…
- Conditions
- Excessive Daytime Sleepiness, Narcolepsy, Obstructive Sleep Apnea/Hypopnea Syndrome, Chronic Shift Work Sleep Disorder
- Trial name
- NCT00228553
- Testing
- Armodafinil 100 to 250 mg/day
- Where
- 100 sites in United States, Australia and 5 more
- Volunteers
- 743 people
- Sponsor
- Cephalon
OSA - Obstructive Sleep Apnea
Parallel Arm Trial of AD109 and AD504 In Patients With OSA
This is a phase 2 randomized double-blind placebo-controlled parallel-arm dose finding study to compare fixed dose combinations of AD109 and AD504 to atomoxetine or placebo in Obstructive Sleep Apnea.
- Trial name
- MARIPOSA (NCT05071612)
- Testing
- AD109, AD504, Atomoxetine Hydrochloride
- Where
- 25 sites in United States
- Volunteers
- 294 people
- Sponsor
- Apnimed
Obesity Hypoventilation Syndrome
AVAPS-AE Efficacy Study
The purpose of this study is to evaluate the feasibility of using of the Average Volume Assured Pressure Support (AVAPS-AE) mode versus Continuous Positive Airway Pressure (CPAP) and bilevel pressure support ventilation (PSV)…
- Trial name
- NCT01368614
- Testing
- AVAPS-AE Mode of Therapy, Respironics OnmiLab BiPAP S mode, Respironics OmniLab Advanced CPAP mode
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Philips Respironics
Lung Diseases, Sleep Apnea Syndromes
Apnea Positive Pressure Long-Term Efficacy Study
The purpose of this study is to determine the effectiveness of nasal continuous positive airway pressure (CPAP) therapy for the treatment of obstructive sleep apnea syndrome (OSAS).
- Conditions
- Lung Diseases, Sleep Apnea Syndromes, Sleep
- Trial name
- APPLES (NCT00051363)
- Testing
- Active CPAP
- Where
- 5 sites in United States
- Volunteers
- 1,105 people
- Sponsor
- Stanford University
Polycystic Ovary Syndrome, Obstructive Sleep Apnea
Polycystic Ovary Syndrome (PCOS) and Sleep Apnea
Polycystic ovary syndrome (PCOS) affects 5-10% of women in the United States. Its onset is usually at the time of puberty with manifestations of menstrual irregularity, hirsutism, and obesity.
- Trial name
- NCT00203996
- Testing
- continuous positive airway pressure (CPAP), depot leuprolide plus estrogen/progestin replacement, pioglitazone
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Obstructive Sleep Apnea
Self-Management of Continuous Positive Airway Pressure Settings
Obstructive sleep apnea (OSA) is a major chronic condition affecting the quality of life of millions of Americans. Per the Institute of Medicine new treatment adherence strategies are needed to help improve the quality of care…
- Trial name
- ImPRESS (NCT03536572)
- Testing
- Sleep Apnea Self-Management Program
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- VA Office of Research and Development
Apnea, Sleep
Radiofrequency Ablation for Multi-level Obstructive Sleep Apnea: A Single-arm, Multicenter Study
The United States is currently experiencing an increase in the incidence and prevalence of obstructive sleep apnea (OSA). With prevalence in middle-aged adults of 2 to 4% of the population, untreated OSA has been implicated in…
- Trial name
- NCT02349893
- Testing
- RFA treatment
- Where
- 6 sites in United States
- Volunteers
- 56 people
- Sponsor
- Olympus Surgical Technologies Europe
Obstructive Sleep Apnea (OSA)
Pilot Study of the Comparison of the Upper Airway Dynamics of Oronasal vs Nasal Masks With PAP Treatment
Our group has recently found that the choice of positive airway pressure mask can significantly affect the pressure required to adequately treat sleep disordered breathing.
- Trial name
- Mask_MRI (NCT01939938)
- Testing
- Nasal and Oronasal PAP Mask
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Sleep Apnea, Obstructive
Investigation of a Novel Sleep Surface for Treatment of Positional Sleep Apnea
Body position during sleep influences the severity of obstructive sleep apnea (OSA). The AHI is the number of times per hour of sleep that the airway temporarily collapses at the level of the tongue or soft palate.
- Trial name
- NCT02250417
- Testing
- Wave sleep surface
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Ohio State University