Clinical trials: Sleep Deprivation
Physician Fatigue
Multi-center Clinical Trial of Limiting Resident Work Hours on ICU Patient Safety
In this proposal, we seek to address conclusively two knowledge gaps: 1) the lack of data on the relationship between PGY2+ (post graduate year 2) sleep deprivation and patient safety; and 2) the lack of data on the relationship…
- Trial name
- ROSTERS (NCT02134847)
- Testing
- SCS intervention schedule
- Where
- 6 sites in United States
- Volunteers
- 413 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Blood Pressure, Depression
Chronic Sleep Deprivation Among the Poor: A Lab-in-the-field Approach
A large body of medical research has shown that sleep deprivation adversely affects outcomes ranging from cognitive function to pain sensitivity and cardiovascular function.
- Trial name
- NCT03322358
- Testing
- Naps, Home sleep aids, Sleep incentives
- Where
- 2 sites in India
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
ICU Hospitalization, Circadian Rhythm
Sleep and Circadian Rhythm Intervention in ICU
Intensive care unit (ICU) patients are frequently exposed to various stressors that contribute to severe sleep disruption and circadian rhythm disturbances.
- Conditions
- ICU Hospitalization, Circadian Rhythm, Sleep Deprivation
- Trial name
- NCT07869901
- Testing
- Sound and Light Optimization, Night-time Patient Care Activities, Enhanced Daytime Mobility
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Shanghai Zhongshan Hospital
Sleep Insufficiency
A Personalized Mind-Body Intervention (MBI) for Improving Sleep Among Women Working in Healthcare
The goal of this pilot study is to determine if a personalized trial testing a Mind-Body Intervention (MBI) can produce a meaningful increase in the average daily sleep duration among women 40-60 years of age working in…
- Trial name
- NCT05789212
- Testing
- Personalized Trial ABCCBA, Personalized Trial CBAABC
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Sleep, Sleep Deprivation
Sleep Duration Required to Restore Performance During Chronic Sleep Restriction
The purpose of this study is to test the hypothesis that sleep and performance depend on length of time awake, length of time asleep, the amount of sleep over several sleep episodes, and circadian phase.
- Conditions
- Sleep, Sleep Deprivation, Insufficient Sleep Syndrome
- Trial name
- NCT01581125
- Testing
- Sleep:wake 1, Sleep:wake 2
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Sleep Deprivation, Healthy Volunteers
Effects of Sleep Deprivation on Diaphragm Command During an Inspiratory Endurance Trial in Healthy Volunteers.
The purpose of this study is to assess the impact of sleep deprivation on subjective inspiratory endurance in healthy subjects.
- Conditions
- Sleep Deprivation, Healthy Volunteers, Diaphragm
- Trial name
- NoSleepDiaph (NCT02725190)
- Testing
- Sleepless night, Normal sleep night
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Delirium, Sleep Deprivation
The Impact of Ramelteon on Sleep and Delirium in Patients Who Undergo Pulmonary Thromboendarterectomy (PTE) Surgery
Sleep deprivation is known to affect brain function but is often ignored in the sickest patients including those in the intensive care unit after major surgery. In these patients, the levels of melatonin can also be altered.
- Trial name
- NCT02691013
- Testing
- Ramelteon
- Volunteers
- 120 people
- Sponsor
- University of California, San Diego
Sleep Deprivation, Sleepiness
Metabolomics-based Sleepiness Markers
Estimating that people sleep on average up to two hours less over the last decades, sleepiness and fatigue need to be considered as significant societal problems of the modern world.
- Conditions
- Sleep Deprivation, Sleepiness, Insufficient Sleep Syndrome
- Trial name
- ME-SMART (NCT05585515)
- Testing
- Sleep deprivation, Sleep restriction
- Where
- Switzerland
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Obesity, Childhood, Nutrition, Healthy
Mobile Apps for Preschool Parents (MAPP) Study
The purpose of Mobile Apps for Preschool Parents (MAPP) Study is to test the effectiveness of two mobile applications for parents of preschool aged children: 1) an app focused on child and family nutrition and wellness, and 2) an…
- Conditions
- Obesity, Childhood, Nutrition, Healthy, Physical Inactivity, Sleep, Inadequate
- Trial name
- MAPP (NCT06520072)
- Testing
- Children Eating Well (CHEW) mobile app, Beanstalk mobile app
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Pamela Hull
Sleep, Metabolism Changes
Nighttime Synchrony of Your Nutrition and Circadian Health
Sleep is an important factor for overall health. This study will see how different light exposure patterns and food intake impact a person's metabolism (how the body breaks down food) when sleeping is reduced.
