Clinical trials: Sleep Deprivation
Critically Ill
24 Hour Intensivist Coverage in the Medical Intensive Care Unit
The Hospital of the University of Pennsylvania's Medical ICU (MICU) is implementing a model of 24-hour intensivist staffing in September 2011.
- Trial name
- NCT01434823
- Testing
- Nocturnal coverage
- Where
- United States
- Volunteers
- 1,609 people
- Sponsor
- University of Pennsylvania
Postpartum Period, Sleep
Relationship Between the Severity of Sleep Deprivation in the First 48 Hours Postpartum, Breastfeeding Motivation, and Breastfeeding Success
The postpartum period is a critical time marked by significant physiological and psychosocial changes that can affect sleep, emotional well-being, and breastfeeding behaviors.
- Conditions
- Postpartum Period, Sleep, Breastfeeding, Motivation
- Trial name
- NCT07413185
- Where
- Turkey (Türkiye)
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Mood Disorders, Major Depressive Disorder
Immune Activation, Neural Plasticity and Depression
Major depressive disorder (MDD) is a chronic, recurring and potentially life-threatening illness that affects up to 10% of the population across the globe.Increasing evidence indicates a clear link between immune dysfunction and…
- Conditions
- Mood Disorders, Major Depressive Disorder, Sleep Deprivation
- Trial name
- NCT06306248
- Testing
- Total sleep deprivation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS San Raffaele
Sleep, Sleep Deprivation
Effects of Acute Sleep Deprivation on Individuals With Different APOE Genotypes
This study aims to investigate the effects of 24-hour acute sleep deprivation on plasma Alzheimer's disease biomarkers and multi-omics in individuals with different APOE genotypes, to elucidate the potential role of acute sleep…
- Trial name
- NCT07085754
- Testing
- Sleep Deprivation
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yuhui Qiu
Sleep Initiation and Maintenance Disorders
Combined Behavioral/Pharmacological Therapy for Insomnia
This study will determine how sleeping pills can be combined with nondrug treatments to maximize the benefits of therapy for insomnia.
- Trial name
- NCT00044629
- Testing
- Cognitive-Behavioral Therapy for Insomnia, zolpidem tartrate (Ambien)
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Duke University
Obesity, Insufficient Sleep
Project SHINE (Sleep Health INitiative for Equity): Culturally Informing a Sleep Extension Intervention for African American Adults
The proposed research aims to reduce obesity-related health disparities by promoting healthy lifestyle behaviors among African Americans (AAs), given the high disease burdens associated with low physical activity, insufficient…
- Trial name
- NCT06226077
- Testing
- sleep extension intervention, contact control intervention
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Minnesota
Type 1 Diabetes, Insufficient Sleep
Assessment of Sleep and Sleep Disruptors in Adolescents With Type 1 Diabetes
The goal of this study is to identify causes of insufficient sleep and sleep disruptors in adolescents with type 1 diabetes. For this study, adolescents will wear an actigraphy watch and complete sleep diaries for seven days.
- Trial name
- NCT05370339
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Colorado, Denver
Sleep Deprivation, Sleep
Effects of Napping in Sleep-Restricted Adolescents
To examine the neurobehavioural responses to two successive cycles of sleep restriction and recovery in adolescents, and to determine the benefits of napping on cognitive performance, alertness, and mood.
- Trial name
- NCT02838095
- Testing
- Nap
- Where
- Singapore
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Nocturia, Sleep Deprivation
Abdominal Muscle Exercises on Nocturia and Sleep Quality in Women With Type 2 Diabetes
Nocturia is the leading cause of sleep disruption with its subsequent negative impact on general health and QoL for a large proportion of the adult population.
- Trial name
- NCT05222477
- Testing
- pelvic floor exercise, Abdominal muscles exercise
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Histamine, Cowhage
Investigation of the Effects of Sleep Fragmentation on Itch and Pain Sensitivity
In This experiment, the investigators would like to test following hypotheses regarding the influence of sleep fragmentation on itch: To investigate similarity and differences between itch and pain by comparing the effect of…
- Conditions
- Histamine, Cowhage, Sleep Fragmentation
- Trial name
- NCT06081946
- Testing
- Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Sleep Deprivation
Olfactory Contributions to Sleep-dependent Food Craving
This within-subject experiment uses one night of acute sleep restriction (4h) vs normal sleep (8h) to study state-dependent changes in olfactory processing.
- Trial name
- SDFC (NCT04179838)
- Testing
- Sleep-Deprived, Non-Sleep Deprived
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Northwestern University
COPD
Effect of Sleep Deprivation on Breathlessness and Exercise Capacity in COPD
This is a randomized controlled cross-over trial designed to measure the effect of one night's sleep deprivation on exercise endurance, ventilation and breathlessness in outpatients with COPD.
- Trial name
- NCT04997200
- Testing
- One night's sleeplessness
- Where
- 2 sites in Sweden
- Volunteers
- 20 people
- Sponsor
- Skane University Hospital
Sleep, Inadequate, Overweight and Obesity
Improving Metabolic & Mental Health in Female Healthcare Shift Workers
Circadian rhythm disruption caused by shift work alters metabolic and hormonal pathways, which accelerates chronic disease onset, leading to decreased quality and quantity of life.
- Conditions
- Sleep, Inadequate, Overweight and Obesity, Work Related Stress, Healthy Lifestyle
- Trial name
- NCT06158204
- Testing
- Lifestyle Intervention
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Auburn University
Healthy, Cognition
Reliability of Standardized IQ Testing Under Modafinil, Racetam-Class Compounds, Sleep Restriction and Daily Activity
This study examined whether standardized IQ test scores in healthy adults aged 18-35 are stable measures of cognitive ability and evaluated whether standardized cognitive-test performance and response-initiation measures vary…
- Conditions
- Healthy, Cognition, Sleep Deprivation
- Trial name
- NCT07852130
- Testing
- Modafinil, Oxiracetam, Pramiracetam
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Abdulraheem Mohamed Gouda
Critical Illness, Physiological Stress
Trial to Evaluate the Effects of Sound Modulation on Critically Ill Patients
The goal of the project is to determine the effects of noise masking and noise reduction on stress related physiological parameters in critically ill patients admitted to the intensive care unit.
- Conditions
- Critical Illness, Physiological Stress, Delirium, Sleep Deprivation
- Trial name
- SMART (NCT03019133)
- Testing
- Sound reduction, Sound masking
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Brian Gehlbach
Intensive Sleep Retraining, Total Sleep Deprivation
Intensive Sleep Retraining and Total Sleep Deprivation for Treating Chronic Insomnia
The present study was designed to evaluate the efficacy of intensive sleep retraining for treating insomnia and explore its potential mechanisms of action.
- Conditions
- Intensive Sleep Retraining, Total Sleep Deprivation, Control Condition
- Trial name
- NCT06615336
- Testing
- Intensive Sleep retraining, Total Sleep Deprivation
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Laval University
Healthy
Effects of Sleep Deprivation on Food Intake and Motor Activity in Man
Evidence that shortened period of sleep could be a risk factor for weight gain and obesity has grown over the past decade. Concurrent with the obesity epidemic, numerous studies have reported a parallel epidemic of chronic sleep…
- Trial name
- NCT00986492
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Sleep Apnea, Insomnia
Adult Sleep Health in the Rural Appalachia and Mississippi Delta Region and Its Relationships With Cardiometabolic Health Disparities.
Rural communities in the southern U.S. suffer a disproportionate burden of morbidity and mortality from cardiometabolic disease, with traditional risk factors explaining only a modest proportion of the excess burden of disease.
- Conditions
- Sleep Apnea, Insomnia, Sleep Deprivation, Sleep Disorders, Circadian Rhythm
- Trial name
- NCT06336525
- Where
- United States
- Volunteers
- 3,680 people
- Sponsor
- Brigham and Women's Hospital
Sleep Deprivation
Benefits of Sleep Extension on Performances During Total Sleep Deprivation (BankingSleep)
Objectives: investigate the effects of 6 nights of sleep extension on physical and cognitive performances before, during total sleep deprivation (39 hours continuous awaking) and after a subsequent recovery sleep.
- Trial name
- BankingSleep (NCT02352272)
- Testing
- Total Sleep deprivation
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche Biomedicale des Armees
Physician Well-being, Cognitive Function
Performance Nutrition for Residents and Fellows
Currently, residents commonly experience dehydration and poor nutrition during nighttime duty hours as a result of heavy work load, lack of time to take nutrition and hydration breaks, or limited or no access to healthy food and…
- Conditions
- Physician Well-being, Cognitive Function, Diet Modification, Diet Habit
- Trial name
- NCT03698123
- Testing
- Dietary Modification
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Stanford University