- Conditions
- Sleep, Metabolism Changes, Circadian Rhythm, Lifestyle Factors
- Trial name
- N-Sync (NCT07329283)
- Testing
- Central Clock Misalignment, Peripheral Misalignment
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Utah
Sleep Initiation and Maintenance Disorders
Behavioral and Pharmacological Treatment for Insomnia
This study will evaluate the long- and short-term effects of cognitive-behavior therapy (CBT), alone and in combination with zolpidem (Ambien®), for chronic insomnia.
- Trial name
- NCT00042146
- Testing
- Cognitive-behavior therapy, zolpidem
- Where
- Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Laval University
Sleep Deprivation, Insufficient Sleep Syndrome
Biomarkers of Insufficient Sleep and Sleepiness
Sleep and wakefulness disorders impact 50 to 70 million Americans and insufficient sleep is epidemic with over 50% of Americans reporting less than 7 hours of sleep per night.
- Conditions
- Sleep Deprivation, Insufficient Sleep Syndrome, Sleep Wake Disorders
- Trial name
- NCT03130803
- Testing
- Insufficient Sleep
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Delayed-onset Muscle Soreness, Sleep
Sleep and Delayed-onset Muscle Soreness
There is a need for further experimental research in order to gain a more in-depth understanding of this vicious cycle of pain and sleep disorders.
- Conditions
- Delayed-onset Muscle Soreness, Sleep, Pain
- Trial name
- NCT06699186
- Testing
- Sleep, Non-sleep
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Major Depressive Disorder, Bipolar Disorder
The Role of Dopamine Metabolism in the Antidepressant Effects of Sleep Deprivation and Sertraline in Depressed Patients
This study evaluates the efficacy of sleep deprivation treatment in accelerating antidepressant responses when administered during the first week of medications and augmenting a sustained response with chronobiological…
- Trial name
- NCT00581009
- Testing
- chronobiological augmentation, sertraline, lithium, one night of sleep deprivation and two FDG PET scans
- Where
- 2 sites in United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Epilepsy
Melatonin vs Sleep Deprivation for Nap EEG
In the pediatric population, electroencephalographic (EEG) recordings are frequently performed in sleep, as it reduces the amount of artifacts and might activate epileptiform discharges.
- Trial name
- NCT05654415
- Testing
- Melatonin, Deprivation
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Sleep Deprivation, Sleep Initiation and Maintenance Disorders
Comparing Tai Chi Training to a Low-Stress Physical Activity to Enhance Sleep in Older Adults
The purpose of this study is to examine the effects of Tai Chi, in comparison to conventional exercise, on the quality of sleep among sedentary older adults.
- Trial name
- NCT00079664
- Testing
- Tai Chi
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Oregon Research Institute
Sleep Deprivation
EEG Analysis for the Objective Assessment of Drowsiness
The objective of this clinical study is to develop solutions for the evaluation and management of drowsiness, based on 2 EEG sensors only, aiming at reducing the risk of accidents related to secondary hypersomnolence (sleepiness…
- Trial name
- MEEGASAFE (NCT05453643)
- Testing
- sleep deprivation patterns
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Physip S.A
Glucose Metabolism Disorders
Snooze Control: Sleep Duration & Glucose Metabolism
This project investigated how glucose metabolism differs due to sleep deprivation for three consecutive nights as compared to sufficient sleep for three nights by examining concentrations of glucose, insulin, and other factors…
- Trial name
- NCT02583750
- Testing
- OGTT after deprived sleep first, OGTT after sufficient sleep first
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Xuewen Wang
Depression, Sleep
The Acute Effect of Aerobic Exercise on Sleep in Patients With Depression
The aim of this trial is to investigate the effects of a single bout of aerobic exercise on sleep in patients with depression.
- Conditions
- Depression, Sleep, Sleep Disorder, Sleep Disturbance
- Trial name
- EASED (NCT03673397)
- Testing
- Aerobic exercise, bicycle ergometer
- Where
- Switzerland
- Volunteers
- 92 people
- Sponsor
- Oberwaid AG
Substance Use, Stress
Automating Peer Learning to Reduce Alcohol Use and Related Deviant Behavior in Secondary School
Deviant peer affiliation is one of the most important predictors of alcohol use in adolescence. These affiliations arise when socially marginalized youth self-aggregate and reinforce alcohol use and other deviant activity (i.e.…
- Conditions
- Substance Use, Stress, Relation, Interpersonal, Bullying
- Trial name
- PeerLearning (NCT04478240)
- Testing
- PeerLearning.net
- Where
- United States
- Volunteers
- 924 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.